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NCT02354508 · OUTCOME

Core Phase: Percentage of Participants Reporting Levels 0 - 4 by Dimensions of Acromegaly Symptoms

Pasireotide in Patients With Acromegaly Inadequately Controlled With First Generation Somatostatin Analogues · Source last updated 2019-12-10

Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.

Measure
NUMBER
Unit
Percentage of participants
Interval / dispersion
Not reported
Time frame
Weeks 12, 24 & 36

What was measured

Symptoms of acromegaly were collected at various visits. The measurement was to be provided on a scale of 1-15 including half sizes. Investigators asked the participants to score the following symptoms of acromegaly: headache, fatigue, perspiration, paresthesias, osteoarthralgia according to a five-point score scale (0=absent, 1=mild, 2=moderate, 3=severe, 4=very severe).

Analysis population: FAS comprised all patients who had signed informed consent and had been treated with at least one dose of study medication (pasireotide LAR) after enrollment into the study

Groups in this outcome

Pasireotide LAR Overall - Acromegaly Symptom: Headache

This is the sum total of participants in under the previous treatments: lanreotide 120 mg, octreotide 30 mg or octreotide 40 mg.

Pasireotide LAR Overall - Acromegaly Symptom: Fatigue

This is the sum total of participants in under the previous treatments: lanreotide 120 mg, octreotide 30 mg or octreotide 40 mg

Pasireotide LAR Overall - Acromegaly Symptom: Perspiration

This is the sum total of participants in under the previous treatments: lanreotide 120 mg, octreotide 30 mg or octreotide 40 mg.

Pasireotide LAR Overall - Acromegaly Symptom: Osteoarthralgia

This is the sum total of participants in under the previous treatments: lanreotide 120 mg, octreotide 30 mg or octreotide 40 mg

Pasireotide LAR Overall - Acromegaly Symptom: Paresthesiae

This is the sum total of participants in under the previous treatments: lanreotide 120 mg, octreotide 30 mg or octreotide 40 mg

Group identifiers and denominators belong to this outcome only. They may differ in another outcome or in safety reporting.

Analysis denominator · Participants

GroupSource count
Pasireotide LAR Overall - Acromegaly Symptom: Headache123
Pasireotide LAR Overall - Acromegaly Symptom: Fatigue123
Pasireotide LAR Overall - Acromegaly Symptom: Perspiration123
Pasireotide LAR Overall - Acromegaly Symptom: Osteoarthralgia123
Pasireotide LAR Overall - Acromegaly Symptom: Paresthesiae123

Reported measurements

Week 12: Non/absent

Analysis denominator · Participants

GroupSource count
Pasireotide LAR Overall - Acromegaly Symptom: Headache119
Pasireotide LAR Overall - Acromegaly Symptom: Fatigue119
Pasireotide LAR Overall - Acromegaly Symptom: Perspiration119
Pasireotide LAR Overall - Acromegaly Symptom: Osteoarthralgia119
Pasireotide LAR Overall - Acromegaly Symptom: Paresthesiae119
Values in Percentage of participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
Pasireotide LAR Overall - Acromegaly Symptom: Headache56.9Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Fatigue37.4Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Perspiration56.9Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Osteoarthralgia43.1Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Paresthesiae69.1Not reportedNot reportedNot reportedNot reported
Week 12: Mild

Analysis denominator · Participants

GroupSource count
Pasireotide LAR Overall - Acromegaly Symptom: Headache119
Pasireotide LAR Overall - Acromegaly Symptom: Fatigue119
Pasireotide LAR Overall - Acromegaly Symptom: Perspiration119
Pasireotide LAR Overall - Acromegaly Symptom: Osteoarthralgia119
Pasireotide LAR Overall - Acromegaly Symptom: Paresthesiae119
Values in Percentage of participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
Pasireotide LAR Overall - Acromegaly Symptom: Headache24.4Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Fatigue26.8Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Perspiration26.8Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Osteoarthralgia27.6Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Paresthesiae15.4Not reportedNot reportedNot reportedNot reported
Week 12: Moderate

Analysis denominator · Participants

GroupSource count
Pasireotide LAR Overall - Acromegaly Symptom: Headache119
Pasireotide LAR Overall - Acromegaly Symptom: Fatigue119
Pasireotide LAR Overall - Acromegaly Symptom: Perspiration119
Pasireotide LAR Overall - Acromegaly Symptom: Osteoarthralgia119
Pasireotide LAR Overall - Acromegaly Symptom: Paresthesiae119
Values in Percentage of participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
Pasireotide LAR Overall - Acromegaly Symptom: Headache14.6Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Fatigue18.7Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Perspiration8.1Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Osteoarthralgia14.6Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Paresthesiae5.7Not reportedNot reportedNot reportedNot reported
Week 12: Severe

Analysis denominator · Participants

GroupSource count
Pasireotide LAR Overall - Acromegaly Symptom: Headache119
Pasireotide LAR Overall - Acromegaly Symptom: Fatigue119
Pasireotide LAR Overall - Acromegaly Symptom: Perspiration119
Pasireotide LAR Overall - Acromegaly Symptom: Osteoarthralgia119
Pasireotide LAR Overall - Acromegaly Symptom: Paresthesiae119
Values in Percentage of participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
Pasireotide LAR Overall - Acromegaly Symptom: Headache0.8Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Fatigue8.9Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Perspiration3.3Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Osteoarthralgia8.9Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Paresthesiae4.9Not reportedNot reportedNot reportedNot reported
Week 12: Very severe

Analysis denominator · Participants

GroupSource count
Pasireotide LAR Overall - Acromegaly Symptom: Headache119
Pasireotide LAR Overall - Acromegaly Symptom: Fatigue119
Pasireotide LAR Overall - Acromegaly Symptom: Perspiration119
Pasireotide LAR Overall - Acromegaly Symptom: Osteoarthralgia119
Pasireotide LAR Overall - Acromegaly Symptom: Paresthesiae119
Values in Percentage of participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
Pasireotide LAR Overall - Acromegaly Symptom: Headache0.0Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Fatigue4.9Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Perspiration1.6Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Osteoarthralgia2.4Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Paresthesiae1.6Not reportedNot reportedNot reportedNot reported
Week 12: Not done

Analysis denominator · Participants

GroupSource count
Pasireotide LAR Overall - Acromegaly Symptom: Headache119
Pasireotide LAR Overall - Acromegaly Symptom: Fatigue119
Pasireotide LAR Overall - Acromegaly Symptom: Perspiration119
Pasireotide LAR Overall - Acromegaly Symptom: Osteoarthralgia119
Pasireotide LAR Overall - Acromegaly Symptom: Paresthesiae119
Values in Percentage of participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
Pasireotide LAR Overall - Acromegaly Symptom: Headache0.0Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Fatigue0.0Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Perspiration0.0Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Osteoarthralgia0.0Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Paresthesiae0.0Not reportedNot reportedNot reportedNot reported
Week 24: Non/absent

Analysis denominator · Participants

GroupSource count
Pasireotide LAR Overall - Acromegaly Symptom: Headache119
Pasireotide LAR Overall - Acromegaly Symptom: Fatigue119
Pasireotide LAR Overall - Acromegaly Symptom: Perspiration119
Pasireotide LAR Overall - Acromegaly Symptom: Osteoarthralgia119
Pasireotide LAR Overall - Acromegaly Symptom: Paresthesiae119
Values in Percentage of participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
Pasireotide LAR Overall - Acromegaly Symptom: Headache59.3Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Fatigue46.3Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Perspiration64.2Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Osteoarthralgia47.2Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Paresthesiae72.4Not reportedNot reportedNot reportedNot reported
Week 24: Mild

Analysis denominator · Participants

GroupSource count
Pasireotide LAR Overall - Acromegaly Symptom: Headache119
Pasireotide LAR Overall - Acromegaly Symptom: Fatigue119
Pasireotide LAR Overall - Acromegaly Symptom: Perspiration119
Pasireotide LAR Overall - Acromegaly Symptom: Osteoarthralgia119
Pasireotide LAR Overall - Acromegaly Symptom: Paresthesiae119
Values in Percentage of participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
Pasireotide LAR Overall - Acromegaly Symptom: Headache27.6Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Fatigue20.3Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Perspiration21.1Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Osteoarthralgia26.8Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Paresthesiae13.8Not reportedNot reportedNot reportedNot reported
Week 24: Moderate

Analysis denominator · Participants

GroupSource count
Pasireotide LAR Overall - Acromegaly Symptom: Headache119
Pasireotide LAR Overall - Acromegaly Symptom: Fatigue119
Pasireotide LAR Overall - Acromegaly Symptom: Perspiration119
Pasireotide LAR Overall - Acromegaly Symptom: Osteoarthralgia119
Pasireotide LAR Overall - Acromegaly Symptom: Paresthesiae119
Values in Percentage of participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
Pasireotide LAR Overall - Acromegaly Symptom: Headache8.1Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Fatigue17.9Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Perspiration8.9Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Osteoarthralgia14.6Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Paresthesiae7.3Not reportedNot reportedNot reportedNot reported
Week 24: Severe

Analysis denominator · Participants

GroupSource count
Pasireotide LAR Overall - Acromegaly Symptom: Headache119
Pasireotide LAR Overall - Acromegaly Symptom: Fatigue119
Pasireotide LAR Overall - Acromegaly Symptom: Perspiration119
Pasireotide LAR Overall - Acromegaly Symptom: Osteoarthralgia119
Pasireotide LAR Overall - Acromegaly Symptom: Paresthesiae119
Values in Percentage of participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
Pasireotide LAR Overall - Acromegaly Symptom: Headache1.6Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Fatigue7.3Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Perspiration1.6Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Osteoarthralgia3.3Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Paresthesiae0.8Not reportedNot reportedNot reportedNot reported
Week 24: Very severe

Analysis denominator · Participants

GroupSource count
Pasireotide LAR Overall - Acromegaly Symptom: Headache119
Pasireotide LAR Overall - Acromegaly Symptom: Fatigue119
Pasireotide LAR Overall - Acromegaly Symptom: Perspiration119
Pasireotide LAR Overall - Acromegaly Symptom: Osteoarthralgia119
Pasireotide LAR Overall - Acromegaly Symptom: Paresthesiae119
Values in Percentage of participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
Pasireotide LAR Overall - Acromegaly Symptom: Headache0.0Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Fatigue4.9Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Perspiration0.8Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Osteoarthralgia4.9Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Paresthesiae2.4Not reportedNot reportedNot reportedNot reported
Week 24: Not done

Analysis denominator · Participants

GroupSource count
Pasireotide LAR Overall - Acromegaly Symptom: Headache119
Pasireotide LAR Overall - Acromegaly Symptom: Fatigue119
Pasireotide LAR Overall - Acromegaly Symptom: Perspiration119
Pasireotide LAR Overall - Acromegaly Symptom: Osteoarthralgia119
Pasireotide LAR Overall - Acromegaly Symptom: Paresthesiae119
Values in Percentage of participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
Pasireotide LAR Overall - Acromegaly Symptom: Headache0.0Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Fatigue0.0Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Perspiration0.0Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Osteoarthralgia0.0Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Paresthesiae0.0Not reportedNot reportedNot reportedNot reported
Week 36: Non/absent

Analysis denominator · Participants

GroupSource count
Pasireotide LAR Overall - Acromegaly Symptom: Headache113
Pasireotide LAR Overall - Acromegaly Symptom: Fatigue113
Pasireotide LAR Overall - Acromegaly Symptom: Perspiration113
Pasireotide LAR Overall - Acromegaly Symptom: Osteoarthralgia113
Pasireotide LAR Overall - Acromegaly Symptom: Paresthesiae113
Values in Percentage of participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
Pasireotide LAR Overall - Acromegaly Symptom: Headache63.4Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Fatigue47.2Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Perspiration61.8Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Osteoarthralgia47.2Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Paresthesiae69.1Not reportedNot reportedNot reportedNot reported
Week 36: Mild

Analysis denominator · Participants

GroupSource count
Pasireotide LAR Overall - Acromegaly Symptom: Headache113
Pasireotide LAR Overall - Acromegaly Symptom: Fatigue113
Pasireotide LAR Overall - Acromegaly Symptom: Perspiration113
Pasireotide LAR Overall - Acromegaly Symptom: Osteoarthralgia113
Pasireotide LAR Overall - Acromegaly Symptom: Paresthesiae113
Values in Percentage of participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
Pasireotide LAR Overall - Acromegaly Symptom: Headache17.1Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Fatigue23.6Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Perspiration18.7Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Osteoarthralgia26.8Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Paresthesiae14.6Not reportedNot reportedNot reportedNot reported
Week 36: Moderate

Analysis denominator · Participants

GroupSource count
Pasireotide LAR Overall - Acromegaly Symptom: Headache113
Pasireotide LAR Overall - Acromegaly Symptom: Fatigue113
Pasireotide LAR Overall - Acromegaly Symptom: Perspiration113
Pasireotide LAR Overall - Acromegaly Symptom: Osteoarthralgia113
Pasireotide LAR Overall - Acromegaly Symptom: Paresthesiae113
Values in Percentage of participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
Pasireotide LAR Overall - Acromegaly Symptom: Headache9.8Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Fatigue13.0Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Perspiration7.3Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Osteoarthralgia12.2Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Paresthesiae5.7Not reportedNot reportedNot reportedNot reported
Week 36: Severe

Analysis denominator · Participants

GroupSource count
Pasireotide LAR Overall - Acromegaly Symptom: Headache113
Pasireotide LAR Overall - Acromegaly Symptom: Fatigue113
Pasireotide LAR Overall - Acromegaly Symptom: Perspiration113
Pasireotide LAR Overall - Acromegaly Symptom: Osteoarthralgia113
Pasireotide LAR Overall - Acromegaly Symptom: Paresthesiae113
Values in Percentage of participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
Pasireotide LAR Overall - Acromegaly Symptom: Headache1.6Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Fatigue4.9Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Perspiration4.1Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Osteoarthralgia3.3Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Paresthesiae1.6Not reportedNot reportedNot reportedNot reported
Week 36: Very severe

Analysis denominator · Participants

GroupSource count
Pasireotide LAR Overall - Acromegaly Symptom: Headache113
Pasireotide LAR Overall - Acromegaly Symptom: Fatigue113
Pasireotide LAR Overall - Acromegaly Symptom: Perspiration113
Pasireotide LAR Overall - Acromegaly Symptom: Osteoarthralgia113
Pasireotide LAR Overall - Acromegaly Symptom: Paresthesiae113
Values in Percentage of participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
Pasireotide LAR Overall - Acromegaly Symptom: Headache0.0Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Fatigue3.3Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Perspiration0.0Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Osteoarthralgia2.4Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Paresthesiae0.8Not reportedNot reportedNot reportedNot reported
Week 36: Not done

Analysis denominator · Participants

GroupSource count
Pasireotide LAR Overall - Acromegaly Symptom: Headache113
Pasireotide LAR Overall - Acromegaly Symptom: Fatigue113
Pasireotide LAR Overall - Acromegaly Symptom: Perspiration113
Pasireotide LAR Overall - Acromegaly Symptom: Osteoarthralgia113
Pasireotide LAR Overall - Acromegaly Symptom: Paresthesiae113
Values in Percentage of participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
Pasireotide LAR Overall - Acromegaly Symptom: Headache0.0Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Fatigue0.0Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Perspiration0.0Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Osteoarthralgia0.0Not reportedNot reportedNot reportedNot reported
Pasireotide LAR Overall - Acromegaly Symptom: Paresthesiae0.0Not reportedNot reportedNot reportedNot reported
Complete source fields
classes
  1. categories
    1. measurements
      1. group Id
        OG000
        value
        56.9
      2. group Id
        OG001
        value
        37.4
      3. group Id
        OG002
        value
        56.9
      4. group Id
        OG003
        value
        43.1
      5. group Id
        OG004
        value
        69.1
    denoms
    1. counts
      1. group Id
        OG000
        value
        119
      2. group Id
        OG001
        value
        119
      3. group Id
        OG002
        value
        119
      4. group Id
        OG003
        value
        119
      5. group Id
        OG004
        value
        119
      units
      Participants
    title
    Week 12: Non/absent
  2. categories
    1. measurements
      1. group Id
        OG000
        value
        24.4
      2. group Id
        OG001
        value
        26.8
      3. group Id
        OG002
        value
        26.8
      4. group Id
        OG003
        value
        27.6
      5. group Id
        OG004
        value
        15.4
    denoms
    1. counts
      1. group Id
        OG000
        value
        119
      2. group Id
        OG001
        value
        119
      3. group Id
        OG002
        value
        119
      4. group Id
        OG003
        value
        119
      5. group Id
        OG004
        value
        119
      units
      Participants
    title
    Week 12: Mild
  3. categories
    1. measurements
      1. group Id
        OG000
        value
        14.6
      2. group Id
        OG001
        value
        18.7
      3. group Id
        OG002
        value
        8.1
      4. group Id
        OG003
        value
        14.6
      5. group Id
        OG004
        value
        5.7
    denoms
    1. counts
      1. group Id
        OG000
        value
        119
      2. group Id
        OG001
        value
        119
      3. group Id
        OG002
        value
        119
      4. group Id
        OG003
        value
        119
      5. group Id
        OG004
        value
        119
      units
      Participants
    title
    Week 12: Moderate
  4. categories
    1. measurements
      1. group Id
        OG000
        value
        0.8
      2. group Id
        OG001
        value
        8.9
      3. group Id
        OG002
        value
        3.3
      4. group Id
        OG003
        value
        8.9
      5. group Id
        OG004
        value
        4.9
    denoms
    1. counts
      1. group Id
        OG000
        value
        119
      2. group Id
        OG001
        value
        119
      3. group Id
        OG002
        value
        119
      4. group Id
        OG003
        value
        119
      5. group Id
        OG004
        value
        119
      units
      Participants
    title
    Week 12: Severe
  5. categories
    1. measurements
      1. group Id
        OG000
        value
        0.0
      2. group Id
        OG001
        value
        4.9
      3. group Id
        OG002
        value
        1.6
      4. group Id
        OG003
        value
        2.4
      5. group Id
        OG004
        value
        1.6
    denoms
    1. counts
      1. group Id
        OG000
        value
        119
      2. group Id
        OG001
        value
        119
      3. group Id
        OG002
        value
        119
      4. group Id
        OG003
        value
        119
      5. group Id
        OG004
        value
        119
      units
      Participants
    title
    Week 12: Very severe
  6. categories
    1. measurements
      1. group Id
        OG000
        value
        0.0
      2. group Id
        OG001
        value
        0.0
      3. group Id
        OG002
        value
        0.0
      4. group Id
        OG003
        value
        0.0
      5. group Id
        OG004
        value
        0.0
    denoms
    1. counts
      1. group Id
        OG000
        value
        119
      2. group Id
        OG001
        value
        119
      3. group Id
        OG002
        value
        119
      4. group Id
        OG003
        value
        119
      5. group Id
        OG004
        value
        119
      units
      Participants
    title
    Week 12: Not done
  7. categories
    1. measurements
      1. group Id
        OG000
        value
        59.3
      2. group Id
        OG001
        value
        46.3
      3. group Id
        OG002
        value
        64.2
      4. group Id
        OG003
        value
        47.2
      5. group Id
        OG004
        value
        72.4
    denoms
    1. counts
      1. group Id
        OG000
        value
        119
      2. group Id
        OG001
        value
        119
      3. group Id
        OG002
        value
        119
      4. group Id
        OG003
        value
        119
      5. group Id
        OG004
        value
        119
      units
      Participants
    title
    Week 24: Non/absent
  8. categories
    1. measurements
      1. group Id
        OG000
        value
        27.6
      2. group Id
        OG001
        value
        20.3
      3. group Id
        OG002
        value
        21.1
      4. group Id
        OG003
        value
        26.8
      5. group Id
        OG004
        value
        13.8
    denoms
    1. counts
      1. group Id
        OG000
        value
        119
      2. group Id
        OG001
        value
        119
      3. group Id
        OG002
        value
        119
      4. group Id
        OG003
        value
        119
      5. group Id
        OG004
        value
        119
      units
      Participants
    title
    Week 24: Mild
  9. categories
    1. measurements
      1. group Id
        OG000
        value
        8.1
      2. group Id
        OG001
        value
        17.9
      3. group Id
        OG002
        value
        8.9
      4. group Id
        OG003
        value
        14.6
      5. group Id
        OG004
        value
        7.3
    denoms
    1. counts
      1. group Id
        OG000
        value
        119
      2. group Id
        OG001
        value
        119
      3. group Id
        OG002
        value
        119
      4. group Id
        OG003
        value
        119
      5. group Id
        OG004
        value
        119
      units
      Participants
    title
    Week 24: Moderate
  10. categories
    1. measurements
      1. group Id
        OG000
        value
        1.6
      2. group Id
        OG001
        value
        7.3
      3. group Id
        OG002
        value
        1.6
      4. group Id
        OG003
        value
        3.3
      5. group Id
        OG004
        value
        0.8
    denoms
    1. counts
      1. group Id
        OG000
        value
        119
      2. group Id
        OG001
        value
        119
      3. group Id
        OG002
        value
        119
      4. group Id
        OG003
        value
        119
      5. group Id
        OG004
        value
        119
      units
      Participants
    title
    Week 24: Severe
  11. categories
    1. measurements
      1. group Id
        OG000
        value
        0.0
      2. group Id
        OG001
        value
        4.9
      3. group Id
        OG002
        value
        0.8
      4. group Id
        OG003
        value
        4.9
      5. group Id
        OG004
        value
        2.4
    denoms
    1. counts
      1. group Id
        OG000
        value
        119
      2. group Id
        OG001
        value
        119
      3. group Id
        OG002
        value
        119
      4. group Id
        OG003
        value
        119
      5. group Id
        OG004
        value
        119
      units
      Participants
    title
    Week 24: Very severe
  12. categories
    1. measurements
      1. group Id
        OG000
        value
        0.0
      2. group Id
        OG001
        value
        0.0
      3. group Id
        OG002
        value
        0.0
      4. group Id
        OG003
        value
        0.0
      5. group Id
        OG004
        value
        0.0
    denoms
    1. counts
      1. group Id
        OG000
        value
        119
      2. group Id
        OG001
        value
        119
      3. group Id
        OG002
        value
        119
      4. group Id
        OG003
        value
        119
      5. group Id
        OG004
        value
        119
      units
      Participants
    title
    Week 24: Not done
denoms
  1. counts
    1. group Id
      OG000
      value
      123
    2. group Id
      OG001
      value
      123
    3. group Id
      OG002
      value
      123
    4. group Id
      OG003
      value
      123
    5. group Id
      OG004
      value
      123
    units
    Participants
description
Symptoms of acromegaly were collected at various visits. The measurement was to be provided on a scale of 1-15 including half sizes. Investigators asked the participants to score the following symptoms of acromegaly: headache, fatigue, perspiration, paresthesias, osteoarthralgia according to a five-point score scale (0=absent, 1=mild, 2=moderate, 3=severe, 4=very severe).
groups
  1. description
    This is the sum total of participants in under the previous treatments: lanreotide 120 mg, octreotide 30 mg or octreotide 40 mg.
    id
    OG000
    title
    Pasireotide LAR Overall - Acromegaly Symptom: Headache
  2. description
    This is the sum total of participants in under the previous treatments: lanreotide 120 mg, octreotide 30 mg or octreotide 40 mg
    id
    OG001
    title
    Pasireotide LAR Overall - Acromegaly Symptom: Fatigue
  3. description
    This is the sum total of participants in under the previous treatments: lanreotide 120 mg, octreotide 30 mg or octreotide 40 mg.
    id
    OG002
    title
    Pasireotide LAR Overall - Acromegaly Symptom: Perspiration
  4. description
    This is the sum total of participants in under the previous treatments: lanreotide 120 mg, octreotide 30 mg or octreotide 40 mg
    id
    OG003
    title
    Pasireotide LAR Overall - Acromegaly Symptom: Osteoarthralgia
  5. description
    This is the sum total of participants in under the previous treatments: lanreotide 120 mg, octreotide 30 mg or octreotide 40 mg
    id
    OG004
    title
    Pasireotide LAR Overall - Acromegaly Symptom: Paresthesiae
param Type
NUMBER
population Description
FAS comprised all patients who had signed informed consent and had been treated with at least one dose of study medication (pasireotide LAR) after enrollment into the study
reporting Status
POSTED
time Frame
Weeks 12, 24 & 36
title
Core Phase: Percentage of Participants Reporting Levels 0 - 4 by Dimensions of Acromegaly Symptoms
type
SECONDARY
unit Of Measure
Percentage of participants

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