Skip to content
Triangle logo TriangleGet started
← All settings

DISEASE & TREATMENT SETTING

Cancer of Unknown Primary (CUP)

Source-derived catalogue. This is not a treatment recommendation or a personalised trial match.

Exact scope

Cancer of Unknown Primary (CUP)

Source population
Not part of this definition
Disease extent
Not part of this definition
Treatment line
Not part of this definition
Stage
Not part of this definition
Resectability
Not part of this definition
Biomarkers, prior therapy and derivation
molecular
    prior therapy
      derivation status
      clinically-proposed
      derivation note
      Derived from NCI topic(s): Cancer of Unknown Primary (CUP). Strongest NCIt resolution: candidate. Entity-level scope; stage, biomarker and treatment line are not yet part of this definition.
      source wording
      Source null
      2 more-specific settings
      Cancer of Unknown Primary (CUP) →recurrent Cancer of Unknown Primary (CUP) →

      Study evidence for this setting

      9 linked studies · Applicability is a draft source assessment, not a determination of your eligibility.

      NCT00588770 · Registry condition search · Scope: narrower

      Chemotherapy With or Without Bevacizumab in Treating Patients With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma

      5 outcome links · 2 safety-group records · 0 quality-of-life measures

      →

      NCT01256385 · Registry condition search · Scope: narrower

      Temsirolimus With or Without Cetuximab in Patients With Recurrent and/or Metastatic Head and Neck Cancer Who Did Not Respond to Previous Therapy

      6 outcome links · 2 safety-group records · 0 quality-of-life measures

      →

      NCT01274338 · Source cited / selected · Scope: narrower

      Ipilimumab or High-Dose Interferon Alfa-2b in Treating Patients With High-Risk Stage III-IV Melanoma That Has Been Removed by Surgery

      6 outcome links · 6 safety-group records · 3 quality-of-life measures

      →

      NCT02196168 · Registry condition search · Scope: narrower

      Cisplatin With or Without WEE1 Inhibitor MK-1775 in Treating Patients With Recurrent or Metastatic Head and Neck Cancer

      6 outcome links · 2 safety-group records · 0 quality-of-life measures

      →

      NCT02538510 · Registry condition search · Scope: narrower

      Pembrolizumab and Vorinostat in Treating Patients With Recurrent Squamous Cell Head and Neck Cancer or Salivary Gland Cancer That Is Metastatic and/or Cannot Be Removed by Surgery

      4 outcome links · 2 safety-group records · 0 quality-of-life measures

      →

      NCT02567422 · Registry condition search · Scope: narrower

      Testing the Addition of M6620 (VX-970, Berzosertib) to Usual Chemotherapy and Radiation for Head and Neck Cancer

      6 outcome links · 4 safety-group records · 0 quality-of-life measures

      →

      NCT02721732 · Registry condition search · Scope: narrower

      Pembrolizumab in Treating Patients With Rare Tumors That Cannot Be Removed by Surgery or Are Metastatic

      6 outcome links · 1 safety-group records · 0 quality-of-life measures

      →

      NCT03258554 · Registry condition search · Scope: narrower

      Radiation Therapy With Durvalumab or Cetuximab in Treating Patients With Locoregionally Advanced Head and Neck Cancer Who Cannot Take Cisplatin

      6 outcome links · 3 safety-group records · 12 quality-of-life measures

      →

      NCT05245682 · Registry condition search · Scope: narrower

      Tolinapant and Radiation for Cisplatin-Ineligible, Previously Untreated, Locally Advanced Head and Neck Cancer

      2 outcome links · 1 safety-group records · 0 quality-of-life measures

      →
      Source relationships and population-mapping limitations
      bindings
      1. release id
        clinical-indications-draft-1
        disease state id
        ds-cancer-of-unknown-primary-cup
        binding id
        ncit-C8566
        source collection
        ncit-concept
        source key
        C8566
        source excerpt
        Source null
        match status
        candidate
        match note
        Resolution status: candidate.
        recorded at
        2026-09-10T00:00:00Z
      mappings

        Download this complete draft source relationship record →

        Preserved source evidence · Not medical advice