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NCT00262847 · BASELINE

Baseline characteristics

Carboplatin and Paclitaxel With or Without Bevacizumab in Treating Patients With Stage III or Stage IV Ovarian Epithelial, Primary Peritoneal, or Fallopian Tube Cancer · Source last updated 2019-07-23

Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.

denoms
  1. counts
    1. group Id
      BG000
      value
      625
    2. group Id
      BG001
      value
      625
    3. group Id
      BG002
      value
      623
    4. group Id
      BG003
      value
      1873
    units
    Participants
groups
  1. description
    Control therapy: Cycles 1-6 received paclitaxel, 175 mg/m2 plus carboplatin AUC 6 plus placebo (starting in cycle 2) every 3 weeks. Cycles 7-22 received placebo every 3 weeks.
    id
    BG000
    title
    Arm I (Placebo, Paclitaxel, Carboplatin)
  2. description
    Bevacizumab-initiation therapy: Cycles 1-6 received paclitaxel, 175 mg/m2 plus carboplatin AUC 6 plus bevacizumab, 15 mg/kg (starting in cycle 2) every 3 weeks. Cycles 7-22 received placebo every 3 weeks.
    id
    BG001
    title
    Arm II (Placebo, Paclitaxel, Carboplatin, Bevacizumab)
  3. description
    Bevacizumab-throughout therapy: Cycles 1-6 received paclitaxel, 175 mg/m2 plus carboplatin AUC 6 plus bevacizumab, 15 mg/kg (starting in cycle 2) every 3 weeks. Cycles 7-22 received bevacizumab, 15 mg/kg every 3 weeks.
    id
    BG002
    title
    Arm III (Paclitaxel, Carboplatin, Bevacizumab)
  4. description
    Total of all reporting groups
    id
    BG003
    title
    Total
measures
  1. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          spread
          10.9
          value
          59.3
        2. group Id
          BG001
          spread
          10.3
          value
          60.1
        3. group Id
          BG002
          spread
          10.6
          value
          59.7
        4. group Id
          BG003
          spread
          10.6
          value
          59.7
    dispersion Type
    STANDARD_DEVIATION
    param Type
    MEAN
    title
    Age, Continuous
    unit Of Measure
    years
  2. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          625
        2. group Id
          BG001
          value
          625
        3. group Id
          BG002
          value
          623
        4. group Id
          BG003
          value
          1873
        title
        Female
      2. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          0
        4. group Id
          BG003
          value
          0
        title
        Male
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Sex: Female, Male
    unit Of Measure
    Participants
  3. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          526
        2. group Id
          BG001
          value
          519
        3. group Id
          BG002
          value
          521
        4. group Id
          BG003
          value
          1566
      title
      Non-Hispanic white
    2. categories
      1. measurements
        1. group Id
          BG000
          value
          41
        2. group Id
          BG001
          value
          37
        3. group Id
          BG002
          value
          39
        4. group Id
          BG003
          value
          117
      title
      Asian
    3. categories
      1. measurements
        1. group Id
          BG000
          value
          25
        2. group Id
          BG001
          value
          28
        3. group Id
          BG002
          value
          27
        4. group Id
          BG003
          value
          80
      title
      Non-Hispanic black
    4. categories
      1. measurements
        1. group Id
          BG000
          value
          21
        2. group Id
          BG001
          value
          28
        3. group Id
          BG002
          value
          25
        4. group Id
          BG003
          value
          74
      title
      Hispanic
    5. categories
      1. measurements
        1. group Id
          BG000
          value
          12
        2. group Id
          BG001
          value
          13
        3. group Id
          BG002
          value
          11
        4. group Id
          BG003
          value
          36
      title
      Other or unspecified
    param Type
    NUMBER
    title
    Race/Ethnicity, Customized
    unit Of Measure
    participant
  4. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          596
        2. group Id
          BG001
          value
          596
        3. group Id
          BG002
          value
          599
        4. group Id
          BG003
          value
          1791
      title
      United States
    2. categories
      1. measurements
        1. group Id
          BG000
          value
          1
        2. group Id
          BG001
          value
          5
        3. group Id
          BG002
          value
          3
        4. group Id
          BG003
          value
          9
      title
      Canada
    3. categories
      1. measurements
        1. group Id
          BG000
          value
          21
        2. group Id
          BG001
          value
          12
        3. group Id
          BG002
          value
          12
        4. group Id
          BG003
          value
          45
      title
      Japan
    4. categories
      1. measurements
        1. group Id
          BG000
          value
          7
        2. group Id
          BG001
          value
          12
        3. group Id
          BG002
          value
          9
        4. group Id
          BG003
          value
          28
      title
      Korea, Republic of
    param Type
    NUMBER
    title
    Region of Enrollment
    unit Of Measure
    participants
  5. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          311
        2. group Id
          BG001
          value
          315
        3. group Id
          BG002
          value
          305
        4. group Id
          BG003
          value
          931
      title
      0 - fully active
    2. categories
      1. measurements
        1. group Id
          BG000
          value
          272
        2. group Id
          BG001
          value
          270
        3. group Id
          BG002
          value
          267
        4. group Id
          BG003
          value
          809
      title
      1 - restricted strenuous activity, ambulatory
    3. categories
      1. measurements
        1. group Id
          BG000
          value
          42
        2. group Id
          BG001
          value
          40
        3. group Id
          BG002
          value
          51
        4. group Id
          BG003
          value
          133
      title
      2 - ambulatory, difficulty walking
    4. categories
      1. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          0
        4. group Id
          BG003
          value
          0
      title
      3 - limited self-care, partly confined to bed
    5. categories
      1. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          0
        4. group Id
          BG003
          value
          0
      title
      4 - completely disabled, no self-care
    description
    5-point, ordinal scale specifying patient's ability to perform activities from 0(fully active) to 4(completely disabled, no self-care).
    param Type
    NUMBER
    title
    Gynecologic Oncology Group (GOG) Performance Status
    unit Of Measure
    participants
  6. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          0
        4. group Id
          BG003
          value
          0
      title
      1-limited to ovaries
    2. categories
      1. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          0
        4. group Id
          BG003
          value
          0
      title
      1A-1 ovary involved, no ascites
    3. categories
      1. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          0
        4. group Id
          BG003
          value
          0
      title
      1B-both ovaries involved, no ascites
    4. categories
      1. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          0
        4. group Id
          BG003
          value
          0
      title
      1C-disease with capsules ruptured or ascites
    5. categories
      1. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          0
        4. group Id
          BG003
          value
          0
      title
      2-disease with pelvic extension
    6. categories
      1. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          0
        4. group Id
          BG003
          value
          0
      title
      2A-disease with extension to uterus and or tubes
    7. categories
      1. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          0
        4. group Id
          BG003
          value
          0
      title
      2B-disease with extension to other pelvic tissues
    8. categories
      1. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          0
        4. group Id
          BG003
          value
          0
      title
      2C-disease with capsules ruptured or ascites
    9. categories
      1. measurements
        1. group Id
          BG000
          value
          218
        2. group Id
          BG001
          value
          205
        3. group Id
          BG002
          value
          216
        4. group Id
          BG003
          value
          639
      title
      3-disease w/ macroscopic implants outside pelvis
    10. categories
      1. measurements
        1. group Id
          BG000
          value
          254
        2. group Id
          BG001
          value
          256
        3. group Id
          BG002
          value
          242
        4. group Id
          BG003
          value
          752
      title
      3-disease w/ implants > 1 cm outside pelvis
    11. categories
      1. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          0
        4. group Id
          BG003
          value
          0
      title
      3A-disease w/ microscopic implants, negative nodes
    12. categories
      1. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          0
        4. group Id
          BG003
          value
          0
      title
      3B-disease w/ abdominal implants <2cm, neg nodes
    description
    Clinical staging for primary carcinoma of the ovary (1985) from Stage 1 (limited to ovaries) to Stage 4 (distant metastatis)
    param Type
    NUMBER
    title
    International Federation of Gynecologic and Obstetrics (FIGO) Stage
    unit Of Measure
    participants
  7. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          541
        2. group Id
          BG001
          value
          519
        3. group Id
          BG002
          value
          524
        4. group Id
          BG003
          value
          1584
      title
      Serous adenocarcinoma
    2. categories
      1. measurements
        1. group Id
          BG000
          value
          21
        2. group Id
          BG001
          value
          14
        3. group Id
          BG002
          value
          24
        4. group Id
          BG003
          value
          59
      title
      Endometrioid
    3. categories
      1. measurements
        1. group Id
          BG000
          value
          12
        2. group Id
          BG001
          value
          23
        3. group Id
          BG002
          value
          20
        4. group Id
          BG003
          value
          55
      title
      Clear cell
    4. categories
      1. measurements
        1. group Id
          BG000
          value
          6
        2. group Id
          BG001
          value
          5
        3. group Id
          BG002
          value
          8
        4. group Id
          BG003
          value
          19
      title
      Mucinous
    5. categories
      1. measurements
        1. group Id
          BG000
          value
          45
        2. group Id
          BG001
          value
          64
        3. group Id
          BG002
          value
          47
        4. group Id
          BG003
          value
          156
      title
      Other or not specified
    description
    Histologic(cell) type was obtained from the central GOG Pathology Committee review updated in September 2010.
    param Type
    NUMBER
    title
    Histologic Type
    unit Of Measure
    participants
  8. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          445
        2. group Id
          BG001
          value
          465
        3. group Id
          BG002
          value
          460
        4. group Id
          BG003
          value
          1370
      title
      3
    2. categories
      1. measurements
        1. group Id
          BG000
          value
          102
        2. group Id
          BG001
          value
          86
        3. group Id
          BG002
          value
          97
        4. group Id
          BG003
          value
          285
      title
      2
    3. categories
      1. measurements
        1. group Id
          BG000
          value
          36
        2. group Id
          BG001
          value
          28
        3. group Id
          BG002
          value
          18
        4. group Id
          BG003
          value
          82
      title
      1
    4. categories
      1. measurements
        1. group Id
          BG000
          value
          42
        2. group Id
          BG001
          value
          46
        3. group Id
          BG002
          value
          48
        4. group Id
          BG003
          value
          136
      title
      Not graded
    description
    Tumor grade was obtained from the central GOG Pathology Committee review updated in September 2010. All clear-cell tumors were classified as grade 3.
    param Type
    NUMBER
    title
    Tumor Grade
    unit Of Measure
    participants
Complete source fields
denoms
  1. counts
    1. group Id
      BG000
      value
      625
    2. group Id
      BG001
      value
      625
    3. group Id
      BG002
      value
      623
    4. group Id
      BG003
      value
      1873
    units
    Participants
groups
  1. description
    Control therapy: Cycles 1-6 received paclitaxel, 175 mg/m2 plus carboplatin AUC 6 plus placebo (starting in cycle 2) every 3 weeks. Cycles 7-22 received placebo every 3 weeks.
    id
    BG000
    title
    Arm I (Placebo, Paclitaxel, Carboplatin)
  2. description
    Bevacizumab-initiation therapy: Cycles 1-6 received paclitaxel, 175 mg/m2 plus carboplatin AUC 6 plus bevacizumab, 15 mg/kg (starting in cycle 2) every 3 weeks. Cycles 7-22 received placebo every 3 weeks.
    id
    BG001
    title
    Arm II (Placebo, Paclitaxel, Carboplatin, Bevacizumab)
  3. description
    Bevacizumab-throughout therapy: Cycles 1-6 received paclitaxel, 175 mg/m2 plus carboplatin AUC 6 plus bevacizumab, 15 mg/kg (starting in cycle 2) every 3 weeks. Cycles 7-22 received bevacizumab, 15 mg/kg every 3 weeks.
    id
    BG002
    title
    Arm III (Paclitaxel, Carboplatin, Bevacizumab)
  4. description
    Total of all reporting groups
    id
    BG003
    title
    Total
measures
  1. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          spread
          10.9
          value
          59.3
        2. group Id
          BG001
          spread
          10.3
          value
          60.1
        3. group Id
          BG002
          spread
          10.6
          value
          59.7
        4. group Id
          BG003
          spread
          10.6
          value
          59.7
    dispersion Type
    STANDARD_DEVIATION
    param Type
    MEAN
    title
    Age, Continuous
    unit Of Measure
    years
  2. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          625
        2. group Id
          BG001
          value
          625
        3. group Id
          BG002
          value
          623
        4. group Id
          BG003
          value
          1873
        title
        Female
      2. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          0
        4. group Id
          BG003
          value
          0
        title
        Male
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Sex: Female, Male
    unit Of Measure
    Participants
  3. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          526
        2. group Id
          BG001
          value
          519
        3. group Id
          BG002
          value
          521
        4. group Id
          BG003
          value
          1566
      title
      Non-Hispanic white
    2. categories
      1. measurements
        1. group Id
          BG000
          value
          41
        2. group Id
          BG001
          value
          37
        3. group Id
          BG002
          value
          39
        4. group Id
          BG003
          value
          117
      title
      Asian
    3. categories
      1. measurements
        1. group Id
          BG000
          value
          25
        2. group Id
          BG001
          value
          28
        3. group Id
          BG002
          value
          27
        4. group Id
          BG003
          value
          80
      title
      Non-Hispanic black
    4. categories
      1. measurements
        1. group Id
          BG000
          value
          21
        2. group Id
          BG001
          value
          28
        3. group Id
          BG002
          value
          25
        4. group Id
          BG003
          value
          74
      title
      Hispanic
    5. categories
      1. measurements
        1. group Id
          BG000
          value
          12
        2. group Id
          BG001
          value
          13
        3. group Id
          BG002
          value
          11
        4. group Id
          BG003
          value
          36
      title
      Other or unspecified
    param Type
    NUMBER
    title
    Race/Ethnicity, Customized
    unit Of Measure
    participant
  4. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          596
        2. group Id
          BG001
          value
          596
        3. group Id
          BG002
          value
          599
        4. group Id
          BG003
          value
          1791
      title
      United States
    2. categories
      1. measurements
        1. group Id
          BG000
          value
          1
        2. group Id
          BG001
          value
          5
        3. group Id
          BG002
          value
          3
        4. group Id
          BG003
          value
          9
      title
      Canada
    3. categories
      1. measurements
        1. group Id
          BG000
          value
          21
        2. group Id
          BG001
          value
          12
        3. group Id
          BG002
          value
          12
        4. group Id
          BG003
          value
          45
      title
      Japan
    4. categories
      1. measurements
        1. group Id
          BG000
          value
          7
        2. group Id
          BG001
          value
          12
        3. group Id
          BG002
          value
          9
        4. group Id
          BG003
          value
          28
      title
      Korea, Republic of
    param Type
    NUMBER
    title
    Region of Enrollment
    unit Of Measure
    participants
  5. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          311
        2. group Id
          BG001
          value
          315
        3. group Id
          BG002
          value
          305
        4. group Id
          BG003
          value
          931
      title
      0 - fully active
    2. categories
      1. measurements
        1. group Id
          BG000
          value
          272
        2. group Id
          BG001
          value
          270
        3. group Id
          BG002
          value
          267
        4. group Id
          BG003
          value
          809
      title
      1 - restricted strenuous activity, ambulatory
    3. categories
      1. measurements
        1. group Id
          BG000
          value
          42
        2. group Id
          BG001
          value
          40
        3. group Id
          BG002
          value
          51
        4. group Id
          BG003
          value
          133
      title
      2 - ambulatory, difficulty walking
    4. categories
      1. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          0
        4. group Id
          BG003
          value
          0
      title
      3 - limited self-care, partly confined to bed
    5. categories
      1. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          0
        4. group Id
          BG003
          value
          0
      title
      4 - completely disabled, no self-care
    description
    5-point, ordinal scale specifying patient's ability to perform activities from 0(fully active) to 4(completely disabled, no self-care).
    param Type
    NUMBER
    title
    Gynecologic Oncology Group (GOG) Performance Status
    unit Of Measure
    participants
  6. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          0
        4. group Id
          BG003
          value
          0
      title
      1-limited to ovaries
    2. categories
      1. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          0
        4. group Id
          BG003
          value
          0
      title
      1A-1 ovary involved, no ascites
    3. categories
      1. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          0
        4. group Id
          BG003
          value
          0
      title
      1B-both ovaries involved, no ascites
    4. categories
      1. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          0
        4. group Id
          BG003
          value
          0
      title
      1C-disease with capsules ruptured or ascites
    5. categories
      1. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          0
        4. group Id
          BG003
          value
          0
      title
      2-disease with pelvic extension
    6. categories
      1. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          0
        4. group Id
          BG003
          value
          0
      title
      2A-disease with extension to uterus and or tubes
    7. categories
      1. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          0
        4. group Id
          BG003
          value
          0
      title
      2B-disease with extension to other pelvic tissues
    8. categories
      1. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          0
        4. group Id
          BG003
          value
          0
      title
      2C-disease with capsules ruptured or ascites
    9. categories
      1. measurements
        1. group Id
          BG000
          value
          218
        2. group Id
          BG001
          value
          205
        3. group Id
          BG002
          value
          216
        4. group Id
          BG003
          value
          639
      title
      3-disease w/ macroscopic implants outside pelvis
    10. categories
      1. measurements
        1. group Id
          BG000
          value
          254
        2. group Id
          BG001
          value
          256
        3. group Id
          BG002
          value
          242
        4. group Id
          BG003
          value
          752
      title
      3-disease w/ implants > 1 cm outside pelvis
    11. categories
      1. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          0
        4. group Id
          BG003
          value
          0
      title
      3A-disease w/ microscopic implants, negative nodes
    12. categories
      1. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          0
        4. group Id
          BG003
          value
          0
      title
      3B-disease w/ abdominal implants <2cm, neg nodes
    description
    Clinical staging for primary carcinoma of the ovary (1985) from Stage 1 (limited to ovaries) to Stage 4 (distant metastatis)
    param Type
    NUMBER
    title
    International Federation of Gynecologic and Obstetrics (FIGO) Stage
    unit Of Measure
    participants
  7. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          541
        2. group Id
          BG001
          value
          519
        3. group Id
          BG002
          value
          524
        4. group Id
          BG003
          value
          1584
      title
      Serous adenocarcinoma
    2. categories
      1. measurements
        1. group Id
          BG000
          value
          21
        2. group Id
          BG001
          value
          14
        3. group Id
          BG002
          value
          24
        4. group Id
          BG003
          value
          59
      title
      Endometrioid
    3. categories
      1. measurements
        1. group Id
          BG000
          value
          12
        2. group Id
          BG001
          value
          23
        3. group Id
          BG002
          value
          20
        4. group Id
          BG003
          value
          55
      title
      Clear cell
    4. categories
      1. measurements
        1. group Id
          BG000
          value
          6
        2. group Id
          BG001
          value
          5
        3. group Id
          BG002
          value
          8
        4. group Id
          BG003
          value
          19
      title
      Mucinous
    5. categories
      1. measurements
        1. group Id
          BG000
          value
          45
        2. group Id
          BG001
          value
          64
        3. group Id
          BG002
          value
          47
        4. group Id
          BG003
          value
          156
      title
      Other or not specified
    description
    Histologic(cell) type was obtained from the central GOG Pathology Committee review updated in September 2010.
    param Type
    NUMBER
    title
    Histologic Type
    unit Of Measure
    participants
  8. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          445
        2. group Id
          BG001
          value
          465
        3. group Id
          BG002
          value
          460
        4. group Id
          BG003
          value
          1370
      title
      3
    2. categories
      1. measurements
        1. group Id
          BG000
          value
          102
        2. group Id
          BG001
          value
          86
        3. group Id
          BG002
          value
          97
        4. group Id
          BG003
          value
          285
      title
      2
    3. categories
      1. measurements
        1. group Id
          BG000
          value
          36
        2. group Id
          BG001
          value
          28
        3. group Id
          BG002
          value
          18
        4. group Id
          BG003
          value
          82
      title
      1
    4. categories
      1. measurements
        1. group Id
          BG000
          value
          42
        2. group Id
          BG001
          value
          46
        3. group Id
          BG002
          value
          48
        4. group Id
          BG003
          value
          136
      title
      Not graded
    description
    Tumor grade was obtained from the central GOG Pathology Committee review updated in September 2010. All clear-cell tumors were classified as grade 3.
    param Type
    NUMBER
    title
    Tumor Grade
    unit Of Measure
    participants

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Preserved source evidence · Not medical advice