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NCT02717455 · OUTCOME

Overall Survival (OS) in Stratum 2

Trial of Panobinostat in Children With Diffuse Intrinsic Pontine Glioma · Source last updated 2024-04-25

Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.

Measure
MEDIAN
Unit
months
Interval / dispersion
Full Range
Time frame
From date on treatment until date of death due to any cause or date of last follow-up

What was measured

OS was measured from the time of treatment initiation until the time of death due to any cause for patients who died, or until the time of last follow-up for patients who survived.

Analysis population: Non-progressed DIPG or H3K27M+ thalamic DMG patients who were enrolled on stratum 2 and received at least one dose of panobinostat were included in the analysis. Per the associated protocol objective, all dose levels on stratum 2 were combined to estimate the OS for this stratum. Two patients who did not start protocol therapy were excluded.

Groups in this outcome

Stratum 2

Non-progressed DIPG or H3K27M+ thalamic DMG patients who were treated with the "3 times/week, every other week" schedule.

Group identifiers and denominators belong to this outcome only. They may differ in another outcome or in safety reporting.

Analysis denominator · Participants

GroupSource count
Stratum 232

Reported measurements

Source class 1
Values in months · Interval/dispersion: Full Range
GroupValueSpreadLowerUpperComment
Stratum 29.13Not reported0.2320.30Not reported
Complete source fields
classes
  1. categories
    1. measurements
      1. group Id
        OG000
        lower Limit
        0.23
        upper Limit
        20.30
        value
        9.13
denoms
  1. counts
    1. group Id
      OG000
      value
      32
    units
    Participants
description
OS was measured from the time of treatment initiation until the time of death due to any cause for patients who died, or until the time of last follow-up for patients who survived.
dispersion Type
Full Range
groups
  1. description
    Non-progressed DIPG or H3K27M+ thalamic DMG patients who were treated with the "3 times/week, every other week" schedule.
    id
    OG000
    title
    Stratum 2
param Type
MEDIAN
population Description
Non-progressed DIPG or H3K27M+ thalamic DMG patients who were enrolled on stratum 2 and received at least one dose of panobinostat were included in the analysis. Per the associated protocol objective, all dose levels on stratum 2 were combined to estimate the OS for this stratum. Two patients who did not start protocol therapy were excluded.
reporting Status
POSTED
time Frame
From date on treatment until date of death due to any cause or date of last follow-up
title
Overall Survival (OS) in Stratum 2
type
SECONDARY
unit Of Measure
months

Download exact source JSON → · Snapshot ctgov-results-25a395029948b04d52b1253f

Preserved source evidence · Not medical advice