NCT00932893 · OUTCOME

European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire-Supplement Module for Lung Cancer (EORTC QLQ-LC13)

An Investigational Drug, PF-02341066 Is Being Studied Versus Standard Of Care In Patients With Advanced Non-Small Cell Lung Cancer With A Specific Gene Profile Involving The Anaplastic Lymphoma Kinase (ALK) Gene · Source last updated 2017-01-02

Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.

Measure: MEAN
Unit: units on a scale
Interval / dispersion: Standard Deviation
Time frame: Baseline, Day 1 of each cycle until disease progression, end of treatment (up to 112 weeks)

What was measured

QLQ-LC13 consisted of 13 questions relating to disease symptoms specific to lung cancer and treatment side effects typical of treatment with chemotherapy and radiotherapy. The 13 questions comprised 1 multi-item scale for dyspnea and 10 single-item symptoms and side effects (coughing, hemoptysis, sore mouth, dysphagia, peripheral neuropathy, alopecia, chest pain, arm pain, other pain, and medicine for pain). Recall period: past week; response range: 1 'Not at All' to 4 'Very Much'. Scores averaged, transformed to 0-100 scale; higher symptom score = greater degree of symptoms.

Analysis population: FAS included all participants who were randomized to study treatment. Here "N" (number of participants analyzed) signifies participants who were evaluable for this measure and "n" signifies participants who were evaluable for specified time points for each arm group, respectively.

Groups in this outcome

Crizotinib

Crizotinib (PF-02341066) 250 mg (administered as two 100-mg tablets and one 50-mg tablet) orally twice daily continuously in 21-day cycles. Treatment was continued until disease progression, unacceptable toxicity or withdrawal of consent occurred.

Chemotherapy

Pemetrexed 500 mg/m\^2 intravenous infusion over 10 minutes or docetaxel 75 mg/m\^2 intravenous infusion over 1 hour on Day 1 of 21-day cycle, as per investigator discretion. Treatment was continued until disease progression, unacceptable toxicity or withdrawal of consent occurred.

Group identifiers and denominators belong to this outcome only. They may differ in another outcome or in safety reporting.

Analysis denominator · Participants

Group	Source count
Crizotinib	164
Chemotherapy	162

Reported measurements

Dyspnea: Baseline (n=164, 162)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	27.2	21.7	Not reported	Not reported	Not reported
Chemotherapy	26.9	23.4	Not reported	Not reported	Not reported

Dyspnea: C2D1 (n=155, 132)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	17.6	18.1	Not reported	Not reported	Not reported
Chemotherapy	28.6	22.3	Not reported	Not reported	Not reported

Dyspnea: C3D1 (n=153, 106)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	17.9	17.8	Not reported	Not reported	Not reported
Chemotherapy	28.0	25.4	Not reported	Not reported	Not reported

Dyspnea: C4D1 (n=135, 91)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	16.2	17.5	Not reported	Not reported	Not reported
Chemotherapy	27.5	22.8	Not reported	Not reported	Not reported

Dyspnea: C5D1 (n=123, 74)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	16.9	16.7	Not reported	Not reported	Not reported
Chemotherapy	24.8	22.9	Not reported	Not reported	Not reported

Dyspnea: C6D1 (n=119, 70)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	15.2	15.8	Not reported	Not reported	Not reported
Chemotherapy	25.2	23.0	Not reported	Not reported	Not reported

Dyspnea: C7D1 (n=115, 52)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	15.6	16.5	Not reported	Not reported	Not reported
Chemotherapy	24.4	20.3	Not reported	Not reported	Not reported

Dyspnea: C8D1 (n=111, 43)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	14.7	16.0	Not reported	Not reported	Not reported
Chemotherapy	22.0	22.8	Not reported	Not reported	Not reported

Dyspnea: C9D1 (n=101, 37)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	13.9	15.8	Not reported	Not reported	Not reported
Chemotherapy	19.5	19.0	Not reported	Not reported	Not reported

Dyspnea: C10D1 (n=94, 33)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	15.4	17.0	Not reported	Not reported	Not reported
Chemotherapy	21.5	21.0	Not reported	Not reported	Not reported

Dyspnea: C11D1 (n=84, 25)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	15.1	17.5	Not reported	Not reported	Not reported
Chemotherapy	20.4	24.1	Not reported	Not reported	Not reported

Dyspnea: C12D1 (n=76, 23)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	13.7	15.5	Not reported	Not reported	Not reported
Chemotherapy	22.7	22.1	Not reported	Not reported	Not reported

Dyspnea: C13D1 (n=74, 21)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	12.8	14.0	Not reported	Not reported	Not reported
Chemotherapy	26.5	25.9	Not reported	Not reported	Not reported

Dyspnea: C14D1 (n=66, 19)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	14.8	16.9	Not reported	Not reported	Not reported
Chemotherapy	26.3	26.8	Not reported	Not reported	Not reported

Dyspnea: C15D1 (n=62, 16)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	13.2	15.4	Not reported	Not reported	Not reported
Chemotherapy	22.9	18.4	Not reported	Not reported	Not reported

Dyspnea: C16D1 (n=53, 12)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	12.6	11.7	Not reported	Not reported	Not reported
Chemotherapy	22.2	18.3	Not reported	Not reported	Not reported

Dyspnea: C17D1 (n=46, 11)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	12.3	11.5	Not reported	Not reported	Not reported
Chemotherapy	30.3	23.9	Not reported	Not reported	Not reported

Dyspnea: C18D1 (n=45, 11)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	14.1	13.5	Not reported	Not reported	Not reported
Chemotherapy	26.3	20.7	Not reported	Not reported	Not reported

Dyspnea: C19D1 (n=40, 9)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	14.4	13.8	Not reported	Not reported	Not reported
Chemotherapy	23.5	15.2	Not reported	Not reported	Not reported

Dyspnea: C20D1 (n=35, 8)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	13.7	12.9	Not reported	Not reported	Not reported
Chemotherapy	34.7	24.1	Not reported	Not reported	Not reported

Dyspnea: C21D1 (n=30, 8)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	12.6	13.0	Not reported	Not reported	Not reported
Chemotherapy	25.0	14.2	Not reported	Not reported	Not reported

Dyspnea: C22D1 (n=24, 7)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	10.6	11.1	Not reported	Not reported	Not reported
Chemotherapy	27.0	21.1	Not reported	Not reported	Not reported

Dyspnea: C23D1 (n=23, 4)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	13.8	14.2	Not reported	Not reported	Not reported
Chemotherapy	52.8	19.0	Not reported	Not reported	Not reported

Dyspnea: C24D1 (n=20, 3)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	14.4	14.9	Not reported	Not reported	Not reported
Chemotherapy	48.1	23.1	Not reported	Not reported	Not reported

Dyspnea: C25D1 (n=18, 3)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	15.4	12.1	Not reported	Not reported	Not reported
Chemotherapy	40.7	23.1	Not reported	Not reported	Not reported

Dyspnea: C26D1 (n=14, 3)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	14.3	10.2	Not reported	Not reported	Not reported
Chemotherapy	44.4	22.2	Not reported	Not reported	Not reported

Dyspnea: C27D1 (n=14, 2)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	15.1	11.2	Not reported	Not reported	Not reported
Chemotherapy	55.6	0.0	Not reported	Not reported	Not reported

Dyspnea: C28D1 (n=11, 2)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	11.1	8.6	Not reported	Not reported	Not reported
Chemotherapy	61.1	7.9	Not reported	Not reported	Not reported

Dyspnea: C29D1 (n=8, 2)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	12.5	11.0	Not reported	Not reported	Not reported
Chemotherapy	50.0	7.9	Not reported	Not reported	Not reported

Dyspnea: C30D1 (n=8, 1)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	9.7	7.1	Not reported	Not reported	Not reported
Chemotherapy	77.8	NA	Not reported	Not reported	Standard deviation was not estimable since only one participant was evaluable.

Dyspnea: C31D1 (n=7, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	15.9	8.7	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable

Dyspnea: C32D1 (n=6, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	18.5	9.1	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable

Dyspnea: C33D1 (n=6, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	18.5	9.1	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable

Dyspnea: C34D1 (n=5, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	20.0	5.0	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable

Dyspnea: C35D1 (n=4, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	16.7	6.4	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable

Dyspnea: C36D1 (n=1, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	22.2	NA	Not reported	Not reported	Standard deviation was not estimable since only one participant was evaluable.
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable

Dyspnea: C37D1 (n=1, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	11.1	NA	Not reported	Not reported	Standard deviation was not estimable since only one participant was evaluable.
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable

Dyspnea: EOT (n=49, 90)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	21.8	19.0	Not reported	Not reported	Not reported
Chemotherapy	35.6	26.7	Not reported	Not reported	Not reported

Coughing: Baseline (n=164, 162)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	38.2	27.4	Not reported	Not reported	Not reported
Chemotherapy	42.2	31.3	Not reported	Not reported	Not reported

Coughing: C2D1 (n=155, 132)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	23.0	19.6	Not reported	Not reported	Not reported
Chemotherapy	34.8	26.3	Not reported	Not reported	Not reported

Coughing: C3D1 (n=153, 106)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	23.5	21.6	Not reported	Not reported	Not reported
Chemotherapy	32.4	27.4	Not reported	Not reported	Not reported

Coughing: C4D1 (n=135, 91)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	19.8	22.4	Not reported	Not reported	Not reported
Chemotherapy	27.1	24.8	Not reported	Not reported	Not reported

Coughing: C5D1 (n=123, 74)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	18.4	21.0	Not reported	Not reported	Not reported
Chemotherapy	25.7	25.0	Not reported	Not reported	Not reported

Coughing: C6D1 (n=119, 70)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	14.6	18.2	Not reported	Not reported	Not reported
Chemotherapy	30.0	25.5	Not reported	Not reported	Not reported

Coughing: C7D1 (n=115, 52)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	15.9	18.4	Not reported	Not reported	Not reported
Chemotherapy	26.3	23.2	Not reported	Not reported	Not reported

Coughing: C8D1 (n=111, 43)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	13.2	18.7	Not reported	Not reported	Not reported
Chemotherapy	22.5	23.8	Not reported	Not reported	Not reported

Coughing: C9D1 (n=101, 37)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	13.5	18.4	Not reported	Not reported	Not reported
Chemotherapy	25.2	28.8	Not reported	Not reported	Not reported

Coughing: C10D1 (n=94, 33)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	14.2	19.2	Not reported	Not reported	Not reported
Chemotherapy	20.2	26.3	Not reported	Not reported	Not reported

Coughing: C11D1 (n=83, 25)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	12.9	20.7	Not reported	Not reported	Not reported
Chemotherapy	18.7	25.6	Not reported	Not reported	Not reported

Coughing: C12D1 (n=76, 23)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	14.5	20.6	Not reported	Not reported	Not reported
Chemotherapy	23.2	25.5	Not reported	Not reported	Not reported

Coughing: C13D1 (n=74, 21)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	14.0	21.4	Not reported	Not reported	Not reported
Chemotherapy	27.0	27.1	Not reported	Not reported	Not reported

Coughing: C14D1 (n=66, 19)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	13.1	19.3	Not reported	Not reported	Not reported
Chemotherapy	24.6	31.1	Not reported	Not reported	Not reported

Coughing: C15D1 (n=62, 16)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	11.8	21.0	Not reported	Not reported	Not reported
Chemotherapy	20.8	20.6	Not reported	Not reported	Not reported

Coughing: C16D1 (n=53, 12)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	13.8	19.0	Not reported	Not reported	Not reported
Chemotherapy	22.2	21.7	Not reported	Not reported	Not reported

Coughing: C17D1 (n=47, 11)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	6.4	15.0	Not reported	Not reported	Not reported
Chemotherapy	27.3	25.0	Not reported	Not reported	Not reported

Coughing: C18D1 (n=45, 11)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	13.3	18.0	Not reported	Not reported	Not reported
Chemotherapy	18.2	17.4	Not reported	Not reported	Not reported

Coughing: C19D1 (n=40, 9)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	12.5	18.0	Not reported	Not reported	Not reported
Chemotherapy	14.8	17.6	Not reported	Not reported	Not reported

Coughing: C20D1 (n=35, 8)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	10.5	15.7	Not reported	Not reported	Not reported
Chemotherapy	29.2	21.4	Not reported	Not reported	Not reported

Coughing: C21D1 (n=30, 8)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	13.3	24.1	Not reported	Not reported	Not reported
Chemotherapy	33.3	25.2	Not reported	Not reported	Not reported

Coughing: C22D1 (n=24, 7)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	8.3	14.7	Not reported	Not reported	Not reported
Chemotherapy	28.6	23.0	Not reported	Not reported	Not reported

Coughing: C23D1 (n=23, 4)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	11.6	19.1	Not reported	Not reported	Not reported
Chemotherapy	33.3	0.0	Not reported	Not reported	Not reported

Coughing: C24D1 (n=20, 3)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	8.3	14.8	Not reported	Not reported	Not reported
Chemotherapy	44.4	19.2	Not reported	Not reported	Not reported

Coughing: C25D1 (n=18, 3)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	5.6	12.8	Not reported	Not reported	Not reported
Chemotherapy	44.4	19.2	Not reported	Not reported	Not reported

Coughing: C26D1 (n=14, 3)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	2.4	8.9	Not reported	Not reported	Not reported
Chemotherapy	33.3	0.0	Not reported	Not reported	Not reported

Coughing: C27D1 (n=14, 2)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	7.1	14.2	Not reported	Not reported	Not reported
Chemotherapy	50.0	23.6	Not reported	Not reported	Not reported

Coughing: C28D1 (n=11, 2)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	18.2	31.1	Not reported	Not reported	Not reported
Chemotherapy	50.0	23.6	Not reported	Not reported	Not reported

Coughing: C29D1 (n=8, 2)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	8.3	15.4	Not reported	Not reported	Not reported
Chemotherapy	33.3	0.0	Not reported	Not reported	Not reported

Coughing: C30D1 (n=8, 1)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	20.8	24.8	Not reported	Not reported	Not reported
Chemotherapy	33.3	NA	Not reported	Not reported	Standard deviation was not estimable since only one participant was evaluable.

Coughing: C31D1 (n=7, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	19.0	17.8	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Coughing: C32D1 (n=6, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	16.7	27.9	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Coughing: C33D1 (n=6, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	11.1	17.2	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Coughing: C34D1 (n=5, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	20.0	29.8	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Coughing: C35D1 (n=4, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	33.3	47.1	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Coughing: C36D1 (n=1, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	33.3	NA	Not reported	Not reported	Standard deviation was not estimable since only one participant was evaluable.
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Coughing: C37D1 (n=1, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	33.3	NA	Not reported	Not reported	Standard deviation was not estimable since only one participant was evaluable.
Chemotherapy	NA	NA	Not reported	Not reported	Standard deviation was not estimable since only one participant was evaluable.

Coughing: EOT (n=49, 90)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	25.9	23.8	Not reported	Not reported	Not reported
Chemotherapy	37.4	29.1	Not reported	Not reported	Not reported

Hemoptysis: Baseline (n=164, 162)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	2.4	9.5	Not reported	Not reported	Not reported
Chemotherapy	3.7	12.3	Not reported	Not reported	Not reported

Hemoptysis: C2D1 (n=155, 132)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	1.7	7.4	Not reported	Not reported	Not reported
Chemotherapy	3.5	12.5	Not reported	Not reported	Not reported

Hemoptysis: C3D1 (n=153, 106)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	0.9	5.3	Not reported	Not reported	Not reported
Chemotherapy	2.2	8.3	Not reported	Not reported	Not reported

Hemoptysis: C4D1 (n=135, 91)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	1.0	5.7	Not reported	Not reported	Not reported
Chemotherapy	1.5	6.9	Not reported	Not reported	Not reported

Hemoptysis: C5D1 (n=123, 74)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	0.3	3.0	Not reported	Not reported	Not reported
Chemotherapy	0.9	5.4	Not reported	Not reported	Not reported

Hemoptysis: C6D1 (n=119, 70)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	0.6	4.3	Not reported	Not reported	Not reported
Chemotherapy	3.8	14.5	Not reported	Not reported	Not reported

Hemoptysis: C7D1 (n=115, 52)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	0.0	0.0	Not reported	Not reported	Not reported
Chemotherapy	1.3	9.2	Not reported	Not reported	Not reported

Hemoptysis: C8D1 (n=111, 43)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	0.9	7.0	Not reported	Not reported	Not reported
Chemotherapy	2.3	11.3	Not reported	Not reported	Not reported

Hemoptysis: C9D1 (n=101, 37)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	0.3	3.3	Not reported	Not reported	Not reported
Chemotherapy	2.7	12.1	Not reported	Not reported	Not reported

Hemoptysis: C10D1 (n=94, 33)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	0.4	3.4	Not reported	Not reported	Not reported
Chemotherapy	3.0	17.4	Not reported	Not reported	Not reported

Hemoptysis: C11D1 (n=83, 25)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	2.4	11.4	Not reported	Not reported	Not reported
Chemotherapy	4.0	14.7	Not reported	Not reported	Not reported

Hemoptysis: C12D1 (n=76, 23)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	0.9	5.4	Not reported	Not reported	Not reported
Chemotherapy	5.8	21.7	Not reported	Not reported	Not reported

Hemoptysis: C13D1 (n=74, 21)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	2.3	10.1	Not reported	Not reported	Not reported
Chemotherapy	4.8	15.9	Not reported	Not reported	Not reported

Hemoptysis: C14D1 (n=66, 19)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	0.5	4.1	Not reported	Not reported	Not reported
Chemotherapy	0.0	0.0	Not reported	Not reported	Not reported

Hemoptysis: C15D1 (n=62, 16)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	1.1	5.9	Not reported	Not reported	Not reported
Chemotherapy	0.0	0.0	Not reported	Not reported	Not reported

Hemoptysis: C16D1 (n=53, 12)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	0.6	4.6	Not reported	Not reported	Not reported
Chemotherapy	5.6	13.0	Not reported	Not reported	Not reported

Hemoptysis: C17D1 (n=47, 11)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	0.0	0.0	Not reported	Not reported	Not reported
Chemotherapy	9.1	21.6	Not reported	Not reported	Not reported

Hemoptysis: C18D1 (n=45, 11)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	1.5	6.9	Not reported	Not reported	Not reported
Chemotherapy	3.0	10.1	Not reported	Not reported	Not reported

Hemoptysis: C19D1 (n=40, 9)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	0.0	0.0	Not reported	Not reported	Not reported
Chemotherapy	3.7	11.1	Not reported	Not reported	Not reported

Hemoptysis: C20D1 (n=35, 8)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	1.0	5.6	Not reported	Not reported	Not reported
Chemotherapy	8.3	15.4	Not reported	Not reported	Not reported

Hemoptysis: C21D1 (n=30, 8)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	0.0	0.0	Not reported	Not reported	Not reported
Chemotherapy	4.2	11.8	Not reported	Not reported	Not reported

Hemoptysis: C22D1 (n=24, 7)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	0.0	0.0	Not reported	Not reported	Not reported
Chemotherapy	9.5	16.3	Not reported	Not reported	Not reported

Hemoptysis: C23D1 (n=23, 4)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	1.4	7.0	Not reported	Not reported	Not reported
Chemotherapy	0.0	0.0	Not reported	Not reported	Not reported

Hemoptysis: C24D1 (n=20, 3)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	0.0	0.0	Not reported	Not reported	Not reported
Chemotherapy	0.0	0.0	Not reported	Not reported	Not reported

Hemoptysis: C25D1 (n=18, 3)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	0.0	0.0	Not reported	Not reported	Not reported
Chemotherapy	0.0	0.0	Not reported	Not reported	Not reported

Hemoptysis: C26D1 (n=14, 3)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	0.0	0.0	Not reported	Not reported	Not reported
Chemotherapy	0.0	0.0	Not reported	Not reported	Not reported

Hemoptysis: C27D1 (n=14, 2)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	0.0	0.0	Not reported	Not reported	Not reported
Chemotherapy	0.0	0.0	Not reported	Not reported	Not reported

Hemoptysis: C28D1 (n=11, 2)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	0.0	0.0	Not reported	Not reported	Not reported
Chemotherapy	0.0	0.0	Not reported	Not reported	Not reported

Hemoptysis: C29D1 (n=8, 2)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	0.0	0.0	Not reported	Not reported	Not reported
Chemotherapy	0.0	0.0	Not reported	Not reported	Not reported

Hemoptysis: C30D1 (n=8, 1)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	0.0	0.0	Not reported	Not reported	Not reported
Chemotherapy	0.0	NA	Not reported	Not reported	Standard deviation was not estimable since only one participant was evaluable.

Hemoptysis: C31D1 (n=7, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	0.0	0.0	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Hemoptysis: C32D1 (n=6, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	0.0	0.0	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Hemoptysis: C33D1 (n=6, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	0.0	0.0	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Hemoptysis: C34D1 (n=5, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	0.0	0.0	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Hemoptysis: C35D1 (n=4, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	0.0	0.0	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Hemoptysis: C36D1 (n=1, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	0.0	NA	Not reported	Not reported	Standard deviation was not estimable since only one participant was evaluable.
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Hemoptysis: C37D1 (n=1, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	0.0	NA	Not reported	Not reported	Standard deviation was not estimable since only one participant was evaluable.
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Hemoptysis: EOT (n=49, 90)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	0.7	4.8	Not reported	Not reported	Not reported
Chemotherapy	4.8	13.7	Not reported	Not reported	Not reported

Sore Mouth: Baseline (n=164, 162)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	5.5	15.3	Not reported	Not reported	Not reported
Chemotherapy	6.4	18.4	Not reported	Not reported	Not reported

Sore Mouth: C2D1 (n=155, 132)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	8.0	17.9	Not reported	Not reported	Not reported
Chemotherapy	9.1	18.5	Not reported	Not reported	Not reported

Sore Mouth: C3D1 (n=153, 106)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	7.0	14.6	Not reported	Not reported	Not reported
Chemotherapy	9.4	21.0	Not reported	Not reported	Not reported

Sore Mouth: C4D1 (n=135, 91)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	8.1	16.5	Not reported	Not reported	Not reported
Chemotherapy	10.3	21.5	Not reported	Not reported	Not reported

Sore Mouth: C5D1 (n=123, 73)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	5.1	12.1	Not reported	Not reported	Not reported
Chemotherapy	9.6	20.4	Not reported	Not reported	Not reported

Sore Mouth: C6D1 (n=119, 70)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	4.8	13.9	Not reported	Not reported	Not reported
Chemotherapy	10.5	19.3	Not reported	Not reported	Not reported

Sore Mouth: C7D1 (n=115, 52)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	5.2	15.0	Not reported	Not reported	Not reported
Chemotherapy	7.7	15.6	Not reported	Not reported	Not reported

Sore Mouth: C8D1 (n=111, 43)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	3.0	9.6	Not reported	Not reported	Not reported
Chemotherapy	10.9	18.9	Not reported	Not reported	Not reported

Sore Mouth: C9D1 (n=101, 37)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	4.8	12.5	Not reported	Not reported	Not reported
Chemotherapy	10.8	22.3	Not reported	Not reported	Not reported

Sore Mouth: C10D1 (n=94, 33)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	6.4	14.9	Not reported	Not reported	Not reported
Chemotherapy	12.1	23.3	Not reported	Not reported	Not reported

Sore Mouth: C11D1 (n=84, 25)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	4.8	14.8	Not reported	Not reported	Not reported
Chemotherapy	9.3	18.1	Not reported	Not reported	Not reported

Sore Mouth: C12D1 (n=76, 23)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	3.9	12.1	Not reported	Not reported	Not reported
Chemotherapy	8.7	18.0	Not reported	Not reported	Not reported

Sore Mouth: C13D1 (n=74, 21)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	4.5	12.7	Not reported	Not reported	Not reported
Chemotherapy	9.5	15.4	Not reported	Not reported	Not reported

Sore Mouth: C14D1 (n=66, 19)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	4.5	12.9	Not reported	Not reported	Not reported
Chemotherapy	7.0	14.0	Not reported	Not reported	Not reported

Sore Mouth: C15D1 (n=62, 16)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	5.4	12.4	Not reported	Not reported	Not reported
Chemotherapy	14.6	29.7	Not reported	Not reported	Not reported

Sore Mouth: C16D1 (n=53, 12)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	6.3	14.7	Not reported	Not reported	Not reported
Chemotherapy	8.3	15.1	Not reported	Not reported	Not reported

Sore Mouth: C17D1 (n=47, 11)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	3.5	10.4	Not reported	Not reported	Not reported
Chemotherapy	6.1	13.5	Not reported	Not reported	Not reported

Sore Mouth: C18D1 (n=45, 11)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	5.2	12.2	Not reported	Not reported	Not reported
Chemotherapy	12.1	16.8	Not reported	Not reported	Not reported

Sore Mouth: C19D1 (n=40, 9)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	4.2	11.2	Not reported	Not reported	Not reported
Chemotherapy	7.4	14.7	Not reported	Not reported	Not reported

Sore Mouth: C20D1 (n=35, 8)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	7.6	16.3	Not reported	Not reported	Not reported
Chemotherapy	12.5	24.8	Not reported	Not reported	Not reported

Sore Mouth: C21D1 (n=30, 8)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	4.4	11.5	Not reported	Not reported	Not reported
Chemotherapy	4.2	11.8	Not reported	Not reported	Not reported

Sore Mouth: C22D1 (n=24, 7)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	5.6	12.7	Not reported	Not reported	Not reported
Chemotherapy	7.1	13.1	Not reported	Not reported	Not reported

Sore Mouth: C23D1 (n=23, 4)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	5.1	11.7	Not reported	Not reported	Not reported
Chemotherapy	16.7	19.2	Not reported	Not reported	Not reported

Sore Mouth: C24D1 (n=20, 3)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	6.7	17.4	Not reported	Not reported	Not reported
Chemotherapy	0.0	0.0	Not reported	Not reported	Not reported

Sore Mouth: C25D1 (n=18, 3)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	0.0	0.0	Not reported	Not reported	Not reported
Chemotherapy	0.0	0.0	Not reported	Not reported	Not reported

Sore Mouth: C26D1 (n=14, 3)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	4.8	17.8	Not reported	Not reported	Not reported
Chemotherapy	11.1	19.2	Not reported	Not reported	Not reported

Sore Mouth: C27D1 (n=14, 2)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	7.1	19.3	Not reported	Not reported	Not reported
Chemotherapy	16.7	23.6	Not reported	Not reported	Not reported

Sore Mouth: C28D1 (n=11, 2)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	6.1	20.1	Not reported	Not reported	Not reported
Chemotherapy	0.0	0.0	Not reported	Not reported	Not reported

Sore Mouth: C29D1 (n=8, 2)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	8.3	15.4	Not reported	Not reported	Not reported
Chemotherapy	16.7	23.6	Not reported	Not reported	Not reported

Sore Mouth: C30D1 (n=8, 1)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	8.3	23.6	Not reported	Not reported	Not reported
Chemotherapy	0.0	NA	Not reported	Not reported	Standard deviation was not estimable since only one participant was evaluable.

Sore Mouth: C31D1 (n=7, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	9.5	25.2	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Sore Mouth: C32D1 (n=6, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	0.0	0.0	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Sore Mouth: C33D1 (n=6, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	0.0	0.0	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Sore Mouth: C34D1 (n=5, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	0.0	0.0	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Sore Mouth: C35D1 (n=4, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	0.0	0.0	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Sore Mouth: C36D1 (n=1, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	0.0	NA	Not reported	Not reported	Standard deviation was not estimable since only one participant was evaluable.
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Sore Mouth: C37D1 (n=1, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	0.0	NA	Not reported	Not reported	Standard deviation was not estimable since only one participant was evaluable.
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Sore Mouth: EOT (n=49, 90)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	3.4	10.2	Not reported	Not reported	Not reported
Chemotherapy	8.1	18.2	Not reported	Not reported	Not reported

Dysphagia: Baseline (n=164, 162)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	7.1	16.4	Not reported	Not reported	Not reported
Chemotherapy	8.6	20.9	Not reported	Not reported	Not reported

Dysphagia: C2D1 (n=155, 132)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	8.2	15.4	Not reported	Not reported	Not reported
Chemotherapy	9.8	19.2	Not reported	Not reported	Not reported

Dysphagia: C3D1 (n=153, 106)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	7.6	16.4	Not reported	Not reported	Not reported
Chemotherapy	9.7	20.6	Not reported	Not reported	Not reported

Dysphagia: C4D1 (n=135, 91)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	6.2	15.3	Not reported	Not reported	Not reported
Chemotherapy	8.1	19.5	Not reported	Not reported	Not reported

Dysphagia: C5D1 (n=123, 74)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	6.0	14.8	Not reported	Not reported	Not reported
Chemotherapy	7.7	17.0	Not reported	Not reported	Not reported

Dysphagia: C6D1 (n=119, 70)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	7.0	15.0	Not reported	Not reported	Not reported
Chemotherapy	10.0	16.4	Not reported	Not reported	Not reported

Dysphagia: C7D1 (n=115, 52)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	4.1	11.8	Not reported	Not reported	Not reported
Chemotherapy	5.1	13.8	Not reported	Not reported	Not reported

Dysphagia: C8D1 (n=111, 43)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	3.2	11.1	Not reported	Not reported	Not reported
Chemotherapy	6.2	15.0	Not reported	Not reported	Not reported

Dysphagia: C9D1 (n=101, 37)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	5.0	11.9	Not reported	Not reported	Not reported
Chemotherapy	7.2	16.0	Not reported	Not reported	Not reported

Dysphagia: C10D1 (n=94, 33)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	4.3	12.2	Not reported	Not reported	Not reported
Chemotherapy	6.1	13.1	Not reported	Not reported	Not reported

Dysphagia: C11D1 (n=84, 25)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	3.2	9.8	Not reported	Not reported	Not reported
Chemotherapy	4.0	11.1	Not reported	Not reported	Not reported

Dysphagia: C12D1 (n=76, 23)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	3.5	10.3	Not reported	Not reported	Not reported
Chemotherapy	7.2	17.3	Not reported	Not reported	Not reported

Dysphagia: C13D1 (n=74, 21)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	4.1	11.0	Not reported	Not reported	Not reported
Chemotherapy	6.3	13.4	Not reported	Not reported	Not reported

Dysphagia: C14D1 (n=66, 19)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	3.0	11.3	Not reported	Not reported	Not reported
Chemotherapy	7.0	14.0	Not reported	Not reported	Not reported

Dysphagia: C15D1 (n=62, 16)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	3.8	13.6	Not reported	Not reported	Not reported
Chemotherapy	4.2	16.7	Not reported	Not reported	Not reported

Dysphagia: C16D1 (n=53, 12)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	4.4	11.4	Not reported	Not reported	Not reported
Chemotherapy	2.8	9.6	Not reported	Not reported	Not reported

Dysphagia: C17D1 (n=47, 11)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	2.8	9.4	Not reported	Not reported	Not reported
Chemotherapy	6.1	13.5	Not reported	Not reported	Not reported

Dysphagia: C18D1 (n=45, 11)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	3.7	10.6	Not reported	Not reported	Not reported
Chemotherapy	3.0	10.1	Not reported	Not reported	Not reported

Dysphagia: C19D1 (n=40, 9)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	4.2	11.2	Not reported	Not reported	Not reported
Chemotherapy	0.0	0.0	Not reported	Not reported	Not reported

Dysphagia: C20D1 (n=35, 8)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	4.8	14.3	Not reported	Not reported	Not reported
Chemotherapy	8.3	15.4	Not reported	Not reported	Not reported

Dysphagia: C21D1 (n=30, 8)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	3.3	10.2	Not reported	Not reported	Not reported
Chemotherapy	8.3	15.4	Not reported	Not reported	Not reported

Dysphagia: C22D1 (n=24, 7)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	2.8	9.4	Not reported	Not reported	Not reported
Chemotherapy	0.0	0.0	Not reported	Not reported	Not reported

Dysphagia: C23D1 (n=23, 4)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	2.9	9.6	Not reported	Not reported	Not reported
Chemotherapy	8.3	16.7	Not reported	Not reported	Not reported

Dysphagia: C24D1 (n=20, 3)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	5.0	22.4	Not reported	Not reported	Not reported
Chemotherapy	0.0	0.0	Not reported	Not reported	Not reported

Dysphagia: C25D1 (n=18, 3)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	0.0	0.0	Not reported	Not reported	Not reported
Chemotherapy	11.1	19.2	Not reported	Not reported	Not reported

Dysphagia: C26D1 (n=14, 3)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	9.5	27.5	Not reported	Not reported	Not reported
Chemotherapy	11.1	19.2	Not reported	Not reported	Not reported

Dysphagia: C27D1 (n=14, 2)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	2.4	8.9	Not reported	Not reported	Not reported
Chemotherapy	16.7	23.6	Not reported	Not reported	Not reported

Dysphagia: C28D1 (n=11, 2)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	6.1	13.5	Not reported	Not reported	Not reported
Chemotherapy	16.7	23.6	Not reported	Not reported	Not reported

Dysphagia: C29D1 (n=8, 2)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	8.3	15.4	Not reported	Not reported	Not reported
Chemotherapy	16.7	23.6	Not reported	Not reported	Not reported

Dysphagia: C30D1 (n=8, 1)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	0.0	0.0	Not reported	Not reported	Not reported
Chemotherapy	33.3	NA	Not reported	Not reported	Standard deviation was not estimable since only one participant was evaluable.

Dysphagia: C31D1 (n=7, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	4.8	12.6	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Dysphagia: C32D1 (n=6, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	5.6	13.6	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Dysphagia: C33D1 (n=6, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	0.0	0.0	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Dysphagia: C34D1 (n=5, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	6.7	14.9	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Dysphagia: C35D1 (n=4, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	8.3	16.7	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Dysphagia: C36D1 (n=1, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	0.0	NA	Not reported	Not reported	Standard deviation was not estimable since only one participant was evaluable.
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Dysphagia: C37D1 (n=1, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	0.0	NA	Not reported	Not reported	Standard deviation was not estimable since only one participant was evaluable.
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Dysphagia: EOT (n=49, 90)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	4.8	13.6	Not reported	Not reported	Not reported
Chemotherapy	8.5	19.7	Not reported	Not reported	Not reported

Peripheral Neuropathy: Baseline (n=164, 162)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	14.0	22.1	Not reported	Not reported	Not reported
Chemotherapy	17.7	27.3	Not reported	Not reported	Not reported

Peripheral Neuropathy: C2D1 (n=155, 132)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	18.1	24.1	Not reported	Not reported	Not reported
Chemotherapy	21.5	29.2	Not reported	Not reported	Not reported

Peripheral Neuropathy: C3D1 (n=153, 106)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	17.6	26.2	Not reported	Not reported	Not reported
Chemotherapy	18.2	29.1	Not reported	Not reported	Not reported

Peripheral Neuropathy: C4D1 (n=134, 91)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	15.9	23.0	Not reported	Not reported	Not reported
Chemotherapy	21.6	27.8	Not reported	Not reported	Not reported

Peripheral Neuropathy: C5D1 (n=123, 74)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	15.2	21.0	Not reported	Not reported	Not reported
Chemotherapy	21.2	28.4	Not reported	Not reported	Not reported

Peripheral Neuropathy: C6D1 (n=119, 70)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	13.7	21.9	Not reported	Not reported	Not reported
Chemotherapy	18.1	27.0	Not reported	Not reported	Not reported

Peripheral Neuropathy: C7D1 (n=115, 52)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	13.0	21.0	Not reported	Not reported	Not reported
Chemotherapy	21.8	28.7	Not reported	Not reported	Not reported

Peripheral Neuropathy: C8D1 (n=111, 43)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	10.8	20.2	Not reported	Not reported	Not reported
Chemotherapy	24.0	32.8	Not reported	Not reported	Not reported

Peripheral Neuropathy: C9D1 (n=101, 37)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	11.2	19.6	Not reported	Not reported	Not reported
Chemotherapy	29.7	34.1	Not reported	Not reported	Not reported

Peripheral Neuropathy: C10D1 (n=94, 33)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	11.3	21.1	Not reported	Not reported	Not reported
Chemotherapy	27.3	29.4	Not reported	Not reported	Not reported

Peripheral Neuropathy: C11D1 (n=84, 25)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	11.1	21.5	Not reported	Not reported	Not reported
Chemotherapy	24.0	31.2	Not reported	Not reported	Not reported

Peripheral Neuropathy: C12D1 (n=76, 23)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	11.4	22.1	Not reported	Not reported	Not reported
Chemotherapy	33.3	36.2	Not reported	Not reported	Not reported

Peripheral Neuropathy: C13D1 (n=74, 21)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	10.4	19.1	Not reported	Not reported	Not reported
Chemotherapy	33.3	35.0	Not reported	Not reported	Not reported

Peripheral Neuropathy: C14D1 (n=66, 19)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	10.6	21.2	Not reported	Not reported	Not reported
Chemotherapy	29.8	35.0	Not reported	Not reported	Not reported

Peripheral Neuropathy: C15D1 (n=62, 16)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	8.6	18.0	Not reported	Not reported	Not reported
Chemotherapy	25.0	31.0	Not reported	Not reported	Not reported

Peripheral Neuropathy: C16D1 (n=52, 12)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	10.3	19.3	Not reported	Not reported	Not reported
Chemotherapy	25.0	20.7	Not reported	Not reported	Not reported

Peripheral Neuropathy: C17D1 (n=47, 11)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	12.1	23.5	Not reported	Not reported	Not reported
Chemotherapy	27.3	29.1	Not reported	Not reported	Not reported

Peripheral Neuropathy: C18D1 (n=45, 11)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	11.9	22.6	Not reported	Not reported	Not reported
Chemotherapy	30.3	31.5	Not reported	Not reported	Not reported

Peripheral Neuropathy: C19D1 (n=40, 9)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	9.2	20.0	Not reported	Not reported	Not reported
Chemotherapy	22.2	16.7	Not reported	Not reported	Not reported

Peripheral Neuropathy: C20D1 (n=35, 8)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	12.4	25.7	Not reported	Not reported	Not reported
Chemotherapy	33.3	30.9	Not reported	Not reported	Not reported

Peripheral Neuropathy: C21D1 (n=30, 8)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	11.1	18.2	Not reported	Not reported	Not reported
Chemotherapy	29.2	21.4	Not reported	Not reported	Not reported

Peripheral Neuropathy: C22D1 (n=24, 7)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	8.3	20.3	Not reported	Not reported	Not reported
Chemotherapy	28.6	23.0	Not reported	Not reported	Not reported

Peripheral Neuropathy: C23D1 (n=23, 4)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	8.7	20.6	Not reported	Not reported	Not reported
Chemotherapy	41.7	31.9	Not reported	Not reported	Not reported

Peripheral Neuropathy: C24D1 (n=20, 3)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	3.3	14.9	Not reported	Not reported	Not reported
Chemotherapy	44.4	38.5	Not reported	Not reported	Not reported

Peripheral Neuropathy: C25D1 (n=18, 3)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	9.3	19.2	Not reported	Not reported	Not reported
Chemotherapy	44.4	38.5	Not reported	Not reported	Not reported

Peripheral Neuropathy: C26D1 (n=14, 3)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	16.7	36.4	Not reported	Not reported	Not reported
Chemotherapy	22.2	19.2	Not reported	Not reported	Not reported

Peripheral Neuropathy: C27D1 (n=14, 2)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	9.5	20.4	Not reported	Not reported	Not reported
Chemotherapy	66.7	0.0	Not reported	Not reported	Not reported

Peripheral Neuropathy: C28D1 (n=11, 2)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	15.2	22.9	Not reported	Not reported	Not reported
Chemotherapy	33.3	0.0	Not reported	Not reported	Not reported

Peripheral Neuropathy: C29D1 (n=8, 2)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	12.5	24.8	Not reported	Not reported	Not reported
Chemotherapy	50.0	23.6	Not reported	Not reported	Not reported

Peripheral Neuropathy: C30D1 (n=8, 1)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	16.7	30.9	Not reported	Not reported	Not reported
Chemotherapy	33.3	NA	Not reported	Not reported	Standard deviation was not estimable since only one participant was evaluable.

Peripheral Neuropathy: C31D1 (n=7, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	19.0	32.5	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Peripheral Neuropathy: C32D1 (n=6, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	11.1	27.2	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Peripheral Neuropathy: C33D1 (n=6, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	11.1	27.2	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Peripheral Neuropathy: C34D1 (n=5, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	20.0	44.7	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Peripheral Neuropathy: C35D1 (n=4, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	25.0	50.0	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Peripheral Neuropathy: C36D1 (n=1, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	0.0	NA	Not reported	Not reported	Standard deviation was not estimable since only one participant was evaluable.
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Peripheral Neuropathy: C37D1 (n=1, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	0.0	NA	Not reported	Not reported	Standard deviation was not estimable since only one participant was evaluable.
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Peripheral Neuropathy: EOT (n=49, 90)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	10.2	16.9	Not reported	Not reported	Not reported
Chemotherapy	21.9	29.6	Not reported	Not reported	Not reported

Alopecia: Baseline (n=163, 162)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	17.4	30.6	Not reported	Not reported	Not reported
Chemotherapy	16.9	29.8	Not reported	Not reported	Not reported

Alopecia: C2D1 (n=155, 132)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	9.5	21.4	Not reported	Not reported	Not reported
Chemotherapy	36.6	39.7	Not reported	Not reported	Not reported

Alopecia: C3D1 (n=153, 106)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	7.6	18.1	Not reported	Not reported	Not reported
Chemotherapy	30.5	36.5	Not reported	Not reported	Not reported

Alopecia: C4D1 (n=135, 91)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	8.9	22.0	Not reported	Not reported	Not reported
Chemotherapy	24.9	32.0	Not reported	Not reported	Not reported

Alopecia: C5D1 (n=123, 74)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	6.0	17.1	Not reported	Not reported	Not reported
Chemotherapy	23.9	31.0	Not reported	Not reported	Not reported

Alopecia: C6D1 (n=118, 70)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	4.2	14.8	Not reported	Not reported	Not reported
Chemotherapy	23.3	32.8	Not reported	Not reported	Not reported

Alopecia: C7D1 (n=115, 52)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	4.9	14.1	Not reported	Not reported	Not reported
Chemotherapy	19.9	30.4	Not reported	Not reported	Not reported

Alopecia: C8D1 (n=111, 43)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	3.9	11.7	Not reported	Not reported	Not reported
Chemotherapy	18.6	28.5	Not reported	Not reported	Not reported

Alopecia: C9D1 (n=101, 37)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	4.0	11.8	Not reported	Not reported	Not reported
Chemotherapy	16.2	23.1	Not reported	Not reported	Not reported

Alopecia: C10D1 (n=94, 33)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	4.6	14.3	Not reported	Not reported	Not reported
Chemotherapy	14.1	22.1	Not reported	Not reported	Not reported

Alopecia: C11D1 (n=84, 25)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	4.0	15.0	Not reported	Not reported	Not reported
Chemotherapy	16.0	21.8	Not reported	Not reported	Not reported

Alopecia: C12D1 (n=76, 23)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	4.4	14.7	Not reported	Not reported	Not reported
Chemotherapy	20.3	26.1	Not reported	Not reported	Not reported

Alopecia: C13D1 (n=74, 21)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	6.3	18.0	Not reported	Not reported	Not reported
Chemotherapy	12.7	19.7	Not reported	Not reported	Not reported

Alopecia: C14D1 (n=65, 19)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	3.6	14.6	Not reported	Not reported	Not reported
Chemotherapy	15.8	23.2	Not reported	Not reported	Not reported

Alopecia: C15D1 (n=62, 16)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	4.8	16.9	Not reported	Not reported	Not reported
Chemotherapy	8.3	19.2	Not reported	Not reported	Not reported

Alopecia: C16D1 (n=53, 12)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	6.3	18.6	Not reported	Not reported	Not reported
Chemotherapy	13.9	22.3	Not reported	Not reported	Not reported

Alopecia: C17D1 (n=46, 11)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	5.1	17.2	Not reported	Not reported	Not reported
Chemotherapy	18.2	22.9	Not reported	Not reported	Not reported

Alopecia: C18D1 (n=45, 11)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	3.7	12.8	Not reported	Not reported	Not reported
Chemotherapy	18.2	22.9	Not reported	Not reported	Not reported

Alopecia: C19D1 (n=40, 9)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	5.8	19.8	Not reported	Not reported	Not reported
Chemotherapy	18.5	24.2	Not reported	Not reported	Not reported

Alopecia: C20D1 (n=35, 8)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	3.8	13.5	Not reported	Not reported	Not reported
Chemotherapy	25.0	23.6	Not reported	Not reported	Not reported

Alopecia: C21D1 (n=30, 8)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	7.8	22.6	Not reported	Not reported	Not reported
Chemotherapy	16.7	25.2	Not reported	Not reported	Not reported

Alopecia: C22D1 (n=24, 7)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	2.8	9.4	Not reported	Not reported	Not reported
Chemotherapy	14.3	17.8	Not reported	Not reported	Not reported

Alopecia: C23D1 (n=23, 3)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	1.4	7.0	Not reported	Not reported	Not reported
Chemotherapy	22.2	19.2	Not reported	Not reported	Not reported

Alopecia: C24D1 (n=20, 3)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	6.7	23.2	Not reported	Not reported	Not reported
Chemotherapy	33.3	33.3	Not reported	Not reported	Not reported

Alopecia: C25D1 (n=18, 3)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	9.3	27.5	Not reported	Not reported	Not reported
Chemotherapy	33.3	33.3	Not reported	Not reported	Not reported

Alopecia: C26D1 (n=14, 3)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	7.1	26.7	Not reported	Not reported	Not reported
Chemotherapy	44.4	38.5	Not reported	Not reported	Not reported

Alopecia: C27D1 (n=14, 2)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	16.7	36.4	Not reported	Not reported	Not reported
Chemotherapy	33.3	0.0	Not reported	Not reported	Not reported

Alopecia: C28D1 (n=11, 2)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	6.1	20.1	Not reported	Not reported	Not reported
Chemotherapy	50.0	23.6	Not reported	Not reported	Not reported

Alopecia: C29D1 (n=8, 2)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	16.7	35.6	Not reported	Not reported	Not reported
Chemotherapy	33.3	0.0	Not reported	Not reported	Not reported

Alopecia: C30D1 (n=8, 1)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	12.5	35.4	Not reported	Not reported	Not reported
Chemotherapy	33.3	NA	Not reported	Not reported	Standard deviation was not estimable since only one participant was evaluable.

Alopecia: C31D1 (n=7, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	9.5	25.2	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Alopecia: C32D1 (n=6, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	0.0	0.0	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Alopecia: C33D1 (n=6, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	0.0	0.0	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Alopecia: C34D1 (n=5, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	0.0	0.0	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Alopecia: C35D1 (n=4, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	0.0	0.0	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Alopecia: C36D1 (n=1, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	0.0	NA	Not reported	Not reported	Standard deviation was not estimable since only one participant was evaluable.
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Alopecia: C37D1 (n=1, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	0.0	NA	Not reported	Not reported	Standard deviation was not estimable since only one participant was evaluable.
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Alopecia: EOT (n=49, 90)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	6.8	18.0	Not reported	Not reported	Not reported
Chemotherapy	33.3	37.7	Not reported	Not reported	Not reported

Pain in Chest: Baseline (n=163, 160)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	18.8	22.8	Not reported	Not reported	Not reported
Chemotherapy	24.0	27.5	Not reported	Not reported	Not reported

Pain in Chest: C2D1 (n=155, 132)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	9.5	17.7	Not reported	Not reported	Not reported
Chemotherapy	23.7	25.9	Not reported	Not reported	Not reported

Pain in Chest: C3D1 (n=153, 106)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	7.0	13.6	Not reported	Not reported	Not reported
Chemotherapy	23.3	26.5	Not reported	Not reported	Not reported

Pain in Chest: C4D1 (n=135, 91)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	7.4	13.9	Not reported	Not reported	Not reported
Chemotherapy	19.8	22.8	Not reported	Not reported	Not reported

Pain in Chest: C5D1 (n=123, 74)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	6.8	14.1	Not reported	Not reported	Not reported
Chemotherapy	17.1	21.5	Not reported	Not reported	Not reported

Pain in Chest: C6D1 (n=119, 70)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	6.2	13.0	Not reported	Not reported	Not reported
Chemotherapy	16.2	22.5	Not reported	Not reported	Not reported

Pain in Chest: C7D1 (n=115, 52)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	7.5	14.7	Not reported	Not reported	Not reported
Chemotherapy	16.7	22.4	Not reported	Not reported	Not reported

Pain in Chest: C8D1 (n=111, 43)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	5.1	14.4	Not reported	Not reported	Not reported
Chemotherapy	14.0	20.9	Not reported	Not reported	Not reported

Pain in Chest: C9D1 (n=101, 37)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	5.9	12.8	Not reported	Not reported	Not reported
Chemotherapy	17.1	23.1	Not reported	Not reported	Not reported

Pain in Chest: C10D1 (n=94, 33)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	6.7	14.3	Not reported	Not reported	Not reported
Chemotherapy	18.2	31.3	Not reported	Not reported	Not reported

Pain in Chest: C11D1 (n=84, 25)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	6.3	13.2	Not reported	Not reported	Not reported
Chemotherapy	20.0	25.5	Not reported	Not reported	Not reported

Pain in Chest: C12D1 (n=76, 23)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	5.3	12.2	Not reported	Not reported	Not reported
Chemotherapy	23.2	30.9	Not reported	Not reported	Not reported

Pain in Chest: C13D1 (n=74, 21)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	6.3	13.1	Not reported	Not reported	Not reported
Chemotherapy	23.8	30.1	Not reported	Not reported	Not reported

Pain in Chest: C14D1 (n=66, 19)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	7.6	16.3	Not reported	Not reported	Not reported
Chemotherapy	22.8	22.4	Not reported	Not reported	Not reported

Pain in Chest: C15D1 (n=62, 16)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	5.9	14.2	Not reported	Not reported	Not reported
Chemotherapy	18.7	24.2	Not reported	Not reported	Not reported

Pain in Chest: C16D1 (n=53, 12)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	3.8	10.7	Not reported	Not reported	Not reported
Chemotherapy	16.7	17.4	Not reported	Not reported	Not reported

Pain in Chest: C17D1 (n=46, 11)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	7.2	15.6	Not reported	Not reported	Not reported
Chemotherapy	21.2	22.5	Not reported	Not reported	Not reported

Pain in Chest: C18D1 (n=45, 11)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	5.9	16.3	Not reported	Not reported	Not reported
Chemotherapy	24.2	33.6	Not reported	Not reported	Not reported

Pain in Chest: C19D1 (n=40, 9)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	5.0	14.2	Not reported	Not reported	Not reported
Chemotherapy	18.5	24.2	Not reported	Not reported	Not reported

Pain in Chest: C20D1 (n=35, 8)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	5.7	15.1	Not reported	Not reported	Not reported
Chemotherapy	29.2	21.4	Not reported	Not reported	Not reported

Pain in Chest: C21D1 (n=30, 8)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	5.6	15.4	Not reported	Not reported	Not reported
Chemotherapy	25.0	23.6	Not reported	Not reported	Not reported

Pain in Chest: C22D1 (n=24, 7)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	4.2	11.3	Not reported	Not reported	Not reported
Chemotherapy	26.2	30.2	Not reported	Not reported	Not reported

Pain in Chest: C23D1 (n=23, 4)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	3.6	10.0	Not reported	Not reported	Not reported
Chemotherapy	41.7	31.9	Not reported	Not reported	Not reported

Pain in Chest: C24D1 (n=20, 3)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	1.7	7.5	Not reported	Not reported	Not reported
Chemotherapy	33.3	33.3	Not reported	Not reported	Not reported

Pain in Chest: C25D1 (n=18, 3)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	5.6	12.8	Not reported	Not reported	Not reported
Chemotherapy	33.3	33.3	Not reported	Not reported	Not reported

Pain in Chest: C26D1 (n=14, 3)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	7.1	19.3	Not reported	Not reported	Not reported
Chemotherapy	33.3	33.3	Not reported	Not reported	Not reported

Pain in Chest: C27D1 (n=14, 2)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	4.8	12.1	Not reported	Not reported	Not reported
Chemotherapy	50.0	23.6	Not reported	Not reported	Not reported

Pain in Chest: C28D1 (n=11, 2)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	9.1	15.6	Not reported	Not reported	Not reported
Chemotherapy	50.0	23.6	Not reported	Not reported	Not reported

Pain in Chest: C29D1 (n=8, 2)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	0.0	0.0	Not reported	Not reported	Not reported
Chemotherapy	50.0	23.6	Not reported	Not reported	Not reported

Pain in Chest: C30D1 (n=8, 1)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	4.2	11.8	Not reported	Not reported	Not reported
Chemotherapy	66.7	NA	Not reported	Not reported	Standard deviation was not estimable since only one participant was evaluable.

Pain in Chest: C31D1 (n=7, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	9.5	16.3	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Pain in Chest: C32D1 (n=6, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	0.0	0.0	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Pain in Chest: C33D1 (n=6, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	0.0	0.0	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Pain in Chest: C34D1 (n=5, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	6.7	14.9	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Pain in Chest: C35D1 (n=4, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	8.3	16.7	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Pain in Chest: C36D1 (n=1, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	0.0	NA	Not reported	Not reported	Standard deviation was not estimable since only one participant was evaluable.
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Pain in Chest: C37D1 (n=1, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	0.0	NA	Not reported	Not reported	Standard deviation was not estimable since only one participant was evaluable.
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Pain in Chest: EOT (n=49, 90)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	17.0	24.6	Not reported	Not reported	Not reported
Chemotherapy	28.5	29.4	Not reported	Not reported	Not reported

Pain in Arm or Shoulder: Baseline (n=164, 161)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	16.3	24.1	Not reported	Not reported	Not reported
Chemotherapy	19.5	28.0	Not reported	Not reported	Not reported

Pain in Arm or Shoulder: C2D1 (n=155, 132)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	9.0	18.3	Not reported	Not reported	Not reported
Chemotherapy	19.9	27.0	Not reported	Not reported	Not reported

Pain in Arm or Shoulder: C3D1 (n=153, 105)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	8.1	14.8	Not reported	Not reported	Not reported
Chemotherapy	17.5	24.5	Not reported	Not reported	Not reported

Pain in Arm or Shoulder: C4D1 (n=135, 91)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	6.9	15.3	Not reported	Not reported	Not reported
Chemotherapy	14.3	22.3	Not reported	Not reported	Not reported

Pain in Arm or Shoulder: C5D1 (n=123, 74)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	6.2	15.0	Not reported	Not reported	Not reported
Chemotherapy	13.1	21.9	Not reported	Not reported	Not reported

Pain in Arm or Shoulder: C6D1 (n=119, 70)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	6.7	14.1	Not reported	Not reported	Not reported
Chemotherapy	17.1	25.8	Not reported	Not reported	Not reported

Pain in Arm or Shoulder: C7D1 (n=115, 52)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	6.4	13.2	Not reported	Not reported	Not reported
Chemotherapy	17.3	23.3	Not reported	Not reported	Not reported

Pain in Arm or Shoulder: C8D1 (n=111, 43)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	6.9	14.3	Not reported	Not reported	Not reported
Chemotherapy	20.2	28.3	Not reported	Not reported	Not reported

Pain in Arm or Shoulder: C9D1 (n=101, 37)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	5.6	12.5	Not reported	Not reported	Not reported
Chemotherapy	23.4	28.2	Not reported	Not reported	Not reported

Pain in Arm or Shoulder: C10D1 (n=94, 33)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	7.4	17.0	Not reported	Not reported	Not reported
Chemotherapy	25.3	32.3	Not reported	Not reported	Not reported

Pain in Arm or Shoulder: C11D1 (n=84, 25)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	6.0	14.8	Not reported	Not reported	Not reported
Chemotherapy	24.0	26.4	Not reported	Not reported	Not reported

Pain in Arm or Shoulder: C12D1 (n=76, 23)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	6.6	15.4	Not reported	Not reported	Not reported
Chemotherapy	29.0	35.3	Not reported	Not reported	Not reported

Pain in Arm or Shoulder: C13D1 (n=74, 21)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	5.9	12.8	Not reported	Not reported	Not reported
Chemotherapy	25.4	34.8	Not reported	Not reported	Not reported

Pain in Arm or Shoulder: C14D1 (n=66, 19)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	7.6	18.3	Not reported	Not reported	Not reported
Chemotherapy	29.8	31.2	Not reported	Not reported	Not reported

Pain in Arm or Shoulder: C15D1 (n=62, 16)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	5.4	13.8	Not reported	Not reported	Not reported
Chemotherapy	25.0	25.8	Not reported	Not reported	Not reported

Pain in Arm or Shoulder: C16D1 (n=53, 12)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	5.0	12.0	Not reported	Not reported	Not reported
Chemotherapy	16.7	22.5	Not reported	Not reported	Not reported

Pain in Arm or Shoulder: C17D1 (n=47, 11)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	3.5	10.4	Not reported	Not reported	Not reported
Chemotherapy	21.2	22.5	Not reported	Not reported	Not reported

Pain in Arm or Shoulder: C18D1 (n=45, 11)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	8.1	20.3	Not reported	Not reported	Not reported
Chemotherapy	30.3	34.8	Not reported	Not reported	Not reported

Pain in Arm or Shoulder: C19D1 (n=40, 9)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	6.7	15.5	Not reported	Not reported	Not reported
Chemotherapy	18.5	24.2	Not reported	Not reported	Not reported

Pain in Arm or Shoulder: C20D1 (n=35, 8)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	9.5	22.2	Not reported	Not reported	Not reported
Chemotherapy	25.0	23.6	Not reported	Not reported	Not reported

Pain in Arm or Shoulder: C21D1 (n=30, 8)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	7.8	16.8	Not reported	Not reported	Not reported
Chemotherapy	29.2	27.8	Not reported	Not reported	Not reported

Pain in Arm or Shoulder: C22D1 (n=24, 7)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	2.8	9.4	Not reported	Not reported	Not reported
Chemotherapy	21.4	24.9	Not reported	Not reported	Not reported

Pain in Arm or Shoulder: C23D1 (n=23, 4)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	0.7	3.5	Not reported	Not reported	Not reported
Chemotherapy	33.3	38.5	Not reported	Not reported	Not reported

Pain in Arm or Shoulder: C24D1 (n=20, 3)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	3.3	10.3	Not reported	Not reported	Not reported
Chemotherapy	44.4	38.5	Not reported	Not reported	Not reported

Pain in Arm or Shoulder: C25D1 (n=18, 3)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	1.9	7.9	Not reported	Not reported	Not reported
Chemotherapy	33.3	33.3	Not reported	Not reported	Not reported

Pain in Arm or Shoulder: C26D1 (n=14, 3)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	7.1	19.3	Not reported	Not reported	Not reported
Chemotherapy	22.2	19.2	Not reported	Not reported	Not reported

Pain in Arm or Shoulder: C27D1 (n=14, 2)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	4.8	12.1	Not reported	Not reported	Not reported
Chemotherapy	50.0	23.6	Not reported	Not reported	Not reported

Pain in Arm or Shoulder: C28D1 (n=11, 2)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	0.0	0.0	Not reported	Not reported	Not reported
Chemotherapy	33.3	0.0	Not reported	Not reported	Not reported

Pain in Arm or Shoulder: C29D1 (n=8, 2)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	0.0	0.0	Not reported	Not reported	Not reported
Chemotherapy	66.7	0.0	Not reported	Not reported	Not reported

Pain in Arm or Shoulder: C30D1 (n=8, 1)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	0.0	0.0	Not reported	Not reported	Not reported
Chemotherapy	33.3	NA	Not reported	Not reported	Standard deviation was not estimable since only one participant was evaluable.

Pain in Arm or Shoulder: C31D1 (n=7, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	0.0	0.0	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Pain in Arm or Shoulder: C32D1 (n=6, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	11.1	17.2	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Pain in Arm or Shoulder: C33D1 (n=6, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	0.0	0.0	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Pain in Arm or Shoulder: C34D1 (n=5, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	0.0	0.0	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Pain in Arm or Shoulder: C35D1 (n=4, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	0.0	0.0	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Pain in Arm or Shoulder: C36D1 (n=1, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	0.0	NA	Not reported	Not reported	Standard deviation was not estimable since only one participant was evaluable.
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Pain in Arm or Shoulder: C37D1 (n=1, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	0.0	NA	Not reported	Not reported	Standard deviation was not estimable since only one participant was evaluable.
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Pain in Arm or Shoulder: EOT (n=48, 90)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	11.1	21.0	Not reported	Not reported	Not reported
Chemotherapy	21.9	28.8	Not reported	Not reported	Not reported

Pain in Other Parts: Baseline (n=163, 158)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	23.1	27.3	Not reported	Not reported	Not reported
Chemotherapy	31.4	30.4	Not reported	Not reported	Not reported

Pain in Other Parts: C2D1 (n=153, 125)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	15.0	23.2	Not reported	Not reported	Not reported
Chemotherapy	25.9	28.0	Not reported	Not reported	Not reported

Pain in Other Parts: C3D1 (n=152, 104)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	11.4	20.7	Not reported	Not reported	Not reported
Chemotherapy	21.2	27.1	Not reported	Not reported	Not reported

Pain in Other Parts: C4D1 (n=134, 90)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	12.7	22.7	Not reported	Not reported	Not reported
Chemotherapy	21.5	24.6	Not reported	Not reported	Not reported

Pain in Other Parts: C5D1 (n=123, 73)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	14.4	23.0	Not reported	Not reported	Not reported
Chemotherapy	20.5	27.6	Not reported	Not reported	Not reported

Pain in Other Parts: C6D1 (n=118, 68)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	10.7	18.9	Not reported	Not reported	Not reported
Chemotherapy	18.1	26.0	Not reported	Not reported	Not reported

Pain in Other Parts: C7D1 (n=115, 51)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	11.3	20.7	Not reported	Not reported	Not reported
Chemotherapy	16.3	26.1	Not reported	Not reported	Not reported

Pain in Other Parts: C8D1 (n=111, 42)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	10.5	20.6	Not reported	Not reported	Not reported
Chemotherapy	22.2	30.9	Not reported	Not reported	Not reported

Pain in Other Parts: C9D1 (n=100, 37)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	10.7	21.1	Not reported	Not reported	Not reported
Chemotherapy	24.3	31.1	Not reported	Not reported	Not reported

Pain in Other Parts: C10D1 (n=92, 33)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	9.8	18.8	Not reported	Not reported	Not reported
Chemotherapy	28.3	35.5	Not reported	Not reported	Not reported

Pain in Other Parts: C11D1 (n=83, 25)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	12.4	21.3	Not reported	Not reported	Not reported
Chemotherapy	24.0	29.7	Not reported	Not reported	Not reported

Pain in Other Parts: C12D1 (n=74, 23)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	12.2	20.3	Not reported	Not reported	Not reported
Chemotherapy	24.6	30.5	Not reported	Not reported	Not reported

Pain in Other Parts: C13D1 (n=74, 21)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	10.8	19.2	Not reported	Not reported	Not reported
Chemotherapy	31.7	34.1	Not reported	Not reported	Not reported

Pain in Other Parts: C14D1 (n=66, 19)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	11.6	18.0	Not reported	Not reported	Not reported
Chemotherapy	24.6	29.1	Not reported	Not reported	Not reported

Pain in Other Parts: C15D1 (n=61, 16)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	9.8	15.3	Not reported	Not reported	Not reported
Chemotherapy	25.0	22.8	Not reported	Not reported	Not reported

Pain in Other Parts: C16D1 (n=53, 12)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	10.7	19.4	Not reported	Not reported	Not reported
Chemotherapy	38.9	34.3	Not reported	Not reported	Not reported

Pain in Other Parts: C17D1 (n=46, 11)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	13.8	19.3	Not reported	Not reported	Not reported
Chemotherapy	24.2	21.6	Not reported	Not reported	Not reported

Pain in Other Parts: C18D1 (n=45, 11)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	10.4	19.9	Not reported	Not reported	Not reported
Chemotherapy	33.3	39.4	Not reported	Not reported	Not reported

Pain in Other Parts: C19D1 (n=40, 9)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	14.2	22.5	Not reported	Not reported	Not reported
Chemotherapy	25.9	14.7	Not reported	Not reported	Not reported

Pain in Other Parts: C20D1 (n=35, 8)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	13.3	20.1	Not reported	Not reported	Not reported
Chemotherapy	29.2	21.4	Not reported	Not reported	Not reported

Pain in Other Parts: C21D1 (n=30, 8)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	21.1	27.0	Not reported	Not reported	Not reported
Chemotherapy	29.2	37.5	Not reported	Not reported	Not reported

Pain in Other Parts: C22D1 (n=24, 7)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	12.5	21.6	Not reported	Not reported	Not reported
Chemotherapy	40.5	30.2	Not reported	Not reported	Not reported

Pain in Other Parts: C23D1 (n=23, 4)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	5.1	11.7	Not reported	Not reported	Not reported
Chemotherapy	41.7	31.9	Not reported	Not reported	Not reported

Pain in Other Parts: C24D1 (n=20, 3)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	6.7	17.4	Not reported	Not reported	Not reported
Chemotherapy	11.1	19.2	Not reported	Not reported	Not reported

Pain in Other Parts: C25D1 (n=18, 3)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	9.3	15.4	Not reported	Not reported	Not reported
Chemotherapy	44.4	38.5	Not reported	Not reported	Not reported

Pain in Other Parts: C26D1 (n=14, 3)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	23.8	30.5	Not reported	Not reported	Not reported
Chemotherapy	33.3	33.3	Not reported	Not reported	Not reported

Pain in Other Parts: C27D1 (n=14, 2)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	16.7	31.4	Not reported	Not reported	Not reported
Chemotherapy	50.0	23.6	Not reported	Not reported	Not reported

Pain in Other Parts: C28D1 (n=11, 2)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	6.1	13.5	Not reported	Not reported	Not reported
Chemotherapy	33.3	0.0	Not reported	Not reported	Not reported

Pain in Other Parts: C29D1 (n=8, 2)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	4.2	11.8	Not reported	Not reported	Not reported
Chemotherapy	16.7	23.6	Not reported	Not reported	Not reported

Pain in Other Parts: C30D1 (n=8, 1)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	12.5	17.3	Not reported	Not reported	Not reported
Chemotherapy	33.3	NA	Not reported	Not reported	Standard deviation was not estimable since only one participant was evaluable.

Pain in Other Parts: C31D1 (n=7, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	9.5	16.3	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Pain in Other Parts: C32D1 (n=6, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	5.6	13.6	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Pain in Other Parts: C33D1 (n=6, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	0.0	0.0	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Pain in Other Parts: C34D1 (n=5, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	6.7	14.9	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Pain in Other Parts: C35D1 (n=4, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	0.0	0.0	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Pain in Other Parts: C36D1 (n=1, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	0.0	NA	Not reported	Not reported	Standard deviation was not estimable since only one participant was evaluable.
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Pain in Other Parts: C37D1 (n=1, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	0.0	NA	Not reported	Not reported	Standard deviation was not estimable since only one participant was evaluable.
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Pain in Other Parts: EOT (n=49, 90)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	18.4	29.7	Not reported	Not reported	Not reported
Chemotherapy	29.6	34.8	Not reported	Not reported	Not reported

Complete source fields

classes

categories
measurements
group Id
OG000
spread
21.7
value
27.2
group Id
OG001
spread
23.4
value
26.9
title
Dyspnea: Baseline (n=164, 162)
categories
measurements
group Id
OG000
spread
18.1
value
17.6
group Id
OG001
spread
22.3
value
28.6
title
Dyspnea: C2D1 (n=155, 132)
categories
measurements
group Id
OG000
spread
17.8
value
17.9
group Id
OG001
spread
25.4
value
28.0
title
Dyspnea: C3D1 (n=153, 106)
categories
measurements
group Id
OG000
spread
17.5
value
16.2
group Id
OG001
spread
22.8
value
27.5
title
Dyspnea: C4D1 (n=135, 91)
categories
measurements
group Id
OG000
spread
16.7
value
16.9
group Id
OG001
spread
22.9
value
24.8
title
Dyspnea: C5D1 (n=123, 74)
categories
measurements
group Id
OG000
spread
15.8
value
15.2
group Id
OG001
spread
23.0
value
25.2
title
Dyspnea: C6D1 (n=119, 70)
categories
measurements
group Id
OG000
spread
16.5
value
15.6
group Id
OG001
spread
20.3
value
24.4
title
Dyspnea: C7D1 (n=115, 52)
categories
measurements
group Id
OG000
spread
16.0
value
14.7
group Id
OG001
spread
22.8
value
22.0
title
Dyspnea: C8D1 (n=111, 43)
categories
measurements
group Id
OG000
spread
15.8
value
13.9
group Id
OG001
spread
19.0
value
19.5
title
Dyspnea: C9D1 (n=101, 37)
categories
measurements
group Id
OG000
spread
17.0
value
15.4
group Id
OG001
spread
21.0
value
21.5
title
Dyspnea: C10D1 (n=94, 33)
categories
measurements
group Id
OG000
spread
17.5
value
15.1
group Id
OG001
spread
24.1
value
20.4
title
Dyspnea: C11D1 (n=84, 25)
categories
measurements
group Id
OG000
spread
15.5
value
13.7
group Id
OG001
spread
22.1
value
22.7
title
Dyspnea: C12D1 (n=76, 23)

denoms

counts
group Id
OG000
value
164
group Id
OG001
value
162
units
Participants

description

dispersion Type

Standard Deviation

groups

description
Crizotinib (PF-02341066) 250 mg (administered as two 100-mg tablets and one 50-mg tablet) orally twice daily continuously in 21-day cycles. Treatment was continued until disease progression, unacceptable toxicity or withdrawal of consent occurred.
id
OG000
title
Crizotinib
description
Pemetrexed 500 mg/m\^2 intravenous infusion over 10 minutes or docetaxel 75 mg/m\^2 intravenous infusion over 1 hour on Day 1 of 21-day cycle, as per investigator discretion. Treatment was continued until disease progression, unacceptable toxicity or withdrawal of consent occurred.
id
OG001
title
Chemotherapy

param Type

MEAN

population Description

FAS included all participants who were randomized to study treatment. Here "N" (number of participants analyzed) signifies participants who were evaluable for this measure and "n" signifies participants who were evaluable for specified time points for each arm group, respectively.

reporting Status

POSTED

time Frame

Baseline, Day 1 of each cycle until disease progression, end of treatment (up to 112 weeks)

title

European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire-Supplement Module for Lung Cancer (EORTC QLQ-LC13)

type

SECONDARY

unit Of Measure

units on a scale

Download exact source JSON → · Snapshot ctgov-results-191f4516d4760045304b24a0

Preserved source evidence · Not medical advice