TriangleNCT00369785 · OUTCOME
Memory as Quantified by the HVLT-discrimination
Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.
- Measure
- LEAST_SQUARES_MEAN
- Unit
- units on a scale
- Interval / dispersion
- Standard Error
- Time frame
- 24 weeks
What was measured
In the Hopkins Verbal Learning Test - discrimination, participants are given lists of 12 correct words and 12 incorrect words. HVLT-discrimination is the number of correctly recognized words minus the number incorrectly recognized. The range for this outcome measure is -12 to 12. Higher scores represent better memory.
Analysis population: Number of participants with 24 week memory data
Groups in this outcome
Arm I - Donepezil
Weeks 1-6: One 5 mg tablet orally donepezil hydrochloride Weeks 7-24: Two 5mg tablets per day donepezil hydrochloride: Weeks 1-6: One tablet Donepezil 5 mg given daily Weeks 7-24: Two Donepezil 5 mg tablets given daily
Arm II - Control
Weeks 1-6: One placebo tablet per day Weeks 7-24: Two placebo tablets per day Placebo: Weeks 1-6: One tablet per day Weeks 7-24: Two tablets per day
| Group | Source count |
|---|---|
| Arm I - Donepezil | 72 |
| Arm II - Control | 73 |
Reported measurements
Source class 1
| Group | Value | Spread | Lower | Upper | Comment |
|---|---|---|---|---|---|
| Arm I - Donepezil | 10.1 | 0.24 | Not reported | Not reported | Not reported |
| Arm II - Control | 9.2 | 0.24 | Not reported | Not reported | Not reported |
Source statistical analyses
- group Description
- Null Hypothesis: No difference in discrimination memory between the two groups
- group Ids
- OG000
- OG001
- non Inferiority Type
- SUPERIORITY_OR_OTHER_LEGACY
- p Value
- .007
- p Value Comment
- Not adjusted for multiple comparisons.
- statistical Method
- Mixed Models Analysis
Complete source fields
- analyses
- group Description
- Null Hypothesis: No difference in discrimination memory between the two groups
- group Ids
- OG000
- OG001
- non Inferiority Type
- SUPERIORITY_OR_OTHER_LEGACY
- p Value
- .007
- p Value Comment
- Not adjusted for multiple comparisons.
- statistical Method
- Mixed Models Analysis
- classes
- categories
- measurements
- group Id
- OG000
- spread
- 0.24
- value
- 10.1
- group Id
- OG001
- spread
- 0.24
- value
- 9.2
- denoms
- counts
- group Id
- OG000
- value
- 72
- group Id
- OG001
- value
- 73
- units
- Participants
- description
- In the Hopkins Verbal Learning Test - discrimination, participants are given lists of 12 correct words and 12 incorrect words. HVLT-discrimination is the number of correctly recognized words minus the number incorrectly recognized. The range for this outcome measure is -12 to 12. Higher scores represent better memory.
- dispersion Type
- Standard Error
- groups
- description
- Weeks 1-6: One 5 mg tablet orally donepezil hydrochloride Weeks 7-24: Two 5mg tablets per day donepezil hydrochloride: Weeks 1-6: One tablet Donepezil 5 mg given daily Weeks 7-24: Two Donepezil 5 mg tablets given daily
- id
- OG000
- title
- Arm I - Donepezil
- description
- Weeks 1-6: One placebo tablet per day Weeks 7-24: Two placebo tablets per day Placebo: Weeks 1-6: One tablet per day Weeks 7-24: Two tablets per day
- id
- OG001
- title
- Arm II - Control
- param Type
- LEAST_SQUARES_MEAN
- population Description
- Number of participants with 24 week memory data
- reporting Status
- POSTED
- time Frame
- 24 weeks
- title
- Memory as Quantified by the HVLT-discrimination
- type
- PRIMARY
- unit Of Measure
- units on a scale
Download exact source JSON → · Snapshot ctgov-results-25a395029948b04d52b1253f
Preserved source evidence · Not medical advice