Participant flow

Study of Nivolumab (BMS-936558) vs. Everolimus in Pre-Treated Advanced or Metastatic Clear-cell Renal Cell Carcinoma (CheckMate 025) · Source last updated 2022-08-09

Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.

groups

1. description

   Nivolumab at 3 mg/kg solution provided intravenously every 2 weeks until documented disease progression, discontinuation due to toxicity, withdrawal of consent or the study ends.

   id

   FG000

   title

   Nivolumab

2. description

   Everolimus provided in 10 mg tablets by mouth daily until documented disease progression, discontinuation due to toxicity, withdrawal of consent or the study ends.

   id

   FG001

   title

   Everolimus

periods

1. drop Withdraws

   1. reasons

      1. group Id

         FG000

         num Subjects

         0

      2. group Id

         FG001

         num Subjects

         1

      type

      Disease Progression

   2. reasons

      1. group Id

         FG000

         num Subjects

         0

      2. group Id

         FG001

         num Subjects

         3

      type

      Request to Discontinue Study Treatment

   3. reasons

      1. group Id

         FG000

         num Subjects

         1

      2. group Id

         FG001

         num Subjects

         8

      type

      Withdrawal by Subject

   4. reasons

      1. group Id

         FG000

         num Subjects

         1

      2. group Id

         FG001

         num Subjects

         0

      type

      Poor/Non-Compliance

   5. reasons

      1. group Id

         FG000

         num Subjects

         2

      2. group Id

         FG001

         num Subjects

         1

      type

      No Longer Meets Study Criteria

   6. reasons

      1. group Id

         FG000

         num Subjects

         0

      2. group Id

         FG001

         num Subjects

         1

      type

      participant requested to be treated a local facility

   milestones

   1. achievements

      1. group Id

         FG000

         num Subjects

         410

      2. group Id

         FG001

         num Subjects

         411

      type

      STARTED

   2. achievements

      1. group Id

         FG000

         num Subjects

         406

      2. group Id

         FG001

         num Subjects

         397

      type

      COMPLETED

   3. achievements

      1. group Id

         FG000

         num Subjects

         4

      2. group Id

         FG001

         num Subjects

         14

      type

      NOT COMPLETED

   title

   Randomized (Pre-treatment)

2. drop Withdraws

   1. reasons

      1. group Id

         FG000

         num Subjects

         316

      2. group Id

         FG001

         num Subjects

         293

      type

      Disease Progression

   2. reasons

      1. group Id

         FG000

         num Subjects

         46

      2. group Id

         FG001

         num Subjects

         53

      type

      Study Drug Toxicity

   3. reasons

      1. group Id

         FG000

         num Subjects

         1

      2. group Id

         FG001

         num Subjects

         1

      type

      Death

   4. reasons

      1. group Id

         FG000

         num Subjects

         14

      2. group Id

         FG001

         num Subjects

         14

      type

      Adverse Event Unrelated to Study Drug

   5. reasons

      1. group Id

         FG000

         num Subjects

         14

      2. group Id

         FG001

         num Subjects

         21

      type

      Request to Discontinue Study Treatment

   6. reasons

      1. group Id

         FG000

         num Subjects

         5

      2. group Id

         FG001

         num Subjects

         3

      type

      Withdrawal by Subject

   7. reasons

      1. group Id

         FG000

         num Subjects

         3

      2. group Id

         FG001

         num Subjects

         3

      type

      Maximal Clinical Benefit

   8. reasons

      1. group Id

         FG000

         num Subjects

         2

      2. group Id

         FG001

         num Subjects

         8

      type

      Other

   9. reasons

      1. group Id

         FG000

         num Subjects

         5

      2. group Id

         FG001

         num Subjects

         1

      type

      Administrative Reason by Sponsor

   milestones

   1. achievements

      1. group Id

         FG000

         num Subjects

         406

      2. group Id

         FG001

         num Subjects

         397

      type

      STARTED

   2. achievements

      1. group Id

         FG000

         num Subjects

         0

      2. group Id

         FG001

         num Subjects

         0

      type

      COMPLETED

   3. achievements

      1. group Id

         FG000

         num Subjects

         406

      2. group Id

         FG001

         num Subjects

         397

      type

      NOT COMPLETED

   title

   Treatment Period

pre Assignment Details

803 Participants Treated

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Preserved source evidence · Not medical advice