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NCT00217737 · OUTCOME

The Impact of Tumor Biological Characteristics on Overall Survival

Oxaliplatin, Leucovorin, and Fluorouracil With or Without Bevacizumab in Treating Patients Who Have Undergone Surgery for Stage II Colon Cancer · Source last updated 2026-08-25

Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.

Measure
NUMBER
Unit
hazard ratio
Interval / dispersion
95% Confidence Interval
Time frame
Assessed at baseline, every 3 months for patients within 2 years of step 2 randomization, every 6 months during 3-5 years from step 2 randomization, and then every 12 months until 10 years from step 2 randomization

What was measured

Overall survival (OS) is defined as the time from randomization to death from any cause. OS is censored at the date of last contact for patients still alive. The following patient/tumor characteristics were associated with overall survival: * ECOG Performance Status (0, 1, or 2) * Age * Sex (male, female) * Primary tumor site (right-side colon, transverse colon, left-side colon, or other) * Number of regional lymph nodes Hazard ratios with adjustment for other covariates are reported with OS as the outcome variable.

Analysis population: Eligible patients who had advanced to step 2 (Arms A, B and C) and had complete data on patient/tumor characteristics are included.

Groups in this outcome

Tumor Biological Characteristics and Overall Survival Analysis

Eligible patients who had advanced to step 2 (Arms A, B and C) and had complete data on patient/tumor characteristics are included.

Group identifiers and denominators belong to this outcome only. They may differ in another outcome or in safety reporting.

Analysis denominator · Participants

GroupSource count
Tumor Biological Characteristics and Overall Survival Analysis1368

Reported measurements

Hazard ratio: ECOG performance status of 1 (vs. 0)
Values in hazard ratio · Interval/dispersion: 95% Confidence Interval
GroupValueSpreadLowerUpperComment
Tumor Biological Characteristics and Overall Survival Analysis1.67Not reported1.242.25Not reported
Hazard ratio: ECOG performance status of 2 (vs. 0)
Values in hazard ratio · Interval/dispersion: 95% Confidence Interval
GroupValueSpreadLowerUpperComment
Tumor Biological Characteristics and Overall Survival Analysis3.39Not reported1.368.44Not reported
Hazard ratio: Age
Values in hazard ratio · Interval/dispersion: 95% Confidence Interval
GroupValueSpreadLowerUpperComment
Tumor Biological Characteristics and Overall Survival Analysis1.05Not reported1.041.07Not reported
Hazard ratio: Sex of male (vs. female)
Values in hazard ratio · Interval/dispersion: 95% Confidence Interval
GroupValueSpreadLowerUpperComment
Tumor Biological Characteristics and Overall Survival Analysis1.71Not reported1.272.28Not reported
Hazard ratio: Primary site of transverse colon (vs. Right-side colon)
Values in hazard ratio · Interval/dispersion: 95% Confidence Interval
GroupValueSpreadLowerUpperComment
Tumor Biological Characteristics and Overall Survival Analysis0.81Not reported0.441.52Not reported
Hazard ratio: Primary site of left-side colon (vs. Right-side colon)
Values in hazard ratio · Interval/dispersion: 95% Confidence Interval
GroupValueSpreadLowerUpperComment
Tumor Biological Characteristics and Overall Survival Analysis1.13Not reported0.821.55Not reported
Hazard ratio: Primary site of other (vs. Right-side colon)
Values in hazard ratio · Interval/dispersion: 95% Confidence Interval
GroupValueSpreadLowerUpperComment
Tumor Biological Characteristics and Overall Survival Analysis2.68Not reported1.395.17Not reported
Hazard ratio: Number of lymph nodes
Values in hazard ratio · Interval/dispersion: 95% Confidence Interval
GroupValueSpreadLowerUpperComment
Tumor Biological Characteristics and Overall Survival Analysis0.98Not reported0.960.99Not reported
Complete source fields
classes
  1. categories
    1. measurements
      1. group Id
        OG000
        lower Limit
        1.24
        upper Limit
        2.25
        value
        1.67
    title
    Hazard ratio: ECOG performance status of 1 (vs. 0)
  2. categories
    1. measurements
      1. group Id
        OG000
        lower Limit
        1.36
        upper Limit
        8.44
        value
        3.39
    title
    Hazard ratio: ECOG performance status of 2 (vs. 0)
  3. categories
    1. measurements
      1. group Id
        OG000
        lower Limit
        1.04
        upper Limit
        1.07
        value
        1.05
    title
    Hazard ratio: Age
  4. categories
    1. measurements
      1. group Id
        OG000
        lower Limit
        1.27
        upper Limit
        2.28
        value
        1.71
    title
    Hazard ratio: Sex of male (vs. female)
  5. categories
    1. measurements
      1. group Id
        OG000
        lower Limit
        0.44
        upper Limit
        1.52
        value
        0.81
    title
    Hazard ratio: Primary site of transverse colon (vs. Right-side colon)
  6. categories
    1. measurements
      1. group Id
        OG000
        lower Limit
        0.82
        upper Limit
        1.55
        value
        1.13
    title
    Hazard ratio: Primary site of left-side colon (vs. Right-side colon)
  7. categories
    1. measurements
      1. group Id
        OG000
        lower Limit
        1.39
        upper Limit
        5.17
        value
        2.68
    title
    Hazard ratio: Primary site of other (vs. Right-side colon)
  8. categories
    1. measurements
      1. group Id
        OG000
        lower Limit
        0.96
        upper Limit
        0.99
        value
        0.98
    title
    Hazard ratio: Number of lymph nodes
denoms
  1. counts
    1. group Id
      OG000
      value
      1368
    units
    Participants
description
Overall survival (OS) is defined as the time from randomization to death from any cause. OS is censored at the date of last contact for patients still alive. The following patient/tumor characteristics were associated with overall survival: * ECOG Performance Status (0, 1, or 2) * Age * Sex (male, female) * Primary tumor site (right-side colon, transverse colon, left-side colon, or other) * Number of regional lymph nodes Hazard ratios with adjustment for other covariates are reported with OS as the outcome variable.
dispersion Type
95% Confidence Interval
groups
  1. description
    Eligible patients who had advanced to step 2 (Arms A, B and C) and had complete data on patient/tumor characteristics are included.
    id
    OG000
    title
    Tumor Biological Characteristics and Overall Survival Analysis
param Type
NUMBER
population Description
Eligible patients who had advanced to step 2 (Arms A, B and C) and had complete data on patient/tumor characteristics are included.
reporting Status
POSTED
time Frame
Assessed at baseline, every 3 months for patients within 2 years of step 2 randomization, every 6 months during 3-5 years from step 2 randomization, and then every 12 months until 10 years from step 2 randomization
title
The Impact of Tumor Biological Characteristics on Overall Survival
type
SECONDARY
unit Of Measure
hazard ratio

Download exact source JSON → · Snapshot ctgov-results-191f4516d4760045304b24a0

Preserved source evidence · Independent clinical review pending · Not medical advice