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NCT01237054 · OUTCOME

Count of Participants With Positive and Negative 18F-FDG PET CT and F18-NaF PET CT Imaging Results in Individuals With MGUS, SMM, and MM.

Imaging in MGUS, SMM and MM · Source last updated 2026-02-06

Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.

Measure
COUNT_OF_PARTICIPANTS
Unit
Participants
Interval / dispersion
Not reported
Time frame
60 days

What was measured

18F-FDG PET CT and F18-NaF PET CT imaging results were compared in participants with MGUS, SMM, and MM. Lesions were considered positive if focal uptake corresponded to lesions identified on CT for NaF and negative if no uptake seen in lesions. Criteria to define FDG positivity included parameters published by Zamagni et al with focal abnormal uptake more intense than background.

Groups in this outcome

MGUS (Monoclonal Gammopathy of Undetermined Significance)

MGUS (Monoclonal gammopathy of undetermined significance) is a premalignant plasma cell proliferative disorder.

SMM (Smoldering Multiple Myeloma)

Smoldering multiple myeloma (SMM)is a premalignant plasma cell proliferative disorder.

MM (Multiple Myeloma)

Multiple myeloma is a plasma cell neoplasm.

Group identifiers and denominators belong to this outcome only. They may differ in another outcome or in safety reporting.

Analysis denominator · Participants

GroupSource count
MGUS (Monoclonal Gammopathy of Undetermined Significance)10
SMM (Smoldering Multiple Myeloma)10
MM (Multiple Myeloma)10

Reported measurements

Positive 18F-FDG PET CT result
Values in Participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
MGUS (Monoclonal Gammopathy of Undetermined Significance)0Not reportedNot reportedNot reportedNot reported
SMM (Smoldering Multiple Myeloma)1Not reportedNot reportedNot reportedNot reported
MM (Multiple Myeloma)5Not reportedNot reportedNot reportedNot reported
Negative 18F-FDG PET CT result
Values in Participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
MGUS (Monoclonal Gammopathy of Undetermined Significance)10Not reportedNot reportedNot reportedNot reported
SMM (Smoldering Multiple Myeloma)9Not reportedNot reportedNot reportedNot reported
MM (Multiple Myeloma)5Not reportedNot reportedNot reportedNot reported
Positive F18-NaF PET CT result
Values in Participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
MGUS (Monoclonal Gammopathy of Undetermined Significance)0Not reportedNot reportedNot reportedNot reported
SMM (Smoldering Multiple Myeloma)0Not reportedNot reportedNot reportedNot reported
MM (Multiple Myeloma)9Not reportedNot reportedNot reportedNot reported
Negative F18-NaF PET CT result
Values in Participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
MGUS (Monoclonal Gammopathy of Undetermined Significance)10Not reportedNot reportedNot reportedNot reported
SMM (Smoldering Multiple Myeloma)10Not reportedNot reportedNot reportedNot reported
MM (Multiple Myeloma)1Not reportedNot reportedNot reportedNot reported
Complete source fields
classes
  1. categories
    1. measurements
      1. group Id
        OG000
        value
        0
      2. group Id
        OG001
        value
        1
      3. group Id
        OG002
        value
        5
    title
    Positive 18F-FDG PET CT result
  2. categories
    1. measurements
      1. group Id
        OG000
        value
        10
      2. group Id
        OG001
        value
        9
      3. group Id
        OG002
        value
        5
    title
    Negative 18F-FDG PET CT result
  3. categories
    1. measurements
      1. group Id
        OG000
        value
        0
      2. group Id
        OG001
        value
        0
      3. group Id
        OG002
        value
        9
    title
    Positive F18-NaF PET CT result
  4. categories
    1. measurements
      1. group Id
        OG000
        value
        10
      2. group Id
        OG001
        value
        10
      3. group Id
        OG002
        value
        1
    title
    Negative F18-NaF PET CT result
denoms
  1. counts
    1. group Id
      OG000
      value
      10
    2. group Id
      OG001
      value
      10
    3. group Id
      OG002
      value
      10
    units
    Participants
description
18F-FDG PET CT and F18-NaF PET CT imaging results were compared in participants with MGUS, SMM, and MM. Lesions were considered positive if focal uptake corresponded to lesions identified on CT for NaF and negative if no uptake seen in lesions. Criteria to define FDG positivity included parameters published by Zamagni et al with focal abnormal uptake more intense than background.
groups
  1. description
    MGUS (Monoclonal gammopathy of undetermined significance) is a premalignant plasma cell proliferative disorder.
    id
    OG000
    title
    MGUS (Monoclonal Gammopathy of Undetermined Significance)
  2. description
    Smoldering multiple myeloma (SMM)is a premalignant plasma cell proliferative disorder.
    id
    OG001
    title
    SMM (Smoldering Multiple Myeloma)
  3. description
    Multiple myeloma is a plasma cell neoplasm.
    id
    OG002
    title
    MM (Multiple Myeloma)
param Type
COUNT_OF_PARTICIPANTS
reporting Status
POSTED
time Frame
60 days
title
Count of Participants With Positive and Negative 18F-FDG PET CT and F18-NaF PET CT Imaging Results in Individuals With MGUS, SMM, and MM.
type
PRIMARY
unit Of Measure
Participants

Download exact source JSON → · Snapshot ctgov-results-25a395029948b04d52b1253f

Preserved source evidence · Not medical advice