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NCT02511106 · OUTCOME

Plasma Concentrations of AZ5104 Metabolites

AZD9291 Versus Placebo in Patients With Stage IB-IIIA Non-small Cell Lung Carcinoma, Following Complete Tumour Resection With or Without Adjuvant Chemotherapy. · Source last updated 2026-03-30

Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.

Measure
GEOMETRIC_MEAN
Unit
nM
Interval / dispersion
Geometric Coefficient of Variation
Time frame
From date of dosing to week 96 (approximately 24 months)

What was measured

The pharmacokinetics exposure parameters derived from plasma concentrations of AZ5104 metabolites

Analysis population: Pharmacokinetic analysis set

Groups in this outcome

AZ5104

AZD9291 metabolite

Group identifiers and denominators belong to this outcome only. They may differ in another outcome or in safety reporting.

Analysis denominator · Participants

GroupSource count
AZ5104325

Reported measurements

Week 4 - Pre-dose

Analysis denominator · Participants

GroupSource count
AZ5104247
Values in nM · Interval/dispersion: Geometric Coefficient of Variation
GroupValueSpreadLowerUpperComment
AZ510444.461966.2108Not reportedNot reportedNot reported
Week 4 - 0.5-1.5 hours

Analysis denominator · Participants

GroupSource count
AZ5104246
Values in nM · Interval/dispersion: Geometric Coefficient of Variation
GroupValueSpreadLowerUpperComment
AZ510445.228067.0500Not reportedNot reportedNot reported
Week 4 - 2-4 hours

Analysis denominator · Participants

GroupSource count
AZ5104246
Values in nM · Interval/dispersion: Geometric Coefficient of Variation
GroupValueSpreadLowerUpperComment
AZ510449.608165.5757Not reportedNot reportedNot reported
Week 24 - Pre-dose

Analysis denominator · Participants

GroupSource count
AZ5104213
Values in nM · Interval/dispersion: Geometric Coefficient of Variation
GroupValueSpreadLowerUpperComment
AZ510438.7314111.0996Not reportedNot reportedNot reported
Week 24 - 0.5-1.5 hours

Analysis denominator · Participants

GroupSource count
AZ5104212
Values in nM · Interval/dispersion: Geometric Coefficient of Variation
GroupValueSpreadLowerUpperComment
AZ510439.168786.1118Not reportedNot reportedNot reported
Week 24 - 2-4 hours

Analysis denominator · Participants

GroupSource count
AZ5104211
Values in nM · Interval/dispersion: Geometric Coefficient of Variation
GroupValueSpreadLowerUpperComment
AZ510441.325199.2633Not reportedNot reportedNot reported
Week 48 - Pre-dose

Analysis denominator · Participants

GroupSource count
AZ5104198
Values in nM · Interval/dispersion: Geometric Coefficient of Variation
GroupValueSpreadLowerUpperComment
AZ510441.177853.8923Not reportedNot reportedNot reported
Week 48 - 0.5-1.5 hours

Analysis denominator · Participants

GroupSource count
AZ5104196
Values in nM · Interval/dispersion: Geometric Coefficient of Variation
GroupValueSpreadLowerUpperComment
AZ510440.927653.9916Not reportedNot reportedNot reported
Week 48 - 2-4 hours

Analysis denominator · Participants

GroupSource count
AZ5104195
Values in nM · Interval/dispersion: Geometric Coefficient of Variation
GroupValueSpreadLowerUpperComment
AZ510442.914368.8102Not reportedNot reportedNot reported
Week 96 - Pre-dose

Analysis denominator · Participants

GroupSource count
AZ5104126
Values in nM · Interval/dispersion: Geometric Coefficient of Variation
GroupValueSpreadLowerUpperComment
AZ510438.020581.4442Not reportedNot reportedNot reported
Week 96 - 0.5-1.5 hours

Analysis denominator · Participants

GroupSource count
AZ5104127
Values in nM · Interval/dispersion: Geometric Coefficient of Variation
GroupValueSpreadLowerUpperComment
AZ510436.9723101.2317Not reportedNot reportedNot reported
Week 96 - 2-4 hours

Analysis denominator · Participants

GroupSource count
AZ5104127
Values in nM · Interval/dispersion: Geometric Coefficient of Variation
GroupValueSpreadLowerUpperComment
AZ510439.805778.0300Not reportedNot reportedNot reported
Complete source fields
classes
  1. categories
    1. measurements
      1. group Id
        OG000
        spread
        66.2108
        value
        44.4619
    denoms
    1. counts
      1. group Id
        OG000
        value
        247
      units
      Participants
    title
    Week 4 - Pre-dose
  2. categories
    1. measurements
      1. group Id
        OG000
        spread
        67.0500
        value
        45.2280
    denoms
    1. counts
      1. group Id
        OG000
        value
        246
      units
      Participants
    title
    Week 4 - 0.5-1.5 hours
  3. categories
    1. measurements
      1. group Id
        OG000
        spread
        65.5757
        value
        49.6081
    denoms
    1. counts
      1. group Id
        OG000
        value
        246
      units
      Participants
    title
    Week 4 - 2-4 hours
  4. categories
    1. measurements
      1. group Id
        OG000
        spread
        111.0996
        value
        38.7314
    denoms
    1. counts
      1. group Id
        OG000
        value
        213
      units
      Participants
    title
    Week 24 - Pre-dose
  5. categories
    1. measurements
      1. group Id
        OG000
        spread
        86.1118
        value
        39.1687
    denoms
    1. counts
      1. group Id
        OG000
        value
        212
      units
      Participants
    title
    Week 24 - 0.5-1.5 hours
  6. categories
    1. measurements
      1. group Id
        OG000
        spread
        99.2633
        value
        41.3251
    denoms
    1. counts
      1. group Id
        OG000
        value
        211
      units
      Participants
    title
    Week 24 - 2-4 hours
  7. categories
    1. measurements
      1. group Id
        OG000
        spread
        53.8923
        value
        41.1778
    denoms
    1. counts
      1. group Id
        OG000
        value
        198
      units
      Participants
    title
    Week 48 - Pre-dose
  8. categories
    1. measurements
      1. group Id
        OG000
        spread
        53.9916
        value
        40.9276
    denoms
    1. counts
      1. group Id
        OG000
        value
        196
      units
      Participants
    title
    Week 48 - 0.5-1.5 hours
  9. categories
    1. measurements
      1. group Id
        OG000
        spread
        68.8102
        value
        42.9143
    denoms
    1. counts
      1. group Id
        OG000
        value
        195
      units
      Participants
    title
    Week 48 - 2-4 hours
  10. categories
    1. measurements
      1. group Id
        OG000
        spread
        81.4442
        value
        38.0205
    denoms
    1. counts
      1. group Id
        OG000
        value
        126
      units
      Participants
    title
    Week 96 - Pre-dose
  11. categories
    1. measurements
      1. group Id
        OG000
        spread
        101.2317
        value
        36.9723
    denoms
    1. counts
      1. group Id
        OG000
        value
        127
      units
      Participants
    title
    Week 96 - 0.5-1.5 hours
  12. categories
    1. measurements
      1. group Id
        OG000
        spread
        78.0300
        value
        39.8057
    denoms
    1. counts
      1. group Id
        OG000
        value
        127
      units
      Participants
    title
    Week 96 - 2-4 hours
denoms
  1. counts
    1. group Id
      OG000
      value
      325
    units
    Participants
description
The pharmacokinetics exposure parameters derived from plasma concentrations of AZ5104 metabolites
dispersion Type
Geometric Coefficient of Variation
groups
  1. description
    AZD9291 metabolite
    id
    OG000
    title
    AZ5104
param Type
GEOMETRIC_MEAN
population Description
Pharmacokinetic analysis set
reporting Status
POSTED
time Frame
From date of dosing to week 96 (approximately 24 months)
title
Plasma Concentrations of AZ5104 Metabolites
type
SECONDARY
unit Of Measure
nM

Download exact source JSON → · Snapshot ctgov-results-191f4516d4760045304b24a0

Preserved source evidence · Not medical advice