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NCT00602667 · OUTCOME

Number of Participants With Chromosomal Abnormalities

Risk-Adapted Therapy for Young Children With Embryonal Brain Tumors, Choroid Plexus Carcinoma, High Grade Glioma or Ependymoma · Source last updated 2026-05-19

Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.

Measure: COUNT_OF_PARTICIPANTS
Unit: Participants
Interval / dispersion: Not reported
Time frame: Based on samples obtained at the time of initial surgery or repeat surgery prior to treatment

What was measured

Amplifications and deletions (gains and losses) for chromosomes of interest are shown in the table of measured values.

Analysis population: Eligible medulloblastoma patients (n=81) were included in these analyses. 23 of 23 low risk patients had data available for this objective, as did 27/32 and 24/26 intermediate and high risk patients.

Groups in this outcome

Low-Risk Group

Medulloblastoma patients \<3 years of age; histological diagnosis of desmoplastic nodular (DN)/medulloblastoma with extensive nodularity (MBEN); no evidence of metastatic disease (M0); and a surgical gross total resection (GTR) or near total resection (NTR) defined as residual tumor or imaging abnormality (not definite for residual tumor) with a size of less than 1 cm\^2 on post-op computed tomography (CT) or magnetic resonance imaging (MRI) \[R0\])

Intermediate-Risk Group

Medulloblastoma patients \<3 years of age, M0, and either R0 resection with any other medullo histology other than DN/MBEN (i.e., classic or large cell anaplastic (LCA)), or with a subtotal resection (with a residual tumor or imaging abnormality with a size of \>1 cm\^2 on post-op imaging (R+), and DN/MBEN). Children 3-5 years of age were also included in this group High Risk

High-Risk Group

Medulloblastoma patients \<3 years of age with evidence of metastatic disease

Group identifiers and denominators belong to this outcome only. They may differ in another outcome or in safety reporting.

Analysis denominator · Participants

Group	Source count
Low-Risk Group	23
Intermediate-Risk Group	32
High-Risk Group	26

Reported measurements

chr2p gain/amplification

Analysis denominator · Participants

Group	Source count
Low-Risk Group	23
Intermediate-Risk Group	27
High-Risk Group	24

Values in Participants · Interval/dispersion: Not reported
Group	Value	Spread	Lower	Upper	Comment
Low-Risk Group	5	Not reported	Not reported	Not reported	Not reported
Intermediate-Risk Group	1	Not reported	Not reported	Not reported	Not reported
High-Risk Group	6	Not reported	Not reported	Not reported	Not reported

chr2p loss/deletion

Analysis denominator · Participants

Group	Source count
Low-Risk Group	23
Intermediate-Risk Group	27
High-Risk Group	24

Values in Participants · Interval/dispersion: Not reported
Group	Value	Spread	Lower	Upper	Comment
Low-Risk Group	0	Not reported	Not reported	Not reported	Not reported
Intermediate-Risk Group	2	Not reported	Not reported	Not reported	Not reported
High-Risk Group	0	Not reported	Not reported	Not reported	Not reported

chr2q gain/amplification

Analysis denominator · Participants

Group	Source count
Low-Risk Group	23
Intermediate-Risk Group	27
High-Risk Group	24

Values in Participants · Interval/dispersion: Not reported
Group	Value	Spread	Lower	Upper	Comment
Low-Risk Group	5	Not reported	Not reported	Not reported	Not reported
Intermediate-Risk Group	1	Not reported	Not reported	Not reported	Not reported
High-Risk Group	6	Not reported	Not reported	Not reported	Not reported

chr2q loss/deletion

Analysis denominator · Participants

Group	Source count
Low-Risk Group	23
Intermediate-Risk Group	27
High-Risk Group	24

Values in Participants · Interval/dispersion: Not reported
Group	Value	Spread	Lower	Upper	Comment
Low-Risk Group	0	Not reported	Not reported	Not reported	Not reported
Intermediate-Risk Group	2	Not reported	Not reported	Not reported	Not reported
High-Risk Group	0	Not reported	Not reported	Not reported	Not reported

chr6p gain/amplification

Analysis denominator · Participants

Group	Source count
Low-Risk Group	23
Intermediate-Risk Group	27
High-Risk Group	24

Values in Participants · Interval/dispersion: Not reported
Group	Value	Spread	Lower	Upper	Comment
Low-Risk Group	1	Not reported	Not reported	Not reported	Not reported
Intermediate-Risk Group	3	Not reported	Not reported	Not reported	Not reported
High-Risk Group	3	Not reported	Not reported	Not reported	Not reported

chr6p loss/deletion

Analysis denominator · Participants

Group	Source count
Low-Risk Group	23
Intermediate-Risk Group	27
High-Risk Group	24

Values in Participants · Interval/dispersion: Not reported
Group	Value	Spread	Lower	Upper	Comment
Low-Risk Group	0	Not reported	Not reported	Not reported	Not reported
Intermediate-Risk Group	0	Not reported	Not reported	Not reported	Not reported
High-Risk Group	2	Not reported	Not reported	Not reported	Not reported

chr6q gain/amplification

Analysis denominator · Participants

Group	Source count
Low-Risk Group	23
Intermediate-Risk Group	27
High-Risk Group	24

Values in Participants · Interval/dispersion: Not reported
Group	Value	Spread	Lower	Upper	Comment
Low-Risk Group	1	Not reported	Not reported	Not reported	Not reported
Intermediate-Risk Group	3	Not reported	Not reported	Not reported	Not reported
High-Risk Group	3	Not reported	Not reported	Not reported	Not reported

chr6q loss/deletion

Analysis denominator · Participants

Group	Source count
Low-Risk Group	23
Intermediate-Risk Group	27
High-Risk Group	24

Values in Participants · Interval/dispersion: Not reported
Group	Value	Spread	Lower	Upper	Comment
Low-Risk Group	0	Not reported	Not reported	Not reported	Not reported
Intermediate-Risk Group	0	Not reported	Not reported	Not reported	Not reported
High-Risk Group	2	Not reported	Not reported	Not reported	Not reported

chr8p gain/amplification

Analysis denominator · Participants

Group	Source count
Low-Risk Group	23
Intermediate-Risk Group	27
High-Risk Group	24

Values in Participants · Interval/dispersion: Not reported
Group	Value	Spread	Lower	Upper	Comment
Low-Risk Group	1	Not reported	Not reported	Not reported	Not reported
Intermediate-Risk Group	2	Not reported	Not reported	Not reported	Not reported
High-Risk Group	0	Not reported	Not reported	Not reported	Not reported

chr8p loss/deletion

Analysis denominator · Participants

Group	Source count
Low-Risk Group	23
Intermediate-Risk Group	27
High-Risk Group	24

Values in Participants · Interval/dispersion: Not reported
Group	Value	Spread	Lower	Upper	Comment
Low-Risk Group	0	Not reported	Not reported	Not reported	Not reported
Intermediate-Risk Group	6	Not reported	Not reported	Not reported	Not reported
High-Risk Group	8	Not reported	Not reported	Not reported	Not reported

chr8q gain/amplification

Analysis denominator · Participants

Group	Source count
Low-Risk Group	23
Intermediate-Risk Group	27
High-Risk Group	24

Values in Participants · Interval/dispersion: Not reported
Group	Value	Spread	Lower	Upper	Comment
Low-Risk Group	1	Not reported	Not reported	Not reported	Not reported
Intermediate-Risk Group	3	Not reported	Not reported	Not reported	Not reported
High-Risk Group	0	Not reported	Not reported	Not reported	Not reported

chr8q loss/deletion

Analysis denominator · Participants

Group	Source count
Low-Risk Group	23
Intermediate-Risk Group	27
High-Risk Group	24

Values in Participants · Interval/dispersion: Not reported
Group	Value	Spread	Lower	Upper	Comment
Low-Risk Group	0	Not reported	Not reported	Not reported	Not reported
Intermediate-Risk Group	5	Not reported	Not reported	Not reported	Not reported
High-Risk Group	7	Not reported	Not reported	Not reported	Not reported

chr9p gain/amplification

Analysis denominator · Participants

Group	Source count
Low-Risk Group	23
Intermediate-Risk Group	27
High-Risk Group	24

Values in Participants · Interval/dispersion: Not reported
Group	Value	Spread	Lower	Upper	Comment
Low-Risk Group	4	Not reported	Not reported	Not reported	Not reported
Intermediate-Risk Group	6	Not reported	Not reported	Not reported	Not reported
High-Risk Group	3	Not reported	Not reported	Not reported	Not reported

chr9p loss/deletion

Analysis denominator · Participants

Group	Source count
Low-Risk Group	23
Intermediate-Risk Group	27
High-Risk Group	24

Values in Participants · Interval/dispersion: Not reported
Group	Value	Spread	Lower	Upper	Comment
Low-Risk Group	4	Not reported	Not reported	Not reported	Not reported
Intermediate-Risk Group	0	Not reported	Not reported	Not reported	Not reported
High-Risk Group	3	Not reported	Not reported	Not reported	Not reported

chr9q gain/amplification

Analysis denominator · Participants

Group	Source count
Low-Risk Group	23
Intermediate-Risk Group	27
High-Risk Group	24

Values in Participants · Interval/dispersion: Not reported
Group	Value	Spread	Lower	Upper	Comment
Low-Risk Group	2	Not reported	Not reported	Not reported	Not reported
Intermediate-Risk Group	1	Not reported	Not reported	Not reported	Not reported
High-Risk Group	1	Not reported	Not reported	Not reported	Not reported

chr9q loss/deletion

Analysis denominator · Participants

Group	Source count
Low-Risk Group	23
Intermediate-Risk Group	27
High-Risk Group	24

Values in Participants · Interval/dispersion: Not reported
Group	Value	Spread	Lower	Upper	Comment
Low-Risk Group	6	Not reported	Not reported	Not reported	Not reported
Intermediate-Risk Group	5	Not reported	Not reported	Not reported	Not reported
High-Risk Group	5	Not reported	Not reported	Not reported	Not reported

chr10p gain/amplification

Analysis denominator · Participants

Group	Source count
Low-Risk Group	23
Intermediate-Risk Group	27
High-Risk Group	24

Values in Participants · Interval/dispersion: Not reported
Group	Value	Spread	Lower	Upper	Comment
Low-Risk Group	0	Not reported	Not reported	Not reported	Not reported
Intermediate-Risk Group	0	Not reported	Not reported	Not reported	Not reported
High-Risk Group	0	Not reported	Not reported	Not reported	Not reported

chr10p loss/deletion

Analysis denominator · Participants

Group	Source count
Low-Risk Group	23
Intermediate-Risk Group	27
High-Risk Group	24

Values in Participants · Interval/dispersion: Not reported
Group	Value	Spread	Lower	Upper	Comment
Low-Risk Group	0	Not reported	Not reported	Not reported	Not reported
Intermediate-Risk Group	5	Not reported	Not reported	Not reported	Not reported
High-Risk Group	7	Not reported	Not reported	Not reported	Not reported

chr10q gain/amplification

Analysis denominator · Participants

Group	Source count
Low-Risk Group	23
Intermediate-Risk Group	27
High-Risk Group	24

Values in Participants · Interval/dispersion: Not reported
Group	Value	Spread	Lower	Upper	Comment
Low-Risk Group	0	Not reported	Not reported	Not reported	Not reported
Intermediate-Risk Group	0	Not reported	Not reported	Not reported	Not reported
High-Risk Group	0	Not reported	Not reported	Not reported	Not reported

chr10q loss/deletion

Analysis denominator · Participants

Group	Source count
Low-Risk Group	23
Intermediate-Risk Group	27
High-Risk Group	24

Values in Participants · Interval/dispersion: Not reported
Group	Value	Spread	Lower	Upper	Comment
Low-Risk Group	3	Not reported	Not reported	Not reported	Not reported
Intermediate-Risk Group	7	Not reported	Not reported	Not reported	Not reported
High-Risk Group	9	Not reported	Not reported	Not reported	Not reported

chr20p gain/amplification

Analysis denominator · Participants

Group	Source count
Low-Risk Group	23
Intermediate-Risk Group	27
High-Risk Group	24

Values in Participants · Interval/dispersion: Not reported
Group	Value	Spread	Lower	Upper	Comment
Low-Risk Group	0	Not reported	Not reported	Not reported	Not reported
Intermediate-Risk Group	0	Not reported	Not reported	Not reported	Not reported
High-Risk Group	0	Not reported	Not reported	Not reported	Not reported

chr20p loss/deletion

Analysis denominator · Participants

Group	Source count
Low-Risk Group	23
Intermediate-Risk Group	27
High-Risk Group	24

Values in Participants · Interval/dispersion: Not reported
Group	Value	Spread	Lower	Upper	Comment
Low-Risk Group	2	Not reported	Not reported	Not reported	Not reported
Intermediate-Risk Group	4	Not reported	Not reported	Not reported	Not reported
High-Risk Group	5	Not reported	Not reported	Not reported	Not reported

chr20q gain/amplification

Analysis denominator · Participants

Group	Source count
Low-Risk Group	23
Intermediate-Risk Group	27
High-Risk Group	24

Values in Participants · Interval/dispersion: Not reported
Group	Value	Spread	Lower	Upper	Comment
Low-Risk Group	0	Not reported	Not reported	Not reported	Not reported
Intermediate-Risk Group	0	Not reported	Not reported	Not reported	Not reported
High-Risk Group	0	Not reported	Not reported	Not reported	Not reported

chr20q loss/deletion

Analysis denominator · Participants

Group	Source count
Low-Risk Group	23
Intermediate-Risk Group	27
High-Risk Group	24

Values in Participants · Interval/dispersion: Not reported
Group	Value	Spread	Lower	Upper	Comment
Low-Risk Group	1	Not reported	Not reported	Not reported	Not reported
Intermediate-Risk Group	3	Not reported	Not reported	Not reported	Not reported
High-Risk Group	5	Not reported	Not reported	Not reported	Not reported

Complete source fields

classes

categories
measurements
group Id
OG000
value
5
group Id
OG001
value
1
group Id
OG002
value
6
denoms
counts
group Id
OG000
value
23
group Id
OG001
value
27
group Id
OG002
value
24
units
Participants
title
chr2p gain/amplification
categories
measurements
group Id
OG000
value
0
group Id
OG001
value
2
group Id
OG002
value
0
denoms
counts
group Id
OG000
value
23
group Id
OG001
value
27
group Id
OG002
value
24
units
Participants
title
chr2p loss/deletion
categories
measurements
group Id
OG000
value
5
group Id
OG001
value
1
group Id
OG002
value
6
denoms
counts
group Id
OG000
value
23
group Id
OG001
value
27
group Id
OG002
value
24
units
Participants
title
chr2q gain/amplification
categories
measurements
group Id
OG000
value
0
group Id
OG001
value
2
group Id
OG002
value
0
denoms
counts
group Id
OG000
value
23
group Id
OG001
value
27
group Id
OG002
value
24
units
Participants
title
chr2q loss/deletion
categories
measurements
group Id
OG000
value
1
group Id
OG001
value
3
group Id
OG002
value
3
denoms
counts
group Id
OG000
value
23
group Id
OG001
value
27
group Id
OG002
value
24
units
Participants
title
chr6p gain/amplification
categories
measurements
group Id
OG000
value
0
group Id
OG001
value
0
group Id
OG002
value
2
denoms
counts
group Id
OG000
value
23
group Id
OG001
value
27
group Id
OG002
value
24
units
Participants
title
chr6p loss/deletion
categories
measurements
group Id
OG000
value
1
group Id
OG001
value
3
group Id
OG002
value
3
denoms
counts
group Id
OG000
value
23
group Id
OG001
value
27
group Id
OG002
value
24
units
Participants
title
chr6q gain/amplification
categories
measurements
group Id
OG000
value
0
group Id
OG001
value
0
group Id
OG002
value
2
denoms
counts
group Id
OG000
value
23
group Id
OG001
value
27
group Id
OG002
value
24
units
Participants
title
chr6q loss/deletion
categories
measurements
group Id
OG000
value
1
group Id
OG001
value
2
group Id
OG002
value
0
denoms
counts
group Id
OG000
value
23
group Id
OG001
value
27
group Id
OG002
value
24
units
Participants
title
chr8p gain/amplification
categories
measurements
group Id
OG000
value
0
group Id
OG001
value
6
group Id
OG002
value
8
denoms
counts
group Id
OG000
value
23
group Id
OG001
value
27
group Id
OG002
value
24
units
Participants
title
chr8p loss/deletion
categories
measurements
group Id
OG000
value
1
group Id
OG001
value
3
group Id
OG002
value
0
denoms
counts
group Id
OG000
value
23
group Id
OG001
value
27
group Id
OG002
value
24
units
Participants
title
chr8q gain/amplification
categories
measurements
group Id
OG000
value
0
group Id
OG001
value
5
group Id
OG002
value
7
denoms
counts
group Id
OG000
value
23
group Id
OG001
value
27
group Id
OG002
value
24
units
Participants
title
chr8q loss/deletion

denoms

counts
group Id
OG000
value
23
group Id
OG001
value
32
group Id
OG002
value
26
units
Participants

description

Amplifications and deletions (gains and losses) for chromosomes of interest are shown in the table of measured values.

groups

description
Medulloblastoma patients \<3 years of age; histological diagnosis of desmoplastic nodular (DN)/medulloblastoma with extensive nodularity (MBEN); no evidence of metastatic disease (M0); and a surgical gross total resection (GTR) or near total resection (NTR) defined as residual tumor or imaging abnormality (not definite for residual tumor) with a size of less than 1 cm\^2 on post-op computed tomography (CT) or magnetic resonance imaging (MRI) \[R0\])
id
OG000
title
Low-Risk Group
description
Medulloblastoma patients \<3 years of age, M0, and either R0 resection with any other medullo histology other than DN/MBEN (i.e., classic or large cell anaplastic (LCA)), or with a subtotal resection (with a residual tumor or imaging abnormality with a size of \>1 cm\^2 on post-op imaging (R+), and DN/MBEN). Children 3-5 years of age were also included in this group High Risk
id
OG001
title
Intermediate-Risk Group
description
Medulloblastoma patients \<3 years of age with evidence of metastatic disease
id
OG002
title
High-Risk Group

param Type

COUNT_OF_PARTICIPANTS

population Description

Eligible medulloblastoma patients (n=81) were included in these analyses. 23 of 23 low risk patients had data available for this objective, as did 27/32 and 24/26 intermediate and high risk patients.

reporting Status

POSTED

time Frame

Based on samples obtained at the time of initial surgery or repeat surgery prior to treatment

title

Number of Participants With Chromosomal Abnormalities

type

SECONDARY

unit Of Measure

Participants

Download exact source JSON → · Snapshot ctgov-results-191f4516d4760045304b24a0

Preserved source evidence · Not medical advice