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NCT01858740 · OUTCOME

Graft Failure

Selective Depletion of CD45RA+ T Cells From Allogeneic Peripheral Blood Stem Cell Grafts in Preventing GVHD in Children · Source last updated 2024-03-12

Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.

Measure
COUNT_OF_PARTICIPANTS
Unit
Participants
Interval / dispersion
Not reported
Time frame
Up to 5 years

What was measured

Graft failure defined as failure to reach ANC of \>500/uL for 3 consecutive days by day 28, or irreversible decrease in ANC to \<100 after an established donor graft. A reduction in ANC as result of relapse is not considered graft failure

Groups in this outcome

Overall Study Participants

All participants in single arm study received CD45RA+ T cell depletion PBSC transplant and IV Methotrexate and tacrolimus for GVHD prophylaxis

Group identifiers and denominators belong to this outcome only. They may differ in another outcome or in safety reporting.

Analysis denominator · Participants

GroupSource count
Overall Study Participants20

Reported measurements

Fail to engraft by D28
Values in Participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
Overall Study Participants0Not reportedNot reportedNot reportedNot reported
Fail to maintain ANC >100 for 5 years
Values in Participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
Overall Study Participants1Not reportedNot reportedNot reportedNot reported
Complete source fields
classes
  1. categories
    1. measurements
      1. group Id
        OG000
        value
        0
    title
    Fail to engraft by D28
  2. categories
    1. measurements
      1. group Id
        OG000
        value
        1
    title
    Fail to maintain ANC >100 for 5 years
denoms
  1. counts
    1. group Id
      OG000
      value
      20
    units
    Participants
description
Graft failure defined as failure to reach ANC of \>500/uL for 3 consecutive days by day 28, or irreversible decrease in ANC to \<100 after an established donor graft. A reduction in ANC as result of relapse is not considered graft failure
groups
  1. description
    All participants in single arm study received CD45RA+ T cell depletion PBSC transplant and IV Methotrexate and tacrolimus for GVHD prophylaxis
    id
    OG000
    title
    Overall Study Participants
param Type
COUNT_OF_PARTICIPANTS
reporting Status
POSTED
time Frame
Up to 5 years
title
Graft Failure
type
PRIMARY
unit Of Measure
Participants

Download exact source JSON → · Snapshot ctgov-results-25a395029948b04d52b1253f

Preserved source evidence · Not medical advice