{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","value":"0.57"}]}],"title":"Cardiac SUVR change (%) vs NTproBNP change (%)"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0.62"}]}],"title":"Scaled cardiac SUVR change (%) vs NTproBNP change (%)"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0.43"}]}],"title":"Cardiac SUVR change vs NTproBNP change (pg/mL)"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0.76"}]}],"title":"correlation with cardiac SUVR - Left Ventricular (LV) wall thickness (cm) (Repat Imaging)"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0.68"}]}],"title":"Correlation with cardiac SUVR - interventricular septum thickness (cm) (Repeat Imaging)"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0.54"}]}],"title":"Correlation with cardiac SUVR - global longitudinal strain (GLS)(%) (Repeat Imaging)"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0.65"}]}],"title":"Correlation with cardiac SUVR - NTproBNP (pg/mL) (Repeat Imaging)"},{"categories":[{"measurements":[{"groupId":"OG000","value":"-0.43"}]}],"title":"Correlation with renal SUVR - estimated glomerular filtration rate (eGFR) (Repeat Imaging)"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0.47"}]}],"title":"Correlation with renal SUVR - Creatinine (Repat Imaging)"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0.25"}]}],"title":"Correlation with renal SUVR - blood urea nitrogen (BUN) (Repeat Imaging)"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0.00"}]}],"title":"Correlation with renal SUVR - Urinary albumin/cre ratio (mg/g cre) (Repeat Imaging)"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0.06"}]}],"title":"Correlation with hepatic SUVR - Aspartate Aminotransferase (AST) (Repeat Imaging)"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0.18"}]}],"title":"Correlation with hepatic SUVR - Alanine transaminase (ALT) (Repeat Imaging)"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0.29"}]}],"title":"Correlation with hepatic SUVR - Alkaline phosphatase (Repeat Imaging)"}],"denoms":[{"counts":[{"groupId":"OG000","value":"19"}],"units":"Participants"}],"description":"For AL, ATTR and all patients, we will correlate visual and quantitative changes in 124I- AT-01 uptake, from baseline, in the heart, liver and kidney with echocardiographic parameters (including left ventricular wall thickness (cm), intraventricular wall thickness (cm), and global logitudinal strain (%)) and serum biomarker levels (including NTproBNP, eGFR, creatinine, AST and ALT) assessed prior to imaging and from data recorded in the patients' medical record.","groups":[{"description":"Experimental: Patients will receive a single IV injection of 124I-AT-01 radiotracer and PET/CT imaging\n\nIn this repeat imaging study, patients previously enrolled in the AMY1001 study, in whom positive PET/CT imaging findings were observed will undergo repeat imaging to assess changes in radiotracer uptake in the liver, spleen, heart and kidneys.","id":"OG000","title":"All Participants"}],"paramType":"NUMBER","populationDescription":"For serum biomarker (NT-proBNP), correlations are reported for both the absolute repeat values and the change from baseline. Because echocardiographic data was not available from the baseline imaging session, the correlation for echocardiographic parameters was performed using absolute values at repeat imaging.","reportingStatus":"POSTED","timeFrame":"Baseline (assessed during previous study NCT03678259) and Repeat Assessment (Day 1 to Day 2 of current study)","title":"Measures of Interest","type":"OTHER_PRE_SPECIFIED","unitOfMeasure":"spearman correlation coefficient"}