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NCT00006436 · OUTCOME

Number of Participants With ≥ Grades 3-5 Non-hematologic Toxicity

EPOCH and Rituximab to Treat Non-Hodgkin's Lymphoma in Patients With HIV Infection · Source last updated 2026-08-03

Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.

Measure
COUNT_OF_PARTICIPANTS
Unit
Participants
Interval / dispersion
Not reported
Time frame
Date treatment consent signed to date off study, approximately 209 months and 17 days.

What was measured

Non-hematologic (i.e., not begin in bone marrow or blood) toxicity was assessed by the Common Toxicity Criteria (CTC v2.0). Grade 3 is severe. Grade 4 is life-threatening. Grade 5 is death related to adverse event.

Analysis population: One participant declined to participate before treatment started.

Groups in this outcome

Grade 3

Grade 3 is serious.

Grade 4

Grade 4 is life threatening.

Grade 5

Grade 5 is death related to adverse event.

Group identifiers and denominators belong to this outcome only. They may differ in another outcome or in safety reporting.

Analysis denominator · Participants

GroupSource count
Grade 367
Grade 467
Grade 567

Reported measurements

Serious infection
Values in Participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
Grade 317Not reportedNot reportedNot reportedNot reported
Grade 40Not reportedNot reportedNot reportedNot reported
Grade 50Not reportedNot reportedNot reportedNot reported
Neurologic event
Values in Participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
Grade 30Not reportedNot reportedNot reportedNot reported
Grade 40Not reportedNot reportedNot reportedNot reported
Grade 50Not reportedNot reportedNot reportedNot reported
Syncope
Values in Participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
Grade 31Not reportedNot reportedNot reportedNot reported
Grade 40Not reportedNot reportedNot reportedNot reported
Grade 50Not reportedNot reportedNot reportedNot reported
Confusion
Values in Participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
Grade 31Not reportedNot reportedNot reportedNot reported
Grade 40Not reportedNot reportedNot reportedNot reported
Grade 50Not reportedNot reportedNot reportedNot reported
Motor neuropathy
Values in Participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
Grade 30Not reportedNot reportedNot reportedNot reported
Grade 41Not reportedNot reportedNot reportedNot reported
Grade 50Not reportedNot reportedNot reportedNot reported
Vision disturbance
Values in Participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
Grade 31Not reportedNot reportedNot reportedNot reported
Grade 40Not reportedNot reportedNot reportedNot reported
Grade 50Not reportedNot reportedNot reportedNot reported
Hyperglycemia
Values in Participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
Grade 34Not reportedNot reportedNot reportedNot reported
Grade 40Not reportedNot reportedNot reportedNot reported
Grade 50Not reportedNot reportedNot reportedNot reported
Hypophosphatemia
Values in Participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
Grade 32Not reportedNot reportedNot reportedNot reported
Grade 41Not reportedNot reportedNot reportedNot reported
Grade 50Not reportedNot reportedNot reportedNot reported
Hypocalcemia
Values in Participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
Grade 32Not reportedNot reportedNot reportedNot reported
Grade 40Not reportedNot reportedNot reportedNot reported
Grade 50Not reportedNot reportedNot reportedNot reported
Hypokalemia
Values in Participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
Grade 31Not reportedNot reportedNot reportedNot reported
Grade 41Not reportedNot reportedNot reportedNot reported
Grade 50Not reportedNot reportedNot reportedNot reported
Hyponatremia
Values in Participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
Grade 31Not reportedNot reportedNot reportedNot reported
Grade 40Not reportedNot reportedNot reportedNot reported
Grade 50Not reportedNot reportedNot reportedNot reported
Dehydration
Values in Participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
Grade 31Not reportedNot reportedNot reportedNot reported
Grade 40Not reportedNot reportedNot reportedNot reported
Grade 50Not reportedNot reportedNot reportedNot reported
Mucositis/Stomatitis
Values in Participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
Grade 36Not reportedNot reportedNot reportedNot reported
Grade 40Not reportedNot reportedNot reportedNot reported
Grade 50Not reportedNot reportedNot reportedNot reported
Liver test abnormalities
Values in Participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
Grade 36Not reportedNot reportedNot reportedNot reported
Grade 41Not reportedNot reportedNot reportedNot reported
Grade 50Not reportedNot reportedNot reportedNot reported
Pancreatitis
Values in Participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
Grade 31Not reportedNot reportedNot reportedNot reported
Grade 40Not reportedNot reportedNot reportedNot reported
Grade 50Not reportedNot reportedNot reportedNot reported
Diarrhea
Values in Participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
Grade 32Not reportedNot reportedNot reportedNot reported
Grade 40Not reportedNot reportedNot reportedNot reported
Grade 50Not reportedNot reportedNot reportedNot reported
Constipation
Values in Participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
Grade 31Not reportedNot reportedNot reportedNot reported
Grade 40Not reportedNot reportedNot reportedNot reported
Grade 50Not reportedNot reportedNot reportedNot reported
Serious hemorrhage
Values in Participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
Grade 35Not reportedNot reportedNot reportedNot reported
Grade 41Not reportedNot reportedNot reportedNot reported
Grade 50Not reportedNot reportedNot reportedNot reported
Fatigue
Values in Participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
Grade 32Not reportedNot reportedNot reportedNot reported
Grade 40Not reportedNot reportedNot reportedNot reported
Grade 50Not reportedNot reportedNot reportedNot reported
Headache
Values in Participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
Grade 35Not reportedNot reportedNot reportedNot reported
Grade 40Not reportedNot reportedNot reportedNot reported
Grade 50Not reportedNot reportedNot reportedNot reported
Bone pain
Values in Participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
Grade 31Not reportedNot reportedNot reportedNot reported
Grade 40Not reportedNot reportedNot reportedNot reported
Grade 50Not reportedNot reportedNot reportedNot reported
Nausea
Values in Participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
Grade 30Not reportedNot reportedNot reportedNot reported
Grade 41Not reportedNot reportedNot reportedNot reported
Grade 50Not reportedNot reportedNot reportedNot reported
Anorexia
Values in Participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
Grade 30Not reportedNot reportedNot reportedNot reported
Grade 41Not reportedNot reportedNot reportedNot reported
Grade 50Not reportedNot reportedNot reportedNot reported
Hypoxia
Values in Participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
Grade 30Not reportedNot reportedNot reportedNot reported
Grade 44Not reportedNot reportedNot reportedNot reported
Grade 51Not reportedNot reportedNot reportedNot reported
Myelodysplastic syndrome
Values in Participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
Grade 30Not reportedNot reportedNot reportedNot reported
Grade 40Not reportedNot reportedNot reportedNot reported
Grade 51Not reportedNot reportedNot reportedNot reported
Complete source fields
classes
  1. categories
    1. measurements
      1. group Id
        OG000
        value
        17
      2. group Id
        OG001
        value
        0
      3. group Id
        OG002
        value
        0
    title
    Serious infection
  2. categories
    1. measurements
      1. group Id
        OG000
        value
        0
      2. group Id
        OG001
        value
        0
      3. group Id
        OG002
        value
        0
    title
    Neurologic event
  3. categories
    1. measurements
      1. group Id
        OG000
        value
        1
      2. group Id
        OG001
        value
        0
      3. group Id
        OG002
        value
        0
    title
    Syncope
  4. categories
    1. measurements
      1. group Id
        OG000
        value
        1
      2. group Id
        OG001
        value
        0
      3. group Id
        OG002
        value
        0
    title
    Confusion
  5. categories
    1. measurements
      1. group Id
        OG000
        value
        0
      2. group Id
        OG001
        value
        1
      3. group Id
        OG002
        value
        0
    title
    Motor neuropathy
  6. categories
    1. measurements
      1. group Id
        OG000
        value
        1
      2. group Id
        OG001
        value
        0
      3. group Id
        OG002
        value
        0
    title
    Vision disturbance
  7. categories
    1. measurements
      1. group Id
        OG000
        value
        4
      2. group Id
        OG001
        value
        0
      3. group Id
        OG002
        value
        0
    title
    Hyperglycemia
  8. categories
    1. measurements
      1. group Id
        OG000
        value
        2
      2. group Id
        OG001
        value
        1
      3. group Id
        OG002
        value
        0
    title
    Hypophosphatemia
  9. categories
    1. measurements
      1. group Id
        OG000
        value
        2
      2. group Id
        OG001
        value
        0
      3. group Id
        OG002
        value
        0
    title
    Hypocalcemia
  10. categories
    1. measurements
      1. group Id
        OG000
        value
        1
      2. group Id
        OG001
        value
        1
      3. group Id
        OG002
        value
        0
    title
    Hypokalemia
  11. categories
    1. measurements
      1. group Id
        OG000
        value
        1
      2. group Id
        OG001
        value
        0
      3. group Id
        OG002
        value
        0
    title
    Hyponatremia
  12. categories
    1. measurements
      1. group Id
        OG000
        value
        1
      2. group Id
        OG001
        value
        0
      3. group Id
        OG002
        value
        0
    title
    Dehydration
denoms
  1. counts
    1. group Id
      OG000
      value
      67
    2. group Id
      OG001
      value
      67
    3. group Id
      OG002
      value
      67
    units
    Participants
description
Non-hematologic (i.e., not begin in bone marrow or blood) toxicity was assessed by the Common Toxicity Criteria (CTC v2.0). Grade 3 is severe. Grade 4 is life-threatening. Grade 5 is death related to adverse event.
groups
  1. description
    Grade 3 is serious.
    id
    OG000
    title
    Grade 3
  2. description
    Grade 4 is life threatening.
    id
    OG001
    title
    Grade 4
  3. description
    Grade 5 is death related to adverse event.
    id
    OG002
    title
    Grade 5
param Type
COUNT_OF_PARTICIPANTS
population Description
One participant declined to participate before treatment started.
reporting Status
POSTED
time Frame
Date treatment consent signed to date off study, approximately 209 months and 17 days.
title
Number of Participants With ≥ Grades 3-5 Non-hematologic Toxicity
type
SECONDARY
unit Of Measure
Participants

Download exact source JSON → · Snapshot ctgov-results-25a395029948b04d52b1253f

Preserved source evidence · Not medical advice