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NCT01495598 · OUTCOME

Area Under the Curve Extrapolated to Infinity (AUCinf)

Pomalidomide for Kaposi Sarcoma in People With or Without HIV · Source last updated 2022-11-01

Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.

Measure
MEAN
Unit
hours*ng/ml
Interval / dispersion
Standard Deviation
Time frame
At pre-dose, 1, 2, 3, 4, 6, and 8 hours after dose on Cycle 1 Day 1, and pre-dose, 1, 2, 3, 4, 6, 8, and 24 hours after dose on Cycle 1 Day 15.

What was measured

AUC is a measure of the serum concentration of Pomalidomide over time. It is used to characterize drug absorption. The AUC extrapolated to infinity was used, unless the percent extrapolated exceeded 25% in which case AUC to the last quantifiable time point (AUCLast) was used. The steady-state exposure on Day 15 of cycle 1 was calculated using AUCLast.

Groups in this outcome

All Participants - Pomalidomide 5mg Daily

All participants treated with pomalidomide 5 mg by mouth (p.o.) for 21 of 28 days.

Group identifiers and denominators belong to this outcome only. They may differ in another outcome or in safety reporting.

Analysis denominator · Participants

GroupSource count
All Participants - Pomalidomide 5mg Daily28

Reported measurements

Cycle 1 Day 1
Values in hours*ng/ml · Interval/dispersion: Standard Deviation
GroupValueSpreadLowerUpperComment
All Participants - Pomalidomide 5mg Daily567.3423.2Not reportedNot reportedNot reported
Cycle 1 Day 15
Values in hours*ng/ml · Interval/dispersion: Standard Deviation
GroupValueSpreadLowerUpperComment
All Participants - Pomalidomide 5mg Daily805.3986.9Not reportedNot reportedNot reported
Complete source fields
classes
  1. categories
    1. measurements
      1. group Id
        OG000
        spread
        423.2
        value
        567.3
    title
    Cycle 1 Day 1
  2. categories
    1. measurements
      1. group Id
        OG000
        spread
        986.9
        value
        805.3
    title
    Cycle 1 Day 15
denoms
  1. counts
    1. group Id
      OG000
      value
      28
    units
    Participants
description
AUC is a measure of the serum concentration of Pomalidomide over time. It is used to characterize drug absorption. The AUC extrapolated to infinity was used, unless the percent extrapolated exceeded 25% in which case AUC to the last quantifiable time point (AUCLast) was used. The steady-state exposure on Day 15 of cycle 1 was calculated using AUCLast.
dispersion Type
Standard Deviation
groups
  1. description
    All participants treated with pomalidomide 5 mg by mouth (p.o.) for 21 of 28 days.
    id
    OG000
    title
    All Participants - Pomalidomide 5mg Daily
param Type
MEAN
reporting Status
POSTED
time Frame
At pre-dose, 1, 2, 3, 4, 6, and 8 hours after dose on Cycle 1 Day 1, and pre-dose, 1, 2, 3, 4, 6, 8, and 24 hours after dose on Cycle 1 Day 15.
title
Area Under the Curve Extrapolated to Infinity (AUCinf)
type
PRIMARY
unit Of Measure
hours*ng/ml

Download exact source JSON → · Snapshot ctgov-results-191f4516d4760045304b24a0

Preserved source evidence · Not medical advice