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DISEASE & TREATMENT SETTING

Soft Tissue Sarcoma

Source-derived catalogue. This is not a treatment recommendation or a personalised trial match.

Exact scope

Soft Tissue Sarcoma

Source population
Not part of this definition
Disease extent
Not part of this definition
Treatment line
Not part of this definition
Stage
Not part of this definition
Resectability
Not part of this definition
Biomarkers, prior therapy and derivation
molecular
    prior therapy
      derivation status
      unresolved
      derivation note
      Derived from NCI topic(s): Soft Tissue Sarcoma. Strongest NCIt resolution: ambiguous. Entity-level scope; stage, biomarker and treatment line are not yet part of this definition.
      source wording
      Source null
      9 more-specific settings

      Study evidence for this setting

      51 linked studies · Applicability is a draft source assessment, not a determination of your eligibility.

      NCT00112463 · Registry condition search · Scope: narrower

      Depsipeptide (Romidepsin) in Treating Patients With Metastatic or Unresectable Soft Tissue Sarcoma

      4 outcome links · 1 safety-group records · 0 quality-of-life measures

      →

      NCT00140855 · Registry condition search · Scope: narrower

      A Study of Anti-CTLA-4 Antibody in Patients With Advanced Synovial Sarcoma

      3 outcome links · 1 safety-group records · 0 quality-of-life measures

      →

      NCT00245102 · Registry condition search · Scope: narrower

      Sorafenib in Treating Patients With Metastatic, Locally Advanced, or Recurrent Sarcoma

      1 outcome links · 6 safety-group records · 0 quality-of-life measures

      →

      NCT00346164 · Source cited / selected · Scope: narrower

      Observation, Radiation Therapy, Combination Chemotherapy, and/or Surgery in Treating Young Patients With Soft Tissue Sarcoma

      6 outcome links · 4 safety-group records · 0 quality-of-life measures

      →

      NCT00354835 · Source cited / selected · Scope: narrower

      Combination Chemotherapy and Radiation Therapy in Treating Patients With Newly Diagnosed Rhabdomyosarcoma

      6 outcome links · 2 safety-group records · 0 quality-of-life measures

      →

      NCT00356031 · Registry condition search · Scope: narrower

      Bevacizumab and Radiation Therapy for Sarcomas

      6 outcome links · 1 safety-group records · 0 quality-of-life measures

      →

      NCT00390234 · Registry condition search · Scope: narrower

      Ziv-aflibercept in Treating Patients With Locally Advanced, Unresectable, or Metastatic Gynecologic Soft Tissue Sarcoma

      5 outcome links · 1 safety-group records · 0 quality-of-life measures

      →

      NCT00400569 · Registry condition search · Scope: narrower

      Phase II Study of Sunitinib Malate for Metastatic and/or Surgically Unresectable Soft Tissue Sarcoma

      4 outcome links · 1 safety-group records · 0 quality-of-life measures

      →

      NCT00525057 · Registry condition search · Scope: narrower

      Dalteparin in Preventing DVT in Participants With Cancer

      3 outcome links · 2 safety-group records · 0 quality-of-life measures

      →

      NCT00629343 · Registry condition search · Scope: narrower

      Phase I Dose-Escalation Study Of Azacitidine In Combination With Temozolomide

      2 outcome links · 3 safety-group records · 0 quality-of-life measures

      →

      NCT00659360 · Registry condition search · Scope: narrower

      AZD0530 in Treating Patients With Recurrent Locally Advanced or Metastatic Soft Tissue Sarcoma

      6 outcome links · 1 safety-group records · 0 quality-of-life measures

      →

      NCT00753688 · Source cited / selected · Scope: narrower

      Pazopanib Versus Placebo in Patients With Soft Tissue Sarcoma Whose Disease Has Progressed During or Following Prior Therapy

      6 outcome links · 2 safety-group records · 0 quality-of-life measures

      →

      NCT00831844 · Registry condition search · Scope: narrower

      Cixutumumab in Treating Patients With Relapsed or Refractory Solid Tumors

      1 outcome links · 10 safety-group records · 0 quality-of-life measures

      →

      NCT01055314 · Source cited / selected · Scope: narrower

      Temozolomide, Cixutumumab, and Combination Chemotherapy in Treating Patients With Metastatic Rhabdomyosarcoma

      5 outcome links · 2 safety-group records · 0 quality-of-life measures

      →

      NCT01079832 · Registry condition search · Scope: narrower

      Stereotactic Radiosurgery Using CyberKnife in Treating Women With Advanced or Recurrent Gynecological Malignancies

      5 outcome links · 1 safety-group records · 1 quality-of-life measures

      →

      NCT01154452 · Registry condition search · Scope: narrower

      Vismodegib and Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Advanced or Metastatic Sarcoma

      3 outcome links · 4 safety-group records · 0 quality-of-life measures

      →

      NCT01210222 · Registry condition search · Scope: narrower

      Trebananib in Treating Patients With Persistent or Recurrent Endometrial Cancer

      5 outcome links · 1 safety-group records · 0 quality-of-life measures

      →

      NCT01231906 · Source cited / selected · Scope: narrower

      Combination Chemotherapy in Treating Patients With Non-Metastatic Extracranial Ewing Sarcoma

      6 outcome links · 2 safety-group records · 0 quality-of-life measures

      →

      NCT01327885 · Source cited / selected · Scope: narrower

      Phase 3 Study to Compare the Efficacy and Safety of Eribulin With Dacarbazine in Subjects With Soft Tissue Sarcoma

      4 outcome links · 2 safety-group records · 1 quality-of-life measures

      →

      NCT01532687 · Registry condition search · Scope: narrower

      Gemcitabine With or Without Pazopanib in Treating Patients With Refractory Soft Tissue Sarcoma

      4 outcome links · 3 safety-group records · 0 quality-of-life measures

      →

      Indication-specific source history

      Dated source events, not confirmation of current approval for every use of a drug.

      2016-10-19 · Lartruvo (olaratumab) · accelerated approval
      release id
      clinical-indications-draft-1
      disease state id
      ds-soft-tissue-sarcoma
      event id
      fda-5bbe5ac7615f9f31
      event date
      2016-10-19
      event kind
      accelerated-approval
      drug or regimen
      Lartruvo (olaratumab)
      source indication text
      In combination with doxorubicin for adults with soft tissue sarcoma with a histologic subtype for which an anthracycline-containing regimen is appropriate and which is not amenable to curative treatment with radiotherapy or surgery
      match phrase
      soft tissue sarcoma
      match status
      candidate
      status category
      withdrawn
      has date discrepancy
      0
      source collection
      fda-status-row
      source key
      fda-aa-0bce2074ec71ddd1ede2
      source url
      https://www.fda.gov/drugs/resources-information-approved-drugs/withdrawn-cancer-accelerated-approvals
      curation status
      draft
      reviewed by
      Source null
      reviewed at
      Source null
      created at
      2026-09-10T00:00:00Z
      Original event source →
      2020-02-25 · Lartruvo (olaratumab) · withdrawal
      release id
      clinical-indications-draft-1
      disease state id
      ds-soft-tissue-sarcoma
      event id
      fda-04f1981cb409d228
      event date
      2020-02-25
      event kind
      withdrawal
      drug or regimen
      Lartruvo (olaratumab)
      source indication text
      In combination with doxorubicin for adults with soft tissue sarcoma with a histologic subtype for which an anthracycline-containing regimen is appropriate and which is not amenable to curative treatment with radiotherapy or surgery
      match phrase
      soft tissue sarcoma
      match status
      candidate
      status category
      withdrawn
      has date discrepancy
      0
      source collection
      fda-status-row
      source key
      fda-aa-0bce2074ec71ddd1ede2
      source url
      https://www.fda.gov/drugs/resources-information-approved-drugs/withdrawn-cancer-accelerated-approvals
      curation status
      draft
      reviewed by
      Source null
      reviewed at
      Source null
      created at
      2026-09-10T00:00:00Z
      Original event source →
      Source relationships and population-mapping limitations
      bindings
      1. release id
        clinical-indications-draft-1
        disease state id
        ds-soft-tissue-sarcoma
        binding id
        ncit-C115292
        source collection
        ncit-concept
        source key
        C115292
        source excerpt
        Source null
        match status
        ambiguous
        match note
        Resolution status: ambiguous.
        recorded at
        2026-09-10T00:00:00Z
      2. release id
        clinical-indications-draft-1
        disease state id
        ds-soft-tissue-sarcoma
        binding id
        ncit-C7707
        source collection
        ncit-concept
        source key
        C7707
        source excerpt
        Source null
        match status
        ambiguous
        match note
        Resolution status: ambiguous.
        recorded at
        2026-09-10T00:00:00Z
      3. release id
        clinical-indications-draft-1
        disease state id
        ds-soft-tissue-sarcoma
        binding id
        ncit-C7715
        source collection
        ncit-concept
        source key
        C7715
        source excerpt
        Source null
        match status
        ambiguous
        match note
        Resolution status: ambiguous.
        recorded at
        2026-09-10T00:00:00Z
      4. release id
        clinical-indications-draft-1
        disease state id
        ds-soft-tissue-sarcoma
        binding id
        ncit-C9306
        source collection
        ncit-concept
        source key
        C9306
        source excerpt
        Source null
        match status
        ambiguous
        match note
        Resolution status: ambiguous.
        recorded at
        2026-09-10T00:00:00Z
      mappings

        Download this complete draft source relationship record →

        Preserved source evidence · Not medical advice