NCT00932893 · OUTCOME

European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire-Core 30 (EORTC QLQ-C30)

An Investigational Drug, PF-02341066 Is Being Studied Versus Standard Of Care In Patients With Advanced Non-Small Cell Lung Cancer With A Specific Gene Profile Involving The Anaplastic Lymphoma Kinase (ALK) Gene · Source last updated 2017-01-02

Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.

Measure: MEAN
Unit: units on a scale
Interval / dispersion: Standard Deviation
Time frame: Baseline, Day (D) 1 of each cycle (C) until disease progression, end of treatment (EOT, up to 112 weeks)

What was measured

EORTC QLQ-C30: included global health status/quality of life (QoL), functional scales (physical, role, cognitive, emotional, and social), symptom scales (fatigue, pain, nausea/vomiting), and single items (dyspnea, appetite loss, insomnia, constipation, diarrhea, and financial difficulties). Most questions used 4- point scale (1 'Not at All' to 4 'Very Much'); 2 questions used 7-point scale (1 'Very Poor' to 7 'Excellent'). Scores averaged, transformed to 0-100 scale; higher score for Global Qol/functional scales=better level of QoL/functioning or higher score for symptom scale=greater degree of symptoms.

Analysis population: FAS included all participants who were randomized to study treatment. Here "N" (number of participants analyzed) signifies participants who were evaluable for this measure and "n" signifies participants who were evaluable for specified time points for each arm group, respectively.

Groups in this outcome

Crizotinib

Crizotinib (PF-02341066) 250 mg (administered as two 100-mg tablets and one 50-mg tablet) orally twice daily continuously in 21-day cycles. Treatment was continued until disease progression, unacceptable toxicity or withdrawal of consent occurred.

Chemotherapy

Pemetrexed 500 mg/m\^2 intravenous infusion over 10 minutes or docetaxel 75 mg/m\^2 intravenous infusion over 1 hour on Day 1 of 21-day cycle, as per investigator discretion. Treatment was continued until disease progression, unacceptable toxicity or withdrawal of consent occurred.

Group identifiers and denominators belong to this outcome only. They may differ in another outcome or in safety reporting.

Analysis denominator · Participants

Group	Source count
Crizotinib	165
Chemotherapy	163

Reported measurements

Global QoL: Baseline (n=165, 162)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	57.2	21.5	Not reported	Not reported	Not reported
Chemotherapy	58.1	22.2	Not reported	Not reported	Not reported

Global QoL: C2D1 (n=154, 133)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	64.5	21.8	Not reported	Not reported	Not reported
Chemotherapy	58.1	23.1	Not reported	Not reported	Not reported

Global QoL: C3D1 (n=154, 106)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	65.2	22.1	Not reported	Not reported	Not reported
Chemotherapy	59.4	23.1	Not reported	Not reported	Not reported

Global QoL: C4D1 (n=135, 90)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	68.4	19.6	Not reported	Not reported	Not reported
Chemotherapy	61.1	20.8	Not reported	Not reported	Not reported

Global QoL: C5D1 (n=123, 74)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	68.5	20.2	Not reported	Not reported	Not reported
Chemotherapy	64.1	22.7	Not reported	Not reported	Not reported

Global QoL: C6D1 (n=120, 70)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	68.3	19.8	Not reported	Not reported	Not reported
Chemotherapy	67.5	23.5	Not reported	Not reported	Not reported

Global QoL: C7D1 (n=114, 52)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	69.5	19.3	Not reported	Not reported	Not reported
Chemotherapy	66.5	23.1	Not reported	Not reported	Not reported

Global QoL: C8D1 (n=110, 43)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	68.7	20.1	Not reported	Not reported	Not reported
Chemotherapy	66.9	25.3	Not reported	Not reported	Not reported

Global QoL: C9D1 (n=101, 37)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	68.7	21.0	Not reported	Not reported	Not reported
Chemotherapy	66.4	27.8	Not reported	Not reported	Not reported

Global QoL: C10D1 (n=94, 33)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	67.0	21.6	Not reported	Not reported	Not reported
Chemotherapy	67.4	26.8	Not reported	Not reported	Not reported

Global QoL: C11D1 (n=83, 25)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	69.5	20.2	Not reported	Not reported	Not reported
Chemotherapy	71.0	21.8	Not reported	Not reported	Not reported

Global QoL: C12D1 (n=76, 23)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	67.9	22.0	Not reported	Not reported	Not reported
Chemotherapy	65.6	24.1	Not reported	Not reported	Not reported

Global QoL: C13D1 (n=74, 21)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	66.8	23.6	Not reported	Not reported	Not reported
Chemotherapy	66.7	23.6	Not reported	Not reported	Not reported

Global QoL: C14D1 (n=66, 19)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	71.5	20.0	Not reported	Not reported	Not reported
Chemotherapy	65.8	23.4	Not reported	Not reported	Not reported

Global QoL: C15D1 (n=62, 16)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	69.0	22.2	Not reported	Not reported	Not reported
Chemotherapy	66.1	24.1	Not reported	Not reported	Not reported

Global QoL: C16D1 (n=53, 12)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	69.7	18.1	Not reported	Not reported	Not reported
Chemotherapy	63.2	25.5	Not reported	Not reported	Not reported

Global QoL: C17D1 (n=47, 11)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	67.6	20.5	Not reported	Not reported	Not reported
Chemotherapy	69.7	23.4	Not reported	Not reported	Not reported

Global QoL: C18D1 (n=44, 11)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	65.7	19.9	Not reported	Not reported	Not reported
Chemotherapy	70.5	22.5	Not reported	Not reported	Not reported

Global QoL: C19D1 (n=40, 9)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	69.2	19.2	Not reported	Not reported	Not reported
Chemotherapy	72.2	20.0	Not reported	Not reported	Not reported

Global QoL: C20D1 (n=35, 8)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	64.3	20.6	Not reported	Not reported	Not reported
Chemotherapy	60.4	21.2	Not reported	Not reported	Not reported

Global QoL: C21D1 (n=30, 8)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	65.0	18.4	Not reported	Not reported	Not reported
Chemotherapy	63.5	23.5	Not reported	Not reported	Not reported

Global QoL: C22D1 (n=24, 7)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	70.8	19.3	Not reported	Not reported	Not reported
Chemotherapy	64.3	24.9	Not reported	Not reported	Not reported

Global QoL: C23D1 (n=23, 4)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	67.0	22.5	Not reported	Not reported	Not reported
Chemotherapy	50.0	19.2	Not reported	Not reported	Not reported

Global QoL: C24D1 (n=20, 3)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	67.1	18.8	Not reported	Not reported	Not reported
Chemotherapy	55.6	19.2	Not reported	Not reported	Not reported

Global QoL: C25D1 (n=18, 3)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	67.1	17.7	Not reported	Not reported	Not reported
Chemotherapy	61.1	19.2	Not reported	Not reported	Not reported

Global QoL: C26D1 (n=14, 3)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	60.7	22.0	Not reported	Not reported	Not reported
Chemotherapy	55.6	12.7	Not reported	Not reported	Not reported

Global QoL: C27D1 (n=14, 2)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	58.9	20.3	Not reported	Not reported	Not reported
Chemotherapy	41.7	0.0	Not reported	Not reported	Not reported

Global QoL: C28D1 (n=11, 2)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	66.7	18.3	Not reported	Not reported	Not reported
Chemotherapy	54.2	17.7	Not reported	Not reported	Not reported

Global QoL: C29D1 (n=8, 2)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	59.4	18.6	Not reported	Not reported	Not reported
Chemotherapy	41.7	11.8	Not reported	Not reported	Not reported

Global QoL: C30D1 (n=8, 1)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	64.6	19.3	Not reported	Not reported	Not reported
Chemotherapy	33.3	NA	Not reported	Not reported	Standard deviation was not estimable since only one participant was evaluable.

Global QoL: C31D1 (n=7, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	64.3	17.2	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Global QoL: C32D1 (n=6, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	59.7	17.0	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Global QoL: C33D1 (n=6, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	66.7	18.3	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Global QoL: C34D1 (n=5, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	68.3	14.9	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Global QoL: C35D1 (n=4, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	60.4	22.9	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Global QoL: C36D1 (n=1, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	66.7	NA	Not reported	Not reported	Standard deviation was not estimable since only one participant was evaluable.
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Global QoL: C37D1 (n=1, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	66.7	NA	Not reported	Not reported	Standard deviation was not estimable since only one participant was evaluable.
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Physical Functioning: Baseline (n=165, 163)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	76.3	20.7	Not reported	Not reported	Not reported
Chemotherapy	75.8	21.9	Not reported	Not reported	Not reported

Physical Functioning: C2D1 (n=155, 133)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	79.2	20.9	Not reported	Not reported	Not reported
Chemotherapy	73.5	22.3	Not reported	Not reported	Not reported

Physical Functioning: C3D1 (n=154, 106)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	82.3	18.1	Not reported	Not reported	Not reported
Chemotherapy	75.5	20.2	Not reported	Not reported	Not reported

Physical Functioning: C4D1 (n=135, 91)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	83.8	16.2	Not reported	Not reported	Not reported
Chemotherapy	76.6	20.2	Not reported	Not reported	Not reported

Physical Functioning: C5D1 (n=123, 74)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	84.5	16.2	Not reported	Not reported	Not reported
Chemotherapy	78.6	23.0	Not reported	Not reported	Not reported

Physical Functioning: C6D1 (n=120, 70)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	86.2	16.7	Not reported	Not reported	Not reported
Chemotherapy	80.7	19.7	Not reported	Not reported	Not reported

Physical Functioning: C7D1 (n=115, 52)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	86.7	15.0	Not reported	Not reported	Not reported
Chemotherapy	80.3	19.7	Not reported	Not reported	Not reported

Physical Functioning: C8D1 (n=111, 43)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	86.5	16.3	Not reported	Not reported	Not reported
Chemotherapy	81.6	18.5	Not reported	Not reported	Not reported

Physical Functioning: C9D1 (n=101, 37)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	87.7	14.2	Not reported	Not reported	Not reported
Chemotherapy	82.3	19.1	Not reported	Not reported	Not reported

Physical Functioning: C10D1 (n=94, 33)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	87.9	14.8	Not reported	Not reported	Not reported
Chemotherapy	81.8	20.7	Not reported	Not reported	Not reported

Physical Functioning: C11D1 (n=84, 25)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	87.2	16.7	Not reported	Not reported	Not reported
Chemotherapy	83.2	19.0	Not reported	Not reported	Not reported

Physical Functioning: C12D1 (n=76, 23)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	88.1	15.3	Not reported	Not reported	Not reported
Chemotherapy	79.7	22.8	Not reported	Not reported	Not reported

Physical Functioning: C13D1 (n=74, 21)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	89.3	13.9	Not reported	Not reported	Not reported
Chemotherapy	78.4	23.6	Not reported	Not reported	Not reported

Physical Functioning: C14D1 (n=66, 19)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	89.0	14.3	Not reported	Not reported	Not reported
Chemotherapy	80.0	21.4	Not reported	Not reported	Not reported

Physical Functioning: C15D1 (n=62, 16)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	87.8	15.3	Not reported	Not reported	Not reported
Chemotherapy	82.9	15.4	Not reported	Not reported	Not reported

Physical Functioning: C16D1 (n=53, 12)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	89.3	11.5	Not reported	Not reported	Not reported
Chemotherapy	81.1	19.5	Not reported	Not reported	Not reported

Physical Functioning: C17D1 (n=47, 11)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	86.6	16.8	Not reported	Not reported	Not reported
Chemotherapy	81.8	15.8	Not reported	Not reported	Not reported

Physical Functioning: C18D1 (n=45, 11)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	88.4	13.3	Not reported	Not reported	Not reported
Chemotherapy	82.4	16.1	Not reported	Not reported	Not reported

Physical Functioning: C19D1 (n=40, 9)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	88.3	12.4	Not reported	Not reported	Not reported
Chemotherapy	81.5	12.8	Not reported	Not reported	Not reported

Physical Functioning: C20D1 (n=35, 8)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	87.6	12.7	Not reported	Not reported	Not reported
Chemotherapy	79.2	17.3	Not reported	Not reported	Not reported

Physical Functioning: C21D1 (n=30, 8)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	88.4	10.9	Not reported	Not reported	Not reported
Chemotherapy	77.5	22.5	Not reported	Not reported	Not reported

Physical Functioning: C22D1 (n=24, 7)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	90.6	8.3	Not reported	Not reported	Not reported
Chemotherapy	78.1	24.3	Not reported	Not reported	Not reported

Physical Functioning: C23D1 (n=23, 4)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	88.0	13.1	Not reported	Not reported	Not reported
Chemotherapy	60.0	27.2	Not reported	Not reported	Not reported

Physical Functioning: C24D1 (n=20, 3)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	85.0	14.0	Not reported	Not reported	Not reported
Chemotherapy	64.4	32.9	Not reported	Not reported	Not reported

Physical Functioning: C25D1 (n=18, 3)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	87.4	11.6	Not reported	Not reported	Not reported
Chemotherapy	60.0	29.1	Not reported	Not reported	Not reported

Physical Functioning: C26D1 (n=14, 3)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	80.5	25.3	Not reported	Not reported	Not reported
Chemotherapy	62.2	30.8	Not reported	Not reported	Not reported

Physical Functioning: C27D1 (n=14, 2)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	78.6	27.8	Not reported	Not reported	Not reported
Chemotherapy	50.0	23.6	Not reported	Not reported	Not reported

Physical Functioning: C28D1 (n=11, 2)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	81.8	24.1	Not reported	Not reported	Not reported
Chemotherapy	60.0	18.9	Not reported	Not reported	Not reported

Physical Functioning: C29D1 (n=8, 2)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	85.0	15.0	Not reported	Not reported	Not reported
Chemotherapy	46.7	28.3	Not reported	Not reported	Not reported

Physical Functioning: C30D1 (n=8, 1)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	82.5	21.4	Not reported	Not reported	Not reported
Chemotherapy	26.7	NA	Not reported	Not reported	Standard deviation was not estimable since only one participant was evaluable.

Physical Functioning: C31D1 (n=7, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	83.8	17.2	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Physical Functioning: C32D1 (n=6, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	88.9	9.1	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Physical Functioning: C33D1 (n=6, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	90.0	7.0	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Physical Functioning: C34D1 (n=5, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	85.3	7.3	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Physical Functioning: C35D1 (n=4, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	91.7	3.3	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Physical Functioning: C36D1 (n=1, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	86.7	NA	Not reported	Not reported	Standard deviation was not estimable since only one participant was evaluable.
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Physical Functioning: C37D1 (n=1, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	86.7	NA	Not reported	Not reported	Standard deviation was not estimable since only one participant was evaluable.
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Role Functioning: Baseline (n=165, 163)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	69.3	28.7	Not reported	Not reported	Not reported
Chemotherapy	66.6	30.2	Not reported	Not reported	Not reported

Role Functioning: C2D1 (n=155, 133)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	73.8	28.9	Not reported	Not reported	Not reported
Chemotherapy	64.7	29.7	Not reported	Not reported	Not reported

Role Functioning: C3D1 (n=154, 106)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	74.4	28.6	Not reported	Not reported	Not reported
Chemotherapy	65.3	27.7	Not reported	Not reported	Not reported

Role Functioning: C4D1 (n=134, 91)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	77.9	25.7	Not reported	Not reported	Not reported
Chemotherapy	67.2	27.3	Not reported	Not reported	Not reported

Role Functioning: C5D1 (n=123, 74)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	78.2	24.3	Not reported	Not reported	Not reported
Chemotherapy	69.6	27.4	Not reported	Not reported	Not reported

Role Functioning: C6D1 (n=120, 70)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	80.0	24.1	Not reported	Not reported	Not reported
Chemotherapy	69.5	26.2	Not reported	Not reported	Not reported

Role Functioning: C7D1 (n=115, 52)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	81.7	22.6	Not reported	Not reported	Not reported
Chemotherapy	72.1	25.9	Not reported	Not reported	Not reported

Role Functioning: C8D1 (n=111, 43)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	80.4	23.9	Not reported	Not reported	Not reported
Chemotherapy	75.2	28.3	Not reported	Not reported	Not reported

Role Functioning: C9D1 (n=101, 37)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	80.9	25.8	Not reported	Not reported	Not reported
Chemotherapy	76.6	27.6	Not reported	Not reported	Not reported

Role Functioning: C10D1 (n=94, 33)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	81.6	23.1	Not reported	Not reported	Not reported
Chemotherapy	75.3	28.3	Not reported	Not reported	Not reported

Role Functioning: C11D1 (n=84, 25)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	81.3	23.8	Not reported	Not reported	Not reported
Chemotherapy	75.3	25.5	Not reported	Not reported	Not reported

Role Functioning: C12D1 (n=76, 23)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	81.6	23.2	Not reported	Not reported	Not reported
Chemotherapy	72.5	29.6	Not reported	Not reported	Not reported

Role Functioning: C13D1 (n=74, 21)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	80.2	25.5	Not reported	Not reported	Not reported
Chemotherapy	68.3	32.0	Not reported	Not reported	Not reported

Role Functioning: C14D1 (n=66, 19)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	83.8	21.3	Not reported	Not reported	Not reported
Chemotherapy	68.4	30.4	Not reported	Not reported	Not reported

Role Functioning: C15D1 (n=62, 16)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	80.6	24.0	Not reported	Not reported	Not reported
Chemotherapy	77.1	27.8	Not reported	Not reported	Not reported

Role Functioning: C16D1 (n=53, 12)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	84.0	19.0	Not reported	Not reported	Not reported
Chemotherapy	69.4	34.0	Not reported	Not reported	Not reported

Role Functioning: C17D1 (n=47, 11)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	77.7	25.4	Not reported	Not reported	Not reported
Chemotherapy	71.2	38.1	Not reported	Not reported	Not reported

Role Functioning: C18D1 (n=45, 11)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	80.0	22.4	Not reported	Not reported	Not reported
Chemotherapy	71.2	31.7	Not reported	Not reported	Not reported

Role Functioning: C19D1 (n=40, 9)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	82.1	19.4	Not reported	Not reported	Not reported
Chemotherapy	74.1	29.0	Not reported	Not reported	Not reported

Role Functioning: C20D1 (n=35, 8)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	81.9	17.8	Not reported	Not reported	Not reported
Chemotherapy	70.8	36.5	Not reported	Not reported	Not reported

Role Functioning: C21D1 (n=30, 8)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	80.0	24.1	Not reported	Not reported	Not reported
Chemotherapy	66.7	32.1	Not reported	Not reported	Not reported

Role Functioning: C22D1 (n=24, 7)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	84.7	19.0	Not reported	Not reported	Not reported
Chemotherapy	67.9	33.5	Not reported	Not reported	Not reported

Role Functioning: C23D1 (n=23, 4)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	76.8	26.9	Not reported	Not reported	Not reported
Chemotherapy	37.5	25.0	Not reported	Not reported	Not reported

Role Functioning: C24D1 (n=20, 3)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	80.8	24.3	Not reported	Not reported	Not reported
Chemotherapy	44.4	38.5	Not reported	Not reported	Not reported

Role Functioning: C25D1 (n=18, 3)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	87.0	19.4	Not reported	Not reported	Not reported
Chemotherapy	44.4	25.5	Not reported	Not reported	Not reported

Role Functioning: C26D1 (n=14, 3)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	75.0	29.1	Not reported	Not reported	Not reported
Chemotherapy	33.3	33.3	Not reported	Not reported	Not reported

Role Functioning: C27D1 (n=14, 2)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	69.0	35.1	Not reported	Not reported	Not reported
Chemotherapy	25.0	11.8	Not reported	Not reported	Not reported

Role Functioning: C28D1 (n=11, 2)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	77.3	33.6	Not reported	Not reported	Not reported
Chemotherapy	25.0	35.4	Not reported	Not reported	Not reported

Role Functioning: C29D1 (n=8, 2)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	77.1	34.4	Not reported	Not reported	Not reported
Chemotherapy	25.0	11.8	Not reported	Not reported	Not reported

Role Functioning: C30D1 (n=8, 1)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	77.1	34.4	Not reported	Not reported	Not reported
Chemotherapy	0.0	NA	Not reported	Not reported	Standard deviation was not estimable since only one participant was evaluable.

Role Functioning: C31D1 (n=7, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	71.4	36.9	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Role Functioning: C32D1 (n=6, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	86.1	12.5	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Role Functioning: C33D1 (n=6, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	88.9	13.6	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Role Functioning: C34D1 (n=5, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	96.7	7.5	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Role Functioning: C35D1 (n=4, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	91.7	16.7	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Role Functioning: C36D1 (n=1, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	100.0	NA	Not reported	Not reported	Standard deviation was not estimable since only one participant was evaluable.
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Role Functioning: C37D1 (n=1, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	100.0	NA	Not reported	Not reported	Standard deviation was not estimable since only one participant was evaluable.
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Emotional Functioning: Baseline (n=165, 162)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	74.5	21.3	Not reported	Not reported	Not reported
Chemotherapy	73.7	20.7	Not reported	Not reported	Not reported

Emotional Functioning: C2D1 (n=155, 133)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	83.1	18.7	Not reported	Not reported	Not reported
Chemotherapy	77.7	19.3	Not reported	Not reported	Not reported

Emotional Functioning: C3D1 (n=154, 106)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	83.3	16.7	Not reported	Not reported	Not reported
Chemotherapy	77.9	21.5	Not reported	Not reported	Not reported

Emotional Functioning: C4D1 (n=135, 90)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	84.1	17.3	Not reported	Not reported	Not reported
Chemotherapy	80.5	18.9	Not reported	Not reported	Not reported

Emotional Functioning: C5D1 (n=123, 74)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	83.0	19.1	Not reported	Not reported	Not reported
Chemotherapy	79.8	19.9	Not reported	Not reported	Not reported

Emotional Functioning: C6D1 (n=120, 70)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	85.3	17.8	Not reported	Not reported	Not reported
Chemotherapy	81.2	19.4	Not reported	Not reported	Not reported

Emotional Functioning: C7D1 (n=115, 52)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	86.4	16.5	Not reported	Not reported	Not reported
Chemotherapy	81.9	17.6	Not reported	Not reported	Not reported

Emotional Functioning: C8D1 (n=111, 43)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	83.9	19.8	Not reported	Not reported	Not reported
Chemotherapy	81.6	20.7	Not reported	Not reported	Not reported

Emotional Functioning: C9D1 (n=101, 37)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	84.4	19.0	Not reported	Not reported	Not reported
Chemotherapy	82.4	19.6	Not reported	Not reported	Not reported

Emotional Functioning: C10D1 (n=94, 33)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	87.2	16.8	Not reported	Not reported	Not reported
Chemotherapy	81.8	21.2	Not reported	Not reported	Not reported

Emotional Functioning: C11D1 (n=84,25)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	86.1	16.7	Not reported	Not reported	Not reported
Chemotherapy	85.0	17.8	Not reported	Not reported	Not reported

Emotional Functioning: C12D1 (n=76, 23)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	85.3	18.6	Not reported	Not reported	Not reported
Chemotherapy	84.8	18.6	Not reported	Not reported	Not reported

Emotional Functioning: C13D1 (n=74, 21)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	84.9	19.0	Not reported	Not reported	Not reported
Chemotherapy	80.6	19.1	Not reported	Not reported	Not reported

Emotional Functioning: C14D1 (n=66, 19)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	84.5	19.9	Not reported	Not reported	Not reported
Chemotherapy	81.6	21.1	Not reported	Not reported	Not reported

Emotional Functioning: C15D1 (n=62, 16)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	86.3	18.0	Not reported	Not reported	Not reported
Chemotherapy	82.3	18.2	Not reported	Not reported	Not reported

Emotional Functioning: C16D1 (n=53, 12)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	85.8	17.6	Not reported	Not reported	Not reported
Chemotherapy	77.8	27.8	Not reported	Not reported	Not reported

Emotional Functioning: C17D1 (n=47, 11)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	85.6	22.0	Not reported	Not reported	Not reported
Chemotherapy	79.5	23.4	Not reported	Not reported	Not reported

Emotional Functioning: C18D1 (n=44, 11)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	86.4	17.2	Not reported	Not reported	Not reported
Chemotherapy	75.8	27.8	Not reported	Not reported	Not reported

Emotional Functioning: C19D1 (n=40, 9)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	87.3	16.0	Not reported	Not reported	Not reported
Chemotherapy	81.5	20.7	Not reported	Not reported	Not reported

Emotional Functioning: C20D1 (n=35, 8)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	83.8	17.5	Not reported	Not reported	Not reported
Chemotherapy	82.3	25.0	Not reported	Not reported	Not reported

Emotional Functioning: C21D1 (n=30, 8)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	84.5	17.1	Not reported	Not reported	Not reported
Chemotherapy	80.2	29.5	Not reported	Not reported	Not reported

Emotional Functioning: C22D1 (n=24, 7)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	83.7	21.6	Not reported	Not reported	Not reported
Chemotherapy	78.6	24.9	Not reported	Not reported	Not reported

Emotional Functioning: C23D1 (n=23, 4)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	84.1	19.8	Not reported	Not reported	Not reported
Chemotherapy	70.8	21.0	Not reported	Not reported	Not reported

Emotional Functioning: C24D1 (n=20, 3)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	87.9	16.1	Not reported	Not reported	Not reported
Chemotherapy	66.7	30.0	Not reported	Not reported	Not reported

Emotional Functioning: C25D1 (n=18, 3)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	81.5	19.5	Not reported	Not reported	Not reported
Chemotherapy	72.2	24.1	Not reported	Not reported	Not reported

Emotional Functioning: C26D1 (n=14, 3)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	73.2	28.3	Not reported	Not reported	Not reported
Chemotherapy	72.2	24.1	Not reported	Not reported	Not reported

Emotional Functioning: C27D1 (n=14, 2)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	70.8	27.3	Not reported	Not reported	Not reported
Chemotherapy	58.3	0.0	Not reported	Not reported	Not reported

Emotional Functioning: C28D1 (n=11, 2)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	81.1	27.2	Not reported	Not reported	Not reported
Chemotherapy	58.3	0.0	Not reported	Not reported	Not reported

Emotional Functioning: C29D1 (n=8, 2)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	86.5	15.4	Not reported	Not reported	Not reported
Chemotherapy	54.2	5.9	Not reported	Not reported	Not reported

Emotional Functioning: C30D1 (n=8, 1)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	84.4	25.0	Not reported	Not reported	Not reported
Chemotherapy	58.3	NA	Not reported	Not reported	Standard deviation was not estimable since only one participant was evaluable.

Emotional Functioning: C31D1 (n=7, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	76.2	28.2	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Emotional Functioning: C32D1 (n=6, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	87.5	17.3	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Emotional Functioning: C33D1 (n=6, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	90.3	13.4	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Emotional Functioning: C34D1 (n=5, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	91.7	14.4	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Emotional Functioning: C35D1 (n=4, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	83.3	20.4	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Emotional Functioning: C36D1 (n=1, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	58.3	NA	Not reported	Not reported	Standard deviation was not estimable since only one participant was evaluable.
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Emotional Functioning: C37D1 (n=1, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	58.3	NA	Not reported	Not reported	Standard deviation was not estimable since only one participant was evaluable.
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Cognitive Functioning: Baseline (n=165, 162)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	85.6	18.3	Not reported	Not reported	Not reported
Chemotherapy	83.6	22.3	Not reported	Not reported	Not reported

Cognitive Functioning: C2D1 (n=155, 133)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	85.5	18.9	Not reported	Not reported	Not reported
Chemotherapy	84.5	20.6	Not reported	Not reported	Not reported

Cognitive Functioning: C3D1 (n=154, 106)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	87.0	15.7	Not reported	Not reported	Not reported
Chemotherapy	83.8	20.4	Not reported	Not reported	Not reported

Cognitive Functioning: C4D1 (n=135, 90)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	88.1	15.6	Not reported	Not reported	Not reported
Chemotherapy	82.6	20.4	Not reported	Not reported	Not reported

Cognitive Functioning: C5D1 (n=123, 74)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	88.9	14.4	Not reported	Not reported	Not reported
Chemotherapy	82.7	22.0	Not reported	Not reported	Not reported

Cognitive Functioning: C6D1 (n=120, 70)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	87.5	15.3	Not reported	Not reported	Not reported
Chemotherapy	83.8	19.2	Not reported	Not reported	Not reported

Cognitive Functioning: C7D1 (n=115, 52)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	86.7	15.6	Not reported	Not reported	Not reported
Chemotherapy	85.3	18.3	Not reported	Not reported	Not reported

Cognitive Functioning: C8D1 (n=111, 43)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	87.8	14.7	Not reported	Not reported	Not reported
Chemotherapy	82.2	23.4	Not reported	Not reported	Not reported

Cognitive Functioning: C9D1 (n=101, 37)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	88.3	16.6	Not reported	Not reported	Not reported
Chemotherapy	84.7	21.7	Not reported	Not reported	Not reported

Cognitive Functioning: C10D1 (n=94, 33)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	89.2	16.0	Not reported	Not reported	Not reported
Chemotherapy	80.8	22.1	Not reported	Not reported	Not reported

Cognitive Functioning: C11D1 (n=84, 25)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	87.9	14.9	Not reported	Not reported	Not reported
Chemotherapy	85.3	19.4	Not reported	Not reported	Not reported

Cognitive Functioning: C12D1 (n=76, 23)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	89.5	14.4	Not reported	Not reported	Not reported
Chemotherapy	80.4	22.8	Not reported	Not reported	Not reported

Cognitive Functioning: C13D1 (n=74, 21)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	88.5	15.6	Not reported	Not reported	Not reported
Chemotherapy	79.4	27.8	Not reported	Not reported	Not reported

Cognitive Functioning: C14D1 (n=66, 19)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	88.9	14.7	Not reported	Not reported	Not reported
Chemotherapy	81.6	24.1	Not reported	Not reported	Not reported

Cognitive Functioning: C15D1 (n=62, 16)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	87.6	15.4	Not reported	Not reported	Not reported
Chemotherapy	84.4	18.7	Not reported	Not reported	Not reported

Cognitive Functioning: C16D1 (n=53, 12)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	87.4	14.2	Not reported	Not reported	Not reported
Chemotherapy	72.2	25.9	Not reported	Not reported	Not reported

Cognitive Functioning: C17D1 (n=47, 11)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	85.1	15.2	Not reported	Not reported	Not reported
Chemotherapy	75.8	21.6	Not reported	Not reported	Not reported

Cognitive Functioning: C18D1 (n=44, 11)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	88.3	14.6	Not reported	Not reported	Not reported
Chemotherapy	75.8	25.1	Not reported	Not reported	Not reported

Cognitive Functioning: C19D1 (n=40, 9)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	87.5	14.5	Not reported	Not reported	Not reported
Chemotherapy	70.4	23.2	Not reported	Not reported	Not reported

Cognitive Functioning: C20D1 (n=35, 8)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	85.7	15.2	Not reported	Not reported	Not reported
Chemotherapy	72.9	23.5	Not reported	Not reported	Not reported

Cognitive Functioning: C21D1 (n=30, 8)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	85.6	15.0	Not reported	Not reported	Not reported
Chemotherapy	72.9	23.5	Not reported	Not reported	Not reported

Cognitive Functioning: C22D1 (n=24, 7)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	86.1	15.3	Not reported	Not reported	Not reported
Chemotherapy	69.0	24.4	Not reported	Not reported	Not reported

Cognitive Functioning: C23D1 (n=23, 4)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	85.5	14.5	Not reported	Not reported	Not reported
Chemotherapy	58.3	21.5	Not reported	Not reported	Not reported

Cognitive Functioning: C24D1 (n=20, 3)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	85.8	19.7	Not reported	Not reported	Not reported
Chemotherapy	61.1	34.7	Not reported	Not reported	Not reported

Cognitive Functioning: C25D1 (n=18, 3)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	86.1	15.4	Not reported	Not reported	Not reported
Chemotherapy	55.6	25.5	Not reported	Not reported	Not reported

Cognitive Functioning: C26D1 (n=14, 3)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	81.0	26.0	Not reported	Not reported	Not reported
Chemotherapy	61.1	34.7	Not reported	Not reported	Not reported

Cognitive Functioning: C27D1 (n=14, 2)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	76.2	25.9	Not reported	Not reported	Not reported
Chemotherapy	41.7	11.8	Not reported	Not reported	Not reported

Cognitive Functioning: C28D1 (n=11, 2)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	78.8	21.2	Not reported	Not reported	Not reported
Chemotherapy	41.7	11.8	Not reported	Not reported	Not reported

Cognitive Functioning: C29D1 (n=8, 2)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	87.5	11.8	Not reported	Not reported	Not reported
Chemotherapy	33.3	0.0	Not reported	Not reported	Not reported

Cognitive Functioning: C30D1 (n=8, 1)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	83.3	23.6	Not reported	Not reported	Not reported
Chemotherapy	16.7	NA	Not reported	Not reported	Standard deviation was not estimable since only one participant was evaluable.

Cognitive Functioning: C31D1 (n=7, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	81.0	20.2	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Cognitive Functioning: C32D1 (n=6, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	83.3	18.3	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Cognitive Functioning: C33D1 (n=6, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	86.1	16.4	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Cognitive Functioning: C34D1 (n=5, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	90.0	9.1	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Cognitive Functioning: C35D1 (n=4, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	95.8	8.3	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Cognitive Functioning: C36D1 (n=1, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	100.0	NA	Not reported	Not reported	Standard deviation was not estimable since only one participant was evaluable.
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Cognitive Functioning: C37D1 (n=1, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	83.3	NA	Not reported	Not reported	Standard deviation was not estimable since only one participant was evaluable.
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Social Functioning: Baseline (n=165, 162)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	68.0	27.7	Not reported	Not reported	Not reported
Chemotherapy	67.1	29.0	Not reported	Not reported	Not reported

Social Functioning: C2D1 (n=155, 133)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	75.9	25.1	Not reported	Not reported	Not reported
Chemotherapy	69.5	28.1	Not reported	Not reported	Not reported

Social Functioning: C3D1 (n=154, 106)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	78.5	24.0	Not reported	Not reported	Not reported
Chemotherapy	72.5	26.7	Not reported	Not reported	Not reported

Social Functioning: C4D1 (n=135, 90)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	79.4	23.9	Not reported	Not reported	Not reported
Chemotherapy	71.7	26.3	Not reported	Not reported	Not reported

Social Functioning: C5D1 (n=123, 74)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	79.4	23.8	Not reported	Not reported	Not reported
Chemotherapy	74.5	27.1	Not reported	Not reported	Not reported

Social Functioning: C6D1 (n=120, 70)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	81.8	22.1	Not reported	Not reported	Not reported
Chemotherapy	76.4	27.3	Not reported	Not reported	Not reported

Social Functioning: C7D1 (n=115, 52)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	82.3	21.8	Not reported	Not reported	Not reported
Chemotherapy	77.9	24.6	Not reported	Not reported	Not reported

Social Functioning: C8D1 (n=111, 43)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	82.0	21.3	Not reported	Not reported	Not reported
Chemotherapy	77.5	24.4	Not reported	Not reported	Not reported

Social Functioning: C9D1 (n=101, 37)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	80.4	24.7	Not reported	Not reported	Not reported
Chemotherapy	80.2	21.8	Not reported	Not reported	Not reported

Social Functioning: C10D1 (n=94, 33)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	81.9	25.1	Not reported	Not reported	Not reported
Chemotherapy	76.3	27.0	Not reported	Not reported	Not reported

Social Functioning: C11D1 (n=84, 25)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	81.9	23.0	Not reported	Not reported	Not reported
Chemotherapy	78.7	24.8	Not reported	Not reported	Not reported

Social Functioning: C12D1 (n=76, 23)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	82.0	23.5	Not reported	Not reported	Not reported
Chemotherapy	71.0	31.9	Not reported	Not reported	Not reported

Social Functioning: C13D1 (n=74, 21)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	81.8	24.7	Not reported	Not reported	Not reported
Chemotherapy	71.4	28.9	Not reported	Not reported	Not reported

Social Functioning: C14D1 (n=66, 19)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	81.3	23.8	Not reported	Not reported	Not reported
Chemotherapy	69.3	34.8	Not reported	Not reported	Not reported

Social Functioning: C15D1 (n=62, 16)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	81.5	25.6	Not reported	Not reported	Not reported
Chemotherapy	74.0	28.5	Not reported	Not reported	Not reported

Social Functioning: C16D1 (n=53, 12)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	82.7	21.9	Not reported	Not reported	Not reported
Chemotherapy	65.3	35.9	Not reported	Not reported	Not reported

Social Functioning: C17D1 (n=47, 11)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	81.9	24.8	Not reported	Not reported	Not reported
Chemotherapy	69.7	33.2	Not reported	Not reported	Not reported

Social Functioning: C18D1 (n=44, 11)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	82.6	22.7	Not reported	Not reported	Not reported
Chemotherapy	65.2	35.3	Not reported	Not reported	Not reported

Social Functioning: C19D1 (n=40, 9)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	84.6	22.8	Not reported	Not reported	Not reported
Chemotherapy	64.8	31.7	Not reported	Not reported	Not reported

Social Functioning: C20D1 (n=35, 8)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	82.9	23.7	Not reported	Not reported	Not reported
Chemotherapy	70.8	33.0	Not reported	Not reported	Not reported

Social Functioning: C21D1 (n=30, 8)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	82.8	24.2	Not reported	Not reported	Not reported
Chemotherapy	64.6	36.1	Not reported	Not reported	Not reported

Social Functioning: C22D1 (n=24, 7)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	82.6	23.8	Not reported	Not reported	Not reported
Chemotherapy	65.5	39.8	Not reported	Not reported	Not reported

Social Functioning: C23D1 (n=23, 4)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	84.4	23.9	Not reported	Not reported	Not reported
Chemotherapy	41.7	50.0	Not reported	Not reported	Not reported

Social Functioning: C24D1 (n=20, 3)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	84.2	27.3	Not reported	Not reported	Not reported
Chemotherapy	61.1	53.6	Not reported	Not reported	Not reported

Social Functioning: C25D1 (n=18, 3)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	89.8	19.1	Not reported	Not reported	Not reported
Chemotherapy	50.0	50.0	Not reported	Not reported	Not reported

Social Functioning: C26D1 (n=14, 3)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	78.6	28.8	Not reported	Not reported	Not reported
Chemotherapy	50.0	50.0	Not reported	Not reported	Not reported

Social Functioning: C27D1 (n=14, 2)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	85.7	15.8	Not reported	Not reported	Not reported
Chemotherapy	33.3	47.1	Not reported	Not reported	Not reported

Social Functioning: C28D1 (n=11, 2)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	83.3	26.9	Not reported	Not reported	Not reported
Chemotherapy	33.3	47.1	Not reported	Not reported	Not reported

Social Functioning: C29D1 (n=8, 2)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	83.3	25.2	Not reported	Not reported	Not reported
Chemotherapy	33.3	47.1	Not reported	Not reported	Not reported

Social Functioning: C30D1 (n=8, 1)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	85.4	24.3	Not reported	Not reported	Not reported
Chemotherapy	0.0	NA	Not reported	Not reported	Standard deviation was not estimable since only one participant was evaluable.

Social Functioning: C31D1 (n=7, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	73.8	38.3	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Social Functioning: C32D1 (n=6, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	83.3	18.3	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Social Functioning: C33D1 (n=6, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	94.4	13.6	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Social Functioning: C34D1 (n=5, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	96.7	7.5	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Social Functioning: C35D1 (n=4, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	91.7	16.7	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Social Functioning: C36D1 (n=1, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	66.7	NA	Not reported	Not reported	Standard deviation was not estimable since only one participant was evaluable.
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Social Functioning: C37D1 (n=1, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	66.7	NA	Not reported	Not reported	Standard deviation was not estimable since only one participant was evaluable.
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Fatigue: Baseline (n=165, 163)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	38.3	24.4	Not reported	Not reported	Not reported
Chemotherapy	36.1	25.3	Not reported	Not reported	Not reported

Fatigue: C2D1 (n=155, 133)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	31.4	23.4	Not reported	Not reported	Not reported
Chemotherapy	39.5	24.8	Not reported	Not reported	Not reported

Fatigue: C3D1 (n=154, 106)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	30.8	24.1	Not reported	Not reported	Not reported
Chemotherapy	39.4	24.5	Not reported	Not reported	Not reported

Fatigue: C4D1 (n=135, 91)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	27.1	22.3	Not reported	Not reported	Not reported
Chemotherapy	34.1	22.1	Not reported	Not reported	Not reported

Fatigue: C5D1 (n=123, 74)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	24.7	19.8	Not reported	Not reported	Not reported
Chemotherapy	31.5	25.2	Not reported	Not reported	Not reported

Fatigue: C6D1 (n=120, 70)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	24.6	19.3	Not reported	Not reported	Not reported
Chemotherapy	31.0	22.8	Not reported	Not reported	Not reported

Fatigue: C7D1 (n=115, 52)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	23.9	19.8	Not reported	Not reported	Not reported
Chemotherapy	27.6	23.1	Not reported	Not reported	Not reported

Fatigue: C8D1 (n=111, 43)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	23.2	18.9	Not reported	Not reported	Not reported
Chemotherapy	26.6	23.6	Not reported	Not reported	Not reported

Fatigue: C9D1 (n=101, 37)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	22.9	21.7	Not reported	Not reported	Not reported
Chemotherapy	28.5	26.6	Not reported	Not reported	Not reported

Fatigue: C10D1 (n=94, 33)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	21.4	20.0	Not reported	Not reported	Not reported
Chemotherapy	28.6	27.9	Not reported	Not reported	Not reported

Fatigue: C11D1 (n=84, 25)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	22.1	19.6	Not reported	Not reported	Not reported
Chemotherapy	22.2	22.9	Not reported	Not reported	Not reported

Fatigue: C12D1 (n=76, 23)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	21.9	22.9	Not reported	Not reported	Not reported
Chemotherapy	26.1	24.1	Not reported	Not reported	Not reported

Fatigue: C13D1 (n=74, 21)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	23.3	21.3	Not reported	Not reported	Not reported
Chemotherapy	27.5	25.2	Not reported	Not reported	Not reported

Fatigue: C14D1 (n=66, 19)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	21.7	21.7	Not reported	Not reported	Not reported
Chemotherapy	28.1	26.8	Not reported	Not reported	Not reported

Fatigue: C15D1 (n=62, 16)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	20.8	22.5	Not reported	Not reported	Not reported
Chemotherapy	24.3	24.8	Not reported	Not reported	Not reported

Fatigue: C16D1 (n=53, 12)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	22.2	18.0	Not reported	Not reported	Not reported
Chemotherapy	24.1	21.6	Not reported	Not reported	Not reported

Fatigue: C17D1 (n=47, 11)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	23.4	20.0	Not reported	Not reported	Not reported
Chemotherapy	23.2	23.0	Not reported	Not reported	Not reported

Fatigue: C18D1 (n=45, 11)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	21.5	18.3	Not reported	Not reported	Not reported
Chemotherapy	27.3	22.4	Not reported	Not reported	Not reported

Fatigue: C19D1 (n=40, 9)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	20.8	18.7	Not reported	Not reported	Not reported
Chemotherapy	24.7	20.6	Not reported	Not reported	Not reported

Fatigue: C20D1 (n=35, 8)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	24.4	19.2	Not reported	Not reported	Not reported
Chemotherapy	27.8	26.6	Not reported	Not reported	Not reported

Fatigue: C21D1 (n=30, 8)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	23.9	17.8	Not reported	Not reported	Not reported
Chemotherapy	25.7	27.7	Not reported	Not reported	Not reported

Fatigue: C22D1 (n=24, 7)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	23.6	16.2	Not reported	Not reported	Not reported
Chemotherapy	27.0	23.9	Not reported	Not reported	Not reported

Fatigue: C23D1 (n=23, 4)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	25.1	19.3	Not reported	Not reported	Not reported
Chemotherapy	47.2	14.0	Not reported	Not reported	Not reported

Fatigue: C24D1 (n=20, 3)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	24.4	18.9	Not reported	Not reported	Not reported
Chemotherapy	40.7	23.1	Not reported	Not reported	Not reported

Fatigue: C25D1 (n=18, 3)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	24.7	16.0	Not reported	Not reported	Not reported
Chemotherapy	44.4	19.2	Not reported	Not reported	Not reported

Fatigue: C26D1 (n=14, 3)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	30.2	25.6	Not reported	Not reported	Not reported
Chemotherapy	44.4	19.2	Not reported	Not reported	Not reported

Fatigue: C27D1 (n=14, 2)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	35.7	25.1	Not reported	Not reported	Not reported
Chemotherapy	55.6	15.7	Not reported	Not reported	Not reported

Fatigue: C28D1 (n=11, 2)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	28.3	22.4	Not reported	Not reported	Not reported
Chemotherapy	38.9	7.9	Not reported	Not reported	Not reported

Fatigue: C29D1 (n=8, 2)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	30.6	22.8	Not reported	Not reported	Not reported
Chemotherapy	50.0	23.6	Not reported	Not reported	Not reported

Fatigue: C30D1 (n=8, 1)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	26.4	24.4	Not reported	Not reported	Not reported
Chemotherapy	55.6	NA	Not reported	Not reported	Standard deviation was not estimable since only one participant was evaluable.

Fatigue: C31D1 (n=7, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	28.6	16.8	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Fatigue: C32D1 (n=6, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	25.9	5.7	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Standard deviation was not estimable since only one participant was evaluable.

Fatigue: C33D1 (n=6, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	18.5	11.5	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Fatigue: C34D1 (n=5, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	15.6	16.9	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Fatigue: C35D1 (n=4, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	27.8	14.3	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Fatigue: C36D1 (n=1, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	33.3	NA	Not reported	Not reported	Standard deviation was not estimable since only one participant was evaluable.
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Fatigue: C37D1 (n=1, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	11.1	NA	Not reported	Not reported	Standard deviation was not estimable since only one participant was evaluable.
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Nausea and Vomiting: Baseline (n=165, 163)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	8.4	14.4	Not reported	Not reported	Not reported
Chemotherapy	11.7	18.0	Not reported	Not reported	Not reported

Nausea and Vomiting: C2D1 (n=155, 133)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	15.2	20.9	Not reported	Not reported	Not reported
Chemotherapy	12.7	19.0	Not reported	Not reported	Not reported

Nausea and Vomiting: C3D1 (n=154, 106)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	13.9	21.2	Not reported	Not reported	Not reported
Chemotherapy	9.9	16.6	Not reported	Not reported	Not reported

Nausea and Vomiting: C4D1 (n=135, 91)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	9.9	18.1	Not reported	Not reported	Not reported
Chemotherapy	8.1	14.1	Not reported	Not reported	Not reported

Nausea and Vomiting: C5D1 (n=123, 74)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	9.2	14.7	Not reported	Not reported	Not reported
Chemotherapy	9.0	16.8	Not reported	Not reported	Not reported

Nausea and Vomiting: C6D1 (n=120, 70)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	10.1	15.2	Not reported	Not reported	Not reported
Chemotherapy	6.9	13.2	Not reported	Not reported	Not reported

Nausea and Vomiting: C7D1 (n=115, 52)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	7.1	11.9	Not reported	Not reported	Not reported
Chemotherapy	7.7	11.7	Not reported	Not reported	Not reported

Nausea and Vomiting: C8D1 (n=111, 43)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	8.8	13.7	Not reported	Not reported	Not reported
Chemotherapy	8.9	14.7	Not reported	Not reported	Not reported

Nausea and Vomiting: C9D1 (n=101, 37)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	6.9	13.0	Not reported	Not reported	Not reported
Chemotherapy	9.5	19.9	Not reported	Not reported	Not reported

Nausea and Vomiting: C10D1 (n=94, 33)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	8.5	14.6	Not reported	Not reported	Not reported
Chemotherapy	8.1	15.7	Not reported	Not reported	Not reported

Nausea and Vomiting: C11D1 (n=84, 25)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	8.3	12.8	Not reported	Not reported	Not reported
Chemotherapy	8.0	16.0	Not reported	Not reported	Not reported

Nausea and Vomiting: C12D1 (n=76, 23)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	6.4	12.8	Not reported	Not reported	Not reported
Chemotherapy	7.2	15.8	Not reported	Not reported	Not reported

Nausea and Vomiting: C13D1 (n=74, 21)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	8.6	14.1	Not reported	Not reported	Not reported
Chemotherapy	7.1	16.3	Not reported	Not reported	Not reported

Nausea and Vomiting: C14D1 (n=66, 19)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	5.8	13.9	Not reported	Not reported	Not reported
Chemotherapy	7.0	14.0	Not reported	Not reported	Not reported

Nausea and Vomiting: C15D1 (n=62, 16)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	5.9	11.3	Not reported	Not reported	Not reported
Chemotherapy	6.2	13.4	Not reported	Not reported	Not reported

Nausea and Vomiting: C16D1 (n=53, 12)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	5.3	9.7	Not reported	Not reported	Not reported
Chemotherapy	6.9	11.1	Not reported	Not reported	Not reported

Nausea and Vomiting: C17D1 (n=47, 11)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	7.8	12.5	Not reported	Not reported	Not reported
Chemotherapy	10.6	11.2	Not reported	Not reported	Not reported

Nausea and Vomiting: C18D1 (n=45, 11)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	7.0	13.5	Not reported	Not reported	Not reported
Chemotherapy	3.0	6.7	Not reported	Not reported	Not reported

Nausea and Vomiting: C19D1 (n=40, 9)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	8.8	14.6	Not reported	Not reported	Not reported
Chemotherapy	9.3	12.1	Not reported	Not reported	Not reported

Nausea and Vomiting: C20D1 (n=35, 8)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	7.4	13.5	Not reported	Not reported	Not reported
Chemotherapy	10.4	15.3	Not reported	Not reported	Not reported

Nausea and Vomiting: C21D1 (n=30, 8)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	7.8	12.9	Not reported	Not reported	Not reported
Chemotherapy	8.3	12.6	Not reported	Not reported	Not reported

Nausea and Vomiting: C22D1 (n=24, 7)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	2.8	6.3	Not reported	Not reported	Not reported
Chemotherapy	14.3	17.8	Not reported	Not reported	Not reported

Nausea and Vomiting: C23D1 (n=23, 4)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	5.4	10.5	Not reported	Not reported	Not reported
Chemotherapy	45.8	21.0	Not reported	Not reported	Not reported

Nausea and Vomiting: C24D1 (n=20, 3)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	7.5	14.8	Not reported	Not reported	Not reported
Chemotherapy	33.3	28.9	Not reported	Not reported	Not reported

Nausea and Vomiting: C25D1 (n=18, 3)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	3.7	9.1	Not reported	Not reported	Not reported
Chemotherapy	27.8	25.5	Not reported	Not reported	Not reported

Nausea and Vomiting: C26D1 (n=14, 3)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	10.7	27.4	Not reported	Not reported	Not reported
Chemotherapy	33.3	16.7	Not reported	Not reported	Not reported

Nausea and Vomiting: C27D1 (n=14, 2)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	11.9	27.3	Not reported	Not reported	Not reported
Chemotherapy	33.3	23.6	Not reported	Not reported	Not reported

Nausea and Vomiting: C28D1 (n=11, 2)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	3.0	6.7	Not reported	Not reported	Not reported
Chemotherapy	25.0	11.8	Not reported	Not reported	Not reported

Nausea and Vomiting: C29D1 (n=8, 2)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	10.4	15.3	Not reported	Not reported	Not reported
Chemotherapy	25.0	11.8	Not reported	Not reported	Not reported

Nausea and Vomiting: C30D1 (n=8, 1)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	6.3	12.4	Not reported	Not reported	Not reported
Chemotherapy	33.3	NA	Not reported	Not reported	Standard deviation was not estimable since only one participant was evaluable.

Nausea and Vomiting: C31D1 (n=7, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	14.3	17.8	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Nausea and Vomiting: C32D1 (n=6, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	11.1	17.2	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Nausea and Vomiting: C33D1 (n=6, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	11.1	17.2	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Nausea and Vomiting: C34D1 (n=5, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	13.3	18.3	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Nausea and Vomiting: C35D1 (n=4, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	12.5	16.0	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Nausea and Vomiting: C36D1 (n=1, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	0.0	NA	Not reported	Not reported	Standard deviation was not estimable since only one participant was evaluable.
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Nausea and Vomiting: C37D1 (n=1, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	0.0	NA	Not reported	Not reported	Standard deviation was not estimable since only one participant was evaluable.
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Pain: Baseline (n=165, 163)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	23.9	24.7	Not reported	Not reported	Not reported
Chemotherapy	28.0	27.3	Not reported	Not reported	Not reported

Pain: C2D1 (n=155, 133)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	13.9	19.8	Not reported	Not reported	Not reported
Chemotherapy	25.7	25.3	Not reported	Not reported	Not reported

Pain: C3D1 (n=154, 106)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	13.7	20.4	Not reported	Not reported	Not reported
Chemotherapy	23.3	26.6	Not reported	Not reported	Not reported

Pain: C4D1 (n=135, 91)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	13.0	19.5	Not reported	Not reported	Not reported
Chemotherapy	19.0	21.5	Not reported	Not reported	Not reported

Pain: C5D1 (n=123, 74)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	11.5	16.7	Not reported	Not reported	Not reported
Chemotherapy	20.5	23.0	Not reported	Not reported	Not reported

Pain: C6D1 (n=120, 70)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	10.6	15.0	Not reported	Not reported	Not reported
Chemotherapy	19.5	23.0	Not reported	Not reported	Not reported

Pain: C7D1 (n=115, 52)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	9.6	14.3	Not reported	Not reported	Not reported
Chemotherapy	21.5	24.3	Not reported	Not reported	Not reported

Pain: C8D1 (n=111, 43)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	11.3	18.0	Not reported	Not reported	Not reported
Chemotherapy	17.4	23.6	Not reported	Not reported	Not reported

Pain: C9D1 (n=101, 37)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	11.8	18.8	Not reported	Not reported	Not reported
Chemotherapy	23.0	27.6	Not reported	Not reported	Not reported

Pain: C10D1 (n=94, 33)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	8.7	14.0	Not reported	Not reported	Not reported
Chemotherapy	24.2	28.6	Not reported	Not reported	Not reported

Pain: C11D1 (n=84, 25)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	10.5	16.3	Not reported	Not reported	Not reported
Chemotherapy	22.0	27.9	Not reported	Not reported	Not reported

Pain: C12D1 (n=76, 23)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	8.6	14.3	Not reported	Not reported	Not reported
Chemotherapy	25.4	29.7	Not reported	Not reported	Not reported

Pain: C13D1 (n=74, 21)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	10.1	15.3	Not reported	Not reported	Not reported
Chemotherapy	27.8	30.4	Not reported	Not reported	Not reported

Pain: C14D1 (n=66, 19)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	8.1	12.8	Not reported	Not reported	Not reported
Chemotherapy	23.7	26.2	Not reported	Not reported	Not reported

Pain: C15D1 (n=62, 16)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	9.4	15.6	Not reported	Not reported	Not reported
Chemotherapy	22.9	25.7	Not reported	Not reported	Not reported

Pain: C16D1 (n=53, 12)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	9.4	14.4	Not reported	Not reported	Not reported
Chemotherapy	31.9	28.8	Not reported	Not reported	Not reported

Pain: C17D1 (n=47, 11)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	10.6	16.1	Not reported	Not reported	Not reported
Chemotherapy	24.2	27.2	Not reported	Not reported	Not reported

Pain: C18D1 (n=45, 11)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	11.1	18.1	Not reported	Not reported	Not reported
Chemotherapy	24.2	29.2	Not reported	Not reported	Not reported

Pain: C19D1 (n=40, 9)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	11.3	17.0	Not reported	Not reported	Not reported
Chemotherapy	24.1	20.6	Not reported	Not reported	Not reported

Pain: C20D1 (n=35, 8)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	11.9	18.8	Not reported	Not reported	Not reported
Chemotherapy	22.9	28.1	Not reported	Not reported	Not reported

Pain: C21D1 (n=30, 8)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	11.7	15.3	Not reported	Not reported	Not reported
Chemotherapy	29.2	30.5	Not reported	Not reported	Not reported

Pain: C22D1 (n=24, 7)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	6.9	12.9	Not reported	Not reported	Not reported
Chemotherapy	33.3	28.9	Not reported	Not reported	Not reported

Pain: C23D1 (n=23, 4)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	9.1	16.1	Not reported	Not reported	Not reported
Chemotherapy	33.3	36.0	Not reported	Not reported	Not reported

Pain: C24D1 (n=20, 3)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	4.2	11.9	Not reported	Not reported	Not reported
Chemotherapy	27.8	48.1	Not reported	Not reported	Not reported

Pain: C25D1 (n=18, 3)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	4.6	7.7	Not reported	Not reported	Not reported
Chemotherapy	38.9	41.9	Not reported	Not reported	Not reported

Pain: C26D1 (n=14, 3)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	17.9	27.3	Not reported	Not reported	Not reported
Chemotherapy	38.9	41.9	Not reported	Not reported	Not reported

Pain: C27D1 (n=14, 2)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	13.1	25.5	Not reported	Not reported	Not reported
Chemotherapy	58.3	35.4	Not reported	Not reported	Not reported

Pain: C28D1 (n=11, 2)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	4.5	7.8	Not reported	Not reported	Not reported
Chemotherapy	50.0	47.1	Not reported	Not reported	Not reported

Pain: C29D1 (n=8, 2)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	2.1	5.9	Not reported	Not reported	Not reported
Chemotherapy	41.7	35.4	Not reported	Not reported	Not reported

Pain: C30D1 (n=8, 1)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	4.2	7.7	Not reported	Not reported	Not reported
Chemotherapy	83.3	NA	Not reported	Not reported	Standard deviation was not estimable since only one participant was evaluable.

Pain: C31D1 (n=7, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	4.8	8.1	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Pain: C32D1 (n=6, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	5.6	8.6	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Pain: C33D1 (n=6, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	2.8	6.8	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Pain: C34D1 (n=5, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	3.3	7.5	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Pain: C35D1 (n=4, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	8.3	16.7	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Pain: C36D1 (n=1, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	0.0	NA	Not reported	Not reported	Standard deviation was not estimable since only one participant was evaluable.
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Pain: C37D1 (n=1, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	0.0	NA	Not reported	Not reported	Standard deviation was not estimable since only one participant was evaluable.
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Dyspnea: Baseline (n=165, 163)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	31.1	28.3	Not reported	Not reported	Not reported
Chemotherapy	32.5	28.2	Not reported	Not reported	Not reported

Dyspnea: C2D1 (n=155, 133)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	21.5	21.4	Not reported	Not reported	Not reported
Chemotherapy	33.6	27.7	Not reported	Not reported	Not reported

Dyspnea: C3D1 (n=154, 106)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	21.6	23.0	Not reported	Not reported	Not reported
Chemotherapy	33.3	28.4	Not reported	Not reported	Not reported

Dyspnea: C4D1 (n=135, 91)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	17.3	20.7	Not reported	Not reported	Not reported
Chemotherapy	29.3	26.2	Not reported	Not reported	Not reported

Dyspnea: C5D1 (n=123, 74)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	16.0	20.6	Not reported	Not reported	Not reported
Chemotherapy	29.3	24.0	Not reported	Not reported	Not reported

Dyspnea: C6D1 (n=120, 70)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	15.8	22.0	Not reported	Not reported	Not reported
Chemotherapy	26.2	24.7	Not reported	Not reported	Not reported

Dyspnea: C7D1 (n=115, 52)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	17.4	20.9	Not reported	Not reported	Not reported
Chemotherapy	28.2	22.3	Not reported	Not reported	Not reported

Dyspnea: C8D1 (n=111, 43)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	15.8	19.7	Not reported	Not reported	Not reported
Chemotherapy	22.5	28.8	Not reported	Not reported	Not reported

Dyspnea: C9D1 (n=101, 37)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	13.9	19.0	Not reported	Not reported	Not reported
Chemotherapy	23.4	24.7	Not reported	Not reported	Not reported

Dyspnea: C10D1 (n=94, 33)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	17.7	20.6	Not reported	Not reported	Not reported
Chemotherapy	24.2	22.5	Not reported	Not reported	Not reported

Dyspnea: C11D1 (n=84, 25)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	17.5	22.8	Not reported	Not reported	Not reported
Chemotherapy	25.3	22.1	Not reported	Not reported	Not reported

Dyspnea: C12D1 (n=76, 23)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	14.5	19.9	Not reported	Not reported	Not reported
Chemotherapy	30.4	28.3	Not reported	Not reported	Not reported

Dyspnea: C13D1 (n=74, 21)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	14.0	20.6	Not reported	Not reported	Not reported
Chemotherapy	23.8	23.9	Not reported	Not reported	Not reported

Dyspnea: C14D1 (n=66, 19)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	15.2	21.2	Not reported	Not reported	Not reported
Chemotherapy	29.8	24.6	Not reported	Not reported	Not reported

Dyspnea: C15D1 (n=62, 16)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	15.6	21.5	Not reported	Not reported	Not reported
Chemotherapy	20.8	20.6	Not reported	Not reported	Not reported

Dyspnea: C16D1 (n=53, 12)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	13.8	17.8	Not reported	Not reported	Not reported
Chemotherapy	19.4	22.3	Not reported	Not reported	Not reported

Dyspnea: C17D1 (n=46, 11)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	14.5	20.7	Not reported	Not reported	Not reported
Chemotherapy	24.2	21.6	Not reported	Not reported	Not reported

Dyspnea: C18D1 (n=45, 11)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	14.1	16.6	Not reported	Not reported	Not reported
Chemotherapy	24.2	26.2	Not reported	Not reported	Not reported

Dyspnea: C19D1 (n=40, 9)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	14.2	18.3	Not reported	Not reported	Not reported
Chemotherapy	25.9	22.2	Not reported	Not reported	Not reported

Dyspnea: C20D1 (n=35, 8)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	10.5	17.7	Not reported	Not reported	Not reported
Chemotherapy	33.3	25.2	Not reported	Not reported	Not reported

Dyspnea: C21D1 (n=30, 8)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	13.3	16.6	Not reported	Not reported	Not reported
Chemotherapy	33.3	17.8	Not reported	Not reported	Not reported

Dyspnea: C22D1 (n=24, 7)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	13.9	19.5	Not reported	Not reported	Not reported
Chemotherapy	28.6	23.0	Not reported	Not reported	Not reported

Dyspnea: C23D1 (n=23, 4)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	9.4	14.9	Not reported	Not reported	Not reported
Chemotherapy	41.7	16.7	Not reported	Not reported	Not reported

Dyspnea: C24D1 (n=20, 3)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	18.3	20.2	Not reported	Not reported	Not reported
Chemotherapy	44.4	19.2	Not reported	Not reported	Not reported

Dyspnea: C25D1 (n=18, 3)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	11.1	16.2	Not reported	Not reported	Not reported
Chemotherapy	33.3	33.3	Not reported	Not reported	Not reported

Dyspnea: C26D1 (n=14, 3)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	14.3	28.4	Not reported	Not reported	Not reported
Chemotherapy	33.3	33.3	Not reported	Not reported	Not reported

Dyspnea: C27D1 (n=14, 2)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	11.9	16.6	Not reported	Not reported	Not reported
Chemotherapy	50.0	23.6	Not reported	Not reported	Not reported

Dyspnea: C28D1 (n=11, 2)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	12.1	16.8	Not reported	Not reported	Not reported
Chemotherapy	50.0	23.6	Not reported	Not reported	Not reported

Dyspnea: C29D1 (n=8, 2)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	4.2	11.8	Not reported	Not reported	Not reported
Chemotherapy	50.0	23.6	Not reported	Not reported	Not reported

Dyspnea: C30D1 (n=8, 1)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	8.3	15.4	Not reported	Not reported	Not reported
Chemotherapy	66.7	NA	Not reported	Not reported	Standard deviation was not estimable since only one participant was evaluable.

Dyspnea: C31D1 (n=7, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	9.5	16.3	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Dyspnea: C32D1 (n=6, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	16.7	18.3	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Dyspnea: C33D1 (n=6, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	11.1	17.2	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Dyspnea: C34D1 (n=5, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	13.3	18.3	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Dyspnea: C35D1 (n=4, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	16.7	19.2	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Dyspnea: C36D1 (n=1, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	0.0	NA	Not reported	Not reported	Standard deviation was not estimable since only one participant was evaluable.
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Dyspnea: C37D1 (n=1, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	0.0	NA	Not reported	Not reported	Standard deviation was not estimable since only one participant was evaluable.
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Insomnia : Baseline (n=164, 163)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	22.6	26.4	Not reported	Not reported	Not reported
Chemotherapy	27.8	27.3	Not reported	Not reported	Not reported

Insomnia : C2D1 (n=155, 133)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	15.3	23.5	Not reported	Not reported	Not reported
Chemotherapy	27.1	25.3	Not reported	Not reported	Not reported

Insomnia : C3D1 (n=154, 106)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	16.2	26.2	Not reported	Not reported	Not reported
Chemotherapy	23.6	26.0	Not reported	Not reported	Not reported

Insomnia : C4D1 (n=135, 91)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	13.3	21.2	Not reported	Not reported	Not reported
Chemotherapy	23.8	26.9	Not reported	Not reported	Not reported

Insomnia : C5D1 (n=123, 74)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	13.6	21.3	Not reported	Not reported	Not reported
Chemotherapy	25.7	26.8	Not reported	Not reported	Not reported

Insomnia : C6D1 (n=120, 70)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	14.2	21.9	Not reported	Not reported	Not reported
Chemotherapy	23.3	25.0	Not reported	Not reported	Not reported

Insomnia : C7D1 (n=114, 52)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	9.4	17.5	Not reported	Not reported	Not reported
Chemotherapy	21.8	25.5	Not reported	Not reported	Not reported

Insomnia : C8D1 (n=111, 43)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	12.5	21.5	Not reported	Not reported	Not reported
Chemotherapy	21.7	22.9	Not reported	Not reported	Not reported

Insomnia : C9D1 (n=100, 37)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	12.3	21.5	Not reported	Not reported	Not reported
Chemotherapy	22.5	24.9	Not reported	Not reported	Not reported

Insomnia : C10D1 (n=94, 33)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	13.5	23.6	Not reported	Not reported	Not reported
Chemotherapy	24.2	25.4	Not reported	Not reported	Not reported

Insomnia : C11D1 (n=84, 25)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	13.9	22.1	Not reported	Not reported	Not reported
Chemotherapy	22.7	24.9	Not reported	Not reported	Not reported

Insomnia : C12D1 (n=76, 23)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	13.6	21.9	Not reported	Not reported	Not reported
Chemotherapy	23.2	25.5	Not reported	Not reported	Not reported

Insomnia : C13D1 (n=74, 21)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	10.8	19.2	Not reported	Not reported	Not reported
Chemotherapy	25.4	25.6	Not reported	Not reported	Not reported

Insomnia : C14D1 (n=66, 19)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	11.1	18.8	Not reported	Not reported	Not reported
Chemotherapy	24.6	29.1	Not reported	Not reported	Not reported

Insomnia : C15D1 (n=62, 16)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	11.3	20.0	Not reported	Not reported	Not reported
Chemotherapy	29.2	26.9	Not reported	Not reported	Not reported

Insomnia : C16D1 (n=53, 11)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	13.8	20.1	Not reported	Not reported	Not reported
Chemotherapy	21.2	22.5	Not reported	Not reported	Not reported

Insomnia : C17D1 (n=47, 11)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	13.5	21.6	Not reported	Not reported	Not reported
Chemotherapy	15.2	22.9	Not reported	Not reported	Not reported

Insomnia : C18D1 (n=45, 11)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	12.6	17.8	Not reported	Not reported	Not reported
Chemotherapy	21.2	27.0	Not reported	Not reported	Not reported

Insomnia : C19D1 (n=40, 9)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	13.3	19.7	Not reported	Not reported	Not reported
Chemotherapy	22.2	28.9	Not reported	Not reported	Not reported

Insomnia : C20D1 (n=35, 8)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	15.2	20.4	Not reported	Not reported	Not reported
Chemotherapy	20.8	24.8	Not reported	Not reported	Not reported

Insomnia : C21D1 (n=30, 8)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	12.2	18.5	Not reported	Not reported	Not reported
Chemotherapy	29.2	27.8	Not reported	Not reported	Not reported

Insomnia : C22D1 (n=24, 7)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	12.5	19.2	Not reported	Not reported	Not reported
Chemotherapy	31.0	24.4	Not reported	Not reported	Not reported

Insomnia : C23D1 (n=23, 4)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	17.4	26.3	Not reported	Not reported	Not reported
Chemotherapy	50.0	19.2	Not reported	Not reported	Not reported

Insomnia : C24D1 (n=20, 3)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	11.7	22.4	Not reported	Not reported	Not reported
Chemotherapy	22.2	38.5	Not reported	Not reported	Not reported

Insomnia : C25D1 (n=18, 3)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	20.4	30.5	Not reported	Not reported	Not reported
Chemotherapy	44.4	19.2	Not reported	Not reported	Not reported

Insomnia : C26D1 (n=14, 3)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	21.4	33.6	Not reported	Not reported	Not reported
Chemotherapy	22.2	38.5	Not reported	Not reported	Not reported

Insomnia : C27D1 (n=14, 2)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	16.7	21.7	Not reported	Not reported	Not reported
Chemotherapy	50.0	23.6	Not reported	Not reported	Not reported

Insomnia : C28D1 (n=11, 2)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	9.1	15.6	Not reported	Not reported	Not reported
Chemotherapy	50.0	23.6	Not reported	Not reported	Not reported

Insomnia : C29D1 (n=8, 2)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	8.3	15.4	Not reported	Not reported	Not reported
Chemotherapy	33.0	0.0	Not reported	Not reported	Not reported

Insomnia : C30D1 (n=8, 1)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	12.5	24.8	Not reported	Not reported	Not reported
Chemotherapy	33.3	NA	Not reported	Not reported	Standard deviation was not estimable since only one participant was evaluable.

Insomnia : C31D1 (n=7, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	0.0	0.0	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Insomnia : C32D1 (n=6, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	5.6	13.6	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Insomnia : C33D1 (n=6, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	5.6	13.6	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Insomnia : C34D1 (n=5, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	13.3	18.3	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Insomnia : C35D1 (n=4, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	16.7	19.2	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Insomnia : C36D1 (n=1, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	0.0	NA	Not reported	Not reported	Standard deviation was not estimable since only one participant was evaluable.
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Insomnia : C37D1 (n=1, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	0.0	NA	Not reported	Not reported	Standard deviation was not estimable since only one participant was evaluable.
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Appetite loss : Baseline(n=165, 163)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	24.4	28.8	Not reported	Not reported	Not reported
Chemotherapy	23.3	28.2	Not reported	Not reported	Not reported

Appetite loss : C2/D1(n=155, 133)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	21.1	30.2	Not reported	Not reported	Not reported
Chemotherapy	24.3	28.5	Not reported	Not reported	Not reported

Appetite loss : C3/D1(n=154, 106)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	18.4	29.0	Not reported	Not reported	Not reported
Chemotherapy	21.7	27.2	Not reported	Not reported	Not reported

Appetite loss : C4/D1(n=135, 91)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	14.6	24.3	Not reported	Not reported	Not reported
Chemotherapy	19.4	23.3	Not reported	Not reported	Not reported

Appetite loss : C5/D1(n=123, 74)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	12.7	22.4	Not reported	Not reported	Not reported
Chemotherapy	19.4	28.1	Not reported	Not reported	Not reported

Appetite loss : C6/D1(n=120, 70)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	13.6	21.8	Not reported	Not reported	Not reported
Chemotherapy	12.9	23.6	Not reported	Not reported	Not reported

Appetite loss : C7/D1(n=115, 52)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	10.4	19.4	Not reported	Not reported	Not reported
Chemotherapy	12.8	22.0	Not reported	Not reported	Not reported

Appetite loss : C8/D1(n=111, 43)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	12.8	20.8	Not reported	Not reported	Not reported
Chemotherapy	10.9	22.7	Not reported	Not reported	Not reported

Appetite loss : C9/D1(n=101, 37)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	12.2	239	Not reported	Not reported	Not reported
Chemotherapy	14.4	27.8	Not reported	Not reported	Not reported

Appetite loss : C10/D1(n=94, 33)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	12.4	22.9	Not reported	Not reported	Not reported
Chemotherapy	14.1	25.0	Not reported	Not reported	Not reported

Appetite loss : C11/D1(n=84, 25)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	13.5	19.4	Not reported	Not reported	Not reported
Chemotherapy	14.7	25.6	Not reported	Not reported	Not reported

Appetite loss : C12/D1(n=76, 23)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	11.0	21.4	Not reported	Not reported	Not reported
Chemotherapy	14.5	24.3	Not reported	Not reported	Not reported

Appetite loss : C13/D1(n=74, 21)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	9.5	20.3	Not reported	Not reported	Not reported
Chemotherapy	17.5	27.1	Not reported	Not reported	Not reported

Appetite loss : C15/D1(n=62, 16)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	8.6	20.9	Not reported	Not reported	Not reported
Chemotherapy	12.5	26.9	Not reported	Not reported	Not reported

Appetite loss : C16/D1(n=53, 12)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	8.8	18.7	Not reported	Not reported	Not reported
Chemotherapy	16.7	30.2	Not reported	Not reported	Not reported

Appetite loss : C17/D1(n=47, 11)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	8.5	16.3	Not reported	Not reported	Not reported
Chemotherapy	15.2	31.1	Not reported	Not reported	Not reported

Appetite loss : C18/D1(n=45, 11)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	11.1	17.4	Not reported	Not reported	Not reported
Chemotherapy	12.1	22.5	Not reported	Not reported	Not reported

Appetite loss : C19/D1(n=40, 9)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	8.3	16.5	Not reported	Not reported	Not reported
Chemotherapy	18.5	33.8	Not reported	Not reported	Not reported

Appetite loss : C20/D1(n=35, 8)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	7.6	16.3	Not reported	Not reported	Not reported
Chemotherapy	20.8	35.4	Not reported	Not reported	Not reported

Appetite loss : C21/D1(n=30, 8)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	11.1	16.0	Not reported	Not reported	Not reported
Chemotherapy	25.0	34.5	Not reported	Not reported	Not reported

Appetite loss : C22/D1(n=24, 7)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	6.9	13.8	Not reported	Not reported	Not reported
Chemotherapy	14.3	37.8	Not reported	Not reported	Not reported

Appetite loss : C23/D1(n=23, 4)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	9.4	14.9	Not reported	Not reported	Not reported
Chemotherapy	50.0	43.0	Not reported	Not reported	Not reported

Appetite loss : C24/D1(n=20, 3)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	5.0	12.2	Not reported	Not reported	Not reported
Chemotherapy	33.3	33.3	Not reported	Not reported	Not reported

Appetite loss : C25/D1(n=18, 3)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	1.9	7.9	Not reported	Not reported	Not reported
Chemotherapy	44.4	50.9	Not reported	Not reported	Not reported

Appetite loss : C26/D1(n=14, 3)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	11.9	21.1	Not reported	Not reported	Not reported
Chemotherapy	33.3	33.3	Not reported	Not reported	Not reported

Appetite loss : C27/D1(n=14, 2)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	7.1	19.3	Not reported	Not reported	Not reported
Chemotherapy	33.3	47.1	Not reported	Not reported	Not reported

Appetite loss : C28/D1(n=11, 2)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	15.2	17.4	Not reported	Not reported	Not reported
Chemotherapy	33.3	47.1	Not reported	Not reported	Not reported

Appetite loss : C29/D1(n=8, 2)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	12.5	17.3	Not reported	Not reported	Not reported
Chemotherapy	33.3	47.1	Not reported	Not reported	Not reported

Appetite loss : C30/D1(n=8, 1)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	8.3	15.4	Not reported	Not reported	Not reported
Chemotherapy	100.0	NA	Not reported	Not reported	Standard deviation was not estimable since only one participant was evaluable.

Appetite loss : C31/D1(n=7, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	14.3	17.8	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Constipation: Baseline (n=164, 162)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	14.8	25.1	Not reported	Not reported	Not reported
Chemotherapy	16.9	25.0	Not reported	Not reported	Not reported

Constipation: C2D1 (n=155, 133)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	28.6	30.5	Not reported	Not reported	Not reported
Chemotherapy	14.0	24.3	Not reported	Not reported	Not reported

Constipation: C3D1 (n=154, 106)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	27.1	30.0	Not reported	Not reported	Not reported
Chemotherapy	16.0	22.2	Not reported	Not reported	Not reported

Constipation: C4D1 (n=134, 90)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	22.9	26.6	Not reported	Not reported	Not reported
Chemotherapy	14.8	25.5	Not reported	Not reported	Not reported

Constipation: C5D1 (n=123, 74)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	21.4	25.7	Not reported	Not reported	Not reported
Chemotherapy	20.3	29.6	Not reported	Not reported	Not reported

Constipation: C6D1 (n=120, 70)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	21.7	23.9	Not reported	Not reported	Not reported
Chemotherapy	15.7	23.2	Not reported	Not reported	Not reported

Constipation: C7D1 (n=115, 52)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	21.7	26.1	Not reported	Not reported	Not reported
Chemotherapy	19.9	26.6	Not reported	Not reported	Not reported

Constipation: C8D1 (n=111, 43)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	18.6	24.1	Not reported	Not reported	Not reported
Chemotherapy	16.3	24.5	Not reported	Not reported	Not reported

Constipation: C9D1 (n=101, 37)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	18.8	22.3	Not reported	Not reported	Not reported
Chemotherapy	16.2	21.7	Not reported	Not reported	Not reported

Constipation: C10D1 (n=94, 33)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	16.0	22.8	Not reported	Not reported	Not reported
Chemotherapy	19.2	25.0	Not reported	Not reported	Not reported

Constipation: C11D1 (n=84, 25)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	21.0	25.8	Not reported	Not reported	Not reported
Chemotherapy	21.3	19.0	Not reported	Not reported	Not reported

Constipation: C12D1 (n=76, 23)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	19.7	24.5	Not reported	Not reported	Not reported
Chemotherapy	21.7	23.8	Not reported	Not reported	Not reported

Constipation: C13D1 (n=74, 21)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	21.2	26.2	Not reported	Not reported	Not reported
Chemotherapy	22.2	26.5	Not reported	Not reported	Not reported

Constipation: C14D1 (n=66, 19)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	21.7	27.1	Not reported	Not reported	Not reported
Chemotherapy	24.6	31.1	Not reported	Not reported	Not reported

Constipation: C15D1 (n=62, 16)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	22.6	27.5	Not reported	Not reported	Not reported
Chemotherapy	18.7	21.0	Not reported	Not reported	Not reported

Constipation: C16D1 (n=53, 12)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	19.5	26.5	Not reported	Not reported	Not reported
Chemotherapy	22.2	25.9	Not reported	Not reported	Not reported

Constipation: C17D1 (n=47, 11)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	22.0	27.2	Not reported	Not reported	Not reported
Chemotherapy	24.2	30.2	Not reported	Not reported	Not reported

Constipation: C18D1 (n=44, 11)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	22.7	25.7	Not reported	Not reported	Not reported
Chemotherapy	15.2	22.9	Not reported	Not reported	Not reported

Constipation: C19D1 (n=40, 9)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	25.0	25.9	Not reported	Not reported	Not reported
Chemotherapy	22.2	23.6	Not reported	Not reported	Not reported

Constipation: C20D1 (n=35, 8)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	22.9	26.5	Not reported	Not reported	Not reported
Chemotherapy	20.8	24.8	Not reported	Not reported	Not reported

Constipation: C21D1 (n=30, 8)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	24.4	28.9	Not reported	Not reported	Not reported
Chemotherapy	16.7	25.2	Not reported	Not reported	Not reported

Constipation: C22D1 (n=24, 7)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	18.1	24.0	Not reported	Not reported	Not reported
Chemotherapy	19.0	26.2	Not reported	Not reported	Not reported

Constipation: C23D1 (n=23, 4)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	11.6	19.1	Not reported	Not reported	Not reported
Chemotherapy	25.0	31.9	Not reported	Not reported	Not reported

Constipation: C24D1 (n=20, 3)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	21.7	24.8	Not reported	Not reported	Not reported
Chemotherapy	22.2	19.2	Not reported	Not reported	Not reported

Constipation: C25D1 (n=18, 3)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	22.2	32.3	Not reported	Not reported	Not reported
Chemotherapy	33.3	33.3	Not reported	Not reported	Not reported

Constipation: C26D1 (n=14, 3)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	26.2	32.5	Not reported	Not reported	Not reported
Chemotherapy	44.4	50.9	Not reported	Not reported	Not reported

Constipation: C27D1 (n=14, 2)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	35.7	40.2	Not reported	Not reported	Not reported
Chemotherapy	50.0	23.6	Not reported	Not reported	Not reported

Constipation: C28D1 (n=11, 2)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	21.2	16.8	Not reported	Not reported	Not reported
Chemotherapy	50.0	23.6	Not reported	Not reported	Not reported

Constipation: C29D1 (n=8, 2)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	29.2	21.4	Not reported	Not reported	Not reported
Chemotherapy	50.0	23.6	Not reported	Not reported	Not reported

Constipation: C30D1 (n=8, 1)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	29.2	27.8	Not reported	Not reported	Not reported
Chemotherapy	33.3	NA	Not reported	Not reported	Standard deviation was not estimable since only one participant was evaluable.

Constipation: C31D1 (n=7, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	33.3	27.2	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Constipation: C32D1 (n=6, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	33.3	42.2	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Constipation: C33D1 (n=6, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	38.9	25.1	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Constipation: C34D1 (n=5, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	40.0	43.5	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Constipation: C35D1 (n=4, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	33.3	27.2	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Constipation: C36D1 (n=1, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	0.0	NA	Not reported	Not reported	Standard deviation was not estimable since only one participant was evaluable.
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Constipation: C37D1 (n=1, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	0.0	NA	Not reported	Not reported	Standard deviation was not estimable since only one participant was evaluable.
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Constipation: EOT (n=49, 90)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	28.6	27.2	Not reported	Not reported	Not reported
Chemotherapy	18.1	25.6	Not reported	Not reported	Not reported

Diarrhea: Baseline (n=165, 162)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	9.7	19.1	Not reported	Not reported	Not reported
Chemotherapy	7.8	16.0	Not reported	Not reported	Not reported

Diarrhea: C2D1 (n=155, 132)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	18.1	26.7	Not reported	Not reported	Not reported
Chemotherapy	11.1	20.5	Not reported	Not reported	Not reported

Diarrhea: C3D1 (n=153, 106)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	21.6	28.7	Not reported	Not reported	Not reported
Chemotherapy	7.9	18.1	Not reported	Not reported	Not reported

Diarrhea: C4D1 (n=134, 90)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	23.1	26.9	Not reported	Not reported	Not reported
Chemotherapy	8.5	18.4	Not reported	Not reported	Not reported

Diarrhea: C5D1 (n=123, 74)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	24.4	25.6	Not reported	Not reported	Not reported
Chemotherapy	5.9	15.0	Not reported	Not reported	Not reported

Diarrhea: C6D1 (n=120, 70)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	22.2	26.4	Not reported	Not reported	Not reported
Chemotherapy	7.1	16.9	Not reported	Not reported	Not reported

Diarrhea: C7D1 (n=115, 52)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	20.6	24.8	Not reported	Not reported	Not reported
Chemotherapy	9.6	16.6	Not reported	Not reported	Not reported

Diarrhea: C8D1 (n=111, 43)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	18.6	24.1	Not reported	Not reported	Not reported
Chemotherapy	9.3	19.7	Not reported	Not reported	Not reported

Diarrhea: C9D1 (n=101, 37)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	17.3	22.8	Not reported	Not reported	Not reported
Chemotherapy	7.2	16.0	Not reported	Not reported	Not reported

Diarrhea: C10D1 (n=94, 33)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	17.7	22.3	Not reported	Not reported	Not reported
Chemotherapy	7.1	16.2	Not reported	Not reported	Not reported

Diarrhea: C11D1 (n=84, 25)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	21.0	22.4	Not reported	Not reported	Not reported
Chemotherapy	8.0	17.4	Not reported	Not reported	Not reported

Diarrhea: C12D1 (n=76, 23)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	17.5	25.2	Not reported	Not reported	Not reported
Chemotherapy	8.7	15.0	Not reported	Not reported	Not reported

Diarrhea: C13D1 (n=74, 21)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	17.6	23.6	Not reported	Not reported	Not reported
Chemotherapy	12.7	19.7	Not reported	Not reported	Not reported

Diarrhea: C14D1 (n=66, 19)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	17.7	22.8	Not reported	Not reported	Not reported
Chemotherapy	8.8	18.7	Not reported	Not reported	Not reported

Diarrhea: C15D1 (n=62, 16)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	16.1	21.5	Not reported	Not reported	Not reported
Chemotherapy	4.2	11.4	Not reported	Not reported	Not reported

Diarrhea: C16D1 (n=52, 12)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	16.0	20.3	Not reported	Not reported	Not reported
Chemotherapy	5.6	13.0	Not reported	Not reported	Not reported

Diarrhea: C17D1 (n=47, 11)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	19.9	22.7	Not reported	Not reported	Not reported
Chemotherapy	12.1	22.5	Not reported	Not reported	Not reported

Diarrhea: C18D1 (n=44, 11)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	22.7	25.7	Not reported	Not reported	Not reported
Chemotherapy	12.1	22.5	Not reported	Not reported	Not reported

Diarrhea: C19D1 (n=40, 9)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	21.7	25.7	Not reported	Not reported	Not reported
Chemotherapy	7.4	14.7	Not reported	Not reported	Not reported

Diarrhea: C20D1 (n=35, 8)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	21.0	24.4	Not reported	Not reported	Not reported
Chemotherapy	4.2	11.8	Not reported	Not reported	Not reported

Diarrhea: C21D1 (n=30, 8)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	22.2	22.0	Not reported	Not reported	Not reported
Chemotherapy	8.3	15.4	Not reported	Not reported	Not reported

Diarrhea: C22D1 (n=24, 7)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	23.6	25.0	Not reported	Not reported	Not reported
Chemotherapy	11.9	15.9	Not reported	Not reported	Not reported

Diarrhea: C23D1 (n=23, 4)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	15.9	19.8	Not reported	Not reported	Not reported
Chemotherapy	25.0	16.7	Not reported	Not reported	Not reported

Diarrhea: C24D1 (n=20, 3)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	21.7	22.4	Not reported	Not reported	Not reported
Chemotherapy	11.1	19.2	Not reported	Not reported	Not reported

Diarrhea: C25D1 (n=18, 3)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	20.4	25.9	Not reported	Not reported	Not reported
Chemotherapy	22.2	19.2	Not reported	Not reported	Not reported

Diarrhea: C26D1 (n=14, 3)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	19.0	25.2	Not reported	Not reported	Not reported
Chemotherapy	11.1	19.2	Not reported	Not reported	Not reported

Diarrhea: C27D1 (n=14, 2)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	23.8	30.5	Not reported	Not reported	Not reported
Chemotherapy	16.7	23.6	Not reported	Not reported	Not reported

Diarrhea: C28D1 (n=11, 2)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	15.2	17.4	Not reported	Not reported	Not reported
Chemotherapy	16.7	23.6	Not reported	Not reported	Not reported

Diarrhea: C29D1 (n=8, 2)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	20.8	24.8	Not reported	Not reported	Not reported
Chemotherapy	16.7	23.6	Not reported	Not reported	Not reported

Diarrhea: C30D1 (n=8, 1)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	12.5	17.3	Not reported	Not reported	Not reported
Chemotherapy	0.0	NA	Not reported	Not reported	Standard deviation was not estimable since only one participant was evaluable.

Diarrhea: C31D1 (n=7, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	14.3	17.8	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Diarrhea: C32D1 (n=6, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	11.1	17.2	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Diarrhea: C33D1 (n=6, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	11.1	17.2	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Diarrhea: C34D1 (n=5, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	6.7	14.9	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Diarrhea: C35D1 (n=4, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	16.7	19.2	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Diarrhea: C36D1 (n=1, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	33.3	NA	Not reported	Not reported	Standard deviation was not estimable since only one participant was evaluable.
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Diarrhea: C37D1 (n=1, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	33.3	NA	Not reported	Not reported	Standard deviation was not estimable since only one participant was evaluable.
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Diarrhea: EOT (n=49, 90)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	18.4	23.6	Not reported	Not reported	Not reported
Chemotherapy	10.0	21.5	Not reported	Not reported	Not reported

Financial Difficulties: Baseline (n=165, 161)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	28.5	33.0	Not reported	Not reported	Not reported
Chemotherapy	27.3	30.7	Not reported	Not reported	Not reported

Financial Difficulties: C2D1 (n=155, 133)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	21.9	27.2	Not reported	Not reported	Not reported
Chemotherapy	22.3	28.9	Not reported	Not reported	Not reported

Financial Difficulties: C3D1 (n=154, 105)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	19.0	26.6	Not reported	Not reported	Not reported
Chemotherapy	20.3	27.9	Not reported	Not reported	Not reported

Financial Difficulties: C4D1 (n=135, 90)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	17.5	26.0	Not reported	Not reported	Not reported
Chemotherapy	21.9	26.0	Not reported	Not reported	Not reported

Financial Difficulties: C5D1 (n=123, 74)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	16.8	25.0	Not reported	Not reported	Not reported
Chemotherapy	19.4	23.4	Not reported	Not reported	Not reported

Financial Difficulties: C6D1 (n=120, 70)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	15.6	24.0	Not reported	Not reported	Not reported
Chemotherapy	18.6	25.1	Not reported	Not reported	Not reported

Financial Difficulties: C7D1 (n=115, 52)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	14.8	21.3	Not reported	Not reported	Not reported
Chemotherapy	18.6	25.9	Not reported	Not reported	Not reported

Financial Difficulties: C8D1 (n=111, 43)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	16.8	25.0	Not reported	Not reported	Not reported
Chemotherapy	15.5	23.4	Not reported	Not reported	Not reported

Financial Difficulties: C9D1 (n=101, 36)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	17.8	26.1	Not reported	Not reported	Not reported
Chemotherapy	16.7	23.2	Not reported	Not reported	Not reported

Financial Difficulties: C10D1 (n=94, 33)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	16.3	26.2	Not reported	Not reported	Not reported
Chemotherapy	15.2	23.7	Not reported	Not reported	Not reported

Financial Difficulties: C11D1 (n=84, 25)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	17.5	25.1	Not reported	Not reported	Not reported
Chemotherapy	17.3	21.8	Not reported	Not reported	Not reported

Financial Difficulties: C12D1 (n=76, 23)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	17.1	24.6	Not reported	Not reported	Not reported
Chemotherapy	18.8	28.1	Not reported	Not reported	Not reported

Financial Difficulties: C13D1 (n=74, 21)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	16.2	24.2	Not reported	Not reported	Not reported
Chemotherapy	17.5	27.1	Not reported	Not reported	Not reported

Financial Difficulties: C14D1 (n=66, 19)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	14.1	20.3	Not reported	Not reported	Not reported
Chemotherapy	17.5	32.1	Not reported	Not reported	Not reported

Financial Difficulties: C15D1 (n=62, 16)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	14.0	23.0	Not reported	Not reported	Not reported
Chemotherapy	16.7	27.2	Not reported	Not reported	Not reported

Financial Difficulties: C16D1 (n=53, 12)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	15.7	25.0	Not reported	Not reported	Not reported
Chemotherapy	30.6	36.1	Not reported	Not reported	Not reported

Financial Difficulties: C17D1 (n=47, 11)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	17.7	29.4	Not reported	Not reported	Not reported
Chemotherapy	33.3	36.5	Not reported	Not reported	Not reported

Financial Difficulties: C18D1 (n=44, 11)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	18.9	30.0	Not reported	Not reported	Not reported
Chemotherapy	15.2	31.1	Not reported	Not reported	Not reported

Financial Difficulties: C19D1 (n=40, 9)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	17.5	31.1	Not reported	Not reported	Not reported
Chemotherapy	25.9	32.4	Not reported	Not reported	Not reported

Financial Difficulties: C20D1 (n=35, 8)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	16.2	27.3	Not reported	Not reported	Not reported
Chemotherapy	25.0	34.5	Not reported	Not reported	Not reported

Financial Difficulties: C21D1 (n=30, 8)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	13.3	27.1	Not reported	Not reported	Not reported
Chemotherapy	29.2	33.0	Not reported	Not reported	Not reported

Financial Difficulties: C22D1 (n=24, 7)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	18.1	31.1	Not reported	Not reported	Not reported
Chemotherapy	28.6	35.6	Not reported	Not reported	Not reported

Financial Difficulties: C23D1 (n=23, 4)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	17.4	31.6	Not reported	Not reported	Not reported
Chemotherapy	33.3	47.1	Not reported	Not reported	Not reported

Financial Difficulties: C24D1 (n=20, 3)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	20.0	33.2	Not reported	Not reported	Not reported
Chemotherapy	33.3	57.7	Not reported	Not reported	Not reported

Financial Difficulties: C25D1 (n=18, 3)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	11.1	16.2	Not reported	Not reported	Not reported
Chemotherapy	44.4	50.9	Not reported	Not reported	Not reported

Financial Difficulties: C26D1 (n=14, 3)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	14.3	17.1	Not reported	Not reported	Not reported
Chemotherapy	44.4	50.9	Not reported	Not reported	Not reported

Financial Difficulties: C27D1 (n=14, 2)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	14.3	17.1	Not reported	Not reported	Not reported
Chemotherapy	66.7	47.1	Not reported	Not reported	Not reported

Financial Difficulties: C28D1 (n=11, 2)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	15.2	22.9	Not reported	Not reported	Not reported
Chemotherapy	66.7	47.1	Not reported	Not reported	Not reported

Financial Difficulties: C29D1 (n=8, 2)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	8.3	15.4	Not reported	Not reported	Not reported
Chemotherapy	66.7	47.1	Not reported	Not reported	Not reported

Financial Difficulties: C30D1 (n=8, 1)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	4.2	11.8	Not reported	Not reported	Not reported
Chemotherapy	100.0	NA	Not reported	Not reported	Standard deviation was not estimable since only one participant was evaluable.

Financial Difficulties: C31D1 (n=7, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	9.5	16.3	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Financial Difficulties: C32D1 (n=6, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	22.2	27.2	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Financial Difficulties: C33D1 (n=6, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	16.7	27.9	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Financial Difficulties: C34D1 (n=5, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	13.3	18.3	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Financial Difficulties: C35D1 (n=4, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	8.3	16.7	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Financial Difficulties: C36D1 (n=1, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	33.3	NA	Not reported	Not reported	Standard deviation was not estimable since only one participant was evaluable.
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Financial Difficulties: C37D1 (n=1, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	66.7	NA	Not reported	Not reported	Standard deviation was not estimable since only one participant was evaluable.
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Financial Difficulties: EOT (n=49, 90)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	17.0	27.3	Not reported	Not reported	Not reported
Chemotherapy	24.1	30.0	Not reported	Not reported	Not reported

Appetite loss: C32D1 (n=6, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	11.1	17.2	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Appetite loss: C33D1 (n=6, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	11.1	17.2	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Appetite loss: C34D1 (n=5, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	13.3	18.3	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Appetite loss: C35D1 (n=4, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	16.7	19.2	Not reported	Not reported	Not reported
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Appetite loss: C36D1 (n=1, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	0.0	NA	Not reported	Not reported	Standard deviation was not estimable since only one participant was evaluable.
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Appetite loss: C37D1 (n=1, 0)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	0.0	NA	Not reported	Not reported	Standard deviation was not estimable since only one participant was evaluable.
Chemotherapy	NA	NA	Not reported	Not reported	Data was not analyzed as no participants were evaluable.

Appetite loss: EOT (n=49, 90)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	21.8	26.0	Not reported	Not reported	Not reported
Chemotherapy	28.1	30.4	Not reported	Not reported	Not reported

Global Qol: EOT (n=49, 90)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	56.1	24.5	Not reported	Not reported	Not reported
Chemotherapy	46.4	25.4	Not reported	Not reported	Not reported

Physical Functioning: EOT (n=49, 90)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	80.7	23.0	Not reported	Not reported	Not reported
Chemotherapy	66.2	27.7	Not reported	Not reported	Not reported

Role Functioning: EOT (n=49, 90)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	71.8	27.7	Not reported	Not reported	Not reported
Chemotherapy	54.1	34.7	Not reported	Not reported	Not reported

Emotional Functioning: EOT (n=49, 90)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	75.2	25.1	Not reported	Not reported	Not reported
Chemotherapy	74.5	25.2	Not reported	Not reported	Not reported

Cognitive Functioning: EOT (n=49, 90)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	83.7	20.3	Not reported	Not reported	Not reported
Chemotherapy	80.0	24.0	Not reported	Not reported	Not reported

Social Function: EOT (n=49, 90)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	78.2	27.9	Not reported	Not reported	Not reported
Chemotherapy	59.4	33.5	Not reported	Not reported	Not reported

Fatigue: EOT (n=49, 90)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	32.0	28.2	Not reported	Not reported	Not reported
Chemotherapy	46.9	26.9	Not reported	Not reported	Not reported

Nausea and Vomiting: EOT (n=49, 90)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	16.3	22.9	Not reported	Not reported	Not reported
Chemotherapy	15.7	20.4	Not reported	Not reported	Not reported

Pain: EOT (n=49, 90)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	23.8	30.4	Not reported	Not reported	Not reported
Chemotherapy	33.7	31.3	Not reported	Not reported	Not reported

Dyspnea: EOT (n=49, 90)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	23.8	28.1	Not reported	Not reported	Not reported
Chemotherapy	40.0	30.1	Not reported	Not reported	Not reported

Insomnia: EOT (n=49, 90)

Values in units on a scale · Interval/dispersion: Standard Deviation
Group	Value	Spread	Lower	Upper	Comment
Crizotinib	18.4	24.6	Not reported	Not reported	Not reported
Chemotherapy	30.4	27.7	Not reported	Not reported	Not reported

Complete source fields

classes

categories
measurements
group Id
OG000
spread
21.5
value
57.2
group Id
OG001
spread
22.2
value
58.1
title
Global QoL: Baseline (n=165, 162)
categories
measurements
group Id
OG000
spread
21.8
value
64.5
group Id
OG001
spread
23.1
value
58.1
title
Global QoL: C2D1 (n=154, 133)
categories
measurements
group Id
OG000
spread
22.1
value
65.2
group Id
OG001
spread
23.1
value
59.4
title
Global QoL: C3D1 (n=154, 106)
categories
measurements
group Id
OG000
spread
19.6
value
68.4
group Id
OG001
spread
20.8
value
61.1
title
Global QoL: C4D1 (n=135, 90)
categories
measurements
group Id
OG000
spread
20.2
value
68.5
group Id
OG001
spread
22.7
value
64.1
title
Global QoL: C5D1 (n=123, 74)
categories
measurements
group Id
OG000
spread
19.8
value
68.3
group Id
OG001
spread
23.5
value
67.5
title
Global QoL: C6D1 (n=120, 70)
categories
measurements
group Id
OG000
spread
19.3
value
69.5
group Id
OG001
spread
23.1
value
66.5
title
Global QoL: C7D1 (n=114, 52)
categories
measurements
group Id
OG000
spread
20.1
value
68.7
group Id
OG001
spread
25.3
value
66.9
title
Global QoL: C8D1 (n=110, 43)
categories
measurements
group Id
OG000
spread
21.0
value
68.7
group Id
OG001
spread
27.8
value
66.4
title
Global QoL: C9D1 (n=101, 37)
categories
measurements
group Id
OG000
spread
21.6
value
67.0
group Id
OG001
spread
26.8
value
67.4
title
Global QoL: C10D1 (n=94, 33)
categories
measurements
group Id
OG000
spread
20.2
value
69.5
group Id
OG001
spread
21.8
value
71.0
title
Global QoL: C11D1 (n=83, 25)
categories
measurements
group Id
OG000
spread
22.0
value
67.9
group Id
OG001
spread
24.1
value
65.6
title
Global QoL: C12D1 (n=76, 23)

denoms

counts
group Id
OG000
value
165
group Id
OG001
value
163
units
Participants

description

dispersion Type

Standard Deviation

groups

description
Crizotinib (PF-02341066) 250 mg (administered as two 100-mg tablets and one 50-mg tablet) orally twice daily continuously in 21-day cycles. Treatment was continued until disease progression, unacceptable toxicity or withdrawal of consent occurred.
id
OG000
title
Crizotinib
description
Pemetrexed 500 mg/m\^2 intravenous infusion over 10 minutes or docetaxel 75 mg/m\^2 intravenous infusion over 1 hour on Day 1 of 21-day cycle, as per investigator discretion. Treatment was continued until disease progression, unacceptable toxicity or withdrawal of consent occurred.
id
OG001
title
Chemotherapy

param Type

MEAN

population Description

FAS included all participants who were randomized to study treatment. Here "N" (number of participants analyzed) signifies participants who were evaluable for this measure and "n" signifies participants who were evaluable for specified time points for each arm group, respectively.

reporting Status

POSTED

time Frame

Baseline, Day (D) 1 of each cycle (C) until disease progression, end of treatment (EOT, up to 112 weeks)

title

European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire-Core 30 (EORTC QLQ-C30)

type

SECONDARY

unit Of Measure

units on a scale

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Preserved source evidence · Not medical advice