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NCT02414139 · BASELINE

Baseline characteristics

Study of Oral cMET Inhibitor INC280 in Patients With EGFR Wild-type (wt), Advanced Non-small Cell Lung Cancer (NSCLC) (Geometry Mono-1) · Source last updated 2024-03-20

Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.

denoms
  1. counts
    1. group Id
      BG000
      value
      69
    2. group Id
      BG001
      value
      42
    3. group Id
      BG002
      value
      54
    4. group Id
      BG003
      value
      30
    5. group Id
      BG004
      value
      69
    6. group Id
      BG005
      value
      15
    7. group Id
      BG006
      value
      28
    8. group Id
      BG007
      value
      3
    9. group Id
      BG008
      value
      31
    10. group Id
      BG009
      value
      32
    11. group Id
      BG010
      value
      373
    units
    Participants
groups
  1. description
    Pre-treated patients with MET GCN ≥ 10 treated with INC280 at 400mg BID as second or third line (2/3L)
    id
    BG000
    title
    Cohort 1a: Pre-treated Patients With MET GCN ≥ 10 (2/3L)
  2. description
    Pre-treated patients with MET GCN ≥ 6 and \< 10 treated with INC280 at 400 mg BID as second or third line (2/3L)
    id
    BG001
    title
    Cohort 1b: Pre-treated Patients With MET GCN ≥ 6 and < 10 (2/3L)
  3. description
    Pre-treated patients with MET GCN ≥ 4 and \< 6 treated with INC280 at 400mg BID as second or third line (2/3L)
    id
    BG002
    title
    Cohort 2: Pre-treated Patients With MET GCN ≥ 4 and < 6 (2/3L)
  4. description
    Pre-treated patients with MET GCN \< 4 treated with INC280 at 400mg BID as second or third line (2/3L)
    id
    BG003
    title
    Cohort 3: Pre-treated Patients With MET GCN < 4 (2/3L)
  5. description
    Pre-treated patients with MET mutation regardless of MET GCN treated with INC280 at 400mg BID as second or third line (2/3L)
    id
    BG004
    title
    Cohort 4: Pre-treated Patients With MET Mutation Regardless of MET GCN (2/3L)
  6. description
    Treatment-naïve patients with MET GCN ≥10 treated with INC280 at 400mg BID as first-line (1L)
    id
    BG005
    title
    Cohort 5a: Treatment-naïve Patients With MET GCN ≥10 (1L)
  7. description
    Treatment-naïve patients with MET mutation regardless of MET GCN treated with INC280 at 400mg BID as first line (1L)
    id
    BG006
    title
    Cohort 5b: Treatment-naïve Patients With MET Mutation Regardless of MET GCN (1L)
  8. description
    Pre-treated patients with MET GCN ≥ 10 without MET mutation treated with INC280 at 400 mg BID as second line (2L) (expansion cohort of Cohort 1a)
    id
    BG007
    title
    Cohort 6.1 (Expansion of Cohort 1a): Pre-treated Patients MET GCN ≥ 10 Without MET Mutation (2L)
  9. description
    Pre-treated patients with MET mutation regardless of MET GCN treated with INC280 at 400 mg BID as second line (2L)(expansion of Cohort 4)
    id
    BG008
    title
    Cohort 6.2 (Expansion of Cohort 4): Pre-treated Patients With MET Mutation (2L)
  10. description
    Treatment-naïve patients with MET mutation regardless of MET GCN treated with INC280 at 400mg BID as first line (1L) (expansion cohort of Cohort 5b)
    id
    BG009
    title
    Cohort 7 (Expansion of Cohort 5b): Treatment-naïve With MET Mutation Regardless of MET GCN (1L)
  11. description
    Total of all reporting groups
    id
    BG010
    title
    Total
measures
  1. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          spread
          9.56
          value
          60.9
        2. group Id
          BG001
          spread
          9.11
          value
          59.5
        3. group Id
          BG002
          spread
          10.00
          value
          61.7
        4. group Id
          BG003
          spread
          9.23
          value
          61.7
        5. group Id
          BG004
          spread
          8.32
          value
          71.0
        6. group Id
          BG005
          spread
          10.36
          value
          68.2
        7. group Id
          BG006
          spread
          7.02
          value
          72.4
        8. group Id
          BG007
          spread
          10.69
          value
          60.7
        9. group Id
          BG008
          spread
          6.29
          value
          69.0
        10. group Id
          BG009
          spread
          8.35
          value
          73.3
        11. group Id
          BG010
          spread
          10.18
          value
          65.7
    dispersion Type
    STANDARD_DEVIATION
    param Type
    MEAN
    title
    Age, Continuous
    unit Of Measure
    Years
  2. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          15
        2. group Id
          BG001
          value
          21
        3. group Id
          BG002
          value
          15
        4. group Id
          BG003
          value
          11
        5. group Id
          BG004
          value
          40
        6. group Id
          BG005
          value
          4
        7. group Id
          BG006
          value
          18
        8. group Id
          BG007
          value
          1
        9. group Id
          BG008
          value
          16
        10. group Id
          BG009
          value
          23
        11. group Id
          BG010
          value
          164
        title
        Female
      2. measurements
        1. group Id
          BG000
          value
          54
        2. group Id
          BG001
          value
          21
        3. group Id
          BG002
          value
          39
        4. group Id
          BG003
          value
          19
        5. group Id
          BG004
          value
          29
        6. group Id
          BG005
          value
          11
        7. group Id
          BG006
          value
          10
        8. group Id
          BG007
          value
          2
        9. group Id
          BG008
          value
          15
        10. group Id
          BG009
          value
          9
        11. group Id
          BG010
          value
          209
        title
        Male
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Sex: Female, Male
    unit Of Measure
    Participants
  3. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          17
        2. group Id
          BG001
          value
          4
        3. group Id
          BG002
          value
          14
        4. group Id
          BG003
          value
          11
        5. group Id
          BG004
          value
          19
        6. group Id
          BG005
          value
          6
        7. group Id
          BG006
          value
          4
        8. group Id
          BG007
          value
          1
        9. group Id
          BG008
          value
          5
        10. group Id
          BG009
          value
          3
        11. group Id
          BG010
          value
          84
        title
        Asian
      2. measurements
        1. group Id
          BG000
          value
          1
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          0
        4. group Id
          BG003
          value
          0
        5. group Id
          BG004
          value
          0
        6. group Id
          BG005
          value
          0
        7. group Id
          BG006
          value
          0
        8. group Id
          BG007
          value
          0
        9. group Id
          BG008
          value
          1
        10. group Id
          BG009
          value
          1
        11. group Id
          BG010
          value
          3
        title
        Black
      3. measurements
        1. group Id
          BG000
          value
          51
        2. group Id
          BG001
          value
          38
        3. group Id
          BG002
          value
          40
        4. group Id
          BG003
          value
          19
        5. group Id
          BG004
          value
          49
        6. group Id
          BG005
          value
          9
        7. group Id
          BG006
          value
          24
        8. group Id
          BG007
          value
          1
        9. group Id
          BG008
          value
          24
        10. group Id
          BG009
          value
          26
        11. group Id
          BG010
          value
          281
        title
        Caucasian
      4. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          0
        4. group Id
          BG003
          value
          0
        5. group Id
          BG004
          value
          1
        6. group Id
          BG005
          value
          0
        7. group Id
          BG006
          value
          0
        8. group Id
          BG007
          value
          0
        9. group Id
          BG008
          value
          1
        10. group Id
          BG009
          value
          0
        11. group Id
          BG010
          value
          2
        title
        Native American
      5. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          0
        4. group Id
          BG003
          value
          0
        5. group Id
          BG004
          value
          0
        6. group Id
          BG005
          value
          0
        7. group Id
          BG006
          value
          0
        8. group Id
          BG007
          value
          1
        9. group Id
          BG008
          value
          0
        10. group Id
          BG009
          value
          0
        11. group Id
          BG010
          value
          1
        title
        Unknown
      6. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          0
        4. group Id
          BG003
          value
          0
        5. group Id
          BG004
          value
          0
        6. group Id
          BG005
          value
          0
        7. group Id
          BG006
          value
          0
        8. group Id
          BG007
          value
          0
        9. group Id
          BG008
          value
          0
        10. group Id
          BG009
          value
          2
        11. group Id
          BG010
          value
          2
        title
        Other
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Race/Ethnicity, Customized
    unit Of Measure
    Participants
Complete source fields
denoms
  1. counts
    1. group Id
      BG000
      value
      69
    2. group Id
      BG001
      value
      42
    3. group Id
      BG002
      value
      54
    4. group Id
      BG003
      value
      30
    5. group Id
      BG004
      value
      69
    6. group Id
      BG005
      value
      15
    7. group Id
      BG006
      value
      28
    8. group Id
      BG007
      value
      3
    9. group Id
      BG008
      value
      31
    10. group Id
      BG009
      value
      32
    11. group Id
      BG010
      value
      373
    units
    Participants
groups
  1. description
    Pre-treated patients with MET GCN ≥ 10 treated with INC280 at 400mg BID as second or third line (2/3L)
    id
    BG000
    title
    Cohort 1a: Pre-treated Patients With MET GCN ≥ 10 (2/3L)
  2. description
    Pre-treated patients with MET GCN ≥ 6 and \< 10 treated with INC280 at 400 mg BID as second or third line (2/3L)
    id
    BG001
    title
    Cohort 1b: Pre-treated Patients With MET GCN ≥ 6 and < 10 (2/3L)
  3. description
    Pre-treated patients with MET GCN ≥ 4 and \< 6 treated with INC280 at 400mg BID as second or third line (2/3L)
    id
    BG002
    title
    Cohort 2: Pre-treated Patients With MET GCN ≥ 4 and < 6 (2/3L)
  4. description
    Pre-treated patients with MET GCN \< 4 treated with INC280 at 400mg BID as second or third line (2/3L)
    id
    BG003
    title
    Cohort 3: Pre-treated Patients With MET GCN < 4 (2/3L)
  5. description
    Pre-treated patients with MET mutation regardless of MET GCN treated with INC280 at 400mg BID as second or third line (2/3L)
    id
    BG004
    title
    Cohort 4: Pre-treated Patients With MET Mutation Regardless of MET GCN (2/3L)
  6. description
    Treatment-naïve patients with MET GCN ≥10 treated with INC280 at 400mg BID as first-line (1L)
    id
    BG005
    title
    Cohort 5a: Treatment-naïve Patients With MET GCN ≥10 (1L)
  7. description
    Treatment-naïve patients with MET mutation regardless of MET GCN treated with INC280 at 400mg BID as first line (1L)
    id
    BG006
    title
    Cohort 5b: Treatment-naïve Patients With MET Mutation Regardless of MET GCN (1L)
  8. description
    Pre-treated patients with MET GCN ≥ 10 without MET mutation treated with INC280 at 400 mg BID as second line (2L) (expansion cohort of Cohort 1a)
    id
    BG007
    title
    Cohort 6.1 (Expansion of Cohort 1a): Pre-treated Patients MET GCN ≥ 10 Without MET Mutation (2L)
  9. description
    Pre-treated patients with MET mutation regardless of MET GCN treated with INC280 at 400 mg BID as second line (2L)(expansion of Cohort 4)
    id
    BG008
    title
    Cohort 6.2 (Expansion of Cohort 4): Pre-treated Patients With MET Mutation (2L)
  10. description
    Treatment-naïve patients with MET mutation regardless of MET GCN treated with INC280 at 400mg BID as first line (1L) (expansion cohort of Cohort 5b)
    id
    BG009
    title
    Cohort 7 (Expansion of Cohort 5b): Treatment-naïve With MET Mutation Regardless of MET GCN (1L)
  11. description
    Total of all reporting groups
    id
    BG010
    title
    Total
measures
  1. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          spread
          9.56
          value
          60.9
        2. group Id
          BG001
          spread
          9.11
          value
          59.5
        3. group Id
          BG002
          spread
          10.00
          value
          61.7
        4. group Id
          BG003
          spread
          9.23
          value
          61.7
        5. group Id
          BG004
          spread
          8.32
          value
          71.0
        6. group Id
          BG005
          spread
          10.36
          value
          68.2
        7. group Id
          BG006
          spread
          7.02
          value
          72.4
        8. group Id
          BG007
          spread
          10.69
          value
          60.7
        9. group Id
          BG008
          spread
          6.29
          value
          69.0
        10. group Id
          BG009
          spread
          8.35
          value
          73.3
        11. group Id
          BG010
          spread
          10.18
          value
          65.7
    dispersion Type
    STANDARD_DEVIATION
    param Type
    MEAN
    title
    Age, Continuous
    unit Of Measure
    Years
  2. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          15
        2. group Id
          BG001
          value
          21
        3. group Id
          BG002
          value
          15
        4. group Id
          BG003
          value
          11
        5. group Id
          BG004
          value
          40
        6. group Id
          BG005
          value
          4
        7. group Id
          BG006
          value
          18
        8. group Id
          BG007
          value
          1
        9. group Id
          BG008
          value
          16
        10. group Id
          BG009
          value
          23
        11. group Id
          BG010
          value
          164
        title
        Female
      2. measurements
        1. group Id
          BG000
          value
          54
        2. group Id
          BG001
          value
          21
        3. group Id
          BG002
          value
          39
        4. group Id
          BG003
          value
          19
        5. group Id
          BG004
          value
          29
        6. group Id
          BG005
          value
          11
        7. group Id
          BG006
          value
          10
        8. group Id
          BG007
          value
          2
        9. group Id
          BG008
          value
          15
        10. group Id
          BG009
          value
          9
        11. group Id
          BG010
          value
          209
        title
        Male
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Sex: Female, Male
    unit Of Measure
    Participants
  3. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          17
        2. group Id
          BG001
          value
          4
        3. group Id
          BG002
          value
          14
        4. group Id
          BG003
          value
          11
        5. group Id
          BG004
          value
          19
        6. group Id
          BG005
          value
          6
        7. group Id
          BG006
          value
          4
        8. group Id
          BG007
          value
          1
        9. group Id
          BG008
          value
          5
        10. group Id
          BG009
          value
          3
        11. group Id
          BG010
          value
          84
        title
        Asian
      2. measurements
        1. group Id
          BG000
          value
          1
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          0
        4. group Id
          BG003
          value
          0
        5. group Id
          BG004
          value
          0
        6. group Id
          BG005
          value
          0
        7. group Id
          BG006
          value
          0
        8. group Id
          BG007
          value
          0
        9. group Id
          BG008
          value
          1
        10. group Id
          BG009
          value
          1
        11. group Id
          BG010
          value
          3
        title
        Black
      3. measurements
        1. group Id
          BG000
          value
          51
        2. group Id
          BG001
          value
          38
        3. group Id
          BG002
          value
          40
        4. group Id
          BG003
          value
          19
        5. group Id
          BG004
          value
          49
        6. group Id
          BG005
          value
          9
        7. group Id
          BG006
          value
          24
        8. group Id
          BG007
          value
          1
        9. group Id
          BG008
          value
          24
        10. group Id
          BG009
          value
          26
        11. group Id
          BG010
          value
          281
        title
        Caucasian
      4. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          0
        4. group Id
          BG003
          value
          0
        5. group Id
          BG004
          value
          1
        6. group Id
          BG005
          value
          0
        7. group Id
          BG006
          value
          0
        8. group Id
          BG007
          value
          0
        9. group Id
          BG008
          value
          1
        10. group Id
          BG009
          value
          0
        11. group Id
          BG010
          value
          2
        title
        Native American
      5. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          0
        4. group Id
          BG003
          value
          0
        5. group Id
          BG004
          value
          0
        6. group Id
          BG005
          value
          0
        7. group Id
          BG006
          value
          0
        8. group Id
          BG007
          value
          1
        9. group Id
          BG008
          value
          0
        10. group Id
          BG009
          value
          0
        11. group Id
          BG010
          value
          1
        title
        Unknown
      6. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          0
        4. group Id
          BG003
          value
          0
        5. group Id
          BG004
          value
          0
        6. group Id
          BG005
          value
          0
        7. group Id
          BG006
          value
          0
        8. group Id
          BG007
          value
          0
        9. group Id
          BG008
          value
          0
        10. group Id
          BG009
          value
          2
        11. group Id
          BG010
          value
          2
        title
        Other
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Race/Ethnicity, Customized
    unit Of Measure
    Participants

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Preserved source evidence · Not medical advice