NCT00085202 · OUTCOME

Frequency of Mutations Associated With SHH and WNT Tumors

Treatment of Patients With Newly Diagnosed Medulloblastoma, Supratentorial Primitive Neuroectodermal Tumor, or Atypical Teratoid Rhabdoid Tumor · Source last updated 2024-02-08

Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.

Measure: COUNT_OF_PARTICIPANTS
Unit: Participants
Interval / dispersion: Not reported
Time frame: within 3.5 years following completion of accrual

What was measured

The frequency of mutations for the main genes associated with SHH and WNT tumors identified via targeted sequencing based on formalin fixed paraffin embedded material is provided.

Analysis population: Only patients with WNT and SHH tumors with available tissue for targeted sequencing were analyzed for frequency of mutation. WNT and SHH subgroups were identified by methylation profiling.

Groups in this outcome

SHH Pathway - In/Del Somatic

Tissue from this subgroup of patients was analyzed for somatic insertion/deletion (In/Del).

WNT Pathway - In/Del Somatic

Tissue from this subgroup of patients was analyzed for somatic insertion/deletion (In/Del).

SHH Pathway - In/Del Germline

Tissue from this subgroup of patients was analyzed for germline insertion/deletion (In/Del).

WNT Pathway - In/Del Germline

Tissue from this subgroup of patients was analyzed for germline insertion/deletion (In/Del).

SHH Pathway - SNV Somatic

Tissue from this subgroup of patients was analyzed for somatic single nucleotide variation (SNV).

WNT Pathway - SNV Somatic

Tissue from this subgroup of patients was analyzed for somatic single nucleotide variation (SNV).

SHH Pathway - SNV Germline

Tissue from this subgroup of patients was analyzed for germline single nucleotide variation (SNV).

WNT Pathway - SNV Germline

Tissue from this subgroup of patients was analyzed for germline single nucleotide variation (SNV).

Group identifiers and denominators belong to this outcome only. They may differ in another outcome or in safety reporting.

Analysis denominator · Participants

Group	Source count
SHH Pathway - In/Del Somatic	20
WNT Pathway - In/Del Somatic	18
SHH Pathway - In/Del Germline	20
WNT Pathway - In/Del Germline	18
SHH Pathway - SNV Somatic	20
WNT Pathway - SNV Somatic	18
SHH Pathway - SNV Germline	20
WNT Pathway - SNV Germline	18

Reported measurements

PTCH1

Values in Participants · Interval/dispersion: Not reported
Group	Value	Spread	Lower	Upper	Comment
SHH Pathway - In/Del Somatic	7	Not reported	Not reported	Not reported	Not reported
WNT Pathway - In/Del Somatic	0	Not reported	Not reported	Not reported	Not reported
SHH Pathway - In/Del Germline	0	Not reported	Not reported	Not reported	Not reported
WNT Pathway - In/Del Germline	0	Not reported	Not reported	Not reported	Not reported
SHH Pathway - SNV Somatic	4	Not reported	Not reported	Not reported	Not reported
WNT Pathway - SNV Somatic	0	Not reported	Not reported	Not reported	Not reported
SHH Pathway - SNV Germline	0	Not reported	Not reported	Not reported	Not reported
WNT Pathway - SNV Germline	0	Not reported	Not reported	Not reported	Not reported

DDX3X

Values in Participants · Interval/dispersion: Not reported
Group	Value	Spread	Lower	Upper	Comment
SHH Pathway - In/Del Somatic	0	Not reported	Not reported	Not reported	Not reported
WNT Pathway - In/Del Somatic	0	Not reported	Not reported	Not reported	Not reported
SHH Pathway - In/Del Germline	0	Not reported	Not reported	Not reported	Not reported
WNT Pathway - In/Del Germline	0	Not reported	Not reported	Not reported	Not reported
SHH Pathway - SNV Somatic	3	Not reported	Not reported	Not reported	Not reported
WNT Pathway - SNV Somatic	7	Not reported	Not reported	Not reported	Not reported
SHH Pathway - SNV Germline	0	Not reported	Not reported	Not reported	Not reported
WNT Pathway - SNV Germline	0	Not reported	Not reported	Not reported	Not reported

TP53

Values in Participants · Interval/dispersion: Not reported
Group	Value	Spread	Lower	Upper	Comment
SHH Pathway - In/Del Somatic	0	Not reported	Not reported	Not reported	Not reported
WNT Pathway - In/Del Somatic	0	Not reported	Not reported	Not reported	Not reported
SHH Pathway - In/Del Germline	0	Not reported	Not reported	Not reported	Not reported
WNT Pathway - In/Del Germline	0	Not reported	Not reported	Not reported	Not reported
SHH Pathway - SNV Somatic	5	Not reported	Not reported	Not reported	Not reported
WNT Pathway - SNV Somatic	3	Not reported	Not reported	Not reported	Not reported
SHH Pathway - SNV Germline	0	Not reported	Not reported	Not reported	Not reported
WNT Pathway - SNV Germline	0	Not reported	Not reported	Not reported	Not reported

KMT2D

Values in Participants · Interval/dispersion: Not reported
Group	Value	Spread	Lower	Upper	Comment
SHH Pathway - In/Del Somatic	2	Not reported	Not reported	Not reported	Not reported
WNT Pathway - In/Del Somatic	2	Not reported	Not reported	Not reported	Not reported
SHH Pathway - In/Del Germline	0	Not reported	Not reported	Not reported	Not reported
WNT Pathway - In/Del Germline	0	Not reported	Not reported	Not reported	Not reported
SHH Pathway - SNV Somatic	0	Not reported	Not reported	Not reported	Not reported
WNT Pathway - SNV Somatic	0	Not reported	Not reported	Not reported	Not reported
SHH Pathway - SNV Germline	0	Not reported	Not reported	Not reported	Not reported
WNT Pathway - SNV Germline	0	Not reported	Not reported	Not reported	Not reported

SUFU

Values in Participants · Interval/dispersion: Not reported
Group	Value	Spread	Lower	Upper	Comment
SHH Pathway - In/Del Somatic	2	Not reported	Not reported	Not reported	Not reported
WNT Pathway - In/Del Somatic	0	Not reported	Not reported	Not reported	Not reported
SHH Pathway - In/Del Germline	0	Not reported	Not reported	Not reported	Not reported
WNT Pathway - In/Del Germline	0	Not reported	Not reported	Not reported	Not reported
SHH Pathway - SNV Somatic	0	Not reported	Not reported	Not reported	Not reported
WNT Pathway - SNV Somatic	0	Not reported	Not reported	Not reported	Not reported
SHH Pathway - SNV Germline	0	Not reported	Not reported	Not reported	Not reported
WNT Pathway - SNV Germline	0	Not reported	Not reported	Not reported	Not reported

CREBBP

Values in Participants · Interval/dispersion: Not reported
Group	Value	Spread	Lower	Upper	Comment
SHH Pathway - In/Del Somatic	1	Not reported	Not reported	Not reported	Not reported
WNT Pathway - In/Del Somatic	2	Not reported	Not reported	Not reported	Not reported
SHH Pathway - In/Del Germline	0	Not reported	Not reported	Not reported	Not reported
WNT Pathway - In/Del Germline	0	Not reported	Not reported	Not reported	Not reported
SHH Pathway - SNV Somatic	0	Not reported	Not reported	Not reported	Not reported
WNT Pathway - SNV Somatic	1	Not reported	Not reported	Not reported	Not reported
SHH Pathway - SNV Germline	0	Not reported	Not reported	Not reported	Not reported
WNT Pathway - SNV Germline	0	Not reported	Not reported	Not reported	Not reported

GLI2

Values in Participants · Interval/dispersion: Not reported
Group	Value	Spread	Lower	Upper	Comment
SHH Pathway - In/Del Somatic	0	Not reported	Not reported	Not reported	Not reported
WNT Pathway - In/Del Somatic	0	Not reported	Not reported	Not reported	Not reported
SHH Pathway - In/Del Germline	0	Not reported	Not reported	Not reported	Not reported
WNT Pathway - In/Del Germline	0	Not reported	Not reported	Not reported	Not reported
SHH Pathway - SNV Somatic	0	Not reported	Not reported	Not reported	Not reported
WNT Pathway - SNV Somatic	1	Not reported	Not reported	Not reported	Not reported
SHH Pathway - SNV Germline	0	Not reported	Not reported	Not reported	Not reported
WNT Pathway - SNV Germline	0	Not reported	Not reported	Not reported	Not reported

TCF4

Values in Participants · Interval/dispersion: Not reported
Group	Value	Spread	Lower	Upper	Comment
SHH Pathway - In/Del Somatic	0	Not reported	Not reported	Not reported	Not reported
WNT Pathway - In/Del Somatic	0	Not reported	Not reported	Not reported	Not reported
SHH Pathway - In/Del Germline	0	Not reported	Not reported	Not reported	Not reported
WNT Pathway - In/Del Germline	0	Not reported	Not reported	Not reported	Not reported
SHH Pathway - SNV Somatic	1	Not reported	Not reported	Not reported	Not reported
WNT Pathway - SNV Somatic	0	Not reported	Not reported	Not reported	Not reported
SHH Pathway - SNV Germline	0	Not reported	Not reported	Not reported	Not reported
WNT Pathway - SNV Germline	0	Not reported	Not reported	Not reported	Not reported

PTEN

Values in Participants · Interval/dispersion: Not reported
Group	Value	Spread	Lower	Upper	Comment
SHH Pathway - In/Del Somatic	0	Not reported	Not reported	Not reported	Not reported
WNT Pathway - In/Del Somatic	0	Not reported	Not reported	Not reported	Not reported
SHH Pathway - In/Del Germline	0	Not reported	Not reported	Not reported	Not reported
WNT Pathway - In/Del Germline	0	Not reported	Not reported	Not reported	Not reported
SHH Pathway - SNV Somatic	3	Not reported	Not reported	Not reported	Not reported
WNT Pathway - SNV Somatic	0	Not reported	Not reported	Not reported	Not reported
SHH Pathway - SNV Germline	0	Not reported	Not reported	Not reported	Not reported
WNT Pathway - SNV Germline	0	Not reported	Not reported	Not reported	Not reported

KMT2C

Values in Participants · Interval/dispersion: Not reported
Group	Value	Spread	Lower	Upper	Comment
SHH Pathway - In/Del Somatic	0	Not reported	Not reported	Not reported	Not reported
WNT Pathway - In/Del Somatic	1	Not reported	Not reported	Not reported	Not reported
SHH Pathway - In/Del Germline	0	Not reported	Not reported	Not reported	Not reported
WNT Pathway - In/Del Germline	0	Not reported	Not reported	Not reported	Not reported
SHH Pathway - SNV Somatic	2	Not reported	Not reported	Not reported	Not reported
WNT Pathway - SNV Somatic	1	Not reported	Not reported	Not reported	Not reported
SHH Pathway - SNV Germline	0	Not reported	Not reported	Not reported	Not reported
WNT Pathway - SNV Germline	0	Not reported	Not reported	Not reported	Not reported

FBXW7

Values in Participants · Interval/dispersion: Not reported
Group	Value	Spread	Lower	Upper	Comment
SHH Pathway - In/Del Somatic	0	Not reported	Not reported	Not reported	Not reported
WNT Pathway - In/Del Somatic	0	Not reported	Not reported	Not reported	Not reported
SHH Pathway - In/Del Germline	0	Not reported	Not reported	Not reported	Not reported
WNT Pathway - In/Del Germline	0	Not reported	Not reported	Not reported	Not reported
SHH Pathway - SNV Somatic	1	Not reported	Not reported	Not reported	Not reported
WNT Pathway - SNV Somatic	4	Not reported	Not reported	Not reported	Not reported
SHH Pathway - SNV Germline	0	Not reported	Not reported	Not reported	Not reported
WNT Pathway - SNV Germline	0	Not reported	Not reported	Not reported	Not reported

GSE1

Values in Participants · Interval/dispersion: Not reported
Group	Value	Spread	Lower	Upper	Comment
SHH Pathway - In/Del Somatic	3	Not reported	Not reported	Not reported	Not reported
WNT Pathway - In/Del Somatic	0	Not reported	Not reported	Not reported	Not reported
SHH Pathway - In/Del Germline	0	Not reported	Not reported	Not reported	Not reported
WNT Pathway - In/Del Germline	0	Not reported	Not reported	Not reported	Not reported
SHH Pathway - SNV Somatic	0	Not reported	Not reported	Not reported	Not reported
WNT Pathway - SNV Somatic	0	Not reported	Not reported	Not reported	Not reported
SHH Pathway - SNV Germline	0	Not reported	Not reported	Not reported	Not reported
WNT Pathway - SNV Germline	0	Not reported	Not reported	Not reported	Not reported

CTNNB1

Values in Participants · Interval/dispersion: Not reported
Group	Value	Spread	Lower	Upper	Comment
SHH Pathway - In/Del Somatic	0	Not reported	Not reported	Not reported	Not reported
WNT Pathway - In/Del Somatic	0	Not reported	Not reported	Not reported	Not reported
SHH Pathway - In/Del Germline	0	Not reported	Not reported	Not reported	Not reported
WNT Pathway - In/Del Germline	0	Not reported	Not reported	Not reported	Not reported
SHH Pathway - SNV Somatic	1	Not reported	Not reported	Not reported	Not reported
WNT Pathway - SNV Somatic	18	Not reported	Not reported	Not reported	Not reported
SHH Pathway - SNV Germline	0	Not reported	Not reported	Not reported	Not reported
WNT Pathway - SNV Germline	0	Not reported	Not reported	Not reported	Not reported

SMARCA4

Values in Participants · Interval/dispersion: Not reported
Group	Value	Spread	Lower	Upper	Comment
SHH Pathway - In/Del Somatic	0	Not reported	Not reported	Not reported	Not reported
WNT Pathway - In/Del Somatic	0	Not reported	Not reported	Not reported	Not reported
SHH Pathway - In/Del Germline	0	Not reported	Not reported	Not reported	Not reported
WNT Pathway - In/Del Germline	0	Not reported	Not reported	Not reported	Not reported
SHH Pathway - SNV Somatic	0	Not reported	Not reported	Not reported	Not reported
WNT Pathway - SNV Somatic	4	Not reported	Not reported	Not reported	Not reported
SHH Pathway - SNV Germline	0	Not reported	Not reported	Not reported	Not reported
WNT Pathway - SNV Germline	0	Not reported	Not reported	Not reported	Not reported

PIK3CA

Values in Participants · Interval/dispersion: Not reported
Group	Value	Spread	Lower	Upper	Comment
SHH Pathway - In/Del Somatic	0	Not reported	Not reported	Not reported	Not reported
WNT Pathway - In/Del Somatic	0	Not reported	Not reported	Not reported	Not reported
SHH Pathway - In/Del Germline	0	Not reported	Not reported	Not reported	Not reported
WNT Pathway - In/Del Germline	0	Not reported	Not reported	Not reported	Not reported
SHH Pathway - SNV Somatic	2	Not reported	Not reported	Not reported	Not reported
WNT Pathway - SNV Somatic	1	Not reported	Not reported	Not reported	Not reported
SHH Pathway - SNV Germline	0	Not reported	Not reported	Not reported	Not reported
WNT Pathway - SNV Germline	0	Not reported	Not reported	Not reported	Not reported

APC

Values in Participants · Interval/dispersion: Not reported
Group	Value	Spread	Lower	Upper	Comment
SHH Pathway - In/Del Somatic	0	Not reported	Not reported	Not reported	Not reported
WNT Pathway - In/Del Somatic	0	Not reported	Not reported	Not reported	Not reported
SHH Pathway - In/Del Germline	0	Not reported	Not reported	Not reported	Not reported
WNT Pathway - In/Del Germline	0	Not reported	Not reported	Not reported	Not reported
SHH Pathway - SNV Somatic	0	Not reported	Not reported	Not reported	Not reported
WNT Pathway - SNV Somatic	0	Not reported	Not reported	Not reported	Not reported
SHH Pathway - SNV Germline	0	Not reported	Not reported	Not reported	Not reported
WNT Pathway - SNV Germline	1	Not reported	Not reported	Not reported	Not reported

EPHA7

Values in Participants · Interval/dispersion: Not reported
Group	Value	Spread	Lower	Upper	Comment
SHH Pathway - In/Del Somatic	0	Not reported	Not reported	Not reported	Not reported
WNT Pathway - In/Del Somatic	1	Not reported	Not reported	Not reported	Not reported
SHH Pathway - In/Del Germline	0	Not reported	Not reported	Not reported	Not reported
WNT Pathway - In/Del Germline	0	Not reported	Not reported	Not reported	Not reported
SHH Pathway - SNV Somatic	0	Not reported	Not reported	Not reported	Not reported
WNT Pathway - SNV Somatic	0	Not reported	Not reported	Not reported	Not reported
SHH Pathway - SNV Germline	0	Not reported	Not reported	Not reported	Not reported
WNT Pathway - SNV Germline	0	Not reported	Not reported	Not reported	Not reported

ARID1A

Values in Participants · Interval/dispersion: Not reported
Group	Value	Spread	Lower	Upper	Comment
SHH Pathway - In/Del Somatic	0	Not reported	Not reported	Not reported	Not reported
WNT Pathway - In/Del Somatic	1	Not reported	Not reported	Not reported	Not reported
SHH Pathway - In/Del Germline	0	Not reported	Not reported	Not reported	Not reported
WNT Pathway - In/Del Germline	0	Not reported	Not reported	Not reported	Not reported
SHH Pathway - SNV Somatic	1	Not reported	Not reported	Not reported	Not reported
WNT Pathway - SNV Somatic	0	Not reported	Not reported	Not reported	Not reported
SHH Pathway - SNV Germline	0	Not reported	Not reported	Not reported	Not reported
WNT Pathway - SNV Germline	0	Not reported	Not reported	Not reported	Not reported

ARID2

Values in Participants · Interval/dispersion: Not reported
Group	Value	Spread	Lower	Upper	Comment
SHH Pathway - In/Del Somatic	0	Not reported	Not reported	Not reported	Not reported
WNT Pathway - In/Del Somatic	0	Not reported	Not reported	Not reported	Not reported
SHH Pathway - In/Del Germline	0	Not reported	Not reported	Not reported	Not reported
WNT Pathway - In/Del Germline	0	Not reported	Not reported	Not reported	Not reported
SHH Pathway - SNV Somatic	0	Not reported	Not reported	Not reported	Not reported
WNT Pathway - SNV Somatic	1	Not reported	Not reported	Not reported	Not reported
SHH Pathway - SNV Germline	0	Not reported	Not reported	Not reported	Not reported
WNT Pathway - SNV Germline	0	Not reported	Not reported	Not reported	Not reported

ATM

Values in Participants · Interval/dispersion: Not reported
Group	Value	Spread	Lower	Upper	Comment
SHH Pathway - In/Del Somatic	0	Not reported	Not reported	Not reported	Not reported
WNT Pathway - In/Del Somatic	0	Not reported	Not reported	Not reported	Not reported
SHH Pathway - In/Del Germline	0	Not reported	Not reported	Not reported	Not reported
WNT Pathway - In/Del Germline	0	Not reported	Not reported	Not reported	Not reported
SHH Pathway - SNV Somatic	1	Not reported	Not reported	Not reported	Not reported
WNT Pathway - SNV Somatic	0	Not reported	Not reported	Not reported	Not reported
SHH Pathway - SNV Germline	0	Not reported	Not reported	Not reported	Not reported
WNT Pathway - SNV Germline	0	Not reported	Not reported	Not reported	Not reported

BRCA2

Values in Participants · Interval/dispersion: Not reported
Group	Value	Spread	Lower	Upper	Comment
SHH Pathway - In/Del Somatic	0	Not reported	Not reported	Not reported	Not reported
WNT Pathway - In/Del Somatic	0	Not reported	Not reported	Not reported	Not reported
SHH Pathway - In/Del Germline	1	Not reported	Not reported	Not reported	Not reported
WNT Pathway - In/Del Germline	0	Not reported	Not reported	Not reported	Not reported
SHH Pathway - SNV Somatic	0	Not reported	Not reported	Not reported	Not reported
WNT Pathway - SNV Somatic	0	Not reported	Not reported	Not reported	Not reported
SHH Pathway - SNV Germline	0	Not reported	Not reported	Not reported	Not reported
WNT Pathway - SNV Germline	0	Not reported	Not reported	Not reported	Not reported

Complete source fields

calculate Pct

false

classes

categories
measurements
group Id
OG000
value
7
group Id
OG001
value
0
group Id
OG002
value
0
group Id
OG003
value
0
group Id
OG004
value
4
group Id
OG005
value
0
group Id
OG006
value
0
group Id
OG007
value
0
title
PTCH1
categories
measurements
group Id
OG000
value
0
group Id
OG001
value
0
group Id
OG002
value
0
group Id
OG003
value
0
group Id
OG004
value
3
group Id
OG005
value
7
group Id
OG006
value
0
group Id
OG007
value
0
title
DDX3X
categories
measurements
group Id
OG000
value
0
group Id
OG001
value
0
group Id
OG002
value
0
group Id
OG003
value
0
group Id
OG004
value
5
group Id
OG005
value
3
group Id
OG006
value
0
group Id
OG007
value
0
title
TP53
categories
measurements
group Id
OG000
value
2
group Id
OG001
value
2
group Id
OG002
value
0
group Id
OG003
value
0
group Id
OG004
value
0
group Id
OG005
value
0
group Id
OG006
value
0
group Id
OG007
value
0
title
KMT2D
categories
measurements
group Id
OG000
value
2
group Id
OG001
value
0
group Id
OG002
value
0
group Id
OG003
value
0
group Id
OG004
value
0
group Id
OG005
value
0
group Id
OG006
value
0
group Id
OG007
value
0
title
SUFU
categories
measurements
group Id
OG000
value
1
group Id
OG001
value
2
group Id
OG002
value
0
group Id
OG003
value
0
group Id
OG004
value
0
group Id
OG005
value
1
group Id
OG006
value
0
group Id
OG007
value
0
title
CREBBP
categories
measurements
group Id
OG000
value
0
group Id
OG001
value
0
group Id
OG002
value
0
group Id
OG003
value
0
group Id
OG004
value
0
group Id
OG005
value
1
group Id
OG006
value
0
group Id
OG007
value
0
title
GLI2
categories
measurements
group Id
OG000
value
0
group Id
OG001
value
0
group Id
OG002
value
0
group Id
OG003
value
0
group Id
OG004
value
1
group Id
OG005
value
0
group Id
OG006
value
0
group Id
OG007
value
0
title
TCF4
categories
measurements
group Id
OG000
value
0
group Id
OG001
value
0
group Id
OG002
value
0
group Id
OG003
value
0
group Id
OG004
value
3
group Id
OG005
value
0
group Id
OG006
value
0
group Id
OG007
value
0
title
PTEN
categories
measurements
group Id
OG000
value
0
group Id
OG001
value
1
group Id
OG002
value
0
group Id
OG003
value
0
group Id
OG004
value
2
group Id
OG005
value
1
group Id
OG006
value
0
group Id
OG007
value
0
title
KMT2C
categories
measurements
group Id
OG000
value
0
group Id
OG001
value
0
group Id
OG002
value
0
group Id
OG003
value
0
group Id
OG004
value
1
group Id
OG005
value
4
group Id
OG006
value
0
group Id
OG007
value
0
title
FBXW7
categories
measurements
group Id
OG000
value
3
group Id
OG001
value
0
group Id
OG002
value
0
group Id
OG003
value
0
group Id
OG004
value
0
group Id
OG005
value
0
group Id
OG006
value
0
group Id
OG007
value
0
title
GSE1

denoms

counts
group Id
OG000
value
20
group Id
OG001
value
18
group Id
OG002
value
20
group Id
OG003
value
18
group Id
OG004
value
20
group Id
OG005
value
18
group Id
OG006
value
20
group Id
OG007
value
18
units
Participants

description

The frequency of mutations for the main genes associated with SHH and WNT tumors identified via targeted sequencing based on formalin fixed paraffin embedded material is provided.

groups

description
Tissue from this subgroup of patients was analyzed for somatic insertion/deletion (In/Del).
id
OG000
title
SHH Pathway - In/Del Somatic
description
Tissue from this subgroup of patients was analyzed for somatic insertion/deletion (In/Del).
id
OG001
title
WNT Pathway - In/Del Somatic
description
Tissue from this subgroup of patients was analyzed for germline insertion/deletion (In/Del).
id
OG002
title
SHH Pathway - In/Del Germline
description
Tissue from this subgroup of patients was analyzed for germline insertion/deletion (In/Del).
id
OG003
title
WNT Pathway - In/Del Germline
description
Tissue from this subgroup of patients was analyzed for somatic single nucleotide variation (SNV).
id
OG004
title
SHH Pathway - SNV Somatic
description
Tissue from this subgroup of patients was analyzed for somatic single nucleotide variation (SNV).
id
OG005
title
WNT Pathway - SNV Somatic
description
Tissue from this subgroup of patients was analyzed for germline single nucleotide variation (SNV).
id
OG006
title
SHH Pathway - SNV Germline
description
Tissue from this subgroup of patients was analyzed for germline single nucleotide variation (SNV).
id
OG007
title
WNT Pathway - SNV Germline

param Type

COUNT_OF_PARTICIPANTS

population Description

Only patients with WNT and SHH tumors with available tissue for targeted sequencing were analyzed for frequency of mutation. WNT and SHH subgroups were identified by methylation profiling.

reporting Status

POSTED

time Frame

within 3.5 years following completion of accrual

title

Frequency of Mutations Associated With SHH and WNT Tumors

type

PRIMARY

unit Of Measure

Participants

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Preserved source evidence · Not medical advice