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NCT02354508 · OUTCOME

Extension Phase: Percentage of Participants Reporting Levels 1 - 5 by Dimensions of Acromegaly Symptoms

Pasireotide in Patients With Acromegaly Inadequately Controlled With First Generation Somatostatin Analogues · Source last updated 2019-12-10

Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.

Measure
NUMBER
Unit
Percentage of participants
Interval / dispersion
Not reported
Time frame
Weeks 48, 60 & 72

What was measured

Symptoms of acromegaly were collected at various visits. The measurement was to be provided on a scale of 1-15 including half sizes. Investigators asked the participants to score the following symptoms of acromegaly: headache, fatigue, perspiration, paresthesias, osteoarthralgia according to a five-point score scale (0=absent, 1=mild, 2=moderate, 3=severe, 4=very severe).

Analysis population: Extension FAS included all the patients who received at least one dose of pasireotide LAR in the extension phase.

Groups in this outcome

Pasireotide LAR Overall - Acromegaly Symptom: Headache

This is the sum total of participants who were treated with at least one dose of pasireotide LAR in the extension phase

Pasireotide LAR Overall - Acromegaly Symptom: Fatigue

This is the sum total of participants who were treated with at least one dose of pasireotide LAR in the extension phase

Pasireotide LAR Overall - Acromegaly Symptom: Perspiration

This is the sum total of participants who were treated with at least one dose of pasireotide LAR in the extension phase

Pasireotide LAR Overall - Acromegaly Symptom: Osteoarthralgia

This is the sum total of participants who were treated with at least one dose of pasireotide LAR in the extension phase

Pasireotide LAR Overall - Acromegaly Symptom: Paresthesiae

This is the sum total of participants who were treated with at least one dose of pasireotide LAR in the extension phase

Group identifiers and denominators belong to this outcome only. They may differ in another outcome or in safety reporting.

Analysis denominator · Participants

GroupSource count
Pasireotide LAR Overall - Acromegaly Symptom: Headache88
Pasireotide LAR Overall - Acromegaly Symptom: Fatigue88
Pasireotide LAR Overall - Acromegaly Symptom: Perspiration88
Pasireotide LAR Overall - Acromegaly Symptom: Osteoarthralgia88
Pasireotide LAR Overall - Acromegaly Symptom: Paresthesiae88

Reported measurements

Week 48: None/absent

Analysis denominator · Participants

GroupSource count
Pasireotide LAR Overall - Acromegaly Symptom: Headache81
Pasireotide LAR Overall - Acromegaly Symptom: Fatigue81
Pasireotide LAR Overall - Acromegaly Symptom: Perspiration81
Pasireotide LAR Overall - Acromegaly Symptom: Osteoarthralgia81
Pasireotide LAR Overall - Acromegaly Symptom: Paresthesiae81
Values in Percentage of participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
Pasireotide LAR Overall - Acromegaly Symptom: Headache63.6Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Fatigue59.1Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Perspiration69.3Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Osteoarthralgia53.4Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Paresthesiae71.6Not reportedNot reportedNot reportedNot reported
Week 48: Mild

Analysis denominator · Participants

GroupSource count
Pasireotide LAR Overall - Acromegaly Symptom: Headache81
Pasireotide LAR Overall - Acromegaly Symptom: Fatigue81
Pasireotide LAR Overall - Acromegaly Symptom: Perspiration81
Pasireotide LAR Overall - Acromegaly Symptom: Osteoarthralgia81
Pasireotide LAR Overall - Acromegaly Symptom: Paresthesiae81
Values in Percentage of participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
Pasireotide LAR Overall - Acromegaly Symptom: Headache19.3Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Fatigue17.0Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Perspiration13.6Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Osteoarthralgia25.0Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Paresthesiae14.8Not reportedNot reportedNot reportedNot reported
Week 48: Moderate

Analysis denominator · Participants

GroupSource count
Pasireotide LAR Overall - Acromegaly Symptom: Headache81
Pasireotide LAR Overall - Acromegaly Symptom: Fatigue81
Pasireotide LAR Overall - Acromegaly Symptom: Perspiration81
Pasireotide LAR Overall - Acromegaly Symptom: Osteoarthralgia81
Pasireotide LAR Overall - Acromegaly Symptom: Paresthesiae81
Values in Percentage of participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
Pasireotide LAR Overall - Acromegaly Symptom: Headache8.0Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Fatigue12.5Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Perspiration9.1Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Osteoarthralgia9.1Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Paresthesiae4.5Not reportedNot reportedNot reportedNot reported
Week 48: Severe

Analysis denominator · Participants

GroupSource count
Pasireotide LAR Overall - Acromegaly Symptom: Headache81
Pasireotide LAR Overall - Acromegaly Symptom: Fatigue81
Pasireotide LAR Overall - Acromegaly Symptom: Perspiration81
Pasireotide LAR Overall - Acromegaly Symptom: Osteoarthralgia81
Pasireotide LAR Overall - Acromegaly Symptom: Paresthesiae81
Values in Percentage of participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
Pasireotide LAR Overall - Acromegaly Symptom: Headache1.1Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Fatigue3.4Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Perspiration0.0Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Osteoarthralgia3.4Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Paresthesiae0.0Not reportedNot reportedNot reportedNot reported
Week 48: Very severe

Analysis denominator · Participants

GroupSource count
Pasireotide LAR Overall - Acromegaly Symptom: Headache81
Pasireotide LAR Overall - Acromegaly Symptom: Fatigue81
Pasireotide LAR Overall - Acromegaly Symptom: Perspiration81
Pasireotide LAR Overall - Acromegaly Symptom: Osteoarthralgia81
Pasireotide LAR Overall - Acromegaly Symptom: Paresthesiae81
Values in Percentage of participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
Pasireotide LAR Overall - Acromegaly Symptom: Headache0.0Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Fatigue0.0Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Perspiration0.0Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Osteoarthralgia1.1Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Paresthesiae1.1Not reportedNot reportedNot reportedNot reported
Week 48: Not done

Analysis denominator · Participants

GroupSource count
Pasireotide LAR Overall - Acromegaly Symptom: Headache81
Pasireotide LAR Overall - Acromegaly Symptom: Fatigue81
Pasireotide LAR Overall - Acromegaly Symptom: Perspiration81
Pasireotide LAR Overall - Acromegaly Symptom: Osteoarthralgia81
Pasireotide LAR Overall - Acromegaly Symptom: Paresthesiae81
Values in Percentage of participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
Pasireotide LAR Overall - Acromegaly Symptom: Headache0.0Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Fatigue0.0Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Perspiration0.0Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Osteoarthralgia0.0Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Paresthesiae0.0Not reportedNot reportedNot reportedNot reported
Week 60: None/absent

Analysis denominator · Participants

GroupSource count
Pasireotide LAR Overall - Acromegaly Symptom: Headache77
Pasireotide LAR Overall - Acromegaly Symptom: Fatigue77
Pasireotide LAR Overall - Acromegaly Symptom: Perspiration77
Pasireotide LAR Overall - Acromegaly Symptom: Osteoarthralgia77
Pasireotide LAR Overall - Acromegaly Symptom: Paresthesiae77
Values in Percentage of participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
Pasireotide LAR Overall - Acromegaly Symptom: Headache60.2Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Fatigue48.9Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Perspiration60.2Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Osteoarthralgia56.8Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Paresthesiae70.5Not reportedNot reportedNot reportedNot reported
Week 60: Mild

Analysis denominator · Participants

GroupSource count
Pasireotide LAR Overall - Acromegaly Symptom: Headache77
Pasireotide LAR Overall - Acromegaly Symptom: Fatigue77
Pasireotide LAR Overall - Acromegaly Symptom: Perspiration77
Pasireotide LAR Overall - Acromegaly Symptom: Osteoarthralgia77
Pasireotide LAR Overall - Acromegaly Symptom: Paresthesiae77
Values in Percentage of participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
Pasireotide LAR Overall - Acromegaly Symptom: Headache17.0Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Fatigue20.5Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Perspiration20.5Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Osteoarthralgia14.8Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Paresthesiae10.2Not reportedNot reportedNot reportedNot reported
Week 60: Moderate

Analysis denominator · Participants

GroupSource count
Pasireotide LAR Overall - Acromegaly Symptom: Headache77
Pasireotide LAR Overall - Acromegaly Symptom: Fatigue77
Pasireotide LAR Overall - Acromegaly Symptom: Perspiration77
Pasireotide LAR Overall - Acromegaly Symptom: Osteoarthralgia77
Pasireotide LAR Overall - Acromegaly Symptom: Paresthesiae77
Values in Percentage of participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
Pasireotide LAR Overall - Acromegaly Symptom: Headache6.8Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Fatigue13.6Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Perspiration6.8Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Osteoarthralgia11.4Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Paresthesiae4.5Not reportedNot reportedNot reportedNot reported
Week 60: Severe

Analysis denominator · Participants

GroupSource count
Pasireotide LAR Overall - Acromegaly Symptom: Headache77
Pasireotide LAR Overall - Acromegaly Symptom: Fatigue77
Pasireotide LAR Overall - Acromegaly Symptom: Perspiration77
Pasireotide LAR Overall - Acromegaly Symptom: Osteoarthralgia77
Pasireotide LAR Overall - Acromegaly Symptom: Paresthesiae77
Values in Percentage of participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
Pasireotide LAR Overall - Acromegaly Symptom: Headache3.4Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Fatigue4.5Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Perspiration0.0Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Osteoarthralgia3.4Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Paresthesiae1.1Not reportedNot reportedNot reportedNot reported
Week 60: Very severe

Analysis denominator · Participants

GroupSource count
Pasireotide LAR Overall - Acromegaly Symptom: Headache77
Pasireotide LAR Overall - Acromegaly Symptom: Fatigue77
Pasireotide LAR Overall - Acromegaly Symptom: Perspiration77
Pasireotide LAR Overall - Acromegaly Symptom: Osteoarthralgia77
Pasireotide LAR Overall - Acromegaly Symptom: Paresthesiae77
Values in Percentage of participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
Pasireotide LAR Overall - Acromegaly Symptom: Headache0.0Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Fatigue0.0Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Perspiration0.0Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Osteoarthralgia1.1Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Paresthesiae1.1Not reportedNot reportedNot reportedNot reported
Week 60: Not done

Analysis denominator · Participants

GroupSource count
Pasireotide LAR Overall - Acromegaly Symptom: Headache77
Pasireotide LAR Overall - Acromegaly Symptom: Fatigue77
Pasireotide LAR Overall - Acromegaly Symptom: Perspiration77
Pasireotide LAR Overall - Acromegaly Symptom: Osteoarthralgia77
Pasireotide LAR Overall - Acromegaly Symptom: Paresthesiae77
Values in Percentage of participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
Pasireotide LAR Overall - Acromegaly Symptom: Headache0.0Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Fatigue0.0Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Perspiration0.0Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Osteoarthralgia0.0Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Paresthesiae0.0Not reportedNot reportedNot reportedNot reported
Week 72: None/absent

Analysis denominator · Participants

GroupSource count
Pasireotide LAR Overall - Acromegaly Symptom: Headache74
Pasireotide LAR Overall - Acromegaly Symptom: Fatigue74
Pasireotide LAR Overall - Acromegaly Symptom: Perspiration74
Pasireotide LAR Overall - Acromegaly Symptom: Osteoarthralgia74
Pasireotide LAR Overall - Acromegaly Symptom: Paresthesiae74
Values in Percentage of participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
Pasireotide LAR Overall - Acromegaly Symptom: Headache56.8Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Fatigue44.3Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Perspiration61.4Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Osteoarthralgia51.1Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Paresthesiae67.0Not reportedNot reportedNot reportedNot reported
Week 72: Mild

Analysis denominator · Participants

GroupSource count
Pasireotide LAR Overall - Acromegaly Symptom: Headache74
Pasireotide LAR Overall - Acromegaly Symptom: Fatigue74
Pasireotide LAR Overall - Acromegaly Symptom: Perspiration74
Pasireotide LAR Overall - Acromegaly Symptom: Osteoarthralgia74
Pasireotide LAR Overall - Acromegaly Symptom: Paresthesiae74
Values in Percentage of participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
Pasireotide LAR Overall - Acromegaly Symptom: Headache17.0Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Fatigue23.9Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Perspiration15.9Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Osteoarthralgia20.5Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Paresthesiae11.4Not reportedNot reportedNot reportedNot reported
Week 72: Moderate

Analysis denominator · Participants

GroupSource count
Pasireotide LAR Overall - Acromegaly Symptom: Headache74
Pasireotide LAR Overall - Acromegaly Symptom: Fatigue74
Pasireotide LAR Overall - Acromegaly Symptom: Perspiration74
Pasireotide LAR Overall - Acromegaly Symptom: Osteoarthralgia74
Pasireotide LAR Overall - Acromegaly Symptom: Paresthesiae74
Values in Percentage of participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
Pasireotide LAR Overall - Acromegaly Symptom: Headache8.0Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Fatigue10.2Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Perspiration6.8Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Osteoarthralgia10.2Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Paresthesiae5.7Not reportedNot reportedNot reportedNot reported
Week 72: Severe

Analysis denominator · Participants

GroupSource count
Pasireotide LAR Overall - Acromegaly Symptom: Headache74
Pasireotide LAR Overall - Acromegaly Symptom: Fatigue74
Pasireotide LAR Overall - Acromegaly Symptom: Perspiration74
Pasireotide LAR Overall - Acromegaly Symptom: Osteoarthralgia74
Pasireotide LAR Overall - Acromegaly Symptom: Paresthesiae74
Values in Percentage of participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
Pasireotide LAR Overall - Acromegaly Symptom: Headache2.3Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Fatigue4.5Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Perspiration0.0Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Osteoarthralgia1.1Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Paresthesiae0.0Not reportedNot reportedNot reportedNot reported
Week 72: Very severe

Analysis denominator · Participants

GroupSource count
Pasireotide LAR Overall - Acromegaly Symptom: Headache74
Pasireotide LAR Overall - Acromegaly Symptom: Fatigue74
Pasireotide LAR Overall - Acromegaly Symptom: Perspiration74
Pasireotide LAR Overall - Acromegaly Symptom: Osteoarthralgia74
Pasireotide LAR Overall - Acromegaly Symptom: Paresthesiae74
Values in Percentage of participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
Pasireotide LAR Overall - Acromegaly Symptom: Headache0.0Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Fatigue1.1Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Perspiration0.0Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Osteoarthralgia1.1Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Paresthesiae0.0Not reportedNot reportedNot reportedNot reported
Week 72: Not done

Analysis denominator · Participants

GroupSource count
Pasireotide LAR Overall - Acromegaly Symptom: Headache74
Pasireotide LAR Overall - Acromegaly Symptom: Fatigue74
Pasireotide LAR Overall - Acromegaly Symptom: Perspiration74
Pasireotide LAR Overall - Acromegaly Symptom: Osteoarthralgia74
Pasireotide LAR Overall - Acromegaly Symptom: Paresthesiae74
Values in Percentage of participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
Pasireotide LAR Overall - Acromegaly Symptom: Headache0.0Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Fatigue0.0Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Perspiration0.0Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Osteoarthralgia0.0Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Paresthesiae0.0Not reportedNot reportedNot reportedNot reported
Complete source fields
classes
  1. categories
    1. measurements
      1. group Id
        OG000
        value
        63.6
      2. group Id
        OG001
        value
        59.1
      3. group Id
        OG002
        value
        69.3
      4. group Id
        OG003
        value
        53.4
      5. group Id
        OG004
        value
        71.6
    denoms
    1. counts
      1. group Id
        OG000
        value
        81
      2. group Id
        OG001
        value
        81
      3. group Id
        OG002
        value
        81
      4. group Id
        OG003
        value
        81
      5. group Id
        OG004
        value
        81
      units
      Participants
    title
    Week 48: None/absent
  2. categories
    1. measurements
      1. group Id
        OG000
        value
        19.3
      2. group Id
        OG001
        value
        17.0
      3. group Id
        OG002
        value
        13.6
      4. group Id
        OG003
        value
        25.0
      5. group Id
        OG004
        value
        14.8
    denoms
    1. counts
      1. group Id
        OG000
        value
        81
      2. group Id
        OG001
        value
        81
      3. group Id
        OG002
        value
        81
      4. group Id
        OG003
        value
        81
      5. group Id
        OG004
        value
        81
      units
      Participants
    title
    Week 48: Mild
  3. categories
    1. measurements
      1. group Id
        OG000
        value
        8.0
      2. group Id
        OG001
        value
        12.5
      3. group Id
        OG002
        value
        9.1
      4. group Id
        OG003
        value
        9.1
      5. group Id
        OG004
        value
        4.5
    denoms
    1. counts
      1. group Id
        OG000
        value
        81
      2. group Id
        OG001
        value
        81
      3. group Id
        OG002
        value
        81
      4. group Id
        OG003
        value
        81
      5. group Id
        OG004
        value
        81
      units
      Participants
    title
    Week 48: Moderate
  4. categories
    1. measurements
      1. group Id
        OG000
        value
        1.1
      2. group Id
        OG001
        value
        3.4
      3. group Id
        OG002
        value
        0.0
      4. group Id
        OG003
        value
        3.4
      5. group Id
        OG004
        value
        0.0
    denoms
    1. counts
      1. group Id
        OG000
        value
        81
      2. group Id
        OG001
        value
        81
      3. group Id
        OG002
        value
        81
      4. group Id
        OG003
        value
        81
      5. group Id
        OG004
        value
        81
      units
      Participants
    title
    Week 48: Severe
  5. categories
    1. measurements
      1. group Id
        OG000
        value
        0.0
      2. group Id
        OG001
        value
        0.0
      3. group Id
        OG002
        value
        0.0
      4. group Id
        OG003
        value
        1.1
      5. group Id
        OG004
        value
        1.1
    denoms
    1. counts
      1. group Id
        OG000
        value
        81
      2. group Id
        OG001
        value
        81
      3. group Id
        OG002
        value
        81
      4. group Id
        OG003
        value
        81
      5. group Id
        OG004
        value
        81
      units
      Participants
    title
    Week 48: Very severe
  6. categories
    1. measurements
      1. group Id
        OG000
        value
        0.0
      2. group Id
        OG001
        value
        0.0
      3. group Id
        OG002
        value
        0.0
      4. group Id
        OG003
        value
        0.0
      5. group Id
        OG004
        value
        0.0
    denoms
    1. counts
      1. group Id
        OG000
        value
        81
      2. group Id
        OG001
        value
        81
      3. group Id
        OG002
        value
        81
      4. group Id
        OG003
        value
        81
      5. group Id
        OG004
        value
        81
      units
      Participants
    title
    Week 48: Not done
  7. categories
    1. measurements
      1. group Id
        OG000
        value
        60.2
      2. group Id
        OG001
        value
        48.9
      3. group Id
        OG002
        value
        60.2
      4. group Id
        OG003
        value
        56.8
      5. group Id
        OG004
        value
        70.5
    denoms
    1. counts
      1. group Id
        OG000
        value
        77
      2. group Id
        OG001
        value
        77
      3. group Id
        OG002
        value
        77
      4. group Id
        OG003
        value
        77
      5. group Id
        OG004
        value
        77
      units
      Participants
    title
    Week 60: None/absent
  8. categories
    1. measurements
      1. group Id
        OG000
        value
        17.0
      2. group Id
        OG001
        value
        20.5
      3. group Id
        OG002
        value
        20.5
      4. group Id
        OG003
        value
        14.8
      5. group Id
        OG004
        value
        10.2
    denoms
    1. counts
      1. group Id
        OG000
        value
        77
      2. group Id
        OG001
        value
        77
      3. group Id
        OG002
        value
        77
      4. group Id
        OG003
        value
        77
      5. group Id
        OG004
        value
        77
      units
      Participants
    title
    Week 60: Mild
  9. categories
    1. measurements
      1. group Id
        OG000
        value
        6.8
      2. group Id
        OG001
        value
        13.6
      3. group Id
        OG002
        value
        6.8
      4. group Id
        OG003
        value
        11.4
      5. group Id
        OG004
        value
        4.5
    denoms
    1. counts
      1. group Id
        OG000
        value
        77
      2. group Id
        OG001
        value
        77
      3. group Id
        OG002
        value
        77
      4. group Id
        OG003
        value
        77
      5. group Id
        OG004
        value
        77
      units
      Participants
    title
    Week 60: Moderate
  10. categories
    1. measurements
      1. group Id
        OG000
        value
        3.4
      2. group Id
        OG001
        value
        4.5
      3. group Id
        OG002
        value
        0.0
      4. group Id
        OG003
        value
        3.4
      5. group Id
        OG004
        value
        1.1
    denoms
    1. counts
      1. group Id
        OG000
        value
        77
      2. group Id
        OG001
        value
        77
      3. group Id
        OG002
        value
        77
      4. group Id
        OG003
        value
        77
      5. group Id
        OG004
        value
        77
      units
      Participants
    title
    Week 60: Severe
  11. categories
    1. measurements
      1. group Id
        OG000
        value
        0.0
      2. group Id
        OG001
        value
        0.0
      3. group Id
        OG002
        value
        0.0
      4. group Id
        OG003
        value
        1.1
      5. group Id
        OG004
        value
        1.1
    denoms
    1. counts
      1. group Id
        OG000
        value
        77
      2. group Id
        OG001
        value
        77
      3. group Id
        OG002
        value
        77
      4. group Id
        OG003
        value
        77
      5. group Id
        OG004
        value
        77
      units
      Participants
    title
    Week 60: Very severe
  12. categories
    1. measurements
      1. group Id
        OG000
        value
        0.0
      2. group Id
        OG001
        value
        0.0
      3. group Id
        OG002
        value
        0.0
      4. group Id
        OG003
        value
        0.0
      5. group Id
        OG004
        value
        0.0
    denoms
    1. counts
      1. group Id
        OG000
        value
        77
      2. group Id
        OG001
        value
        77
      3. group Id
        OG002
        value
        77
      4. group Id
        OG003
        value
        77
      5. group Id
        OG004
        value
        77
      units
      Participants
    title
    Week 60: Not done
denoms
  1. counts
    1. group Id
      OG000
      value
      88
    2. group Id
      OG001
      value
      88
    3. group Id
      OG002
      value
      88
    4. group Id
      OG003
      value
      88
    5. group Id
      OG004
      value
      88
    units
    Participants
description
Symptoms of acromegaly were collected at various visits. The measurement was to be provided on a scale of 1-15 including half sizes. Investigators asked the participants to score the following symptoms of acromegaly: headache, fatigue, perspiration, paresthesias, osteoarthralgia according to a five-point score scale (0=absent, 1=mild, 2=moderate, 3=severe, 4=very severe).
groups
  1. description
    This is the sum total of participants who were treated with at least one dose of pasireotide LAR in the extension phase
    id
    OG000
    title
    Pasireotide LAR Overall - Acromegaly Symptom: Headache
  2. description
    This is the sum total of participants who were treated with at least one dose of pasireotide LAR in the extension phase
    id
    OG001
    title
    Pasireotide LAR Overall - Acromegaly Symptom: Fatigue
  3. description
    This is the sum total of participants who were treated with at least one dose of pasireotide LAR in the extension phase
    id
    OG002
    title
    Pasireotide LAR Overall - Acromegaly Symptom: Perspiration
  4. description
    This is the sum total of participants who were treated with at least one dose of pasireotide LAR in the extension phase
    id
    OG003
    title
    Pasireotide LAR Overall - Acromegaly Symptom: Osteoarthralgia
  5. description
    This is the sum total of participants who were treated with at least one dose of pasireotide LAR in the extension phase
    id
    OG004
    title
    Pasireotide LAR Overall - Acromegaly Symptom: Paresthesiae
param Type
NUMBER
population Description
Extension FAS included all the patients who received at least one dose of pasireotide LAR in the extension phase.
reporting Status
POSTED
time Frame
Weeks 48, 60 & 72
title
Extension Phase: Percentage of Participants Reporting Levels 1 - 5 by Dimensions of Acromegaly Symptoms
type
SECONDARY
unit Of Measure
Percentage of participants

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