TriangleNCT00136084 · OUTCOME
Relationship of Inhibition of DNA Synthesis and Clinical Response
Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.
- Measure
- MEAN
- Unit
- Percent inhibition of DNA Synthesis
- Interval / dispersion
- Standard Error
- Time frame
- Measurements were assessed in Induction I chemotherapy
What was measured
Clinical response is defined as MRD (minimal residual disease) measured by flow cytometry at day 22. The MRD at day 22 is classified as positive (with MRD) or negative (no detectable MRD). The relation between inhibition of DNA synthesis and MRD was performed by logistic regression. In the model, logit of probability of MRD positive was regressed on inhibition of DNA synthesis.
Analysis population: Of 232 eligible patients, 49 had DNA synthesis rate performed prior to araC treatment. Of the 49 patients, 23 had no 24-hr samples and 3 did not have enough cells in 24-hr samples. 21 patients with both pre and post araC samples were included in the DNA inhibition study. 17 of the 21 patients had evaluable day 22 MRD.
Groups in this outcome
Overall
17 of the 232 eligible patients
| Group | Source count |
|---|---|
| Overall | 17 |
Reported measurements
Source class 1
| Group | Value | Spread | Lower | Upper | Comment |
|---|---|---|---|---|---|
| Overall | 66.7 | 12.6 | Not reported | Not reported | Not reported |
Source statistical analyses
- ci Lower Limit
- -0.0365
- ci Num Sides
- TWO_SIDED
- ci Pct Value
- 95
- ci Upper Limit
- 0.00873
- group Ids
- OG000
- non Inferiority Type
- SUPERIORITY_OR_OTHER
- p Value
- 0.2287
- param Type
- Odds Ratio, log
- param Value
- -0.0139
- statistical Method
- Regression, Logistic
- tested Non Inferiority
- false
Complete source fields
- analyses
- ci Lower Limit
- -0.0365
- ci Num Sides
- TWO_SIDED
- ci Pct Value
- 95
- ci Upper Limit
- 0.00873
- group Ids
- OG000
- non Inferiority Type
- SUPERIORITY_OR_OTHER
- p Value
- 0.2287
- param Type
- Odds Ratio, log
- param Value
- -0.0139
- statistical Method
- Regression, Logistic
- tested Non Inferiority
- false
- classes
- categories
- measurements
- group Id
- OG000
- spread
- 12.6
- value
- 66.7
- denoms
- counts
- group Id
- OG000
- value
- 17
- units
- Participants
- description
- Clinical response is defined as MRD (minimal residual disease) measured by flow cytometry at day 22. The MRD at day 22 is classified as positive (with MRD) or negative (no detectable MRD). The relation between inhibition of DNA synthesis and MRD was performed by logistic regression. In the model, logit of probability of MRD positive was regressed on inhibition of DNA synthesis.
- dispersion Type
- Standard Error
- groups
- description
- 17 of the 232 eligible patients
- id
- OG000
- title
- Overall
- param Type
- MEAN
- population Description
- Of 232 eligible patients, 49 had DNA synthesis rate performed prior to araC treatment. Of the 49 patients, 23 had no 24-hr samples and 3 did not have enough cells in 24-hr samples. 21 patients with both pre and post araC samples were included in the DNA inhibition study. 17 of the 21 patients had evaluable day 22 MRD.
- reporting Status
- POSTED
- time Frame
- Measurements were assessed in Induction I chemotherapy
- title
- Relationship of Inhibition of DNA Synthesis and Clinical Response
- type
- SECONDARY
- unit Of Measure
- Percent inhibition of DNA Synthesis
Download exact source JSON → · Snapshot ctgov-results-191f4516d4760045304b24a0
Preserved source evidence · Not medical advice