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NCT00621244 · OUTCOME

Geometric Mean Ratio (GMR) Comparing Treatment Days in Arm 1

A Study of Oral LBH589 in Adult Patients With Advanced Hematological Malignancies · Source last updated 2021-01-05

Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.

Measure
GEOMETRIC_MEAN
Unit
Ratio
Interval / dispersion
90% Confidence Interval
Time frame
Day 15/day 1

What was measured

MWF Every week schedule n = number of subjects with non-missing values.

Analysis population: Pharmacokinetic set

Groups in this outcome

20 mg

Panobinostat was administered orally, once-a-day, on Monday-Wednesday-Friday (MWF)

30 mg

Panobinostat was administered orally, once-a-day, on Monday-Wednesday-Friday (MWF)

40 mg

Panobinostat was administered orally, once-a-day, on Monday-Wednesday-Friday (MWF)

60 mg

Panobinostat was administered orally, once-a-day, on Monday-Wednesday-Friday (MWF)

80 mg

Panobinostat was administered orally, once-a-day, on Monday-Wednesday-Friday (MWF)

Group identifiers and denominators belong to this outcome only. They may differ in another outcome or in safety reporting.

Analysis denominator · Participants

GroupSource count
20 mg8
30 mg12
40 mg18
60 mg17
80 mg4

Reported measurements

AUC
Values in Ratio · Interval/dispersion: 90% Confidence Interval
GroupValueSpreadLowerUpperComment
20 mg2.16Not reported1.682.77Not reported
30 mg1.07Not reported0.661.73Not reported
40 mg0.98Not reported0.781.22Not reported
60 mg1.17Not reported1.001.38Not reported
80 mg1.12Not reported0.582.15Not reported
C (max) N=8,12,18,17,4
Values in Ratio · Interval/dispersion: 90% Confidence Interval
GroupValueSpreadLowerUpperComment
20 mg1.86Not reported1.412.45Not reported
30 mg1.02Not reported0.711.46Not reported
40 mg0.63Not reported0.450.89Not reported
60 mg0.74Not reported0.550.99Not reported
80 mg1.41Not reported0.892.21Not reported
Complete source fields
classes
  1. categories
    1. measurements
      1. group Id
        OG000
        lower Limit
        1.68
        upper Limit
        2.77
        value
        2.16
      2. group Id
        OG001
        lower Limit
        0.66
        upper Limit
        1.73
        value
        1.07
      3. group Id
        OG002
        lower Limit
        0.78
        upper Limit
        1.22
        value
        0.98
      4. group Id
        OG003
        lower Limit
        1.00
        upper Limit
        1.38
        value
        1.17
      5. group Id
        OG004
        lower Limit
        0.58
        upper Limit
        2.15
        value
        1.12
    title
    AUC
  2. categories
    1. measurements
      1. group Id
        OG000
        lower Limit
        1.41
        upper Limit
        2.45
        value
        1.86
      2. group Id
        OG001
        lower Limit
        0.71
        upper Limit
        1.46
        value
        1.02
      3. group Id
        OG002
        lower Limit
        0.45
        upper Limit
        0.89
        value
        0.63
      4. group Id
        OG003
        lower Limit
        0.55
        upper Limit
        0.99
        value
        0.74
      5. group Id
        OG004
        lower Limit
        0.89
        upper Limit
        2.21
        value
        1.41
    title
    C (max) N=8,12,18,17,4
denoms
  1. counts
    1. group Id
      OG000
      value
      8
    2. group Id
      OG001
      value
      12
    3. group Id
      OG002
      value
      18
    4. group Id
      OG003
      value
      17
    5. group Id
      OG004
      value
      4
    units
    Participants
description
MWF Every week schedule n = number of subjects with non-missing values.
dispersion Type
90% Confidence Interval
groups
  1. description
    Panobinostat was administered orally, once-a-day, on Monday-Wednesday-Friday (MWF)
    id
    OG000
    title
    20 mg
  2. description
    Panobinostat was administered orally, once-a-day, on Monday-Wednesday-Friday (MWF)
    id
    OG001
    title
    30 mg
  3. description
    Panobinostat was administered orally, once-a-day, on Monday-Wednesday-Friday (MWF)
    id
    OG002
    title
    40 mg
  4. description
    Panobinostat was administered orally, once-a-day, on Monday-Wednesday-Friday (MWF)
    id
    OG003
    title
    60 mg
  5. description
    Panobinostat was administered orally, once-a-day, on Monday-Wednesday-Friday (MWF)
    id
    OG004
    title
    80 mg
param Type
GEOMETRIC_MEAN
population Description
Pharmacokinetic set
reporting Status
POSTED
time Frame
Day 15/day 1
title
Geometric Mean Ratio (GMR) Comparing Treatment Days in Arm 1
type
SECONDARY
unit Of Measure
Ratio

Download exact source JSON → · Snapshot ctgov-results-25a395029948b04d52b1253f

Preserved source evidence · Not medical advice