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NCT00416624 · OUTCOME

Weekly Change in Hemoglobin Levels

Epoetin Alfa or Darbepoetin Alfa in Treating Patients With Anemia Caused by Chemotherapy · Source last updated 2017-02-10

Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.

Measure
MEAN
Unit
g/dL
Interval / dispersion
Standard Deviation
Time frame
Baseline and Week 4, 7, 10, 13, 16

What was measured

To compare the effects of the 3 different epoetin alfa dosing schedules and an every-3-weeks darbepoetin alfa schedule

Analysis population: All patients that were evaluable per protocol and had hemoglobin data at baseline, week 4, 7, 10, 13 or 16.

Groups in this outcome

Epoetin Alfa - 40k Weekly

Patients receive Epoetin alfa 40,000 units subcutaneously every week for 15 weeks (15 doses)

Epoetin Alfa - 80k Every 3 Weeks

Patients receive Epoetin alfa 80,000 units subcutaneously every 3 weeks for 15 weeks (5 doses)

Epoetin Alfa - 120k Every 3 Weeks

Patients receive Epoetin alfa 120,000 units subcutaneously every 3 weeks for 15 weeks (5 doses)

Darbepoetin Alfa - 500 mcg Every 3 Weeks

Patients receive Darbepoetin alfa 500 micrograms (mcg) subcutaneously every 3 weeks for 15 weeks (5 doses)

Group identifiers and denominators belong to this outcome only. They may differ in another outcome or in safety reporting.

Analysis denominator · Participants

GroupSource count
Epoetin Alfa - 40k Weekly61
Epoetin Alfa - 80k Every 3 Weeks60
Epoetin Alfa - 120k Every 3 Weeks58
Darbepoetin Alfa - 500 mcg Every 3 Weeks57

Reported measurements

Week 4 Minus Baseline
Values in g/dL · Interval/dispersion: Standard Deviation
GroupValueSpreadLowerUpperComment
Epoetin Alfa - 40k Weekly1.01.26Not reportedNot reportedNot reported
Epoetin Alfa - 80k Every 3 Weeks0.61.02Not reportedNot reportedNot reported
Epoetin Alfa - 120k Every 3 Weeks0.71.21Not reportedNot reportedNot reported
Darbepoetin Alfa - 500 mcg Every 3 Weeks0.41.21Not reportedNot reportedNot reported
Week 7 Minus Baseline
Values in g/dL · Interval/dispersion: Standard Deviation
GroupValueSpreadLowerUpperComment
Epoetin Alfa - 40k Weekly1.71.28Not reportedNot reportedNot reported
Epoetin Alfa - 80k Every 3 Weeks1.01.58Not reportedNot reportedNot reported
Epoetin Alfa - 120k Every 3 Weeks1.11.25Not reportedNot reportedNot reported
Darbepoetin Alfa - 500 mcg Every 3 Weeks1.51.59Not reportedNot reportedNot reported
Week 10 Minus Baseline
Values in g/dL · Interval/dispersion: Standard Deviation
GroupValueSpreadLowerUpperComment
Epoetin Alfa - 40k Weekly1.71.39Not reportedNot reportedNot reported
Epoetin Alfa - 80k Every 3 Weeks1.21.42Not reportedNot reportedNot reported
Epoetin Alfa - 120k Every 3 Weeks1.21.37Not reportedNot reportedNot reported
Darbepoetin Alfa - 500 mcg Every 3 Weeks1.51.44Not reportedNot reportedNot reported
Week 13 Minus Baseline
Values in g/dL · Interval/dispersion: Standard Deviation
GroupValueSpreadLowerUpperComment
Epoetin Alfa - 40k Weekly2.11.27Not reportedNot reportedNot reported
Epoetin Alfa - 80k Every 3 Weeks1.21.51Not reportedNot reportedNot reported
Epoetin Alfa - 120k Every 3 Weeks1.31.32Not reportedNot reportedNot reported
Darbepoetin Alfa - 500 mcg Every 3 Weeks1.61.65Not reportedNot reportedNot reported
Week 16 Minus Baseline
Values in g/dL · Interval/dispersion: Standard Deviation
GroupValueSpreadLowerUpperComment
Epoetin Alfa - 40k Weekly1.71.67Not reportedNot reportedNot reported
Epoetin Alfa - 80k Every 3 Weeks1.21.64Not reportedNot reportedNot reported
Epoetin Alfa - 120k Every 3 Weeks1.61.44Not reportedNot reportedNot reported
Darbepoetin Alfa - 500 mcg Every 3 Weeks1.91.41Not reportedNot reportedNot reported
Complete source fields
classes
  1. categories
    1. measurements
      1. group Id
        OG000
        spread
        1.26
        value
        1.0
      2. group Id
        OG001
        spread
        1.02
        value
        0.6
      3. group Id
        OG002
        spread
        1.21
        value
        0.7
      4. group Id
        OG003
        spread
        1.21
        value
        0.4
    title
    Week 4 Minus Baseline
  2. categories
    1. measurements
      1. group Id
        OG000
        spread
        1.28
        value
        1.7
      2. group Id
        OG001
        spread
        1.58
        value
        1.0
      3. group Id
        OG002
        spread
        1.25
        value
        1.1
      4. group Id
        OG003
        spread
        1.59
        value
        1.5
    title
    Week 7 Minus Baseline
  3. categories
    1. measurements
      1. group Id
        OG000
        spread
        1.39
        value
        1.7
      2. group Id
        OG001
        spread
        1.42
        value
        1.2
      3. group Id
        OG002
        spread
        1.37
        value
        1.2
      4. group Id
        OG003
        spread
        1.44
        value
        1.5
    title
    Week 10 Minus Baseline
  4. categories
    1. measurements
      1. group Id
        OG000
        spread
        1.27
        value
        2.1
      2. group Id
        OG001
        spread
        1.51
        value
        1.2
      3. group Id
        OG002
        spread
        1.32
        value
        1.3
      4. group Id
        OG003
        spread
        1.65
        value
        1.6
    title
    Week 13 Minus Baseline
  5. categories
    1. measurements
      1. group Id
        OG000
        spread
        1.67
        value
        1.7
      2. group Id
        OG001
        spread
        1.64
        value
        1.2
      3. group Id
        OG002
        spread
        1.44
        value
        1.6
      4. group Id
        OG003
        spread
        1.41
        value
        1.9
    title
    Week 16 Minus Baseline
denoms
  1. counts
    1. group Id
      OG000
      value
      61
    2. group Id
      OG001
      value
      60
    3. group Id
      OG002
      value
      58
    4. group Id
      OG003
      value
      57
    units
    Participants
description
To compare the effects of the 3 different epoetin alfa dosing schedules and an every-3-weeks darbepoetin alfa schedule
dispersion Type
Standard Deviation
groups
  1. description
    Patients receive Epoetin alfa 40,000 units subcutaneously every week for 15 weeks (15 doses)
    id
    OG000
    title
    Epoetin Alfa - 40k Weekly
  2. description
    Patients receive Epoetin alfa 80,000 units subcutaneously every 3 weeks for 15 weeks (5 doses)
    id
    OG001
    title
    Epoetin Alfa - 80k Every 3 Weeks
  3. description
    Patients receive Epoetin alfa 120,000 units subcutaneously every 3 weeks for 15 weeks (5 doses)
    id
    OG002
    title
    Epoetin Alfa - 120k Every 3 Weeks
  4. description
    Patients receive Darbepoetin alfa 500 micrograms (mcg) subcutaneously every 3 weeks for 15 weeks (5 doses)
    id
    OG003
    title
    Darbepoetin Alfa - 500 mcg Every 3 Weeks
param Type
MEAN
population Description
All patients that were evaluable per protocol and had hemoglobin data at baseline, week 4, 7, 10, 13 or 16.
reporting Status
POSTED
time Frame
Baseline and Week 4, 7, 10, 13, 16
title
Weekly Change in Hemoglobin Levels
type
SECONDARY
unit Of Measure
g/dL

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Preserved source evidence · Not medical advice