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NCT00248170 · OUTCOME

Change From Baseline in Serum Lipid Profiles

Comparison Trial of Letrozole to Anastrozole in the Adjuvant Treatment of Postmenopausal Women With Hormone Receptor and Node Positive Breast Cancer · Source last updated 2016-04-19

Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.

Measure
MEAN
Unit
mg/dL
Interval / dispersion
95% Confidence Interval
Time frame
baseline, 6, 12, 24, 36, 48 and 60 months

What was measured

Total cholesterol was analyzed to assess the impact on serum lipids profiles. The adjusted means was calculated.

Analysis population: Safety Set: The safety set included randomized participants who received at least one of study medication and had at least one post baseline assessment.

Groups in this outcome

Letrozole

2.5 mg by mouth (p.o.) once daily

Anastrozole

1 mg p.o. once daily

Group identifiers and denominators belong to this outcome only. They may differ in another outcome or in safety reporting.

Analysis denominator · Participants

GroupSource count
Letrozole2049
Anastrozole2062

Reported measurements

6 months
Values in mg/dL · Interval/dispersion: 95% Confidence Interval
GroupValueSpreadLowerUpperComment
Letrozole5.643Not reported5.5845.701Not reported
Anastrozole5.553Not reported5.4955.611Not reported
12 months
Values in mg/dL · Interval/dispersion: 95% Confidence Interval
GroupValueSpreadLowerUpperComment
Letrozole5.569Not reported5.5105.629Not reported
Anastrozole5.511Not reported5.4525.570Not reported
24 months
Values in mg/dL · Interval/dispersion: 95% Confidence Interval
GroupValueSpreadLowerUpperComment
Letrozole5.508Not reported5.4455.572Not reported
Anastrozole5.436Not reported5.3735.499Not reported
36 months
Values in mg/dL · Interval/dispersion: 95% Confidence Interval
GroupValueSpreadLowerUpperComment
Letrozole5.429Not reported5.3595.500Not reported
Anastrozole5.427Not reported5.3575.497Not reported
48 months
Values in mg/dL · Interval/dispersion: 95% Confidence Interval
GroupValueSpreadLowerUpperComment
Letrozole5.395Not reported5.3235.468Not reported
Anastrozole5.366Not reported5.2935.438Not reported
60 months
Values in mg/dL · Interval/dispersion: 95% Confidence Interval
GroupValueSpreadLowerUpperComment
Letrozole5.375Not reported5.3005.451Not reported
Anastrozole5.368Not reported5.2925.443Not reported
Complete source fields
classes
  1. categories
    1. measurements
      1. group Id
        OG000
        lower Limit
        5.584
        upper Limit
        5.701
        value
        5.643
      2. group Id
        OG001
        lower Limit
        5.495
        upper Limit
        5.611
        value
        5.553
    title
    6 months
  2. categories
    1. measurements
      1. group Id
        OG000
        lower Limit
        5.510
        upper Limit
        5.629
        value
        5.569
      2. group Id
        OG001
        lower Limit
        5.452
        upper Limit
        5.570
        value
        5.511
    title
    12 months
  3. categories
    1. measurements
      1. group Id
        OG000
        lower Limit
        5.445
        upper Limit
        5.572
        value
        5.508
      2. group Id
        OG001
        lower Limit
        5.373
        upper Limit
        5.499
        value
        5.436
    title
    24 months
  4. categories
    1. measurements
      1. group Id
        OG000
        lower Limit
        5.359
        upper Limit
        5.500
        value
        5.429
      2. group Id
        OG001
        lower Limit
        5.357
        upper Limit
        5.497
        value
        5.427
    title
    36 months
  5. categories
    1. measurements
      1. group Id
        OG000
        lower Limit
        5.323
        upper Limit
        5.468
        value
        5.395
      2. group Id
        OG001
        lower Limit
        5.293
        upper Limit
        5.438
        value
        5.366
    title
    48 months
  6. categories
    1. measurements
      1. group Id
        OG000
        lower Limit
        5.300
        upper Limit
        5.451
        value
        5.375
      2. group Id
        OG001
        lower Limit
        5.292
        upper Limit
        5.443
        value
        5.368
    title
    60 months
denoms
  1. counts
    1. group Id
      OG000
      value
      2049
    2. group Id
      OG001
      value
      2062
    units
    Participants
description
Total cholesterol was analyzed to assess the impact on serum lipids profiles. The adjusted means was calculated.
dispersion Type
95% Confidence Interval
groups
  1. description
    2.5 mg by mouth (p.o.) once daily
    id
    OG000
    title
    Letrozole
  2. description
    1 mg p.o. once daily
    id
    OG001
    title
    Anastrozole
param Type
MEAN
population Description
Safety Set: The safety set included randomized participants who received at least one of study medication and had at least one post baseline assessment.
reporting Status
POSTED
time Frame
baseline, 6, 12, 24, 36, 48 and 60 months
title
Change From Baseline in Serum Lipid Profiles
type
SECONDARY
unit Of Measure
mg/dL

Download exact source JSON → · Snapshot ctgov-results-191f4516d4760045304b24a0

Preserved source evidence · Not medical advice