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NCT00351468 · OUTCOME

Number of Subjects Who Required Rescue Therapy During Treatment With Eltrombopag.

EXTEND (Eltrombopag Extended Dosing Study) · Source last updated 2017-04-17

Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.

Measure
NUMBER
Unit
Participants
Interval / dispersion
Not reported
Time frame
Baseline up to 2 years

What was measured

Rescue treatment is defined as a composite of: new ITP medication, increased dose of a concomitant ITP medication, platelet transfusion, and splenectomy. Subjects may have received more than 1 type of rescue therapy

Groups in this outcome

Eltrombopag

Open-label eltrombopag was supplied in 25, 50, 75 mg tablets. All subjects started at 50mg once daily and dose was increased or decreased based on platelet count (target range 50-200Gi/L). Alternate days and interruption of dosing was permitted to maintain target range of platelet count. Doses could range from 25 to 75mg. Subjects could remain on treatment up to 2 years.

Group identifiers and denominators belong to this outcome only. They may differ in another outcome or in safety reporting.

Analysis denominator · Participants

GroupSource count
Eltrombopag302

Reported measurements

New ITP medication, n=103
Values in Participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
Eltrombopag82Not reportedNot reportedNot reportedNot reported
Increase in dose of ITP med from baseline, n=103
Values in Participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
Eltrombopag27Not reportedNot reportedNot reportedNot reported
Platelet transfusion, n=103
Values in Participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
Eltrombopag21Not reportedNot reportedNot reportedNot reported
Splenectomy, n=103
Values in Participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
Eltrombopag3Not reportedNot reportedNot reportedNot reported
Complete source fields
classes
  1. categories
    1. measurements
      1. group Id
        OG000
        value
        82
    title
    New ITP medication, n=103
  2. categories
    1. measurements
      1. group Id
        OG000
        value
        27
    title
    Increase in dose of ITP med from baseline, n=103
  3. categories
    1. measurements
      1. group Id
        OG000
        value
        21
    title
    Platelet transfusion, n=103
  4. categories
    1. measurements
      1. group Id
        OG000
        value
        3
    title
    Splenectomy, n=103
denoms
  1. counts
    1. group Id
      OG000
      value
      302
    units
    Participants
description
Rescue treatment is defined as a composite of: new ITP medication, increased dose of a concomitant ITP medication, platelet transfusion, and splenectomy. Subjects may have received more than 1 type of rescue therapy
groups
  1. description
    Open-label eltrombopag was supplied in 25, 50, 75 mg tablets. All subjects started at 50mg once daily and dose was increased or decreased based on platelet count (target range 50-200Gi/L). Alternate days and interruption of dosing was permitted to maintain target range of platelet count. Doses could range from 25 to 75mg. Subjects could remain on treatment up to 2 years.
    id
    OG000
    title
    Eltrombopag
param Type
NUMBER
reporting Status
POSTED
time Frame
Baseline up to 2 years
title
Number of Subjects Who Required Rescue Therapy During Treatment With Eltrombopag.
type
SECONDARY
unit Of Measure
Participants

Download exact source JSON → · Snapshot ctgov-results-191f4516d4760045304b24a0

Preserved source evidence · Not medical advice