TriangleNCT00369785 · OUTCOME
Memory as Quantified by HVLT-immediate Recall
Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.
- Measure
- LEAST_SQUARES_MEAN
- Unit
- units on a scale
- Interval / dispersion
- Standard Error
- Time frame
- 24 weeks
What was measured
Memory is quantified using the Hopkins Verbal Learning Test (HVLT) - immediate recall. Participants are asked to recall 12 words. Each recalled word is given one point. They are given three trials. The total score is the sum of the recalled words. The range for HVLT-Immediate recall is 0 to 36. Higher scores represent better memory.
Analysis population: Participants with 24 week HVLT data.
Groups in this outcome
Arm I - Donepezil
Weeks 1-6: One 5 mg tablet orally donepezil hydrochloride Weeks 7-24: Two 5mg tablets per day donepezil hydrochloride: Weeks 1-6: One tablet Donepezil 5 mg given daily Weeks 7-24: Two Donepezil 5 mg tablets given daily
Arm II - Control
Weeks 1-6: One placebo tablet per day Weeks 7-24: Two placebo tablets per day Placebo: Weeks 1-6: One tablet per day Weeks 7-24: Two tablets per day
| Group | Source count |
|---|---|
| Arm I - Donepezil | 72 |
| Arm II - Control | 73 |
Reported measurements
Source class 1
| Group | Value | Spread | Lower | Upper | Comment |
|---|---|---|---|---|---|
| Arm I - Donepezil | 22.5 | 0.45 | Not reported | Not reported | Not reported |
| Arm II - Control | 22.2 | 0.45 | Not reported | Not reported | Not reported |
Source statistical analyses
- group Description
- Null Hypothesis: No difference in immediate recall memory at 24 weeks
- group Ids
- OG000
- OG001
- non Inferiority Type
- SUPERIORITY_OR_OTHER_LEGACY
- p Value
- .62
- p Value Comment
- Not adjusted for multiple comparisons.
- statistical Method
- Mixed Models Analysis
Complete source fields
- analyses
- group Description
- Null Hypothesis: No difference in immediate recall memory at 24 weeks
- group Ids
- OG000
- OG001
- non Inferiority Type
- SUPERIORITY_OR_OTHER_LEGACY
- p Value
- .62
- p Value Comment
- Not adjusted for multiple comparisons.
- statistical Method
- Mixed Models Analysis
- classes
- categories
- measurements
- group Id
- OG000
- spread
- 0.45
- value
- 22.5
- group Id
- OG001
- spread
- 0.45
- value
- 22.2
- denoms
- counts
- group Id
- OG000
- value
- 72
- group Id
- OG001
- value
- 73
- units
- Participants
- description
- Memory is quantified using the Hopkins Verbal Learning Test (HVLT) - immediate recall. Participants are asked to recall 12 words. Each recalled word is given one point. They are given three trials. The total score is the sum of the recalled words. The range for HVLT-Immediate recall is 0 to 36. Higher scores represent better memory.
- dispersion Type
- Standard Error
- groups
- description
- Weeks 1-6: One 5 mg tablet orally donepezil hydrochloride Weeks 7-24: Two 5mg tablets per day donepezil hydrochloride: Weeks 1-6: One tablet Donepezil 5 mg given daily Weeks 7-24: Two Donepezil 5 mg tablets given daily
- id
- OG000
- title
- Arm I - Donepezil
- description
- Weeks 1-6: One placebo tablet per day Weeks 7-24: Two placebo tablets per day Placebo: Weeks 1-6: One tablet per day Weeks 7-24: Two tablets per day
- id
- OG001
- title
- Arm II - Control
- param Type
- LEAST_SQUARES_MEAN
- population Description
- Participants with 24 week HVLT data.
- reporting Status
- POSTED
- time Frame
- 24 weeks
- title
- Memory as Quantified by HVLT-immediate Recall
- type
- PRIMARY
- unit Of Measure
- units on a scale
Download exact source JSON → · Snapshot ctgov-results-25a395029948b04d52b1253f
Preserved source evidence · Not medical advice