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DISEASE & TREATMENT SETTING

Rectal Cancer

Source-derived catalogue. This is not a treatment recommendation or a personalised trial match.

Exact scope

Rectal Cancer

Source population
Not part of this definition
Disease extent
Not part of this definition
Treatment line
Not part of this definition
Stage
Not part of this definition
Resectability
Not part of this definition
Biomarkers, prior therapy and derivation
molecular
    prior therapy
      derivation status
      unresolved
      derivation note
      Derived from NCI topic(s): Rectal Cancer. Strongest NCIt resolution: ambiguous. Entity-level scope; stage, biomarker and treatment line are not yet part of this definition.
      source wording
      Source null
      8 more-specific settings

      Study evidence for this setting

      15 linked studies · Applicability is a draft source assessment, not a determination of your eligibility.

      NCT00587964 · Registry condition search · Scope: narrower

      Phase II Trial of Stereotactic Radiosurgery Boost Following Surgical Resection for Brain Metastases

      1 outcome links · 1 safety-group records · 0 quality-of-life measures

      →

      NCT01037790 · Registry condition search · Scope: narrower

      Phase II Trial of the Cyclin-Dependent Kinase Inhibitor PD 0332991 in Patients With Cancer

      1 outcome links · 5 safety-group records · 0 quality-of-life measures

      →

      NCT01558921 · Source cited / selected · Scope: narrower

      Rectal Cancer And Pre-operative Induction Therapy Followed by Dedicated Operation. The RAPIDO Trial

      6 outcome links · 2 safety-group records · 3 quality-of-life measures

      →

      NCT01769222 · Registry condition search · Scope: narrower

      Ipilimumab and Local Radiation for Selected Solid Tumors

      6 outcome links · 2 safety-group records · 0 quality-of-life measures

      →

      NCT01806675 · Registry condition search · Scope: narrower

      18F-FPPRGD2 PET/CT or PET/MRI in Predicting Early Response in Patients With Cancer Receiving Anti-Angiogenesis Therapy

      5 outcome links · 3 safety-group records · 1 quality-of-life measures

      →

      NCT02130427 · Registry condition search · Scope: narrower

      A Volume, Motion, and Anatomically Adaptive Approach to Photon and Proton Beam Radiotherapy

      1 outcome links · 1 safety-group records · 0 quality-of-life measures

      →

      NCT02728804 · Source cited / selected · Scope: narrower

      S1417CD Financial Impact Assessment Tool in Patients With Metastatic Colorectal Cancer

      6 outcome links · 1 safety-group records · 1 quality-of-life measures

      →

      NCT02966509 · Registry condition search · Scope: narrower

      Engagement of Patients With Advanced Cancer

      6 outcome links · 2 safety-group records · 0 quality-of-life measures

      →

      NCT03154190 · Registry condition search · Scope: narrower

      Health Care Coach Support in Reducing Acute Care Use and Cost in Patients With Cancer

      6 outcome links · 2 safety-group records · 0 quality-of-life measures

      →

      NCT03345563 · Registry condition search · Scope: narrower

      Project HERO: Health Empowerment & Recovery Outcomes

      2 outcome links · 3 safety-group records · 0 quality-of-life measures

      →

      NCT04066894 · Registry condition search · Scope: narrower

      Sacral Nerve Stimulation in Treating Low Anterior Resection Syndrome or Fecal Incontinence in Patients With Locally Advanced Rectal Cancer or Other Pelvic Cancer, the RESTORE Study

      6 outcome links · 1 safety-group records · 3 quality-of-life measures

      →

      NCT04267575 · Registry condition search · Scope: narrower

      Canady Helios Cold Plasma Scalpel Treatment at the Surgical Margin and Macroscopic Tumor Sites

      1 outcome links · 1 safety-group records · 0 quality-of-life measures

      →

      NCT04287868 · Registry condition search · Scope: narrower

      Combination Immunotherapy in Subjects With Advanced HPV Associated Malignancies

      6 outcome links · 2 safety-group records · 0 quality-of-life measures

      →

      NCT04432597 · Registry condition search · Scope: narrower

      HPV Vaccine PRGN-2009 Alone or in Combination With Anti-PDL1/TGF-Beta Trap (M7824) in Subjects With HPV Associated Cancers

      6 outcome links · 4 safety-group records · 0 quality-of-life measures

      →

      NCT04505553 · Registry condition search · Scope: narrower

      Oral Cryotherapy Plus Acupressure and Acupuncture Versus Oral Cryotherapy for Decreasing Chemotherapy-Induced Peripheral Neuropathy From Oxaliplatin-Based Chemotherapy in Patients

      6 outcome links · 2 safety-group records · 2 quality-of-life measures

      →

      Indication-specific source history

      Dated source events, not confirmation of current approval for every use of a drug.

      1996-06-14 · Camptosar (irinotecan hcl trihydrote) · accelerated approval
      release id
      clinical-indications-draft-1
      disease state id
      ds-rectal-cancer
      event id
      fda-6860d88588087217
      event date
      1996-06-14
      event kind
      accelerated-approval
      drug or regimen
      Camptosar (irinotecan hcl trihydrote)
      source indication text
      Metastatic colon or rectal carcinoma that progressed following 5-FU therapy
      match phrase
      rectal carcinoma
      match status
      candidate
      status category
      verified_clinical_benefit
      has date discrepancy
      0
      source collection
      fda-status-row
      source key
      fda-aa-b8b10cc9fc766ffd301b
      source url
      https://www.fda.gov/drugs/resources-information-approved-drugs/verified-clinical-benefit-cancer-accelerated-approvals
      curation status
      draft
      reviewed by
      Source null
      reviewed at
      Source null
      created at
      2026-09-10T00:00:00Z
      Original event source →
      1998-10-22 · Camptosar (irinotecan hcl trihydrote) · traditional approval
      release id
      clinical-indications-draft-1
      disease state id
      ds-rectal-cancer
      event id
      fda-0f7da73a7e39c5ff
      event date
      1998-10-22
      event kind
      traditional-approval
      drug or regimen
      Camptosar (irinotecan hcl trihydrote)
      source indication text
      Metastatic colon or rectal carcinoma that progressed following 5-FU therapy
      match phrase
      rectal carcinoma
      match status
      candidate
      status category
      verified_clinical_benefit
      has date discrepancy
      0
      source collection
      fda-status-row
      source key
      fda-aa-b8b10cc9fc766ffd301b
      source url
      https://www.fda.gov/drugs/resources-information-approved-drugs/verified-clinical-benefit-cancer-accelerated-approvals
      curation status
      draft
      reviewed by
      Source null
      reviewed at
      Source null
      created at
      2026-09-10T00:00:00Z
      Original event source →
      2002-08-09 · Eloxatin (oxaliplatin) · accelerated approval
      release id
      clinical-indications-draft-1
      disease state id
      ds-rectal-cancer
      event id
      fda-9baa71a66702ad23
      event date
      2002-08-09
      event kind
      accelerated-approval
      drug or regimen
      Eloxatin (oxaliplatin)
      source indication text
      In combination with infusional 5-FU/LV for metastatic color or rectal carcinoma that progressed during or within 6 months of completion of first-line therapy with bolus 5 -FU/LV and irinotectan
      match phrase
      rectal carcinoma
      match status
      candidate
      status category
      verified_clinical_benefit
      has date discrepancy
      0
      source collection
      fda-status-row
      source key
      fda-aa-595e13a3cedd3b1e4109
      source url
      https://www.fda.gov/drugs/resources-information-approved-drugs/verified-clinical-benefit-cancer-accelerated-approvals
      curation status
      draft
      reviewed by
      Source null
      reviewed at
      Source null
      created at
      2026-09-10T00:00:00Z
      Original event source →
      2004-01-09 · Eloxatin (oxaliplatin) · traditional approval
      release id
      clinical-indications-draft-1
      disease state id
      ds-rectal-cancer
      event id
      fda-57de062919b7610c
      event date
      2004-01-09
      event kind
      traditional-approval
      drug or regimen
      Eloxatin (oxaliplatin)
      source indication text
      In combination with infusional 5-FU/LV for metastatic color or rectal carcinoma that progressed during or within 6 months of completion of first-line therapy with bolus 5 -FU/LV and irinotectan
      match phrase
      rectal carcinoma
      match status
      candidate
      status category
      verified_clinical_benefit
      has date discrepancy
      0
      source collection
      fda-status-row
      source key
      fda-aa-595e13a3cedd3b1e4109
      source url
      https://www.fda.gov/drugs/resources-information-approved-drugs/verified-clinical-benefit-cancer-accelerated-approvals
      curation status
      draft
      reviewed by
      Source null
      reviewed at
      Source null
      created at
      2026-09-10T00:00:00Z
      Original event source →
      Source relationships and population-mapping limitations
      bindings
      1. release id
        clinical-indications-draft-1
        disease state id
        ds-rectal-cancer
        binding id
        ncit-C118823
        source collection
        ncit-concept
        source key
        C118823
        source excerpt
        Source null
        match status
        ambiguous
        match note
        Resolution status: ambiguous.
        recorded at
        2026-09-10T00:00:00Z
      2. release id
        clinical-indications-draft-1
        disease state id
        ds-rectal-cancer
        binding id
        ncit-C7418
        source collection
        ncit-concept
        source key
        C7418
        source excerpt
        Source null
        match status
        ambiguous
        match note
        Resolution status: ambiguous.
        recorded at
        2026-09-10T00:00:00Z
      3. release id
        clinical-indications-draft-1
        disease state id
        ds-rectal-cancer
        binding id
        ncit-C9382
        source collection
        ncit-concept
        source key
        C9382
        source excerpt
        Source null
        match status
        ambiguous
        match note
        Resolution status: ambiguous.
        recorded at
        2026-09-10T00:00:00Z
      mappings

        Download this complete draft source relationship record →

        Preserved source evidence · Not medical advice