Participant flow

TORC1/2 Inhibitor MLN0128 and Bevacizumab in Treating Patients With Recurrent Glioblastoma or Advanced Solid Tumors · Source last updated 2026-08-28

Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.

groups

1. description

   Stage 1 (Dose Finding/Escalation Stage) - Dose Level 1: * 3 mg MLN0128 daily * \+ 10 mg/kg bevacizumab every 2 weeks

   id

   FG000

   title

   Stage 1 - Dose Level 1

2. description

   Stage 1 (Dose Finding/Escalation Stage) - Dose Level 2: * 4 mg MLN0128 daily * \+ 10 mg/kg bevacizumab every 2 weeks

   id

   FG001

   title

   Stage 1 - Dose Level 2

3. description

   Stage 1 (Dose Finding/Escalation Stage) - Dose Level 3: * 5 mg MLN0128 daily * \+ 10 mg/kg bevacizumab every 2 weeks

   id

   FG002

   title

   Stage 1 - Dose Level 3

4. description

   Stage 2 - Expansion Cohort at Dose Level 3 - the Maximum Tolerated Dose (MTD) / Recommended Phase 2 Dose (RP2D): * 5 mg MLN0128 daily * \+ 10 mg/kg bevacizumab every 2 weeks

   id

   FG003

   title

   Stage 2 - Maximum Tolerated Dose (MTD)

periods

1. drop Withdraws

   1. reasons

      1. group Id

         FG000

         num Subjects

         0

      2. group Id

         FG001

         num Subjects

         0

      3. group Id

         FG002

         num Subjects

         0

      4. group Id

         FG003

         num Subjects

         1

      type

      Withdrawal by Subject

   milestones

   1. achievements

      1. group Id

         FG000

         num Subjects

         3

      2. group Id

         FG001

         num Subjects

         3

      3. group Id

         FG002

         num Subjects

         6

      4. group Id

         FG003

         num Subjects

         38

      type

      STARTED

   2. achievements

      1. group Id

         FG000

         num Subjects

         3

      2. group Id

         FG001

         num Subjects

         3

      3. group Id

         FG002

         num Subjects

         6

      4. group Id

         FG003

         num Subjects

         37

      type

      COMPLETED

   3. achievements

      1. group Id

         FG000

         num Subjects

         0

      2. group Id

         FG001

         num Subjects

         0

      3. group Id

         FG002

         num Subjects

         0

      4. group Id

         FG003

         num Subjects

         1

      type

      NOT COMPLETED

   title

   Registration to Initiation of Therapy

2. milestones

   1. achievements

      1. group Id

         FG000

         num Subjects

         3

      2. group Id

         FG001

         num Subjects

         3

      3. group Id

         FG002

         num Subjects

         6

      4. group Id

         FG003

         num Subjects

         37

      type

      STARTED

   2. achievements

      1. group Id

         FG000

         num Subjects

         3

      2. group Id

         FG001

         num Subjects

         3

      3. group Id

         FG002

         num Subjects

         6

      4. group Id

         FG003

         num Subjects

         37

      type

      COMPLETED

   3. achievements

      1. group Id

         FG000

         num Subjects

         0

      2. group Id

         FG001

         num Subjects

         0

      3. group Id

         FG002

         num Subjects

         0

      4. group Id

         FG003

         num Subjects

         0

      type

      NOT COMPLETED

   title

   Study Therapy

Download exact source JSON → · Snapshot ctgov-results-25a395029948b04d52b1253f

Preserved source evidence · Not medical advice