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NCT01237054 · OUTCOME

Comparison of Microvessel Density (MVD) Between MGUS and SMM/MM Groups

Imaging in MGUS, SMM and MM · Source last updated 2026-02-06

Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.

Measure
MEAN
Unit
microvessels/hpf
Interval / dispersion
Standard Error
Time frame
60 days

What was measured

Microvessel density was estimated by determining the average number of CD34-stained microvessels in 10 areas of maximal MVD counted at a high-power field (h.p.f. x 500 magnification).

Analysis population: Serum was not available for three patients in the SMM group.

Groups in this outcome

MGUS (Monoclonal Gammopathy of Undetermined Significance)

MGUS (Monoclonal gammopathy of undetermined significance) is a premalignant plasma cell proliferative disorder.

SMM (Smoldering Multiple Myeloma)/MM (Multiple Myeloma)

Smoldering multiple myeloma (SMM)is a premalignant plasma cell proliferative disorder. Multiple myeloma is a plasma cell neoplasm.

Group identifiers and denominators belong to this outcome only. They may differ in another outcome or in safety reporting.

Analysis denominator · Participants

GroupSource count
MGUS (Monoclonal Gammopathy of Undetermined Significance)10
SMM (Smoldering Multiple Myeloma)/MM (Multiple Myeloma)17

Reported measurements

Source class 1
Values in microvessels/hpf · Interval/dispersion: Standard Error
GroupValueSpreadLowerUpperComment
MGUS (Monoclonal Gammopathy of Undetermined Significance)15.041.14Not reportedNot reportedNot reported
SMM (Smoldering Multiple Myeloma)/MM (Multiple Myeloma)21.641.90Not reportedNot reportedNot reported

Source statistical analyses

Group order, estimate direction, methods and comments are retained. No treatment ranking is inferred.

  1. group Ids
    1. OG000
    2. OG001
    non Inferiority Type
    SUPERIORITY
    p Value
    0.011
    statistical Method
    Wilcoxon rank sum test
Complete source fields
analyses
  1. group Ids
    1. OG000
    2. OG001
    non Inferiority Type
    SUPERIORITY
    p Value
    0.011
    statistical Method
    Wilcoxon rank sum test
classes
  1. categories
    1. measurements
      1. group Id
        OG000
        spread
        1.14
        value
        15.04
      2. group Id
        OG001
        spread
        1.90
        value
        21.64
denoms
  1. counts
    1. group Id
      OG000
      value
      10
    2. group Id
      OG001
      value
      17
    units
    Participants
description
Microvessel density was estimated by determining the average number of CD34-stained microvessels in 10 areas of maximal MVD counted at a high-power field (h.p.f. x 500 magnification).
dispersion Type
Standard Error
groups
  1. description
    MGUS (Monoclonal gammopathy of undetermined significance) is a premalignant plasma cell proliferative disorder.
    id
    OG000
    title
    MGUS (Monoclonal Gammopathy of Undetermined Significance)
  2. description
    Smoldering multiple myeloma (SMM)is a premalignant plasma cell proliferative disorder. Multiple myeloma is a plasma cell neoplasm.
    id
    OG001
    title
    SMM (Smoldering Multiple Myeloma)/MM (Multiple Myeloma)
param Type
MEAN
population Description
Serum was not available for three patients in the SMM group.
reporting Status
POSTED
time Frame
60 days
title
Comparison of Microvessel Density (MVD) Between MGUS and SMM/MM Groups
type
SECONDARY
unit Of Measure
microvessels/hpf

Download exact source JSON → · Snapshot ctgov-results-25a395029948b04d52b1253f

Preserved source evidence · Not medical advice