NCT01696994 · OUTCOME

Death Rates From All Causes

Screening for Ovarian Cancer in Older Patients (PLCO Screening Trial) · Source last updated 2026-07-24

Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.

Measure: NUMBER
Unit: Deaths per 10,000 PY
Interval / dispersion: Not reported
Time frame: Events through 13 years of follow-up or through December 31, 2009; median follow-up 11.9 years.

What was measured

Deaths from all causes were compared between the ovarian cancer screening arm and the usual care arm. Rate is the number of deaths divided by person years of follow-up in the study.

Analysis population: Female participants, excluding females without ovaries at baseline, were analyzed. An intention-to-treat analysis was performed.

Groups in this outcome

Control

Participants receive standard medical care.

Ovarian Screening

Participants undergo blood sample collection for CA125 analysis at baseline annually for 5 years. Participants also undergo an OVR (discontinued in December 1998) and TVU at baseline and annually for 3 years.

Group identifiers and denominators belong to this outcome only. They may differ in another outcome or in safety reporting.

Analysis denominator · Participants

Group	Source count
Control	34304
Ovarian Screening	34253

Reported measurements

Source class 1

Values in Deaths per 10,000 PY · Interval/dispersion: Not reported
Group	Value	Spread	Lower	Upper	Comment
Control	92.6	Not reported	Not reported	Not reported	Not reported
Ovarian Screening	91.9	Not reported	Not reported	Not reported	Not reported

Source statistical analyses

Group order, estimate direction, methods and comments are retained. No treatment ranking is inferred.

ci Lower Limit
0.95
ci Num Sides
TWO_SIDED
ci Pct Value
95
ci Upper Limit
1.04
group Ids
OG000
non Inferiority Type
SUPERIORITY_OR_OTHER_LEGACY
param Type
Hazard Ratio (HR)
param Value
0.99
statistical Comment
Two-sided. Not adjusted for multiple comparisons. A-priori threshold for significance 0.05.
statistical Method
Poisson regression

Complete source fields

analyses

ci Lower Limit
0.95
ci Num Sides
TWO_SIDED
ci Pct Value
95
ci Upper Limit
1.04
group Ids
OG000
non Inferiority Type
SUPERIORITY_OR_OTHER_LEGACY
param Type
Hazard Ratio (HR)
param Value
0.99
statistical Comment
Two-sided. Not adjusted for multiple comparisons. A-priori threshold for significance 0.05.
statistical Method
Poisson regression

classes

categories
measurements
group Id
OG000
value
92.6
group Id
OG001
value
91.9

denoms

counts
group Id
OG000
value
34304
group Id
OG001
value
34253
units
Participants

description

Deaths from all causes were compared between the ovarian cancer screening arm and the usual care arm. Rate is the number of deaths divided by person years of follow-up in the study.

groups

description
Participants receive standard medical care.
id
OG000
title
Control
description
Participants undergo blood sample collection for CA125 analysis at baseline annually for 5 years. Participants also undergo an OVR (discontinued in December 1998) and TVU at baseline and annually for 3 years.
id
OG001
title
Ovarian Screening

param Type

NUMBER

population Description

Female participants, excluding females without ovaries at baseline, were analyzed. An intention-to-treat analysis was performed.

reporting Status

POSTED

time Frame

Events through 13 years of follow-up or through December 31, 2009; median follow-up 11.9 years.

title

Death Rates From All Causes

type

SECONDARY

unit Of Measure

Deaths per 10,000 PY

Download exact source JSON → · Snapshot ctgov-results-25a395029948b04d52b1253f

Preserved source evidence · Not medical advice