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NCT01920932 · OUTCOME

Correlation of Agreement Between Patient QoL and Parent Proxy QoL at Multiple Time Points

Adcetris (Brentuximab Vedotin), Combination Chemotherapy, and Radiation Therapy in Treating Younger Patients With Stage IIB, IIIB and IV Hodgkin Lymphoma · Source last updated 2026-05-06

Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.

Measure: NUMBER
Unit: correlation coefficient
Interval / dispersion: 95% Confidence Interval
Time frame: At various time points from diagnosis through 5 years off therapy. (up to approximately 6 years from enrollment)

What was measured

The correlation of agreement between patient and parent Quality of Life is calculated by using the Pearson's Correlation Coefficient, which considers only the record with both parent and patient data. The QL scoring is a 5-point Likert scale from 0 (never) to 4 (almost always). Scores are transformed on a scale from 0 to 100. Items are reverse scored and linearly transformed to a 0-100 scale as follows: 0=100, 1=75, 2=50, 3=25, and 4=0. Total score is the sum of all items over the number of items answered on all scales. For both the total score and subscales the range is 0-100. The total score is the sum of all items from each subscale, over the number of items answered on the scale. The total score is the sum of all items on the scale over the number of items answer. If \>50% of the items are missing the score should not be computed. If \>50% are completed, impute the mean of the completed items in a scale. The Higher the score the better quality of life.

Analysis population: Each institution made the decision whether to complete the QoL objective. Participation in the Quality of Life part of the trial is voluntary for participating institutions and voluntary by participant.

Groups in this outcome

Timepoint 1 (T1)

At Diagnosis (baseline)

Timepoint 4 (T4)

Course 2 Day 1

Timepoint 6 (T6)

Course 3 Day 1

Timepoint 8 (T8)

Course 6 Day 1

Timepoint 10 (T10)

4-6 weeks after chemotherapy or 4-6 weeks after radiation

Timepoint 11 (T11)

1 year off therapy

Timepoint 12 (T12)

2 years off therapy (approximately 2 years and 8 months

Timepoint 13 (T13)

5 years off therapy (approximately 5 years and 8 months)

Group identifiers and denominators belong to this outcome only. They may differ in another outcome or in safety reporting.

Analysis denominator · Participants

Group	Source count
Timepoint 1 (T1)	62
Timepoint 4 (T4)	60
Timepoint 6 (T6)	56
Timepoint 8 (T8)	54
Timepoint 10 (T10)	45
Timepoint 11 (T11)	41
Timepoint 12 (T12)	30
Timepoint 13 (T13)	10

Reported measurements

Physical Functioning

Analysis denominator · Participants

Group	Source count
Timepoint 1 (T1)	62
Timepoint 4 (T4)	60
Timepoint 6 (T6)	56
Timepoint 8 (T8)	54
Timepoint 10 (T10)	45
Timepoint 11 (T11)	41
Timepoint 12 (T12)	30
Timepoint 13 (T13)	10

Values in correlation coefficient · Interval/dispersion: 95% Confidence Interval
Group	Value	Spread	Lower	Upper	Comment
Timepoint 1 (T1)	0.701	Not reported	0.547	0.809	Not reported
Timepoint 4 (T4)	0.503	Not reported	0.286	0.671	Not reported
Timepoint 6 (T6)	0.536	Not reported	0.318	0.7	Not reported
Timepoint 8 (T8)	0.575	Not reported	0.363	0.73	Not reported
Timepoint 10 (T10)	0.406	Not reported	0.128	0.625	Not reported
Timepoint 11 (T11)	0.528	Not reported	0.263	0.719	Not reported
Timepoint 12 (T12)	0.468	Not reported	0.129	0.709	Not reported
Timepoint 13 (T13)	0.294	Not reported	-0.411	0.78	Not reported

Social Functioning

Analysis denominator · Participants

Group	Source count
Timepoint 1 (T1)	62
Timepoint 4 (T4)	59
Timepoint 6 (T6)	56
Timepoint 8 (T8)	54
Timepoint 10 (T10)	45
Timepoint 11 (T11)	41
Timepoint 12 (T12)	30
Timepoint 13 (T13)	10

Values in correlation coefficient · Interval/dispersion: 95% Confidence Interval
Group	Value	Spread	Lower	Upper	Comment
Timepoint 1 (T1)	0.309	Not reported	0.064	0.518	Not reported
Timepoint 4 (T4)	0.566	Not reported	0.362	0.718	Not reported
Timepoint 6 (T6)	0.534	Not reported	0.313	0.7	Not reported
Timepoint 8 (T8)	0.242	Not reported	-0.028	0.479	Not reported
Timepoint 10 (T10)	0.086	Not reported	-0.213	0.371	Not reported
Timepoint 11 (T11)	0.327	Not reported	0.021	0.577	Not reported
Timepoint 12 (T12)	0.135	Not reported	-0.236	0.473	Not reported
Timepoint 13 (T13)	-0.027	Not reported	-0.645	0.613	Not reported

Emotional Functioning

Analysis denominator · Participants

Group	Source count
Timepoint 1 (T1)	62
Timepoint 4 (T4)	59
Timepoint 6 (T6)	55
Timepoint 8 (T8)	54
Timepoint 10 (T10)	45
Timepoint 11 (T11)	41
Timepoint 12 (T12)	30
Timepoint 13 (T13)	10

Values in correlation coefficient · Interval/dispersion: 95% Confidence Interval
Group	Value	Spread	Lower	Upper	Comment
Timepoint 1 (T1)	0.593	Not reported	0.402	0.734	Not reported
Timepoint 4 (T4)	0.664	Not reported	0.491	0.786	Not reported
Timepoint 6 (T6)	0.648	Not reported	0.464	0.778	Not reported
Timepoint 8 (T8)	0.588	Not reported	0.38	0.739	Not reported
Timepoint 10 (T10)	0.344	Not reported	0.056	0.579	Not reported
Timepoint 11 (T11)	0.671	Not reported	0.457	0.811	Not reported
Timepoint 12 (T12)	0.291	Not reported	-0.077	0.59	Not reported
Timepoint 13 (T13)	0.756	Not reported	0.24	0.939	Not reported

School Functioning

Analysis denominator · Participants

Group	Source count
Timepoint 1 (T1)	62
Timepoint 4 (T4)	53
Timepoint 6 (T6)	51
Timepoint 8 (T8)	51
Timepoint 10 (T10)	40
Timepoint 11 (T11)	41
Timepoint 12 (T12)	29
Timepoint 13 (T13)	10

Values in correlation coefficient · Interval/dispersion: 95% Confidence Interval
Group	Value	Spread	Lower	Upper	Comment
Timepoint 1 (T1)	0.444	Not reported	0.211	0.628	Not reported
Timepoint 4 (T4)	0.577	Not reported	0.364	0.733	Not reported
Timepoint 6 (T6)	0.501	Not reported	0.261	0.682	Not reported
Timepoint 8 (T8)	0.441	Not reported	0.188	0.639	Not reported
Timepoint 10 (T10)	0.694	Not reported	0.488	0.827	Not reported
Timepoint 11 (T11)	0.315	Not reported	0.004	0.57	Not reported
Timepoint 12 (T12)	0.209	Not reported	-0.17	0.535	Not reported
Timepoint 13 (T13)	0.574	Not reported	-0.088	0.884	Not reported

Complete source fields

classes

categories
measurements
group Id
OG000
lower Limit
0.547
upper Limit
0.809
value
0.701
group Id
OG001
lower Limit
0.286
upper Limit
0.671
value
0.503
group Id
OG002
lower Limit
0.318
upper Limit
0.7
value
0.536
group Id
OG003
lower Limit
0.363
upper Limit
0.73
value
0.575
group Id
OG004
lower Limit
0.128
upper Limit
0.625
value
0.406
group Id
OG005
lower Limit
0.263
upper Limit
0.719
value
0.528
group Id
OG006
lower Limit
0.129
upper Limit
0.709
value
0.468
group Id
OG007
lower Limit
-0.411
upper Limit
0.78
value
0.294
denoms
counts
group Id
OG000
value
62
group Id
OG001
value
60
group Id
OG002
value
56
group Id
OG003
value
54
group Id
OG004
value
45
group Id
OG005
value
41
group Id
OG006
value
30
group Id
OG007
value
10
units
Participants
title
Physical Functioning
categories
measurements
group Id
OG000
lower Limit
0.064
upper Limit
0.518
value
0.309
group Id
OG001
lower Limit
0.362
upper Limit
0.718
value
0.566
group Id
OG002
lower Limit
0.313
upper Limit
0.7
value
0.534
group Id
OG003
lower Limit
-0.028
upper Limit
0.479
value
0.242
group Id
OG004
lower Limit
-0.213
upper Limit
0.371
value
0.086
group Id
OG005
lower Limit
0.021
upper Limit
0.577
value
0.327
group Id
OG006
lower Limit
-0.236
upper Limit
0.473
value
0.135
group Id
OG007
lower Limit
-0.645
upper Limit
0.613
value
-0.027
denoms
counts
group Id
OG000
value
62
group Id
OG001
value
59
group Id
OG002
value
56
group Id
OG003
value
54
group Id
OG004
value
45
group Id
OG005
value
41
group Id
OG006
value
30
group Id
OG007
value
10
units
Participants
title
Social Functioning
categories
measurements
group Id
OG000
lower Limit
0.402
upper Limit
0.734
value
0.593
group Id
OG001
lower Limit
0.491
upper Limit
0.786
value
0.664
group Id
OG002
lower Limit
0.464
upper Limit
0.778
value
0.648
group Id
OG003
lower Limit
0.38
upper Limit
0.739
value
0.588
group Id
OG004
lower Limit
0.056
upper Limit
0.579
value
0.344
group Id
OG005
lower Limit
0.457
upper Limit
0.811
value
0.671
group Id
OG006
lower Limit
-0.077
upper Limit
0.59
value
0.291
group Id
OG007
lower Limit
0.24
upper Limit
0.939
value
0.756
denoms
counts
group Id
OG000
value
62
group Id
OG001
value
59
group Id
OG002
value
55
group Id
OG003
value
54
group Id
OG004
value
45
group Id
OG005
value
41
group Id
OG006
value
30
group Id
OG007
value
10
units
Participants
title
Emotional Functioning
categories
measurements
group Id
OG000
lower Limit
0.211
upper Limit
0.628
value
0.444
group Id
OG001
lower Limit
0.364
upper Limit
0.733
value
0.577
group Id
OG002
lower Limit
0.261
upper Limit
0.682
value
0.501
group Id
OG003
lower Limit
0.188
upper Limit
0.639
value
0.441
group Id
OG004
lower Limit
0.488
upper Limit
0.827
value
0.694
group Id
OG005
lower Limit
0.004
upper Limit
0.57
value
0.315
group Id
OG006
lower Limit
-0.17
upper Limit
0.535
value
0.209
group Id
OG007
lower Limit
-0.088
upper Limit
0.884
value
0.574
denoms
counts
group Id
OG000
value
62
group Id
OG001
value
53
group Id
OG002
value
51
group Id
OG003
value
51
group Id
OG004
value
40
group Id
OG005
value
41
group Id
OG006
value
29
group Id
OG007
value
10
units
Participants
title
School Functioning

denoms

counts
group Id
OG000
value
62
group Id
OG001
value
60
group Id
OG002
value
56
group Id
OG003
value
54
group Id
OG004
value
45
group Id
OG005
value
41
group Id
OG006
value
30
group Id
OG007
value
10
units
Participants

description

The correlation of agreement between patient and parent Quality of Life is calculated by using the Pearson's Correlation Coefficient, which considers only the record with both parent and patient data. The QL scoring is a 5-point Likert scale from 0 (never) to 4 (almost always). Scores are transformed on a scale from 0 to 100. Items are reverse scored and linearly transformed to a 0-100 scale as follows: 0=100, 1=75, 2=50, 3=25, and 4=0. Total score is the sum of all items over the number of items answered on all scales. For both the total score and subscales the range is 0-100. The total score is the sum of all items from each subscale, over the number of items answered on the scale. The total score is the sum of all items on the scale over the number of items answer. If \>50% of the items are missing the score should not be computed. If \>50% are completed, impute the mean of the completed items in a scale. The Higher the score the better quality of life.

dispersion Type

95% Confidence Interval

groups

description
At Diagnosis (baseline)
id
OG000
title
Timepoint 1 (T1)
description
Course 2 Day 1
id
OG001
title
Timepoint 4 (T4)
description
Course 3 Day 1
id
OG002
title
Timepoint 6 (T6)
description
Course 6 Day 1
id
OG003
title
Timepoint 8 (T8)
description
4-6 weeks after chemotherapy or 4-6 weeks after radiation
id
OG004
title
Timepoint 10 (T10)
description
1 year off therapy
id
OG005
title
Timepoint 11 (T11)
description
2 years off therapy (approximately 2 years and 8 months
id
OG006
title
Timepoint 12 (T12)
description
5 years off therapy (approximately 5 years and 8 months)
id
OG007
title
Timepoint 13 (T13)

param Type

NUMBER

population Description

Each institution made the decision whether to complete the QoL objective. Participation in the Quality of Life part of the trial is voluntary for participating institutions and voluntary by participant.

reporting Status

POSTED

time Frame

At various time points from diagnosis through 5 years off therapy. (up to approximately 6 years from enrollment)

title

Correlation of Agreement Between Patient QoL and Parent Proxy QoL at Multiple Time Points

type

SECONDARY

unit Of Measure

correlation coefficient

Download exact source JSON → · Snapshot ctgov-results-191f4516d4760045304b24a0

Preserved source evidence · Not medical advice