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NCT00565851 · FLOW

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Carboplatin, Paclitaxel and Gemcitabine Hydrochloride With or Without Bevacizumab After Surgery in Treating Patients With Recurrent Ovarian, Epithelial, Primary Peritoneal, or Fallopian Tube Cancer · Source last updated 2025-12-30

Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.

groups
  1. description
    Patients receive paclitaxel IV over 3 hours or docetaxel IV over 1 hour and carboplatin over 30 minutes on day 1. Treatment repeats every 21 days. Patients are not in secondary cytoreductive surgery portion of study.
    id
    FG000
    title
    Arm I (no Surgery; Carboplatin and Paclitaxel)
  2. description
    Patients receive chemotherapy as in arm I and bevacizumab IV over 30-90 minutes on day 1. Treatment repeats every 21 days. Patients are not in secondary cytoreductive surgery portion of study.
    id
    FG001
    title
    Arm II (no Surgery; Carboplatin, Paclitaxel and Bevacizumab)
  3. description
    Patients receive paclitaxel IV over 3 hours or docetaxel IV over 1 hour and carboplatin over 30 minutes on day 1. Treatment repeats every 21 days. Patients receive secondary cytoreductive surgery.
    id
    FG002
    title
    Arm III (Surgery; Carboplatin and Paclitaxel)
  4. description
    Patients receive paclitaxel IV over 3 hours or docetaxel IV over 1 hour and carboplatin over 30 minutes on day 1. Treatment repeats every 21 days. Patients receive secondary cytoreductive surgery.
    id
    FG003
    title
    Arm IV (Surgery; Carboplatin, Paclitaxel and Bevacizumab)
  5. description
    Patients receive carboplatin as in arm I. Patients receive gemcitabine. Treatment repeats every 21 days. Patients do not receive secondary cytoreductive surgery.
    id
    FG004
    title
    Arm V (no Surgery; Carboplatin and Gemcitabine)
  6. description
    Patients receive carboplatin as in arm I and bevacizumab IV over 30-90 minutes on day 1. Patients receive gemcitabine. Treatment repeats every 21 days. Patients do not receive secondary cytoreductive surgery.
    id
    FG005
    title
    Arm VI (no Surgery; Carboplatin, Gemcitabine and Bevacizumab)
  7. description
    Patients receive carboplatin as in arm I. Patients receive gemcitabine. Treatment repeats every 21 days. Patients receive secondary cytoreductive surgery.
    id
    FG006
    title
    Arm VII (Surgery; Carboplatin and Gemcitabine)
  8. description
    Patients receive carboplatin as in arm I and bevacizumab IV over 30-90 minutes on day 1. Patients receive gemcitabine. Treatment repeats every 21 days. Patients receive secondary cytoreductive surgery.
    id
    FG007
    title
    Arm VIII (Surgery; Carboplatin, Gemcitabine and Bevacizumab)
periods
  1. milestones
    1. achievements
      1. group Id
        FG000
        num Subjects
        316
      2. group Id
        FG001
        num Subjects
        456
      3. group Id
        FG002
        num Subjects
        33
      4. group Id
        FG003
        num Subjects
        165
      5. group Id
        FG004
        num Subjects
        6
      6. group Id
        FG005
        num Subjects
        34
      7. group Id
        FG006
        num Subjects
        5
      8. group Id
        FG007
        num Subjects
        37
      type
      STARTED
    2. achievements
      1. group Id
        FG000
        num Subjects
        0
      2. group Id
        FG001
        num Subjects
        0
      3. group Id
        FG002
        num Subjects
        33
      4. group Id
        FG003
        num Subjects
        165
      5. group Id
        FG004
        num Subjects
        0
      6. group Id
        FG005
        num Subjects
        0
      7. group Id
        FG006
        num Subjects
        5
      8. group Id
        FG007
        num Subjects
        37
      type
      Randomized - Yes Surgery
    3. achievements
      1. group Id
        FG000
        num Subjects
        33
      2. group Id
        FG001
        num Subjects
        172
      3. group Id
        FG002
        num Subjects
        0
      4. group Id
        FG003
        num Subjects
        0
      5. group Id
        FG004
        num Subjects
        6
      6. group Id
        FG005
        num Subjects
        34
      7. group Id
        FG006
        num Subjects
        0
      8. group Id
        FG007
        num Subjects
        0
      type
      Randomized - no Surgery
    4. achievements
      1. group Id
        FG000
        num Subjects
        283
      2. group Id
        FG001
        num Subjects
        284
      3. group Id
        FG002
        num Subjects
        0
      4. group Id
        FG003
        num Subjects
        0
      5. group Id
        FG004
        num Subjects
        0
      6. group Id
        FG005
        num Subjects
        0
      7. group Id
        FG006
        num Subjects
        0
      8. group Id
        FG007
        num Subjects
        0
      type
      Not Surgical Candidate
    5. achievements
      1. group Id
        FG000
        num Subjects
        313
      2. group Id
        FG001
        num Subjects
        454
      3. group Id
        FG002
        num Subjects
        31
      4. group Id
        FG003
        num Subjects
        154
      5. group Id
        FG004
        num Subjects
        6
      6. group Id
        FG005
        num Subjects
        34
      7. group Id
        FG006
        num Subjects
        5
      8. group Id
        FG007
        num Subjects
        35
      comment
      Includes participants who followed through with surgical assignment
      type
      COMPLETED
    6. achievements
      1. group Id
        FG000
        num Subjects
        3
      2. group Id
        FG001
        num Subjects
        2
      3. group Id
        FG002
        num Subjects
        2
      4. group Id
        FG003
        num Subjects
        11
      5. group Id
        FG004
        num Subjects
        0
      6. group Id
        FG005
        num Subjects
        0
      7. group Id
        FG006
        num Subjects
        0
      8. group Id
        FG007
        num Subjects
        2
      type
      NOT COMPLETED
    title
    Surgical Assignment
  2. drop Withdraws
    1. reasons
      1. group Id
        FG000
        num Subjects
        9
      2. group Id
        FG001
        num Subjects
        9
      3. group Id
        FG002
        num Subjects
        3
      4. group Id
        FG003
        num Subjects
        18
      5. group Id
        FG004
        num Subjects
        0
      6. group Id
        FG005
        num Subjects
        2
      7. group Id
        FG006
        num Subjects
        0
      8. group Id
        FG007
        num Subjects
        2
      type
      Never Initiated Chemotherapy
    2. reasons
      1. group Id
        FG000
        num Subjects
        0
      2. group Id
        FG001
        num Subjects
        14
      3. group Id
        FG002
        num Subjects
        0
      4. group Id
        FG003
        num Subjects
        18
      5. group Id
        FG004
        num Subjects
        0
      6. group Id
        FG005
        num Subjects
        1
      7. group Id
        FG006
        num Subjects
        0
      8. group Id
        FG007
        num Subjects
        1
      type
      Still On Chemotherapy
    milestones
    1. achievements
      1. group Id
        FG000
        num Subjects
        316
      2. group Id
        FG001
        num Subjects
        456
      3. group Id
        FG002
        num Subjects
        33
      4. group Id
        FG003
        num Subjects
        165
      5. group Id
        FG004
        num Subjects
        6
      6. group Id
        FG005
        num Subjects
        34
      7. group Id
        FG006
        num Subjects
        5
      8. group Id
        FG007
        num Subjects
        37
      type
      STARTED
    2. achievements
      1. group Id
        FG000
        num Subjects
        310
      2. group Id
        FG001
        num Subjects
        311
      3. group Id
        FG002
        num Subjects
        27
      4. group Id
        FG003
        num Subjects
        26
      5. group Id
        FG004
        num Subjects
        0
      6. group Id
        FG005
        num Subjects
        0
      7. group Id
        FG006
        num Subjects
        0
      8. group Id
        FG007
        num Subjects
        0
      type
      Randomized to Chemo
    3. achievements
      1. group Id
        FG000
        num Subjects
        6
      2. group Id
        FG001
        num Subjects
        145
      3. group Id
        FG002
        num Subjects
        6
      4. group Id
        FG003
        num Subjects
        139
      5. group Id
        FG004
        num Subjects
        6
      6. group Id
        FG005
        num Subjects
        34
      7. group Id
        FG006
        num Subjects
        5
      8. group Id
        FG007
        num Subjects
        37
      type
      Pre-specified Chemo
    4. achievements
      1. group Id
        FG000
        num Subjects
        307
      2. group Id
        FG001
        num Subjects
        433
      3. group Id
        FG002
        num Subjects
        30
      4. group Id
        FG003
        num Subjects
        129
      5. group Id
        FG004
        num Subjects
        6
      6. group Id
        FG005
        num Subjects
        31
      7. group Id
        FG006
        num Subjects
        5
      8. group Id
        FG007
        num Subjects
        34
      type
      COMPLETED
    5. achievements
      1. group Id
        FG000
        num Subjects
        9
      2. group Id
        FG001
        num Subjects
        23
      3. group Id
        FG002
        num Subjects
        3
      4. group Id
        FG003
        num Subjects
        36
      5. group Id
        FG004
        num Subjects
        0
      6. group Id
        FG005
        num Subjects
        3
      7. group Id
        FG006
        num Subjects
        0
      8. group Id
        FG007
        num Subjects
        3
      type
      NOT COMPLETED
    title
    Chemotherapy Assignment
recruitment Details
At the beginning of the study participants could be randomized to chemotherapy. On August 29, 2011 randomization to chemotherapy ended and participants could only be randomized to surgery.
Complete source fields
groups
  1. description
    Patients receive paclitaxel IV over 3 hours or docetaxel IV over 1 hour and carboplatin over 30 minutes on day 1. Treatment repeats every 21 days. Patients are not in secondary cytoreductive surgery portion of study.
    id
    FG000
    title
    Arm I (no Surgery; Carboplatin and Paclitaxel)
  2. description
    Patients receive chemotherapy as in arm I and bevacizumab IV over 30-90 minutes on day 1. Treatment repeats every 21 days. Patients are not in secondary cytoreductive surgery portion of study.
    id
    FG001
    title
    Arm II (no Surgery; Carboplatin, Paclitaxel and Bevacizumab)
  3. description
    Patients receive paclitaxel IV over 3 hours or docetaxel IV over 1 hour and carboplatin over 30 minutes on day 1. Treatment repeats every 21 days. Patients receive secondary cytoreductive surgery.
    id
    FG002
    title
    Arm III (Surgery; Carboplatin and Paclitaxel)
  4. description
    Patients receive paclitaxel IV over 3 hours or docetaxel IV over 1 hour and carboplatin over 30 minutes on day 1. Treatment repeats every 21 days. Patients receive secondary cytoreductive surgery.
    id
    FG003
    title
    Arm IV (Surgery; Carboplatin, Paclitaxel and Bevacizumab)
  5. description
    Patients receive carboplatin as in arm I. Patients receive gemcitabine. Treatment repeats every 21 days. Patients do not receive secondary cytoreductive surgery.
    id
    FG004
    title
    Arm V (no Surgery; Carboplatin and Gemcitabine)
  6. description
    Patients receive carboplatin as in arm I and bevacizumab IV over 30-90 minutes on day 1. Patients receive gemcitabine. Treatment repeats every 21 days. Patients do not receive secondary cytoreductive surgery.
    id
    FG005
    title
    Arm VI (no Surgery; Carboplatin, Gemcitabine and Bevacizumab)
  7. description
    Patients receive carboplatin as in arm I. Patients receive gemcitabine. Treatment repeats every 21 days. Patients receive secondary cytoreductive surgery.
    id
    FG006
    title
    Arm VII (Surgery; Carboplatin and Gemcitabine)
  8. description
    Patients receive carboplatin as in arm I and bevacizumab IV over 30-90 minutes on day 1. Patients receive gemcitabine. Treatment repeats every 21 days. Patients receive secondary cytoreductive surgery.
    id
    FG007
    title
    Arm VIII (Surgery; Carboplatin, Gemcitabine and Bevacizumab)
periods
  1. milestones
    1. achievements
      1. group Id
        FG000
        num Subjects
        316
      2. group Id
        FG001
        num Subjects
        456
      3. group Id
        FG002
        num Subjects
        33
      4. group Id
        FG003
        num Subjects
        165
      5. group Id
        FG004
        num Subjects
        6
      6. group Id
        FG005
        num Subjects
        34
      7. group Id
        FG006
        num Subjects
        5
      8. group Id
        FG007
        num Subjects
        37
      type
      STARTED
    2. achievements
      1. group Id
        FG000
        num Subjects
        0
      2. group Id
        FG001
        num Subjects
        0
      3. group Id
        FG002
        num Subjects
        33
      4. group Id
        FG003
        num Subjects
        165
      5. group Id
        FG004
        num Subjects
        0
      6. group Id
        FG005
        num Subjects
        0
      7. group Id
        FG006
        num Subjects
        5
      8. group Id
        FG007
        num Subjects
        37
      type
      Randomized - Yes Surgery
    3. achievements
      1. group Id
        FG000
        num Subjects
        33
      2. group Id
        FG001
        num Subjects
        172
      3. group Id
        FG002
        num Subjects
        0
      4. group Id
        FG003
        num Subjects
        0
      5. group Id
        FG004
        num Subjects
        6
      6. group Id
        FG005
        num Subjects
        34
      7. group Id
        FG006
        num Subjects
        0
      8. group Id
        FG007
        num Subjects
        0
      type
      Randomized - no Surgery
    4. achievements
      1. group Id
        FG000
        num Subjects
        283
      2. group Id
        FG001
        num Subjects
        284
      3. group Id
        FG002
        num Subjects
        0
      4. group Id
        FG003
        num Subjects
        0
      5. group Id
        FG004
        num Subjects
        0
      6. group Id
        FG005
        num Subjects
        0
      7. group Id
        FG006
        num Subjects
        0
      8. group Id
        FG007
        num Subjects
        0
      type
      Not Surgical Candidate
    5. achievements
      1. group Id
        FG000
        num Subjects
        313
      2. group Id
        FG001
        num Subjects
        454
      3. group Id
        FG002
        num Subjects
        31
      4. group Id
        FG003
        num Subjects
        154
      5. group Id
        FG004
        num Subjects
        6
      6. group Id
        FG005
        num Subjects
        34
      7. group Id
        FG006
        num Subjects
        5
      8. group Id
        FG007
        num Subjects
        35
      comment
      Includes participants who followed through with surgical assignment
      type
      COMPLETED
    6. achievements
      1. group Id
        FG000
        num Subjects
        3
      2. group Id
        FG001
        num Subjects
        2
      3. group Id
        FG002
        num Subjects
        2
      4. group Id
        FG003
        num Subjects
        11
      5. group Id
        FG004
        num Subjects
        0
      6. group Id
        FG005
        num Subjects
        0
      7. group Id
        FG006
        num Subjects
        0
      8. group Id
        FG007
        num Subjects
        2
      type
      NOT COMPLETED
    title
    Surgical Assignment
  2. drop Withdraws
    1. reasons
      1. group Id
        FG000
        num Subjects
        9
      2. group Id
        FG001
        num Subjects
        9
      3. group Id
        FG002
        num Subjects
        3
      4. group Id
        FG003
        num Subjects
        18
      5. group Id
        FG004
        num Subjects
        0
      6. group Id
        FG005
        num Subjects
        2
      7. group Id
        FG006
        num Subjects
        0
      8. group Id
        FG007
        num Subjects
        2
      type
      Never Initiated Chemotherapy
    2. reasons
      1. group Id
        FG000
        num Subjects
        0
      2. group Id
        FG001
        num Subjects
        14
      3. group Id
        FG002
        num Subjects
        0
      4. group Id
        FG003
        num Subjects
        18
      5. group Id
        FG004
        num Subjects
        0
      6. group Id
        FG005
        num Subjects
        1
      7. group Id
        FG006
        num Subjects
        0
      8. group Id
        FG007
        num Subjects
        1
      type
      Still On Chemotherapy
    milestones
    1. achievements
      1. group Id
        FG000
        num Subjects
        316
      2. group Id
        FG001
        num Subjects
        456
      3. group Id
        FG002
        num Subjects
        33
      4. group Id
        FG003
        num Subjects
        165
      5. group Id
        FG004
        num Subjects
        6
      6. group Id
        FG005
        num Subjects
        34
      7. group Id
        FG006
        num Subjects
        5
      8. group Id
        FG007
        num Subjects
        37
      type
      STARTED
    2. achievements
      1. group Id
        FG000
        num Subjects
        310
      2. group Id
        FG001
        num Subjects
        311
      3. group Id
        FG002
        num Subjects
        27
      4. group Id
        FG003
        num Subjects
        26
      5. group Id
        FG004
        num Subjects
        0
      6. group Id
        FG005
        num Subjects
        0
      7. group Id
        FG006
        num Subjects
        0
      8. group Id
        FG007
        num Subjects
        0
      type
      Randomized to Chemo
    3. achievements
      1. group Id
        FG000
        num Subjects
        6
      2. group Id
        FG001
        num Subjects
        145
      3. group Id
        FG002
        num Subjects
        6
      4. group Id
        FG003
        num Subjects
        139
      5. group Id
        FG004
        num Subjects
        6
      6. group Id
        FG005
        num Subjects
        34
      7. group Id
        FG006
        num Subjects
        5
      8. group Id
        FG007
        num Subjects
        37
      type
      Pre-specified Chemo
    4. achievements
      1. group Id
        FG000
        num Subjects
        307
      2. group Id
        FG001
        num Subjects
        433
      3. group Id
        FG002
        num Subjects
        30
      4. group Id
        FG003
        num Subjects
        129
      5. group Id
        FG004
        num Subjects
        6
      6. group Id
        FG005
        num Subjects
        31
      7. group Id
        FG006
        num Subjects
        5
      8. group Id
        FG007
        num Subjects
        34
      type
      COMPLETED
    5. achievements
      1. group Id
        FG000
        num Subjects
        9
      2. group Id
        FG001
        num Subjects
        23
      3. group Id
        FG002
        num Subjects
        3
      4. group Id
        FG003
        num Subjects
        36
      5. group Id
        FG004
        num Subjects
        0
      6. group Id
        FG005
        num Subjects
        3
      7. group Id
        FG006
        num Subjects
        0
      8. group Id
        FG007
        num Subjects
        3
      type
      NOT COMPLETED
    title
    Chemotherapy Assignment
recruitment Details
At the beginning of the study participants could be randomized to chemotherapy. On August 29, 2011 randomization to chemotherapy ended and participants could only be randomized to surgery.

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