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NCT02511106 · OUTCOME

Plasma Concentrations of AZD9291

AZD9291 Versus Placebo in Patients With Stage IB-IIIA Non-small Cell Lung Carcinoma, Following Complete Tumour Resection With or Without Adjuvant Chemotherapy. · Source last updated 2026-03-30

Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.

Measure
GEOMETRIC_MEAN
Unit
nM
Interval / dispersion
Geometric Coefficient of Variation
Time frame
Collected at pre-dose, 0.5-1.5hours and 2-4hours post-dose up to 96 weeks (approximately 24 months)

What was measured

The pharmacokinetics exposure parameters derived from plasma concentrations of AZD9291

Analysis population: Pharmacokinetic analysis set

Groups in this outcome

AZD9291 80mg Tablet

Taken once daily

Group identifiers and denominators belong to this outcome only. They may differ in another outcome or in safety reporting.

Analysis denominator · Participants

GroupSource count
AZD9291 80mg Tablet325

Reported measurements

Week 4 - Pre-dose

Analysis denominator · Participants

GroupSource count
AZD9291 80mg Tablet247
Values in nM · Interval/dispersion: Geometric Coefficient of Variation
GroupValueSpreadLowerUpperComment
AZD9291 80mg Tablet380.256360.4465Not reportedNot reportedNot reported
Week 4 - 0.5-1.5 hours

Analysis denominator · Participants

GroupSource count
AZD9291 80mg Tablet246
Values in nM · Interval/dispersion: Geometric Coefficient of Variation
GroupValueSpreadLowerUpperComment
AZD9291 80mg Tablet383.914274.3191Not reportedNot reportedNot reported
Week 4 - 2-4 hours

Analysis denominator · Participants

GroupSource count
AZD9291 80mg Tablet246
Values in nM · Interval/dispersion: Geometric Coefficient of Variation
GroupValueSpreadLowerUpperComment
AZD9291 80mg Tablet463.009856.3562Not reportedNot reportedNot reported
Week 24- Pre-dose

Analysis denominator · Participants

GroupSource count
AZD9291 80mg Tablet213
Values in nM · Interval/dispersion: Geometric Coefficient of Variation
GroupValueSpreadLowerUpperComment
AZD9291 80mg Tablet288.8266181.8255Not reportedNot reportedNot reported
Week 24 - 0.5-1.5 hours

Analysis denominator · Participants

GroupSource count
AZD9291 80mg Tablet212
Values in nM · Interval/dispersion: Geometric Coefficient of Variation
GroupValueSpreadLowerUpperComment
AZD9291 80mg Tablet303.8269116.9411Not reportedNot reportedNot reported
Week 24 - 2-4 hours

Analysis denominator · Participants

GroupSource count
AZD9291 80mg Tablet211
Values in nM · Interval/dispersion: Geometric Coefficient of Variation
GroupValueSpreadLowerUpperComment
AZD9291 80mg Tablet358.831116.0567Not reportedNot reportedNot reported
Week 48- Pre-dose

Analysis denominator · Participants

GroupSource count
AZD9291 80mg Tablet198
Values in nM · Interval/dispersion: Geometric Coefficient of Variation
GroupValueSpreadLowerUpperComment
AZD9291 80mg Tablet301.7346125.4901Not reportedNot reportedNot reported
Week 48 - 0.5-1.5 hours

Analysis denominator · Participants

GroupSource count
AZD9291 80mg Tablet196
Values in nM · Interval/dispersion: Geometric Coefficient of Variation
GroupValueSpreadLowerUpperComment
AZD9291 80mg Tablet311.3503101.1574Not reportedNot reportedNot reported
Week 48 - 2-4 hours

Analysis denominator · Participants

GroupSource count
AZD9291 80mg Tablet195
Values in nM · Interval/dispersion: Geometric Coefficient of Variation
GroupValueSpreadLowerUpperComment
AZD9291 80mg Tablet375.666669.9838Not reportedNot reportedNot reported
Week 96- Pre-dose

Analysis denominator · Participants

GroupSource count
AZD9291 80mg Tablet126
Values in nM · Interval/dispersion: Geometric Coefficient of Variation
GroupValueSpreadLowerUpperComment
AZD9291 80mg Tablet287.537595.6634Not reportedNot reportedNot reported
Week 96 - 0.5-1.5 hours

Analysis denominator · Participants

GroupSource count
AZD9291 80mg Tablet127
Values in nM · Interval/dispersion: Geometric Coefficient of Variation
GroupValueSpreadLowerUpperComment
AZD9291 80mg Tablet273.3198126.003Not reportedNot reportedNot reported
Week 96 - 2-4 hours

Analysis denominator · Participants

GroupSource count
AZD9291 80mg Tablet127
Values in nM · Interval/dispersion: Geometric Coefficient of Variation
GroupValueSpreadLowerUpperComment
AZD9291 80mg Tablet341.580579.0578Not reportedNot reportedNot reported
Complete source fields
classes
  1. categories
    1. measurements
      1. group Id
        OG000
        spread
        60.4465
        value
        380.2563
    denoms
    1. counts
      1. group Id
        OG000
        value
        247
      units
      Participants
    title
    Week 4 - Pre-dose
  2. categories
    1. measurements
      1. group Id
        OG000
        spread
        74.3191
        value
        383.9142
    denoms
    1. counts
      1. group Id
        OG000
        value
        246
      units
      Participants
    title
    Week 4 - 0.5-1.5 hours
  3. categories
    1. measurements
      1. group Id
        OG000
        spread
        56.3562
        value
        463.0098
    denoms
    1. counts
      1. group Id
        OG000
        value
        246
      units
      Participants
    title
    Week 4 - 2-4 hours
  4. categories
    1. measurements
      1. group Id
        OG000
        spread
        181.8255
        value
        288.8266
    denoms
    1. counts
      1. group Id
        OG000
        value
        213
      units
      Participants
    title
    Week 24- Pre-dose
  5. categories
    1. measurements
      1. group Id
        OG000
        spread
        116.9411
        value
        303.8269
    denoms
    1. counts
      1. group Id
        OG000
        value
        212
      units
      Participants
    title
    Week 24 - 0.5-1.5 hours
  6. categories
    1. measurements
      1. group Id
        OG000
        spread
        116.0567
        value
        358.831
    denoms
    1. counts
      1. group Id
        OG000
        value
        211
      units
      Participants
    title
    Week 24 - 2-4 hours
  7. categories
    1. measurements
      1. group Id
        OG000
        spread
        125.4901
        value
        301.7346
    denoms
    1. counts
      1. group Id
        OG000
        value
        198
      units
      Participants
    title
    Week 48- Pre-dose
  8. categories
    1. measurements
      1. group Id
        OG000
        spread
        101.1574
        value
        311.3503
    denoms
    1. counts
      1. group Id
        OG000
        value
        196
      units
      Participants
    title
    Week 48 - 0.5-1.5 hours
  9. categories
    1. measurements
      1. group Id
        OG000
        spread
        69.9838
        value
        375.6666
    denoms
    1. counts
      1. group Id
        OG000
        value
        195
      units
      Participants
    title
    Week 48 - 2-4 hours
  10. categories
    1. measurements
      1. group Id
        OG000
        spread
        95.6634
        value
        287.5375
    denoms
    1. counts
      1. group Id
        OG000
        value
        126
      units
      Participants
    title
    Week 96- Pre-dose
  11. categories
    1. measurements
      1. group Id
        OG000
        spread
        126.003
        value
        273.3198
    denoms
    1. counts
      1. group Id
        OG000
        value
        127
      units
      Participants
    title
    Week 96 - 0.5-1.5 hours
  12. categories
    1. measurements
      1. group Id
        OG000
        spread
        79.0578
        value
        341.5805
    denoms
    1. counts
      1. group Id
        OG000
        value
        127
      units
      Participants
    title
    Week 96 - 2-4 hours
denoms
  1. counts
    1. group Id
      OG000
      value
      325
    units
    Participants
description
The pharmacokinetics exposure parameters derived from plasma concentrations of AZD9291
dispersion Type
Geometric Coefficient of Variation
groups
  1. description
    Taken once daily
    id
    OG000
    title
    AZD9291 80mg Tablet
param Type
GEOMETRIC_MEAN
population Description
Pharmacokinetic analysis set
reporting Status
POSTED
time Frame
Collected at pre-dose, 0.5-1.5hours and 2-4hours post-dose up to 96 weeks (approximately 24 months)
title
Plasma Concentrations of AZD9291
type
SECONDARY
unit Of Measure
nM

Download exact source JSON → · Snapshot ctgov-results-191f4516d4760045304b24a0

Preserved source evidence · Not medical advice