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NCT00666978 · OUTCOME

Number of Participants for Each CYP2B6 Allele

Health Education Counseling With or Without Bupropion in Helping African Americans Stop Smoking · Source last updated 2017-11-13

Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.

Measure
COUNT_OF_PARTICIPANTS
Unit
Participants
Interval / dispersion
Not reported
Time frame
Week 3

What was measured

We genotyped CYP2B6 in 268 from the Bupropion arm as this polymorphism is related to bupropion metabolism.

Groups in this outcome

Bupropion Arm

270 African American adults received bupropion (150mg bid)for 7 weeks in addition to health education counseling.

Group identifiers and denominators belong to this outcome only. They may differ in another outcome or in safety reporting.

Analysis denominator · Participants

GroupSource count
Bupropion Arm268

Reported measurements

CYP2B6*4 Allele Frequency
Values in Participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
Bupropion Arm2Not reportedNot reportedNot reportedNot reported
CYP2B6*5 Allele Frequency
Values in Participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
Bupropion Arm6Not reportedNot reportedNot reportedNot reported
CYP2B6*6 Allele Frequency
Values in Participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
Bupropion Arm95Not reportedNot reportedNot reportedNot reported
CYP2B6*9 Allele Frequency
Values in Participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
Bupropion Arm0Not reportedNot reportedNot reportedNot reported
CYP2B6*16 Allele Frequency
Values in Participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
Bupropion Arm0Not reportedNot reportedNot reportedNot reported
CYP2B6*18 Allele Frequency
Values in Participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
Bupropion Arm17Not reportedNot reportedNot reportedNot reported
CYP2B6*22 Allele Frequency
Values in Participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
Bupropion Arm6Not reportedNot reportedNot reportedNot reported

Source statistical analyses

Group order, estimate direction, methods and comments are retained. No treatment ranking is inferred.

  1. ci Num Sides
    TWO_SIDED
    estimate Comment
    Bupropion adherent individuals with higher hydroxybupropion levels were more likely to be abstinent at Weeks 3, 7 and 26 compared to individuals with lower hydroxybupropion levels.
    group Ids
    1. OG000
    non Inferiority Type
    OTHER
    p Value
    <0.05
    p Value Comment
    Analysis relied on examining quit rates using linear regression, where the hydroxybupropion was a significant predictor of smoking cessation. CYP2B6 genotype was not a direct significant predictor of cessation in either the placebo or bupropion arm.
    param Type
    Odds Ratio (OR)
    param Value
    2.82
    statistical Method
    Regression, Linear
Complete source fields
analyses
  1. ci Num Sides
    TWO_SIDED
    estimate Comment
    Bupropion adherent individuals with higher hydroxybupropion levels were more likely to be abstinent at Weeks 3, 7 and 26 compared to individuals with lower hydroxybupropion levels.
    group Ids
    1. OG000
    non Inferiority Type
    OTHER
    p Value
    <0.05
    p Value Comment
    Analysis relied on examining quit rates using linear regression, where the hydroxybupropion was a significant predictor of smoking cessation. CYP2B6 genotype was not a direct significant predictor of cessation in either the placebo or bupropion arm.
    param Type
    Odds Ratio (OR)
    param Value
    2.82
    statistical Method
    Regression, Linear
classes
  1. categories
    1. measurements
      1. group Id
        OG000
        value
        2
    title
    CYP2B6*4 Allele Frequency
  2. categories
    1. measurements
      1. group Id
        OG000
        value
        6
    title
    CYP2B6*5 Allele Frequency
  3. categories
    1. measurements
      1. group Id
        OG000
        value
        95
    title
    CYP2B6*6 Allele Frequency
  4. categories
    1. measurements
      1. group Id
        OG000
        value
        0
    title
    CYP2B6*9 Allele Frequency
  5. categories
    1. measurements
      1. group Id
        OG000
        value
        0
    title
    CYP2B6*16 Allele Frequency
  6. categories
    1. measurements
      1. group Id
        OG000
        value
        17
    title
    CYP2B6*18 Allele Frequency
  7. categories
    1. measurements
      1. group Id
        OG000
        value
        6
    title
    CYP2B6*22 Allele Frequency
denoms
  1. counts
    1. group Id
      OG000
      value
      268
    units
    Participants
description
We genotyped CYP2B6 in 268 from the Bupropion arm as this polymorphism is related to bupropion metabolism.
groups
  1. description
    270 African American adults received bupropion (150mg bid)for 7 weeks in addition to health education counseling.
    id
    OG000
    title
    Bupropion Arm
param Type
COUNT_OF_PARTICIPANTS
reporting Status
POSTED
time Frame
Week 3
title
Number of Participants for Each CYP2B6 Allele
type
SECONDARY
unit Of Measure
Participants

Download exact source JSON → · Snapshot ctgov-results-25a395029948b04d52b1253f

Preserved source evidence · Not medical advice