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NCT02142803 · BASELINE

Baseline characteristics

TORC1/2 Inhibitor MLN0128 and Bevacizumab in Treating Patients With Recurrent Glioblastoma or Advanced Solid Tumors · Source last updated 2026-08-28

Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.

denoms
  1. counts
    1. group Id
      BG000
      value
      3
    2. group Id
      BG001
      value
      3
    3. group Id
      BG002
      value
      43
    4. group Id
      BG003
      value
      49
    units
    Participants
groups
  1. description
    3 mg/day MLN0128
    id
    BG000
    title
    Dose Level 1
  2. description
    4 mg/day MLN0128
    id
    BG001
    title
    Dose Level 2
  3. description
    5 mg/day MLN0128
    id
    BG002
    title
    Dose Level 3 (MTD)
  4. description
    Total of all reporting groups
    id
    BG003
    title
    Total
measures
  1. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          lower Limit
          55
          upper Limit
          65
          value
          56
        2. group Id
          BG001
          lower Limit
          30
          upper Limit
          62
          value
          42
        3. group Id
          BG002
          lower Limit
          36
          upper Limit
          84
          value
          59
        4. group Id
          BG003
          lower Limit
          30
          upper Limit
          84
          value
          59
    dispersion Type
    FULL_RANGE
    param Type
    MEDIAN
    title
    Age, Continuous
    unit Of Measure
    years
  2. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          1
        2. group Id
          BG001
          value
          2
        3. group Id
          BG002
          value
          35
        4. group Id
          BG003
          value
          38
        title
        Female
      2. measurements
        1. group Id
          BG000
          value
          2
        2. group Id
          BG001
          value
          1
        3. group Id
          BG002
          value
          8
        4. group Id
          BG003
          value
          11
        title
        Male
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Sex: Female, Male
    unit Of Measure
    Participants
  3. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          1
        4. group Id
          BG003
          value
          1
        title
        Hispanic or Latino
      2. measurements
        1. group Id
          BG000
          value
          3
        2. group Id
          BG001
          value
          3
        3. group Id
          BG002
          value
          41
        4. group Id
          BG003
          value
          47
        title
        Not Hispanic or Latino
      3. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          1
        4. group Id
          BG003
          value
          1
        title
        Unknown or Not Reported
    description
    National Institutes of Health (NIH) / Office of Management and Budget (OMB) Standards
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Ethnicity (NIH/OMB)
    unit Of Measure
    Participants
  4. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          0
        4. group Id
          BG003
          value
          0
        title
        American Indian or Alaska Native
      2. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          1
        3. group Id
          BG002
          value
          1
        4. group Id
          BG003
          value
          2
        title
        Asian
      3. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          0
        4. group Id
          BG003
          value
          0
        title
        Native Hawaiian or Other Pacific Islander
      4. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          1
        4. group Id
          BG003
          value
          1
        title
        Black or African American
      5. measurements
        1. group Id
          BG000
          value
          3
        2. group Id
          BG001
          value
          2
        3. group Id
          BG002
          value
          39
        4. group Id
          BG003
          value
          44
        title
        White
      6. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          0
        4. group Id
          BG003
          value
          0
        title
        More than one race
      7. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          2
        4. group Id
          BG003
          value
          2
        title
        Unknown or Not Reported
    description
    National Institutes of Health (NIH) / Office of Management and Budget (OMB) Standards
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Race (NIH/OMB)
    unit Of Measure
    Participants
  5. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          lower Limit
          0
          upper Limit
          0
          value
          0
        2. group Id
          BG001
          lower Limit
          0
          upper Limit
          1
          value
          0
        3. group Id
          BG002
          lower Limit
          0
          upper Limit
          1
          value
          1
        4. group Id
          BG003
          lower Limit
          0
          upper Limit
          1
          value
          1
    description
    ECOG 0 = Normal activity. Fully active, able to carry on all pre-disease performance without restriction. ECOG 1 = Symptoms, but ambulatory. Restricted in physically strenuous activity, but ambulatory and able to carry out work of a light or sedentary nature (e.g., light housework, office work). NOTE: Performance Status (PS) for patients with endometrial and ovarian cancer is reported via ECOG scale (0-5); PS for patients with glioblastoma is reported via Karnofsky (KPS) scale (100-0). Baseline PS for GBM patients has been converted from KPS to ECOG scale for reporting consistency.
    dispersion Type
    FULL_RANGE
    param Type
    MEDIAN
    title
    Baseline Eastern Cooperative Oncology Group (ECOG) Performance Status
    unit Of Measure
    units on a scale
Complete source fields
denoms
  1. counts
    1. group Id
      BG000
      value
      3
    2. group Id
      BG001
      value
      3
    3. group Id
      BG002
      value
      43
    4. group Id
      BG003
      value
      49
    units
    Participants
groups
  1. description
    3 mg/day MLN0128
    id
    BG000
    title
    Dose Level 1
  2. description
    4 mg/day MLN0128
    id
    BG001
    title
    Dose Level 2
  3. description
    5 mg/day MLN0128
    id
    BG002
    title
    Dose Level 3 (MTD)
  4. description
    Total of all reporting groups
    id
    BG003
    title
    Total
measures
  1. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          lower Limit
          55
          upper Limit
          65
          value
          56
        2. group Id
          BG001
          lower Limit
          30
          upper Limit
          62
          value
          42
        3. group Id
          BG002
          lower Limit
          36
          upper Limit
          84
          value
          59
        4. group Id
          BG003
          lower Limit
          30
          upper Limit
          84
          value
          59
    dispersion Type
    FULL_RANGE
    param Type
    MEDIAN
    title
    Age, Continuous
    unit Of Measure
    years
  2. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          1
        2. group Id
          BG001
          value
          2
        3. group Id
          BG002
          value
          35
        4. group Id
          BG003
          value
          38
        title
        Female
      2. measurements
        1. group Id
          BG000
          value
          2
        2. group Id
          BG001
          value
          1
        3. group Id
          BG002
          value
          8
        4. group Id
          BG003
          value
          11
        title
        Male
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Sex: Female, Male
    unit Of Measure
    Participants
  3. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          1
        4. group Id
          BG003
          value
          1
        title
        Hispanic or Latino
      2. measurements
        1. group Id
          BG000
          value
          3
        2. group Id
          BG001
          value
          3
        3. group Id
          BG002
          value
          41
        4. group Id
          BG003
          value
          47
        title
        Not Hispanic or Latino
      3. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          1
        4. group Id
          BG003
          value
          1
        title
        Unknown or Not Reported
    description
    National Institutes of Health (NIH) / Office of Management and Budget (OMB) Standards
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Ethnicity (NIH/OMB)
    unit Of Measure
    Participants
  4. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          0
        4. group Id
          BG003
          value
          0
        title
        American Indian or Alaska Native
      2. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          1
        3. group Id
          BG002
          value
          1
        4. group Id
          BG003
          value
          2
        title
        Asian
      3. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          0
        4. group Id
          BG003
          value
          0
        title
        Native Hawaiian or Other Pacific Islander
      4. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          1
        4. group Id
          BG003
          value
          1
        title
        Black or African American
      5. measurements
        1. group Id
          BG000
          value
          3
        2. group Id
          BG001
          value
          2
        3. group Id
          BG002
          value
          39
        4. group Id
          BG003
          value
          44
        title
        White
      6. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          0
        4. group Id
          BG003
          value
          0
        title
        More than one race
      7. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          2
        4. group Id
          BG003
          value
          2
        title
        Unknown or Not Reported
    description
    National Institutes of Health (NIH) / Office of Management and Budget (OMB) Standards
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Race (NIH/OMB)
    unit Of Measure
    Participants
  5. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          lower Limit
          0
          upper Limit
          0
          value
          0
        2. group Id
          BG001
          lower Limit
          0
          upper Limit
          1
          value
          0
        3. group Id
          BG002
          lower Limit
          0
          upper Limit
          1
          value
          1
        4. group Id
          BG003
          lower Limit
          0
          upper Limit
          1
          value
          1
    description
    ECOG 0 = Normal activity. Fully active, able to carry on all pre-disease performance without restriction. ECOG 1 = Symptoms, but ambulatory. Restricted in physically strenuous activity, but ambulatory and able to carry out work of a light or sedentary nature (e.g., light housework, office work). NOTE: Performance Status (PS) for patients with endometrial and ovarian cancer is reported via ECOG scale (0-5); PS for patients with glioblastoma is reported via Karnofsky (KPS) scale (100-0). Baseline PS for GBM patients has been converted from KPS to ECOG scale for reporting consistency.
    dispersion Type
    FULL_RANGE
    param Type
    MEDIAN
    title
    Baseline Eastern Cooperative Oncology Group (ECOG) Performance Status
    unit Of Measure
    units on a scale

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Preserved source evidence · Not medical advice