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DISEASE & TREATMENT SETTING

Langerhans Cell Histiocytosis

Source-derived catalogue. This is not a treatment recommendation or a personalised trial match.

Exact scope

Langerhans Cell Histiocytosis

Source population
Not part of this definition
Disease extent
Not part of this definition
Treatment line
Not part of this definition
Stage
Not part of this definition
Resectability
Not part of this definition
Biomarkers, prior therapy and derivation
molecular
    prior therapy
      derivation status
      unresolved
      derivation note
      Derived from NCI topic(s): Langerhans Cell Histiocytosis. Strongest NCIt resolution: ambiguous. Entity-level scope; stage, biomarker and treatment line are not yet part of this definition.
      source wording
      Source null
      1 more-specific settings
      recurrent Langerhans Cell Histiocytosis →

      Study evidence for this setting

      6 linked studies · Applicability is a draft source assessment, not a determination of your eligibility.

      NCT01273766 · Registry condition search · Scope: narrower

      Deferasirox in Treating Iron Overload Caused By Blood Transfusions in Patients With Hematologic Malignancies

      3 outcome links · 3 safety-group records · 0 quality-of-life measures

      →

      NCT03096782 · Registry condition search · Scope: narrower

      Umbilical Cord Blood Transplant With Added Sugar and Chemotherapy and Radiation Therapy in Treating Patients With Leukemia or Lymphoma

      3 outcome links · 1 safety-group records · 0 quality-of-life measures

      →

      NCT03213665 · Source cited / selected · Scope: narrower

      Tazemetostat in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With EZH2, SMARCB1, or SMARCA4 Gene Mutations (A

      5 outcome links · 1 safety-group records · 0 quality-of-life measures

      →

      NCT03213678 · Registry condition search · Scope: narrower

      Samotolisib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With TSC or PI3K/MTOR Mutations (A Pediatric MATC

      6 outcome links · 1 safety-group records · 0 quality-of-life measures

      →

      NCT03213704 · Registry condition search · Scope: narrower

      Larotrectinib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With NTRK Fusions (A Pediatric MATCH Treatment

      5 outcome links · 1 safety-group records · 0 quality-of-life measures

      →

      NCT03698994 · Registry condition search · Scope: narrower

      Ulixertinib in Treating Patients With Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With MAPK Pathway Mutations (A Pediatric MATCH Treatment Trial)

      6 outcome links · 1 safety-group records · 0 quality-of-life measures

      →
      Source relationships and population-mapping limitations
      bindings
      1. release id
        clinical-indications-draft-1
        disease state id
        ds-langerhans-cell-histiocytosis
        binding id
        ncit-C114483
        source collection
        ncit-concept
        source key
        C114483
        source excerpt
        Source null
        match status
        ambiguous
        match note
        Resolution status: ambiguous.
        recorded at
        2026-09-10T00:00:00Z
      2. release id
        clinical-indications-draft-1
        disease state id
        ds-langerhans-cell-histiocytosis
        binding id
        ncit-C114929
        source collection
        ncit-concept
        source key
        C114929
        source excerpt
        Source null
        match status
        ambiguous
        match note
        Resolution status: ambiguous.
        recorded at
        2026-09-10T00:00:00Z
      3. release id
        clinical-indications-draft-1
        disease state id
        ds-langerhans-cell-histiocytosis
        binding id
        ncit-C3107
        source collection
        ncit-concept
        source key
        C3107
        source excerpt
        Source null
        match status
        ambiguous
        match note
        Resolution status: ambiguous.
        recorded at
        2026-09-10T00:00:00Z
      mappings

        Download this complete draft source relationship record →

        Preserved source evidence · Not medical advice