TriangleNCT00721799 · OUTCOME
Efficacy of Percent Change in Mean FLT Uptake (SUVmean) Between Scan 1 & 2 in Predicting Progression Free Survival (PFS)
Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.
- Measure
- MEAN
- Unit
- percentage change in SUVmean
- Interval / dispersion
- Standard Deviation
- Time frame
- 36 months
What was measured
Prediction efficacy is estimated using a hazard ratio (HR) and C-statistic (C-stat). Progression free survival is defined as the span of time from day 1 of therapy to date of disease recurrence (measured in months). Results are pooled with subjects from a pilot RDRC study for a total of 25 subjects analyzed.
Analysis population: Participants who underwent both the pre-therapy and mid-therapy FLT PET scan
Groups in this outcome
FLT PET Scan
Subjects receive 2 18F-Fluorothymidine PET scans * Scan 1 at baseline (within 30 days prior to the start of chemotherapy and radiation therapy) * Scan 2 between fraction 5 and 6 of radiation therapy (after 10 Gray of radiation) F-18 Fluorothymidine dose = 0.04 to 0.08 mCi/kg (maximum of 5 mCi +/- 10%). Imaging technology: PET scan
| Group | Source count |
|---|---|
| FLT PET Scan | 25 |
Reported measurements
Source class 1
| Group | Value | Spread | Lower | Upper | Comment |
|---|---|---|---|---|---|
| FLT PET Scan | -0.39 | 0.18 | Not reported | Not reported | Not reported |
Source statistical analyses
- ci Num Sides
- TWO_SIDED
- group Ids
- OG000
- non Inferiority Type
- OTHER
- p Value
- 0.18
- param Type
- Hazard Ratio (HR)
- param Value
- 1.58
- statistical Method
- Regression, Cox
- ci Num Sides
- TWO_SIDED
- group Ids
- OG000
- non Inferiority Type
- OTHER
- p Value
- 0.25
- param Type
- C-statistic
- param Value
- 0.63
- statistical Method
- Regression, Cox
Complete source fields
- analyses
- ci Num Sides
- TWO_SIDED
- group Ids
- OG000
- non Inferiority Type
- OTHER
- p Value
- 0.18
- param Type
- Hazard Ratio (HR)
- param Value
- 1.58
- statistical Method
- Regression, Cox
- ci Num Sides
- TWO_SIDED
- group Ids
- OG000
- non Inferiority Type
- OTHER
- p Value
- 0.25
- param Type
- C-statistic
- param Value
- 0.63
- statistical Method
- Regression, Cox
- classes
- categories
- measurements
- group Id
- OG000
- spread
- 0.18
- value
- -0.39
- denoms
- counts
- group Id
- OG000
- value
- 25
- units
- Participants
- description
- Prediction efficacy is estimated using a hazard ratio (HR) and C-statistic (C-stat). Progression free survival is defined as the span of time from day 1 of therapy to date of disease recurrence (measured in months). Results are pooled with subjects from a pilot RDRC study for a total of 25 subjects analyzed.
- dispersion Type
- Standard Deviation
- groups
- description
- Subjects receive 2 18F-Fluorothymidine PET scans * Scan 1 at baseline (within 30 days prior to the start of chemotherapy and radiation therapy) * Scan 2 between fraction 5 and 6 of radiation therapy (after 10 Gray of radiation) F-18 Fluorothymidine dose = 0.04 to 0.08 mCi/kg (maximum of 5 mCi +/- 10%). Imaging technology: PET scan
- id
- OG000
- title
- FLT PET Scan
- param Type
- MEAN
- population Description
- Participants who underwent both the pre-therapy and mid-therapy FLT PET scan
- reporting Status
- POSTED
- time Frame
- 36 months
- title
- Efficacy of Percent Change in Mean FLT Uptake (SUVmean) Between Scan 1 & 2 in Predicting Progression Free Survival (PFS)
- type
- PRIMARY
- unit Of Measure
- percentage change in SUVmean
Download exact source JSON → · Snapshot ctgov-results-25a395029948b04d52b1253f
Preserved source evidence · Not medical advice