NCT01858740 · OUTCOME

Time to Discontinuation of Systemic Immunosuppression

Selective Depletion of CD45RA+ T Cells From Allogeneic Peripheral Blood Stem Cell Grafts in Preventing GVHD in Children · Source last updated 2024-03-12

Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.

Measure: MEDIAN
Unit: Days
Interval / dispersion: Inter-Quartile Range
Time frame: 5 years post transplant

What was measured

Measure the number of days to discontinuation of systemic immunosuppression (both including and excluding calcineurin inhibitors) in pediatric recipients of CD45RA+ T cell-depleted PBSCT. Possible outcomes range from no systemic immunosuppression (best outcome) to 5 years on immunosuppression (poor outcome)

Groups in this outcome

Overall Study Patients Alive at D100

All participants in single arm study of CD45RA+ T cell depletion PBSC transplant and Methotrexate and tacrolimus for GVHD prophylaxis that were alive at D100

Group identifiers and denominators belong to this outcome only. They may differ in another outcome or in safety reporting.

Analysis denominator · Participants

Group	Source count
Overall Study Patients Alive at D100	18

Reported measurements

Discontinuation (or never started) prednisone

Values in Days · Interval/dispersion: Inter-Quartile Range
Group	Value	Spread	Lower	Upper	Comment
Overall Study Patients Alive at D100	106	Not reported	87	238	Not reported

Discontinuation of systemic immunosuppression (including calcineurin inhibitors)

Values in Days · Interval/dispersion: Inter-Quartile Range
Group	Value	Spread	Lower	Upper	Comment
Overall Study Patients Alive at D100	349	Not reported	266	405	Not reported

Complete source fields

classes

categories
measurements
group Id
OG000
lower Limit
87
upper Limit
238
value
106
title
Discontinuation (or never started) prednisone
categories
measurements
group Id
OG000
lower Limit
266
upper Limit
405
value
349
title
Discontinuation of systemic immunosuppression (including calcineurin inhibitors)

denoms

counts
group Id
OG000
value
18
units
Participants

description

dispersion Type

Inter-Quartile Range

groups

description
All participants in single arm study of CD45RA+ T cell depletion PBSC transplant and Methotrexate and tacrolimus for GVHD prophylaxis that were alive at D100
id
OG000
title
Overall Study Patients Alive at D100

param Type

MEDIAN

reporting Status

POSTED

time Frame

5 years post transplant

title

Time to Discontinuation of Systemic Immunosuppression

type

PRIMARY

unit Of Measure

Days

Download exact source JSON → · Snapshot ctgov-results-25a395029948b04d52b1253f

Preserved source evidence · Not medical advice