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NCT00667342 · OUTCOME

Histologic Response by Number of Participants

A Study of Bevacizumab in Combination With Chemotherapy for Treatment of Osteosarcoma · Source last updated 2023-08-07

Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.

Measure
COUNT_OF_PARTICIPANTS
Unit
Participants
Interval / dispersion
Not reported
Time frame
at week 10 after start of therapy

What was measured

The association of interested variables with response was checked with the Wilcoxon rank-sum test. The response is based on the Huvos grade of histologic response for DCE-MRI comparisons and is defined as good for ≥90% necrosis and poor for less than 90%.

Analysis population: Two Stratum A participants with no histologic response were excluded.

Groups in this outcome

All Participants

All 42 evaluable participants in this study had osteosarcoma. This analysis includes 29 Stratum A participants who had primary tumors potentially resectable by aggressive surgery, such as limb-salvage surgery or amputation, and no evidence of metastasis, and 11 Stratum C participants who had metastatic tumors.

Group identifiers and denominators belong to this outcome only. They may differ in another outcome or in safety reporting.

Analysis denominator · Participants

GroupSource count
All Participants40

Reported measurements

Source class 1

Poor Response

Values in Participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
All Participants22Not reportedNot reportedNot reportedNot reported

Good Response

Values in Participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
All Participants18Not reportedNot reportedNot reportedNot reported
Complete source fields
classes
  1. categories
    1. measurements
      1. group Id
        OG000
        value
        22
      title
      Poor Response
    2. measurements
      1. group Id
        OG000
        value
        18
      title
      Good Response
denoms
  1. counts
    1. group Id
      OG000
      value
      40
    units
    Participants
description
The association of interested variables with response was checked with the Wilcoxon rank-sum test. The response is based on the Huvos grade of histologic response for DCE-MRI comparisons and is defined as good for ≥90% necrosis and poor for less than 90%.
groups
  1. description
    All 42 evaluable participants in this study had osteosarcoma. This analysis includes 29 Stratum A participants who had primary tumors potentially resectable by aggressive surgery, such as limb-salvage surgery or amputation, and no evidence of metastasis, and 11 Stratum C participants who had metastatic tumors.
    id
    OG000
    title
    All Participants
param Type
COUNT_OF_PARTICIPANTS
population Description
Two Stratum A participants with no histologic response were excluded.
reporting Status
POSTED
time Frame
at week 10 after start of therapy
title
Histologic Response by Number of Participants
type
SECONDARY
unit Of Measure
Participants

Download exact source JSON → · Snapshot ctgov-results-25a395029948b04d52b1253f

Preserved source evidence · Not medical advice