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NCT02367781 · BASELINE

Baseline characteristics

A Study of Atezolizumab in Combination With Carboplatin Plus (+) Nab-Paclitaxel Compared With Carboplatin+Nab-Paclitaxel in Participants With Stage IV Non-Squamous Non-Small Cell Lung Cancer (NSCLC) · Source last updated 2021-08-09

Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.

denoms
  1. counts
    1. group Id
      BG000
      value
      483
    2. group Id
      BG001
      value
      240
    3. group Id
      BG002
      value
      723
    units
    Participants
groups
  1. description
    Participants received intravenous (IV) infusion of atezolizumab and carboplatin on Day 1 of each 21-day cycle, and nab-paclitaxel on Days 1, 8, and 15 of each 21-day cycle for 4 or 6 cycles or until loss of clinical benefit whichever occurs first during induction treatment phase. Participants received IV infusion of atezolizumab during maintenance treatment phase until loss of clinical benefit.
    id
    BG000
    title
    Arm A (Atezolizumab+Nab-Paclitaxel+Carboplatin)
  2. description
    Participants received IV infusion of carboplatin on Day 1 and nab-paclitaxel on Days 1, 8, and 15 of each 21-day cycle for 4 or 6 cycles or until disease progression whichever occurs first during induction treatment phase. Participants will receive best supportive care during maintenance treatment phase. Switch maintenance to pemetrexed is also permitted. Participants who were consented prior to approval of protocol Version 5 will be given the option to cross over to receive atezolizumab as monotherapy until disease progression.
    id
    BG001
    title
    Arm B (Nab-Paclitaxel+Carboplatin)
  3. description
    Total of all reporting groups
    id
    BG002
    title
    Total
measures
  1. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          spread
          9.5
          value
          63.8
        2. group Id
          BG001
          spread
          8.9
          value
          64.4
        3. group Id
          BG002
          spread
          9.3
          value
          64.0
    dispersion Type
    STANDARD_DEVIATION
    param Type
    MEAN
    title
    Age, Continuous
    unit Of Measure
    Years
  2. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          206
        2. group Id
          BG001
          value
          102
        3. group Id
          BG002
          value
          308
        title
        Female
      2. measurements
        1. group Id
          BG000
          value
          277
        2. group Id
          BG001
          value
          138
        3. group Id
          BG002
          value
          415
        title
        Male
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Sex: Female, Male
    unit Of Measure
    Participants
  3. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          25
        2. group Id
          BG001
          value
          12
        3. group Id
          BG002
          value
          37
        title
        Hispanic or Latino
      2. measurements
        1. group Id
          BG000
          value
          426
        2. group Id
          BG001
          value
          213
        3. group Id
          BG002
          value
          639
        title
        Not Hispanic or Latino
      3. measurements
        1. group Id
          BG000
          value
          32
        2. group Id
          BG001
          value
          15
        3. group Id
          BG002
          value
          47
        title
        Unknown or Not Reported
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Ethnicity (NIH/OMB)
    unit Of Measure
    Participants
  4. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          0
        title
        American Indian or Alaska Native
      2. measurements
        1. group Id
          BG000
          value
          14
        2. group Id
          BG001
          value
          3
        3. group Id
          BG002
          value
          17
        title
        Asian
      3. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          0
        title
        Native Hawaiian or Other Pacific Islander
      4. measurements
        1. group Id
          BG000
          value
          18
        2. group Id
          BG001
          value
          8
        3. group Id
          BG002
          value
          26
        title
        Black or African American
      5. measurements
        1. group Id
          BG000
          value
          428
        2. group Id
          BG001
          value
          222
        3. group Id
          BG002
          value
          650
        title
        White
      6. measurements
        1. group Id
          BG000
          value
          2
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          2
        title
        More than one race
      7. measurements
        1. group Id
          BG000
          value
          21
        2. group Id
          BG001
          value
          7
        3. group Id
          BG002
          value
          28
        title
        Unknown or Not Reported
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Race (NIH/OMB)
    unit Of Measure
    Participants
Complete source fields
denoms
  1. counts
    1. group Id
      BG000
      value
      483
    2. group Id
      BG001
      value
      240
    3. group Id
      BG002
      value
      723
    units
    Participants
groups
  1. description
    Participants received intravenous (IV) infusion of atezolizumab and carboplatin on Day 1 of each 21-day cycle, and nab-paclitaxel on Days 1, 8, and 15 of each 21-day cycle for 4 or 6 cycles or until loss of clinical benefit whichever occurs first during induction treatment phase. Participants received IV infusion of atezolizumab during maintenance treatment phase until loss of clinical benefit.
    id
    BG000
    title
    Arm A (Atezolizumab+Nab-Paclitaxel+Carboplatin)
  2. description
    Participants received IV infusion of carboplatin on Day 1 and nab-paclitaxel on Days 1, 8, and 15 of each 21-day cycle for 4 or 6 cycles or until disease progression whichever occurs first during induction treatment phase. Participants will receive best supportive care during maintenance treatment phase. Switch maintenance to pemetrexed is also permitted. Participants who were consented prior to approval of protocol Version 5 will be given the option to cross over to receive atezolizumab as monotherapy until disease progression.
    id
    BG001
    title
    Arm B (Nab-Paclitaxel+Carboplatin)
  3. description
    Total of all reporting groups
    id
    BG002
    title
    Total
measures
  1. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          spread
          9.5
          value
          63.8
        2. group Id
          BG001
          spread
          8.9
          value
          64.4
        3. group Id
          BG002
          spread
          9.3
          value
          64.0
    dispersion Type
    STANDARD_DEVIATION
    param Type
    MEAN
    title
    Age, Continuous
    unit Of Measure
    Years
  2. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          206
        2. group Id
          BG001
          value
          102
        3. group Id
          BG002
          value
          308
        title
        Female
      2. measurements
        1. group Id
          BG000
          value
          277
        2. group Id
          BG001
          value
          138
        3. group Id
          BG002
          value
          415
        title
        Male
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Sex: Female, Male
    unit Of Measure
    Participants
  3. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          25
        2. group Id
          BG001
          value
          12
        3. group Id
          BG002
          value
          37
        title
        Hispanic or Latino
      2. measurements
        1. group Id
          BG000
          value
          426
        2. group Id
          BG001
          value
          213
        3. group Id
          BG002
          value
          639
        title
        Not Hispanic or Latino
      3. measurements
        1. group Id
          BG000
          value
          32
        2. group Id
          BG001
          value
          15
        3. group Id
          BG002
          value
          47
        title
        Unknown or Not Reported
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Ethnicity (NIH/OMB)
    unit Of Measure
    Participants
  4. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          0
        title
        American Indian or Alaska Native
      2. measurements
        1. group Id
          BG000
          value
          14
        2. group Id
          BG001
          value
          3
        3. group Id
          BG002
          value
          17
        title
        Asian
      3. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          0
        title
        Native Hawaiian or Other Pacific Islander
      4. measurements
        1. group Id
          BG000
          value
          18
        2. group Id
          BG001
          value
          8
        3. group Id
          BG002
          value
          26
        title
        Black or African American
      5. measurements
        1. group Id
          BG000
          value
          428
        2. group Id
          BG001
          value
          222
        3. group Id
          BG002
          value
          650
        title
        White
      6. measurements
        1. group Id
          BG000
          value
          2
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          2
        title
        More than one race
      7. measurements
        1. group Id
          BG000
          value
          21
        2. group Id
          BG001
          value
          7
        3. group Id
          BG002
          value
          28
        title
        Unknown or Not Reported
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Race (NIH/OMB)
    unit Of Measure
    Participants

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Preserved source evidence · Not medical advice