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NCT01876511 · OUTCOME

Overall Survival (OS)

Study of MK-3475 in Patients With Microsatellite Unstable (MSI) Tumors (Cohorts A, B and C) · Source last updated 2020-02-06

Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.

Measure
MEDIAN
Unit
Weeks
Interval / dispersion
95% Confidence Interval
Time frame
4 years

What was measured

OS will be measured from date of first dose until death or end of follow-up (OS will be censored on the date the subject was last known to be alive for subjects without documentation of death at the time of analysis). Estimation based on the Kaplan-Meier curve.

Groups in this outcome

Cohort A: MSI Positive Colorectal Cancer

MK-3475: MK-3475 10 mg/kg every 14 days

Cohort B: MSI Negative Colorectal Cancer

MK-3475: MK-3475 10 mg/kg every 14 days

Cohort C: MSI Positive Non-Colorectal Cancer

MK-3475: MK-3475 10 mg/kg every 14 days

Group identifiers and denominators belong to this outcome only. They may differ in another outcome or in safety reporting.

Analysis denominator · Participants

GroupSource count
Cohort A: MSI Positive Colorectal Cancer41
Cohort B: MSI Negative Colorectal Cancer25
Cohort C: MSI Positive Non-Colorectal Cancer47

Reported measurements

Source class 1
Values in Weeks · Interval/dispersion: 95% Confidence Interval
GroupValueSpreadLowerUpperComment
Cohort A: MSI Positive Colorectal CancerNANot reported151.86NANA means that the median overall survival and upper bound confidence interval was not reached.
Cohort B: MSI Negative Colorectal Cancer36.71Not reported21.2969.43Not reported
Cohort C: MSI Positive Non-Colorectal Cancer148.86Not reported94.71NANA means that the upper bound confidence interval was not reached.
Complete source fields
classes
  1. categories
    1. measurements
      1. comment
        NA means that the median overall survival and upper bound confidence interval was not reached.
        group Id
        OG000
        lower Limit
        151.86
        upper Limit
        NA
        value
        NA
      2. group Id
        OG001
        lower Limit
        21.29
        upper Limit
        69.43
        value
        36.71
      3. comment
        NA means that the upper bound confidence interval was not reached.
        group Id
        OG002
        lower Limit
        94.71
        upper Limit
        NA
        value
        148.86
denoms
  1. counts
    1. group Id
      OG000
      value
      41
    2. group Id
      OG001
      value
      25
    3. group Id
      OG002
      value
      47
    units
    Participants
description
OS will be measured from date of first dose until death or end of follow-up (OS will be censored on the date the subject was last known to be alive for subjects without documentation of death at the time of analysis). Estimation based on the Kaplan-Meier curve.
dispersion Type
95% Confidence Interval
groups
  1. description
    MK-3475: MK-3475 10 mg/kg every 14 days
    id
    OG000
    title
    Cohort A: MSI Positive Colorectal Cancer
  2. description
    MK-3475: MK-3475 10 mg/kg every 14 days
    id
    OG001
    title
    Cohort B: MSI Negative Colorectal Cancer
  3. description
    MK-3475: MK-3475 10 mg/kg every 14 days
    id
    OG002
    title
    Cohort C: MSI Positive Non-Colorectal Cancer
param Type
MEDIAN
reporting Status
POSTED
time Frame
4 years
title
Overall Survival (OS)
type
SECONDARY
unit Of Measure
Weeks

Download exact source JSON → · Snapshot ctgov-results-191f4516d4760045304b24a0

Preserved source evidence · Independent clinical review pending · Not medical advice