TriangleNCT01536145 · OUTCOME
Single Dose Area Under the Curve From Time Zero to Extrapolated Infinite Time [AUC (0 - ∞)] for CP-751,871
Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.
- Measure
- MEAN
- Unit
- mg•hr/L
- Interval / dispersion
- Standard Deviation
- Time frame
- Cycle 1: predose; 1; 24; 48; 72; 168; 336; 504 and 672 and 1008 (for participants with an up to 8-week Cycle 1 only) hours postdose
Analysis population: All participants treated who had at least 1 of the PK parameters of primary interest.
Groups in this outcome
CP-751,871 0.2 mg/kg
CP-751,871 0.2 mg/kg administered intravenously on Day 1 of Cycle 1 (4 weeks or 8 weeks), and dose of 50% from the Cycle 1 dose administered on Day 1 of subsequent cycles, starting from Cycle 2 (4 weeks)
CP-751,871 0.4 mg/kg
CP-751,871 0.4 mg/kg administered intravenously on Day 1 of Cycle 1 (4 weeks or 8 weeks), and dose of 50% from the Cycle 1 dose administered on Day 1 of subsequent cycles, starting from Cycle 2 (4 weeks)
CP-751,871 0.8 mg/kg
CP-751,871 0.8 mg/kg administered intravenously on Day 1 of Cycle 1 (4 weeks or 8 weeks), and dose of 50% from the Cycle 1 dose administered on Day 1 of subsequent cycles, starting from Cycle 2 (4 weeks)
CP-751,871 1.5 mg/kg
CP-751,871 1.5 mg/kg administered intravenously on Day 1 of Cycle 1 (4 weeks or 8 weeks), and dose of 50% from the Cycle 1 dose administered on Day 1 of subsequent cycles, starting from Cycle 2 (4 weeks)
CP-751,871 3 mg/kg
CP-751,871 3 mg/kg administered intravenously on Day 1 of Cycle 1 (4 weeks or 8 weeks), and dose of 50% from the Cycle 1 dose administered on Day 1 of subsequent Cycles, starting from Cycle 2 (4 weeks)
CP-751,871 6 mg/kg
CP-751,871 6 mg/kg administered intravenously on Day 1 of Cycle 1 (4 weeks or 8 weeks), and dose of 50% from the Cycle 1 dose administered on Day 1 of subsequent cycles, starting from Cycle 2 (4 weeks)
CP-751,871 10 mg/kg
CP-751,871 10 mg/kg administered intravenously on Day 1 of Cycle 1 (4 weeks or 8 weeks) and subsequent cycles, starting from Cycle 2 (4 weeks)
| Group | Source count |
|---|---|
| CP-751,871 0.2 mg/kg | 3 |
| CP-751,871 0.4 mg/kg | 4 |
| CP-751,871 0.8 mg/kg | 3 |
| CP-751,871 1.5 mg/kg | 2 |
| CP-751,871 3 mg/kg | 3 |
| CP-751,871 6 mg/kg | 3 |
| CP-751,871 10 mg/kg | 5 |
Reported measurements
Source class 1
| Group | Value | Spread | Lower | Upper | Comment |
|---|---|---|---|---|---|
| CP-751,871 0.2 mg/kg | 249 | 42.5 | Not reported | Not reported | Not reported |
| CP-751,871 0.4 mg/kg | 1121 | 645 | Not reported | Not reported | Not reported |
| CP-751,871 0.8 mg/kg | 2191 | 1396 | Not reported | Not reported | Not reported |
| CP-751,871 1.5 mg/kg | 11035 | NA | Not reported | Not reported | Number of participants analyzed was less than 3, thus standard deviation was not calculated. |
| CP-751,871 3 mg/kg | 15025 | 3673 | Not reported | Not reported | Not reported |
| CP-751,871 6 mg/kg | 32360 | 4023 | Not reported | Not reported | Not reported |
| CP-751,871 10 mg/kg | 46275 | 16606 | Not reported | Not reported | Not reported |
Complete source fields
- classes
- categories
- measurements
- group Id
- OG000
- spread
- 42.5
- value
- 249
- group Id
- OG001
- spread
- 645
- value
- 1121
- group Id
- OG002
- spread
- 1396
- value
- 2191
- comment
- Number of participants analyzed was less than 3, thus standard deviation was not calculated.
- group Id
- OG003
- spread
- NA
- value
- 11035
- group Id
- OG004
- spread
- 3673
- value
- 15025
- group Id
- OG005
- spread
- 4023
- value
- 32360
- group Id
- OG006
- spread
- 16606
- value
- 46275
- denoms
- counts
- group Id
- OG000
- value
- 3
- group Id
- OG001
- value
- 4
- group Id
- OG002
- value
- 3
- group Id
- OG003
- value
- 2
- group Id
- OG004
- value
- 3
- group Id
- OG005
- value
- 3
- group Id
- OG006
- value
- 5
- units
- Participants
- dispersion Type
- Standard Deviation
- groups
- description
- CP-751,871 0.2 mg/kg administered intravenously on Day 1 of Cycle 1 (4 weeks or 8 weeks), and dose of 50% from the Cycle 1 dose administered on Day 1 of subsequent cycles, starting from Cycle 2 (4 weeks)
- id
- OG000
- title
- CP-751,871 0.2 mg/kg
- description
- CP-751,871 0.4 mg/kg administered intravenously on Day 1 of Cycle 1 (4 weeks or 8 weeks), and dose of 50% from the Cycle 1 dose administered on Day 1 of subsequent cycles, starting from Cycle 2 (4 weeks)
- id
- OG001
- title
- CP-751,871 0.4 mg/kg
- description
- CP-751,871 0.8 mg/kg administered intravenously on Day 1 of Cycle 1 (4 weeks or 8 weeks), and dose of 50% from the Cycle 1 dose administered on Day 1 of subsequent cycles, starting from Cycle 2 (4 weeks)
- id
- OG002
- title
- CP-751,871 0.8 mg/kg
- description
- CP-751,871 1.5 mg/kg administered intravenously on Day 1 of Cycle 1 (4 weeks or 8 weeks), and dose of 50% from the Cycle 1 dose administered on Day 1 of subsequent cycles, starting from Cycle 2 (4 weeks)
- id
- OG003
- title
- CP-751,871 1.5 mg/kg
- description
- CP-751,871 3 mg/kg administered intravenously on Day 1 of Cycle 1 (4 weeks or 8 weeks), and dose of 50% from the Cycle 1 dose administered on Day 1 of subsequent Cycles, starting from Cycle 2 (4 weeks)
- id
- OG004
- title
- CP-751,871 3 mg/kg
- description
- CP-751,871 6 mg/kg administered intravenously on Day 1 of Cycle 1 (4 weeks or 8 weeks), and dose of 50% from the Cycle 1 dose administered on Day 1 of subsequent cycles, starting from Cycle 2 (4 weeks)
- id
- OG005
- title
- CP-751,871 6 mg/kg
- description
- CP-751,871 10 mg/kg administered intravenously on Day 1 of Cycle 1 (4 weeks or 8 weeks) and subsequent cycles, starting from Cycle 2 (4 weeks)
- id
- OG006
- title
- CP-751,871 10 mg/kg
- param Type
- MEAN
- population Description
- All participants treated who had at least 1 of the PK parameters of primary interest.
- reporting Status
- POSTED
- time Frame
- Cycle 1: predose; 1; 24; 48; 72; 168; 336; 504 and 672 and 1008 (for participants with an up to 8-week Cycle 1 only) hours postdose
- title
- Single Dose Area Under the Curve From Time Zero to Extrapolated Infinite Time [AUC (0 - ∞)] for CP-751,871
- type
- SECONDARY
- unit Of Measure
- mg•hr/L
Download exact source JSON → · Snapshot ctgov-results-25a395029948b04d52b1253f
Preserved source evidence · Not medical advice