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NCT02511106 · OUTCOME

Plasma Concentrations of AZ7550 Metabolites

AZD9291 Versus Placebo in Patients With Stage IB-IIIA Non-small Cell Lung Carcinoma, Following Complete Tumour Resection With or Without Adjuvant Chemotherapy. · Source last updated 2026-03-30

Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.

Measure
GEOMETRIC_MEAN
Unit
nM
Interval / dispersion
Geometric Coefficient of Variation
Time frame
From date of dosing to week 96 (approximately 24 months)

What was measured

The pharmacokinetics exposure parameters derived from plasma concentrations of AZ7550 metabolites

Analysis population: Pharmacokinetic analysis set

Groups in this outcome

AZ7550

AZD9291 metabolite

Group identifiers and denominators belong to this outcome only. They may differ in another outcome or in safety reporting.

Analysis denominator · Participants

GroupSource count
AZ7550325

Reported measurements

Week 4 - Pre-dose

Analysis denominator · Participants

GroupSource count
AZ7550225
Values in nM · Interval/dispersion: Geometric Coefficient of Variation
GroupValueSpreadLowerUpperComment
AZ755044.349256.5153Not reportedNot reportedNot reported
Week 4 - 0.5-1.5 hours

Analysis denominator · Participants

GroupSource count
AZ7550224
Values in nM · Interval/dispersion: Geometric Coefficient of Variation
GroupValueSpreadLowerUpperComment
AZ755044.738655.0410Not reportedNot reportedNot reported
Week 4 - 2-4 hours

Analysis denominator · Participants

GroupSource count
AZ7550223
Values in nM · Interval/dispersion: Geometric Coefficient of Variation
GroupValueSpreadLowerUpperComment
AZ755048.086461.8700Not reportedNot reportedNot reported
Week 24 - Pre-dose

Analysis denominator · Participants

GroupSource count
AZ7550171
Values in nM · Interval/dispersion: Geometric Coefficient of Variation
GroupValueSpreadLowerUpperComment
AZ755040.711375.3663Not reportedNot reportedNot reported
Week 24 - 0.5-1.5 hours

Analysis denominator · Participants

GroupSource count
AZ7550170
Values in nM · Interval/dispersion: Geometric Coefficient of Variation
GroupValueSpreadLowerUpperComment
AZ755040.937565.8656Not reportedNot reportedNot reported
Week 24 - 2-4 hours

Analysis denominator · Participants

GroupSource count
AZ7550169
Values in nM · Interval/dispersion: Geometric Coefficient of Variation
GroupValueSpreadLowerUpperComment
AZ755044.147660.2684Not reportedNot reportedNot reported
Week 48 - Pre-dose

Analysis denominator · Participants

GroupSource count
AZ7550104
Values in nM · Interval/dispersion: Geometric Coefficient of Variation
GroupValueSpreadLowerUpperComment
AZ755041.386252.2259Not reportedNot reportedNot reported
Week 48 - 0.5-1.5 hours

Analysis denominator · Participants

GroupSource count
AZ7550103
Values in nM · Interval/dispersion: Geometric Coefficient of Variation
GroupValueSpreadLowerUpperComment
AZ755041.046752.9773Not reportedNot reportedNot reported
Week 48 - 2-4 hours

Analysis denominator · Participants

GroupSource count
AZ7550102
Values in nM · Interval/dispersion: Geometric Coefficient of Variation
GroupValueSpreadLowerUpperComment
AZ755040.448699.6574Not reportedNot reportedNot reported
Week 96 - Pre-dose

Analysis denominator · Participants

GroupSource count
AZ755030
Values in nM · Interval/dispersion: Geometric Coefficient of Variation
GroupValueSpreadLowerUpperComment
AZ755028.1890180.0937Not reportedNot reportedNot reported
Week 96 - 0.5-1.5 hours

Analysis denominator · Participants

GroupSource count
AZ755031
Values in nM · Interval/dispersion: Geometric Coefficient of Variation
GroupValueSpreadLowerUpperComment
AZ755030.2419155.4156Not reportedNot reportedNot reported
Week 96 - 2-4 hours

Analysis denominator · Participants

GroupSource count
AZ755031
Values in nM · Interval/dispersion: Geometric Coefficient of Variation
GroupValueSpreadLowerUpperComment
AZ755033.965379.2841Not reportedNot reportedNot reported
Complete source fields
classes
  1. categories
    1. measurements
      1. group Id
        OG000
        spread
        56.5153
        value
        44.3492
    denoms
    1. counts
      1. group Id
        OG000
        value
        225
      units
      Participants
    title
    Week 4 - Pre-dose
  2. categories
    1. measurements
      1. group Id
        OG000
        spread
        55.0410
        value
        44.7386
    denoms
    1. counts
      1. group Id
        OG000
        value
        224
      units
      Participants
    title
    Week 4 - 0.5-1.5 hours
  3. categories
    1. measurements
      1. group Id
        OG000
        spread
        61.8700
        value
        48.0864
    denoms
    1. counts
      1. group Id
        OG000
        value
        223
      units
      Participants
    title
    Week 4 - 2-4 hours
  4. categories
    1. measurements
      1. group Id
        OG000
        spread
        75.3663
        value
        40.7113
    denoms
    1. counts
      1. group Id
        OG000
        value
        171
      units
      Participants
    title
    Week 24 - Pre-dose
  5. categories
    1. measurements
      1. group Id
        OG000
        spread
        65.8656
        value
        40.9375
    denoms
    1. counts
      1. group Id
        OG000
        value
        170
      units
      Participants
    title
    Week 24 - 0.5-1.5 hours
  6. categories
    1. measurements
      1. group Id
        OG000
        spread
        60.2684
        value
        44.1476
    denoms
    1. counts
      1. group Id
        OG000
        value
        169
      units
      Participants
    title
    Week 24 - 2-4 hours
  7. categories
    1. measurements
      1. group Id
        OG000
        spread
        52.2259
        value
        41.3862
    denoms
    1. counts
      1. group Id
        OG000
        value
        104
      units
      Participants
    title
    Week 48 - Pre-dose
  8. categories
    1. measurements
      1. group Id
        OG000
        spread
        52.9773
        value
        41.0467
    denoms
    1. counts
      1. group Id
        OG000
        value
        103
      units
      Participants
    title
    Week 48 - 0.5-1.5 hours
  9. categories
    1. measurements
      1. group Id
        OG000
        spread
        99.6574
        value
        40.4486
    denoms
    1. counts
      1. group Id
        OG000
        value
        102
      units
      Participants
    title
    Week 48 - 2-4 hours
  10. categories
    1. measurements
      1. group Id
        OG000
        spread
        180.0937
        value
        28.1890
    denoms
    1. counts
      1. group Id
        OG000
        value
        30
      units
      Participants
    title
    Week 96 - Pre-dose
  11. categories
    1. measurements
      1. group Id
        OG000
        spread
        155.4156
        value
        30.2419
    denoms
    1. counts
      1. group Id
        OG000
        value
        31
      units
      Participants
    title
    Week 96 - 0.5-1.5 hours
  12. categories
    1. measurements
      1. group Id
        OG000
        spread
        79.2841
        value
        33.9653
    denoms
    1. counts
      1. group Id
        OG000
        value
        31
      units
      Participants
    title
    Week 96 - 2-4 hours
denoms
  1. counts
    1. group Id
      OG000
      value
      325
    units
    Participants
description
The pharmacokinetics exposure parameters derived from plasma concentrations of AZ7550 metabolites
dispersion Type
Geometric Coefficient of Variation
groups
  1. description
    AZD9291 metabolite
    id
    OG000
    title
    AZ7550
param Type
GEOMETRIC_MEAN
population Description
Pharmacokinetic analysis set
reporting Status
POSTED
time Frame
From date of dosing to week 96 (approximately 24 months)
title
Plasma Concentrations of AZ7550 Metabolites
type
SECONDARY
unit Of Measure
nM

Download exact source JSON → · Snapshot ctgov-results-191f4516d4760045304b24a0

Preserved source evidence · Not medical advice