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NCT00001277 · OUTCOME

Type of Hyperparathyroidism

Studies of Elevated Parathyroid Activity · Source last updated 2022-06-07

Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.

Measure
COUNT_OF_PARTICIPANTS
Unit
Participants
Interval / dispersion
Not reported
Time frame
First year

What was measured

The purpose of this study is to understand the causes of primary hyperparathyroidism, to evaluate and improve methods for diagnosis and treatment, and to provide insight into the mechanisms of normal parathyroid function. Hereditary causes of primary hyperparathyroidism will be characterized. Patients were categorized as follows: 1. MEN1: Diagnosed by demonstration of a germline variant in MEN1 gene or one of the following: a) two of three primary MEN1 manifestations b) one primary MEN1 manifestation with a family member with MEN1. 2. Other familial: Non-MEN1 patients who had a positive family history of hyperparathyroidism suspicious for underlying germline predisposition syndrome. 3. Sporadic: Patients who did not have a positive family history of hyperparathyroidism. 4. Unknown: No data to help categorize the patients in any of the above categories.

Groups in this outcome

Primary Hyperparathyroidism - Incomplete Data

Patients with confirmed or suspected primary hyperparathyroidism or complications who are missing age and other baseline data because of changes in data management system

Primary Hyperparathyroidism

Patients with confirmed or suspected primary hyperparathyroidism or complications

DOTATATE and F-DOPA

Patients scanned using imaging agents 68GALLIUM-DOTATATE and 18F-DOPA 68Ga-Dotatate: 68Ga-Dotatate PET/CT will be administered prior to a PET/CT scan to detect known and occult primary and metastatic bronchial, gastrointestinal and pancreatic neuroendocrine tumors. 18F-DOPA: 18F-DOPA PET/CT will be administered prior to a whole-body scan to detect known and occult primary and metastatic bronchial, gastrointestinal and pancreatic neuroendocrine tumors.

Group identifiers and denominators belong to this outcome only. They may differ in another outcome or in safety reporting.

Analysis denominator · Participants

GroupSource count
Primary Hyperparathyroidism - Incomplete Data634
Primary Hyperparathyroidism900
DOTATATE and F-DOPA19

Reported measurements

Source class 1

MEN1

Values in Participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
Primary Hyperparathyroidism - Incomplete Data90Not reportedNot reportedNot reportedNot reported
Primary Hyperparathyroidism276Not reportedNot reportedNot reportedNot reported
DOTATATE and F-DOPA19Not reportedNot reportedNot reportedNot reported

Other familial

Values in Participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
Primary Hyperparathyroidism - Incomplete Data61Not reportedNot reportedNot reportedNot reported
Primary Hyperparathyroidism116Not reportedNot reportedNot reportedNot reported
DOTATATE and F-DOPA0Not reportedNot reportedNot reportedNot reported

Sporadic

Values in Participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
Primary Hyperparathyroidism - Incomplete Data456Not reportedNot reportedNot reportedNot reported
Primary Hyperparathyroidism419Not reportedNot reportedNot reportedNot reported
DOTATATE and F-DOPA0Not reportedNot reportedNot reportedNot reported

Unknown - insufficient information

Values in Participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
Primary Hyperparathyroidism - Incomplete Data27Not reportedNot reportedNot reportedNot reported
Primary Hyperparathyroidism89Not reportedNot reportedNot reportedNot reported
DOTATATE and F-DOPA0Not reportedNot reportedNot reportedNot reported
Complete source fields
classes
  1. categories
    1. measurements
      1. group Id
        OG000
        value
        90
      2. group Id
        OG001
        value
        276
      3. group Id
        OG002
        value
        19
      title
      MEN1
    2. measurements
      1. group Id
        OG000
        value
        61
      2. group Id
        OG001
        value
        116
      3. group Id
        OG002
        value
        0
      title
      Other familial
    3. measurements
      1. group Id
        OG000
        value
        456
      2. group Id
        OG001
        value
        419
      3. group Id
        OG002
        value
        0
      title
      Sporadic
    4. measurements
      1. group Id
        OG000
        value
        27
      2. group Id
        OG001
        value
        89
      3. group Id
        OG002
        value
        0
      title
      Unknown - insufficient information
denoms
  1. counts
    1. group Id
      OG000
      value
      634
    2. group Id
      OG001
      value
      900
    3. group Id
      OG002
      value
      19
    units
    Participants
description
The purpose of this study is to understand the causes of primary hyperparathyroidism, to evaluate and improve methods for diagnosis and treatment, and to provide insight into the mechanisms of normal parathyroid function. Hereditary causes of primary hyperparathyroidism will be characterized. Patients were categorized as follows: 1. MEN1: Diagnosed by demonstration of a germline variant in MEN1 gene or one of the following: a) two of three primary MEN1 manifestations b) one primary MEN1 manifestation with a family member with MEN1. 2. Other familial: Non-MEN1 patients who had a positive family history of hyperparathyroidism suspicious for underlying germline predisposition syndrome. 3. Sporadic: Patients who did not have a positive family history of hyperparathyroidism. 4. Unknown: No data to help categorize the patients in any of the above categories.
groups
  1. description
    Patients with confirmed or suspected primary hyperparathyroidism or complications who are missing age and other baseline data because of changes in data management system
    id
    OG000
    title
    Primary Hyperparathyroidism - Incomplete Data
  2. description
    Patients with confirmed or suspected primary hyperparathyroidism or complications
    id
    OG001
    title
    Primary Hyperparathyroidism
  3. description
    Patients scanned using imaging agents 68GALLIUM-DOTATATE and 18F-DOPA 68Ga-Dotatate: 68Ga-Dotatate PET/CT will be administered prior to a PET/CT scan to detect known and occult primary and metastatic bronchial, gastrointestinal and pancreatic neuroendocrine tumors. 18F-DOPA: 18F-DOPA PET/CT will be administered prior to a whole-body scan to detect known and occult primary and metastatic bronchial, gastrointestinal and pancreatic neuroendocrine tumors.
    id
    OG002
    title
    DOTATATE and F-DOPA
param Type
COUNT_OF_PARTICIPANTS
reporting Status
POSTED
time Frame
First year
title
Type of Hyperparathyroidism
type
PRIMARY
unit Of Measure
Participants

Download exact source JSON → · Snapshot ctgov-results-25a395029948b04d52b1253f

Preserved source evidence · Not medical advice