{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","value":"16"}],"title":"No change in visual uptake"},{"measurements":[{"groupId":"OG000","value":"1"}],"title":"With visual increase"},{"measurements":[{"groupId":"OG000","value":"2"}],"title":"Decrease in visual uptake"}],"title":"Heart"},{"categories":[{"measurements":[{"groupId":"OG000","value":"12"}],"title":"No change in visual uptake"},{"measurements":[{"groupId":"OG000","value":"1"}],"title":"With visual increase"},{"measurements":[{"groupId":"OG000","value":"6"}],"title":"Decrease in visual uptake"}],"title":"Liver"},{"categories":[{"measurements":[{"groupId":"OG000","value":"14"}],"title":"No change in visual uptake"},{"measurements":[{"groupId":"OG000","value":"0"}],"title":"With visual increase"},{"measurements":[{"groupId":"OG000","value":"5"}],"title":"Decrease in visual uptake"}],"title":"Spleen"},{"categories":[{"measurements":[{"groupId":"OG000","value":"14"}],"title":"No change in visual uptake"},{"measurements":[{"groupId":"OG000","value":"4"}],"title":"With visual increase"},{"measurements":[{"groupId":"OG000","value":"1"}],"title":"Decrease in visual uptake"}],"title":"Kidney"}],"denoms":[{"counts":[{"groupId":"OG000","value":"19"}],"units":"Participants"}],"description":"The goal of this research study is to determine whether changes in organ-specific uptake of 124I- AT-01 can be measured by PET/CT imaging and further, whether these values correlate with changes in a subject's disease status and thereby enable monitoring of disease response over time in terms of organ-specific amyloid load. The specific aim of this study is to measure visual and quantitative changes in organ-specific uptake of 124I-AT-01 from baseline, in patients with systemic amyloidosis, using PET/CT imaging","groups":[{"description":"Experimental: Patients will receive a single IV injection of 124I-AT-01 radiotracer and PET/CT imaging In this repeat imaging study, patients previously enrolled in the AMY1001 study, in whom positive PET/CT imaging findings were observed will undergo repeat imaging to assess changes in radiotracer uptake in the liver, spleen, heart and kidneys.","id":"OG000","title":"All Participants"}],"paramType":"COUNT_OF_PARTICIPANTS","populationDescription":"Summary of change in visual radiotracer uptake from baseline PET/CT imaging","reportingStatus":"POSTED","timeFrame":"Baseline PET/CT imaging from AMY1001 (NCT03678259) and repeat PET/CT imaging on Day 2 of the current study","title":"To Measure Visual Changes and Quantitative Changes in Organ-specific Uptake of 124I-AT-01","type":"PRIMARY","unitOfMeasure":"Participants"}