{"analyses":[{"ciLowerLimit":"0.468","ciNumSides":"TWO_SIDED","ciPctValue":"95","ciUpperLimit":"0.768","estimateComment":"Hazard ratios and 95% CIs are estimated using a stratified Cox proportional hazards model; a hazard ratio \\<1.0 indicates a better survival of tarlatamab arm.","groupIds":["OG000","OG001"],"nonInferiorityType":"SUPERIORITY","pValue":"<0.001","pValueComment":"P-value is calculated using a stratified log-rank test.","paramType":"Hazard Ratio (HR)","paramValue":"0.599","statisticalMethod":"Stratified log-rank test"}],"classes":[{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"7.0","upperLimit":"10.2","value":"8.3"},{"comment":"Upper CI was not calculable due to insufficient event data occurring above the median.","groupId":"OG001","lowerLimit":"11.1","upperLimit":"NA","value":"13.6"}]}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"255"},{"groupId":"OG001","value":"254"}],"units":"Participants"}],"description":"OS was defined as time from randomization until death from any cause. Median overall survival was estimated using Kaplan-Meier method. 95% confidence intervals (CIs) were calculated using the Brookmeyer and Crowley method.","dispersionType":"95% Confidence Interval","groups":[{"description":"Participants were randomized to receive treatment according to the local SOC chemotherapy (lurbinectedin, topotecan, or amrubicin \\[Japan only\\]) in 21-day cycles.","id":"OG000","title":"Standard of Care (SOC)"},{"description":"Participants were randomized to receive tarlatamab as an IV infusion: A step dose of 1 mg on Cycle 1 Day 1 followed by the target dose 10 mg on Cycle 1 Day 8, Cycle 1 Day 15, and Q2W thereafter.","id":"OG001","title":"Tarlatamab 1 mg to 10 mg Q2W"}],"paramType":"MEDIAN","populationDescription":"The ITT analysis set included all randomized participants.","reportingStatus":"POSTED","timeFrame":"From randomization up to minimum of death or primary completion DCO date 29 January 2025; median (min, max) time on the study was 8.6 (0.1, 18.5) months","title":"Overall Survival (OS)","type":"PRIMARY","unitOfMeasure":"months"}