Participant flow

Comparison of Radiation Therapy Regimens in Combination With Chemotherapy in Treating Young Patients With Newly Diagnosed Standard-Risk Medulloblastoma · Source last updated 2026-06-09

Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.

groups

1. description

   Patients 3-7 years of age, LDCSI, IFRT

   id

   FG000

   title

   Arm I (3-7 Yrs of Age, LDCSI, IFRT)

2. description

   Patients 3-7 years of age, LDCSI, PFRT

   id

   FG001

   title

   Arm II (3-7 Yrs of Age, LDCSI, PFRT)

3. description

   Patients 3-7 years of age, SDCSI, IFRT

   id

   FG002

   title

   Arm III (3-7 Yrs of Age, SDCSI, IFRT)

4. description

   Patients 3-7 years of age, SDCSI, PFRT

   id

   FG003

   title

   Arm IV (3-7 Yrs of Age, SDCSI, PFRT)

5. description

   Patients 8-21 years of age, SDCSI, IFRT

   id

   FG004

   title

   Arm V (8-21 Yrs of Age, SDCSI, IFRT)

6. description

   Patients 8-21 yrs of age, SDCSI, PFRT

   id

   FG005

   title

   Arm VI (8-21 Yrs of Age, SDCSI, PFRT)

periods

1. drop Withdraws

   1. reasons

      1. group Id

         FG000

         num Subjects

         1

      2. group Id

         FG001

         num Subjects

         0

      3. group Id

         FG002

         num Subjects

         0

      4. group Id

         FG003

         num Subjects

         0

      5. group Id

         FG004

         num Subjects

         0

      6. group Id

         FG005

         num Subjects

         0

      type

      Adverse Event

   2. reasons

      1. group Id

         FG000

         num Subjects

         2

      2. group Id

         FG001

         num Subjects

         4

      3. group Id

         FG002

         num Subjects

         6

      4. group Id

         FG003

         num Subjects

         3

      5. group Id

         FG004

         num Subjects

         4

      6. group Id

         FG005

         num Subjects

         3

      type

      Lack of Efficacy

   3. reasons

      1. group Id

         FG000

         num Subjects

         0

      2. group Id

         FG001

         num Subjects

         1

      3. group Id

         FG002

         num Subjects

         0

      4. group Id

         FG003

         num Subjects

         0

      5. group Id

         FG004

         num Subjects

         1

      6. group Id

         FG005

         num Subjects

         0

      type

      Lost to Follow-up

   4. reasons

      1. group Id

         FG000

         num Subjects

         2

      2. group Id

         FG001

         num Subjects

         3

      3. group Id

         FG002

         num Subjects

         2

      4. group Id

         FG003

         num Subjects

         3

      5. group Id

         FG004

         num Subjects

         11

      6. group Id

         FG005

         num Subjects

         8

      type

      Physician Decision

   5. reasons

      1. group Id

         FG000

         num Subjects

         1

      2. group Id

         FG001

         num Subjects

         0

      3. group Id

         FG002

         num Subjects

         0

      4. group Id

         FG003

         num Subjects

         0

      5. group Id

         FG004

         num Subjects

         0

      6. group Id

         FG005

         num Subjects

         0

      type

      Protocol Violation

   6. reasons

      1. group Id

         FG000

         num Subjects

         1

      2. group Id

         FG001

         num Subjects

         0

      3. group Id

         FG002

         num Subjects

         4

      4. group Id

         FG003

         num Subjects

         5

      5. group Id

         FG004

         num Subjects

         7

      6. group Id

         FG005

         num Subjects

         8

      type

      Withdrawal by Subject

   7. reasons

      1. group Id

         FG000

         num Subjects

         1

      2. group Id

         FG001

         num Subjects

         0

      3. group Id

         FG002

         num Subjects

         3

      4. group Id

         FG003

         num Subjects

         7

      5. group Id

         FG004

         num Subjects

         17

      6. group Id

         FG005

         num Subjects

         8

      type

      Patient ineligible

   8. reasons

      1. group Id

         FG000

         num Subjects

         2

      2. group Id

         FG001

         num Subjects

         2

      3. group Id

         FG002

         num Subjects

         1

      4. group Id

         FG003

         num Subjects

         1

      5. group Id

         FG004

         num Subjects

         1

      6. group Id

         FG005

         num Subjects

         4

      type

      Excess residual disease

   9. reasons

      1. group Id

         FG000

         num Subjects

         1

      2. group Id

         FG001

         num Subjects

         0

      3. group Id

         FG002

         num Subjects

         1

      4. group Id

         FG003

         num Subjects

         0

      5. group Id

         FG004

         num Subjects

         1

      6. group Id

         FG005

         num Subjects

         0

      type

      Reason not documented

   10. reasons

       1. group Id

          FG000

          num Subjects

          1

       2. group Id

          FG001

          num Subjects

          0

       3. group Id

          FG002

          num Subjects

          0

       4. group Id

          FG003

          num Subjects

          0

       5. group Id

          FG004

          num Subjects

          0

       6. group Id

          FG005

          num Subjects

          0

       type

       Pt transferred to inst w/out study open

   milestones

   1. achievements

      1. group Id

         FG000

         num Subjects

         64

      2. group Id

         FG001

         num Subjects

         64

      3. group Id

         FG002

         num Subjects

         63

      4. group Id

         FG003

         num Subjects

         65

      5. group Id

         FG004

         num Subjects

         147

      6. group Id

         FG005

         num Subjects

         146

      type

      STARTED

   2. achievements

      1. group Id

         FG000

         num Subjects

         52

      2. group Id

         FG001

         num Subjects

         54

      3. group Id

         FG002

         num Subjects

         46

      4. group Id

         FG003

         num Subjects

         46

      5. group Id

         FG004

         num Subjects

         105

      6. group Id

         FG005

         num Subjects

         115

      type

      COMPLETED

   3. achievements

      1. group Id

         FG000

         num Subjects

         12

      2. group Id

         FG001

         num Subjects

         10

      3. group Id

         FG002

         num Subjects

         17

      4. group Id

         FG003

         num Subjects

         19

      5. group Id

         FG004

         num Subjects

         42

      6. group Id

         FG005

         num Subjects

         31

      type

      NOT COMPLETED

   title

   Overall Study

pre Assignment Details

Patients were randomized to receive a smaller volume boost (radiation to tumor bed)(IFRT) or standard volume boost (radiation to the entire posterior fossa) (PFRT).Patients 3-7 years of age were also randomized to receive reduced-dose craniospinal radiation (LDCSI) or standard-dose craniospinal radiation (SDCSI).Patients 8 and older received SDCSI.

recruitment Details

Participants 3-21 years of age were recruited at Children's Oncology Group institutions worldwide and at sites affiliated with the Dutch Childhood Oncology Group. The first patient was enrolled on April 30, 2004 and the last patient was enrolled on January 6, 2014.

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Preserved source evidence · Not medical advice