TriangleNCT02717507 · OUTCOME
Average Cardiac N-terminal Pro B-type Natriuretic Peptide
Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.
- Measure
- MEAN
- Unit
- pg/mL
- Interval / dispersion
- Standard Error
- Time frame
- Baseline before treatment, 6 months, 12 months, 18 months, 24 months after treatment initiation
What was measured
N-terminal pro b-type natriuretic peptide- a biomarker for heart failure (in pg/ml). The mean is reported by arm at each timepoint with corresponding standard errors.
Analysis population: We excluded 31 participants who did not have a second time point assessment of echocardiography, resulting in 151 analyzable participants.
Groups in this outcome
Arm I (Carvedilol)
Patients received Carvedilol PO delivered at 6.25 mg twice daily (for a total dose of 12.5 mg per day) for 24 months.
Arm II (Placebo)
Patients received Placebo PO delivered at 6.25 mg twice daily (for a total dose of 12.5 mg per day) for 24 months.
| Group | Source count |
|---|---|
| Arm I (Carvedilol) | 75 |
| Arm II (Placebo) | 76 |
Reported measurements
BL
| Group | Value | Spread | Lower | Upper | Comment |
|---|---|---|---|---|---|
| Arm I (Carvedilol) | 85.6301 | 13.3731 | Not reported | Not reported | Not reported |
| Arm II (Placebo) | 115.7222 | 22.243 | Not reported | Not reported | Not reported |
6m
| Group | Value | Spread | Lower | Upper | Comment |
|---|---|---|---|---|---|
| Arm I (Carvedilol) | 90.7536 | 11.7877 | Not reported | Not reported | Not reported |
| Arm II (Placebo) | 128.9565 | 23.736 | Not reported | Not reported | Not reported |
12m
| Group | Value | Spread | Lower | Upper | Comment |
|---|---|---|---|---|---|
| Arm I (Carvedilol) | 87.7167 | 13.38 | Not reported | Not reported | Not reported |
| Arm II (Placebo) | 115.6364 | 26.823 | Not reported | Not reported | Not reported |
18m
| Group | Value | Spread | Lower | Upper | Comment |
|---|---|---|---|---|---|
| Arm I (Carvedilol) | 99.4912 | 15.7275 | Not reported | Not reported | Not reported |
| Arm II (Placebo) | 93.2105 | 18.5618 | Not reported | Not reported | Not reported |
24m
| Group | Value | Spread | Lower | Upper | Comment |
|---|---|---|---|---|---|
| Arm I (Carvedilol) | 101.8333 | 14.2521 | Not reported | Not reported | Not reported |
| Arm II (Placebo) | 107.8490 | 26.6515 | Not reported | Not reported | Not reported |
Source statistical analyses
- ci Lower Limit
- -11.608
- ci Num Sides
- TWO_SIDED
- ci Pct Value
- 95
- ci Upper Limit
- 21.835
- dispersion Type
- STANDARD_ERROR_OF_MEAN
- dispersion Value
- 8.532
- estimate Comment
- The treatment can be considered beneficial if the mean difference (treatment - control) slope is negative
- group Ids
- OG000
- OG001
- non Inferiority Type
- OTHER
- p Value
- 0.55
- param Type
- Slope
- param Value
- 5.113
- statistical Comment
- The treatment effect was determined by testing the significance of the group by time interaction in GEE using a one degree-of-freedom (df) test.
- statistical Method
- Generalized Estimating Equation (GEE)
Complete source fields
- analyses
- ci Lower Limit
- -11.608
- ci Num Sides
- TWO_SIDED
- ci Pct Value
- 95
- ci Upper Limit
- 21.835
- dispersion Type
- STANDARD_ERROR_OF_MEAN
- dispersion Value
- 8.532
- estimate Comment
- The treatment can be considered beneficial if the mean difference (treatment - control) slope is negative
- group Ids
- OG000
- OG001
- non Inferiority Type
- OTHER
- p Value
- 0.55
- param Type
- Slope
- param Value
- 5.113
- statistical Comment
- The treatment effect was determined by testing the significance of the group by time interaction in GEE using a one degree-of-freedom (df) test.
- statistical Method
- Generalized Estimating Equation (GEE)
- classes
- categories
- measurements
- group Id
- OG000
- spread
- 13.3731
- value
- 85.6301
- group Id
- OG001
- spread
- 22.243
- value
- 115.7222
- title
- BL
- categories
- measurements
- group Id
- OG000
- spread
- 11.7877
- value
- 90.7536
- group Id
- OG001
- spread
- 23.736
- value
- 128.9565
- title
- 6m
- categories
- measurements
- group Id
- OG000
- spread
- 13.38
- value
- 87.7167
- group Id
- OG001
- spread
- 26.823
- value
- 115.6364
- title
- 12m
- categories
- measurements
- group Id
- OG000
- spread
- 15.7275
- value
- 99.4912
- group Id
- OG001
- spread
- 18.5618
- value
- 93.2105
- title
- 18m
- categories
- measurements
- group Id
- OG000
- spread
- 14.2521
- value
- 101.8333
- group Id
- OG001
- spread
- 26.6515
- value
- 107.8490
- title
- 24m
- denoms
- counts
- group Id
- OG000
- value
- 75
- group Id
- OG001
- value
- 76
- units
- Participants
- description
- N-terminal pro b-type natriuretic peptide- a biomarker for heart failure (in pg/ml). The mean is reported by arm at each timepoint with corresponding standard errors.
- dispersion Type
- Standard Error
- groups
- description
- Patients received Carvedilol PO delivered at 6.25 mg twice daily (for a total dose of 12.5 mg per day) for 24 months.
- id
- OG000
- title
- Arm I (Carvedilol)
- description
- Patients received Placebo PO delivered at 6.25 mg twice daily (for a total dose of 12.5 mg per day) for 24 months.
- id
- OG001
- title
- Arm II (Placebo)
- param Type
- MEAN
- population Description
- We excluded 31 participants who did not have a second time point assessment of echocardiography, resulting in 151 analyzable participants.
- reporting Status
- POSTED
- time Frame
- Baseline before treatment, 6 months, 12 months, 18 months, 24 months after treatment initiation
- title
- Average Cardiac N-terminal Pro B-type Natriuretic Peptide
- type
- SECONDARY
- unit Of Measure
- pg/mL
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Preserved source evidence · Not medical advice