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NCT00334282 · OUTCOME

Baseline Expression Levels of the Indicated Target Proteins in Pazopanib- and Placebo-treated Participants

Safety and Efficacy of GW786034 (Pazopanib) In Metastatic Renal Cell Carcinoma · Source last updated 2016-02-05

Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.

Measure
MEAN
Unit
picograms per milliliter
Interval / dispersion
Standard Deviation
Time frame
Baseline

What was measured

Baseline plasma samples were obtained from participants and were tested for the indicated cytokine and angiogenesis factors. Protein levels were determined using the Searchlight multiplex system based on chemiluminescence.

Analysis population: Subgroup of enrolled participants who agreed to have plasma samples collected for biomarker analyses.

Groups in this outcome

Pazopanib 800 mg

Pazopanib 800 mg (tablets) administered orally once a day

Placebo

Matching placebo administered orally once a day

Group identifiers and denominators belong to this outcome only. They may differ in another outcome or in safety reporting.

Analysis denominator · Participants

GroupSource count
Pazopanib 800 mg225
Placebo119

Reported measurements

Interleukin-6
Values in picograms per milliliter · Interval/dispersion: Standard Deviation
GroupValueSpreadLowerUpperComment
Pazopanib 800 mg31.00365.247Not reportedNot reportedNot reported
Placebo24.14531.708Not reportedNot reportedNot reported
Interleukin-8
Values in picograms per milliliter · Interval/dispersion: Standard Deviation
GroupValueSpreadLowerUpperComment
Pazopanib 800 mg35.429164.12Not reportedNot reportedNot reported
Placebo27.75566.129Not reportedNot reportedNot reported
Vascular endothelial growth factor
Values in picograms per milliliter · Interval/dispersion: Standard Deviation
GroupValueSpreadLowerUpperComment
Pazopanib 800 mg308.61365.19Not reportedNot reportedNot reported
Placebo273.15350.91Not reportedNot reportedNot reported
Hepatocyte growth factor
Values in picograms per milliliter · Interval/dispersion: Standard Deviation
GroupValueSpreadLowerUpperComment
Pazopanib 800 mg383.55308.89Not reportedNot reportedNot reported
Placebo522.941003.8Not reportedNot reportedNot reported
Tissue inhibitor of metalloproteinase 1
Values in picograms per milliliter · Interval/dispersion: Standard Deviation
GroupValueSpreadLowerUpperComment
Pazopanib 800 mg847464690744Not reportedNot reportedNot reported
Placebo735915423493Not reportedNot reportedNot reported
e-Selectin
Values in picograms per milliliter · Interval/dispersion: Standard Deviation
GroupValueSpreadLowerUpperComment
Pazopanib 800 mg41649.2822389.04Not reportedNot reportedNot reported
Placebo41231.4519825.7Not reportedNot reportedNot reported
Osteopotin
Values in picograms per milliliter · Interval/dispersion: Standard Deviation
GroupValueSpreadLowerUpperComment
Pazopanib 800 mg444343707005Not reportedNot reportedNot reported
Placebo369317490931Not reportedNot reportedNot reported
Complete source fields
classes
  1. categories
    1. measurements
      1. group Id
        OG000
        spread
        65.247
        value
        31.003
      2. group Id
        OG001
        spread
        31.708
        value
        24.145
    title
    Interleukin-6
  2. categories
    1. measurements
      1. group Id
        OG000
        spread
        164.12
        value
        35.429
      2. group Id
        OG001
        spread
        66.129
        value
        27.755
    title
    Interleukin-8
  3. categories
    1. measurements
      1. group Id
        OG000
        spread
        365.19
        value
        308.61
      2. group Id
        OG001
        spread
        350.91
        value
        273.15
    title
    Vascular endothelial growth factor
  4. categories
    1. measurements
      1. group Id
        OG000
        spread
        308.89
        value
        383.55
      2. group Id
        OG001
        spread
        1003.8
        value
        522.94
    title
    Hepatocyte growth factor
  5. categories
    1. measurements
      1. group Id
        OG000
        spread
        690744
        value
        847464
      2. group Id
        OG001
        spread
        423493
        value
        735915
    title
    Tissue inhibitor of metalloproteinase 1
  6. categories
    1. measurements
      1. group Id
        OG000
        spread
        22389.04
        value
        41649.28
      2. group Id
        OG001
        spread
        19825.7
        value
        41231.45
    title
    e-Selectin
  7. categories
    1. measurements
      1. group Id
        OG000
        spread
        707005
        value
        444343
      2. group Id
        OG001
        spread
        490931
        value
        369317
    title
    Osteopotin
denoms
  1. counts
    1. group Id
      OG000
      value
      225
    2. group Id
      OG001
      value
      119
    units
    Participants
description
Baseline plasma samples were obtained from participants and were tested for the indicated cytokine and angiogenesis factors. Protein levels were determined using the Searchlight multiplex system based on chemiluminescence.
dispersion Type
Standard Deviation
groups
  1. description
    Pazopanib 800 mg (tablets) administered orally once a day
    id
    OG000
    title
    Pazopanib 800 mg
  2. description
    Matching placebo administered orally once a day
    id
    OG001
    title
    Placebo
param Type
MEAN
population Description
Subgroup of enrolled participants who agreed to have plasma samples collected for biomarker analyses.
reporting Status
POSTED
time Frame
Baseline
title
Baseline Expression Levels of the Indicated Target Proteins in Pazopanib- and Placebo-treated Participants
type
SECONDARY
unit Of Measure
picograms per milliliter

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Preserved source evidence · Not medical advice