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NCT02711137 · OUTCOME

AUC0-24: Area Under the Steady-state Plasma Concentration-time Curve of INCB057643 Administered as Monotherapy

Open-Label Safety and Tolerability Study of INCB057643 in Subjects With Advanced Malignancies · Source last updated 2025-10-21

Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.

Measure
MEAN
Unit
h*nM
Interval / dispersion
Standard Deviation
Time frame
C2D1

What was measured

Area under the steady-state plasma concentration-time curve over 1 dosing interval from Hour 0 to 24 for QD administration of INCB057643 administered as monotherapy in fed state.

Analysis population: PK evaluable population includes all subjects who received at least 1 dose of study drug and had at least 1 PK sample collected and analyzed

Groups in this outcome

12mg QD INCB057643

Initial cohort dose of INCB057643 monotherapy at the protocol specified starting dose in Part 2 TGA and TGB

Group identifiers and denominators belong to this outcome only. They may differ in another outcome or in safety reporting.

Analysis denominator · Participants

GroupSource count
12mg QD INCB05764311

Reported measurements

Source class 1
Values in h*nM · Interval/dispersion: Standard Deviation
GroupValueSpreadLowerUpperComment
12mg QD INCB057643298031.5Not reportedNot reportedNot reported
Complete source fields
classes
  1. categories
    1. measurements
      1. group Id
        OG000
        spread
        31.5
        value
        2980
denoms
  1. counts
    1. group Id
      OG000
      value
      11
    units
    Participants
description
Area under the steady-state plasma concentration-time curve over 1 dosing interval from Hour 0 to 24 for QD administration of INCB057643 administered as monotherapy in fed state.
dispersion Type
Standard Deviation
groups
  1. description
    Initial cohort dose of INCB057643 monotherapy at the protocol specified starting dose in Part 2 TGA and TGB
    id
    OG000
    title
    12mg QD INCB057643
param Type
MEAN
population Description
PK evaluable population includes all subjects who received at least 1 dose of study drug and had at least 1 PK sample collected and analyzed
reporting Status
POSTED
time Frame
C2D1
title
AUC0-24: Area Under the Steady-state Plasma Concentration-time Curve of INCB057643 Administered as Monotherapy
type
SECONDARY
unit Of Measure
h*nM

Download exact source JSON → · Snapshot ctgov-results-25a395029948b04d52b1253f

Preserved source evidence · Not medical advice